JP7373997B2 - 睡眠時無呼吸を治療する方法及び組成物 - Google Patents

睡眠時無呼吸を治療する方法及び組成物 Download PDF

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Publication number
JP7373997B2
JP7373997B2 JP2019558554A JP2019558554A JP7373997B2 JP 7373997 B2 JP7373997 B2 JP 7373997B2 JP 2019558554 A JP2019558554 A JP 2019558554A JP 2019558554 A JP2019558554 A JP 2019558554A JP 7373997 B2 JP7373997 B2 JP 7373997B2
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oxybutynin
atomoxetine
composition
sleep
dosage
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JP2020517719A5 (enExample
JP2020517719A (ja
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ウェルマン,ディー.アンドリュー
タラント-モンテムロ,ルイジ
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Brigham and Womens Hospital Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2019558554A 2017-04-28 2018-04-26 睡眠時無呼吸を治療する方法及び組成物 Active JP7373997B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023108387A JP2023139000A (ja) 2017-04-28 2023-06-30 睡眠時無呼吸を治療する方法及び組成物
JP2025128090A JP2025169279A (ja) 2017-04-28 2025-07-31 睡眠時無呼吸を治療する方法及び組成物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762491504P 2017-04-28 2017-04-28
US62/491,504 2017-04-28
US201762558814P 2017-09-14 2017-09-14
US62/558,814 2017-09-14
PCT/US2018/029518 WO2018200775A1 (en) 2017-04-28 2018-04-26 Methods and compositions for treating sleep apnea

Related Child Applications (1)

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JP2023108387A Division JP2023139000A (ja) 2017-04-28 2023-06-30 睡眠時無呼吸を治療する方法及び組成物

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JP2020517719A JP2020517719A (ja) 2020-06-18
JP2020517719A5 JP2020517719A5 (enExample) 2021-06-10
JP7373997B2 true JP7373997B2 (ja) 2023-11-06

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JP2019558554A Active JP7373997B2 (ja) 2017-04-28 2018-04-26 睡眠時無呼吸を治療する方法及び組成物
JP2023108387A Pending JP2023139000A (ja) 2017-04-28 2023-06-30 睡眠時無呼吸を治療する方法及び組成物
JP2025128090A Pending JP2025169279A (ja) 2017-04-28 2025-07-31 睡眠時無呼吸を治療する方法及び組成物

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JP2023108387A Pending JP2023139000A (ja) 2017-04-28 2023-06-30 睡眠時無呼吸を治療する方法及び組成物
JP2025128090A Pending JP2025169279A (ja) 2017-04-28 2025-07-31 睡眠時無呼吸を治療する方法及び組成物

Country Status (22)

Country Link
US (4) US11123313B2 (enExample)
EP (1) EP3615016A4 (enExample)
JP (3) JP7373997B2 (enExample)
KR (3) KR102682159B1 (enExample)
CN (2) CN110799181A (enExample)
AU (3) AU2018260666B2 (enExample)
BR (1) BR112019022483A2 (enExample)
CA (1) CA3061468A1 (enExample)
CO (1) CO2019013180A2 (enExample)
CR (1) CR20190546A (enExample)
DO (1) DOP2019000274A (enExample)
EC (1) ECSP19084058A (enExample)
GE (4) GEAP202416602A (enExample)
MA (1) MA49069A (enExample)
MX (2) MX394941B (enExample)
MY (1) MY200172A (enExample)
NI (1) NI201900110A (enExample)
PH (1) PH12019502427A1 (enExample)
SG (2) SG10202111623TA (enExample)
UA (1) UA127759C2 (enExample)
WO (1) WO2018200775A1 (enExample)
ZA (1) ZA201907158B (enExample)

