MX2022010349A - Metodos y composiciones para el tratamiento de apnea del sue?o. - Google Patents

Metodos y composiciones para el tratamiento de apnea del sue?o.

Info

Publication number
MX2022010349A
MX2022010349A MX2022010349A MX2022010349A MX2022010349A MX 2022010349 A MX2022010349 A MX 2022010349A MX 2022010349 A MX2022010349 A MX 2022010349A MX 2022010349 A MX2022010349 A MX 2022010349A MX 2022010349 A MX2022010349 A MX 2022010349A
Authority
MX
Mexico
Prior art keywords
compositions
methods
sleep apnea
treating sleep
nri
Prior art date
Application number
MX2022010349A
Other languages
English (en)
Inventor
D Andrew Wellman
Luigi Taranto-Montemurro
Original Assignee
Brigham & Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63918622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2022010349(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Brigham & Womens Hospital Inc filed Critical Brigham & Womens Hospital Inc
Publication of MX2022010349A publication Critical patent/MX2022010349A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Métodos y composiciones para el tratamiento de afecciones asociadas al colapso muscular de la vía aérea faríngea mientras el sujeto está en un estado no completamente consciente, por ejemplo, apnea del sueño y ronquidos, que comprende la administración de un inhibidor de la recaptación de noradrenalina (NRI) y un antagonista de los receptores muscarínicos.
MX2022010349A 2017-04-28 2019-10-24 Metodos y composiciones para el tratamiento de apnea del sue?o. MX2022010349A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762491504P 2017-04-28 2017-04-28
US201762558814P 2017-09-14 2017-09-14

Publications (1)

Publication Number Publication Date
MX2022010349A true MX2022010349A (es) 2022-09-19

Family

ID=63918622

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019012729A MX2019012729A (es) 2017-04-28 2018-04-26 Metodos y composiciones para el tratamiento de apnea del sue?o.
MX2022010349A MX2022010349A (es) 2017-04-28 2019-10-24 Metodos y composiciones para el tratamiento de apnea del sue?o.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019012729A MX2019012729A (es) 2017-04-28 2018-04-26 Metodos y composiciones para el tratamiento de apnea del sue?o.

Country Status (22)

Country Link
US (4) US11123313B2 (es)
EP (1) EP3615016A4 (es)
JP (2) JP7373997B2 (es)
KR (2) KR20240042261A (es)
CN (1) CN110799181A (es)
AU (2) AU2018260666B2 (es)
BR (1) BR112019022483A2 (es)
CA (1) CA3061468A1 (es)
CO (1) CO2019013180A2 (es)
CR (1) CR20190546A (es)
DO (1) DOP2019000274A (es)
EC (1) ECSP19084058A (es)
GE (2) GEP20247617B (es)
MA (1) MA49069A (es)
MX (2) MX2019012729A (es)
MY (1) MY200172A (es)
NI (1) NI201900110A (es)
PH (1) PH12019502427A1 (es)
SG (2) SG11201909973UA (es)
UA (1) UA127759C2 (es)
WO (1) WO2018200775A1 (es)
ZA (1) ZA201907158B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20190546A (es) * 2017-04-28 2020-04-08 Brigham & Womens Hospital Inc Métodos y composiciones para tratar la apnea del sueño
CA3089712A1 (en) * 2018-01-30 2019-08-08 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea
CN108309261B (zh) * 2018-02-11 2020-05-22 西安交通大学 一种猝死预警方法及装置和系统
US20190381056A1 (en) 2018-06-17 2019-12-19 Axsome Therapeutics, Inc. Compositions for delivery of reboxetine
CN112930179A (zh) * 2018-10-31 2021-06-08 爱普宁公司(特拉华) 治疗睡眠呼吸暂停的方法和组合物
EA202192202A1 (ru) * 2019-02-08 2021-11-03 Дзе Брихэм Энд Уимен'З Хоспитал, Инк. Способы и композиции для лечения синдрома обструктивного апноэ, возникающего во сне
US20220362221A1 (en) * 2019-11-04 2022-11-17 Apnimed, Inc. (Delaware) Combination pharmacological interventions for multiple mechanisms of obstructive sleep apnea
RU2757470C1 (ru) * 2020-11-19 2021-10-18 Ренат Рашитович Ахмеров Способ лечения храпа с помощью введения тромбоцитарной аутологичной плазмы
US20240075035A1 (en) * 2021-01-14 2024-03-07 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea
US20240139200A1 (en) * 2021-03-04 2024-05-02 Apnimed, Inc. (Delaware) Combination of reboxetine and a muscarinic receptor antagonist (mra) for use in treating sleep apnea
US20240189328A1 (en) * 2021-04-16 2024-06-13 Apnimed, Inc. (Delaware) Combination of norepinephrine reuptake inhibitor and a cannabinoid for use in treating sleep apnea
CA3221848A1 (en) * 2021-06-17 2022-12-22 Apnimed, Inc. (Delaware) Norepinephrine reuptake inhibitors for treating sleep apnea
CA3230016A1 (en) * 2021-08-31 2023-03-09 David P. White Methods and compositions for treating sleep apnea
AU2022422053A1 (en) 2021-12-22 2024-07-11 Bayer Aktiengesellschaft COMBINATION OF AN α2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS WITH A MUSCARINIC RECEPTOR ANTAGONIST FOR THE TREATMENT OF SLEEP APNEA
AU2022422284A1 (en) * 2021-12-22 2024-07-04 Bayer Aktiengesellschaft Combination of a task1/3 channel blocker with a norepinephrine reuptake inhibitor for the treatment of sleep apnea
CN118475347A (zh) 2021-12-22 2024-08-09 拜耳公司 用于治疗睡眠呼吸暂停的α2-肾上腺素受体亚型C（α-2C）拮抗剂与降肾上腺素重摄取抑制剂的结合物
WO2023219991A1 (en) * 2022-05-13 2023-11-16 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003500354A (ja) 1999-05-20 2003-01-07 セプラコール， インク． Ｓ−オキシブチニンを用いる喘息の治療方法
CN1660435A (zh) * 2000-02-24 2005-08-31 法玛西雅厄普约翰美国公司 新的药物联合形式
US20060039866A1 (en) * 2004-08-20 2006-02-23 Cypress Bioscience, Inc. Method for treating sleep-related breathing disorders
AU2005319367B2 (en) * 2004-12-