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US11123313B2 (en) * 2017-04-28 2021-09-21 The Brigham And Women's Hospital, Inc. Methods and compositions for treating sleep apnea
CA3089712A1 (en) * 2018-01-30 2019-08-08 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea
CN108309261B (zh) * 2018-02-11 2020-05-22 西安交通大学 一种猝死预警方法及装置和系统
US20190381056A1 (en) 2018-06-17 2019-12-19 Axsome Therapeutics, Inc. Compositions for delivery of reboxetine
US11020402B2 (en) 2018-10-15 2021-06-01 Axsome Therapeutics, Inc. Use of reboxetine to treat narcolepsy
US20200147093A1 (en) 2018-10-15 2020-05-14 Axsome Therapeutics, Inc. Use of esreboxetine to treat nervous system disorders such as fibromyalgia
MX2021004883A (es) * 2018-10-31 2021-08-05 Apnimed Inc Delaware Metodos y composiciones para tratar apnea del sue?o.
CA3129270A1 (en) 2019-02-08 2020-08-13 The Brigham And Women's Hospital, Inc. Methods and compositions for treating sleep apnea
US20220362221A1 (en) * 2019-11-04 2022-11-17 Apnimed, Inc. (Delaware) Combination pharmacological interventions for multiple mechanisms of obstructive sleep apnea
CA3177654A1 (en) 2020-05-05 2021-11-11 Dennis MOLNAR Polymorphic forms of (r)-oxybutynin hydrochloride
CN114159568B (zh) * 2020-09-11 2025-08-01 北京原基华毅生物科技有限公司 Sik抑制剂在制备用于预防和/或治疗睡眠障碍的药物中的应用
RU2757470C1 (ru) * 2020-11-19 2021-10-18 Ренат Рашитович Ахмеров Способ лечения храпа с помощью введения тромбоцитарной аутологичной плазмы
US20240075035A1 (en) * 2021-01-14 2024-03-07 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea
AU2022231133A1 (en) * 2021-03-04 2023-09-21 Apnimed, Inc. (Delaware) Combination of reboxetine and a muscarinic receptor antagonist (mra) for use in treating sleep apnea
US20240189328A1 (en) * 2021-04-16 2024-06-13 Apnimed, Inc. (Delaware) Combination of norepinephrine reuptake inhibitor and a cannabinoid for use in treating sleep apnea
BR112023026158A2 (pt) * 2021-06-17 2024-03-05 Apnimed Inc Delaware Inibidores da recaptação de norepinefrina para tratamento da apneia do sono
CN117956959A (zh) * 2021-08-31 2024-04-30 爱普宁公司(特拉华) 用于治疗睡眠呼吸暂停的方法和组合物
CA3259605A1 (en) * 2021-12-22 2023-06-29 Bayer Aktiengesellschaft Combination of a task1/3 channel blocker with a norepinephrine reuptake inhibitor for the treatment of sleep apnea
CA3259602A1 (en) 2021-12-22 2023-06-29 Bayer Aktiengesellschaft Combination of an .alpha.2-adrenoceptor subtype c (alpha-2c) antagonists with a muscarinic receptor antagonist for the treatment of sleep apnea
CN118475347A (zh) 2021-12-22 2024-08-09 拜耳公司 用于治疗睡眠呼吸暂停的α2-肾上腺素受体亚型C(α-2C)拮抗剂与降肾上腺素重摄取抑制剂的结合物
EP4522149A1 (en) * 2022-05-13 2025-03-19 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea

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CN107007602A (zh) * 2011-01-28 2017-08-04 辉达斯医学研究所 治疗阻塞性睡眠呼吸暂停的方法
US11123313B2 (en) * 2017-04-28 2021-09-21 The Brigham And Women's Hospital, Inc. Methods and compositions for treating sleep apnea
CA3089712A1 (en) * 2018-01-30 2019-08-08 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea

Patent Citations (1)

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Also Published As

Publication number Publication date
ZA201907158B (en) 2021-09-29
DOP2019000274A (es) 2019-12-30
US20240261239A1 (en) 2024-08-08
US20200054583A1 (en) 2020-02-20
CN110799181A (zh) 2020-02-14
MA49069A (fr) 2020-03-04
KR102682159B1 (ko) 2024-07-08
UA127759C2 (uk) 2023-12-27
ECSP19084058A (es) 2020-01-31
JP2025169279A (ja) 2025-11-12
JP2020517719A (ja) 2020-06-18
KR20190140019A (ko) 2019-12-18
NI201900110A (es) 2020-03-18
SG10202111623TA (en) 2021-12-30
CR20190546A (es) 2020-04-08
CA3061468A1 (en) 2018-11-01
CO2019013180A2 (es) 2020-02-07
GEAP202416602A (en) 2024-10-10
US20240189261A1 (en) 2024-06-13
MX2019012729A (es) 2019-12-19
AU2018260666A1 (en) 2019-11-14
SG11201909973UA (en) 2019-11-28
KR20240042261A (ko) 2024-04-01
GEP20247617B (en) 2024-04-25
WO2018200775A1 (en) 2018-11-01
CN119185558A (zh) 2024-12-27
AU2022241471A1 (en) 2022-10-27
AU2018260666B2 (en) 2022-07-21
AU2025230729A1 (en) 2025-10-02
GEP20227387B (en) 2022-06-10
BR112019022483A2 (pt) 2020-05-12
GEP20257788B (en) 2025-08-25
US11123313B2 (en) 2021-09-21
US20210401777A1 (en) 2021-12-30
JP2023139000A (ja) 2023-10-03
NZ758564A (en) 2023-12-22
MX2022010349A (es) 2022-09-19
MX394941B (es) 2025-03-24
EP3615016A1 (en) 2020-03-04
KR20250145704A (ko) 2025-10-13
MY200172A (en) 2023-12-12
EP3615016A4 (en) 2021-02-24
PH12019502427A1 (en) 2020-10-05

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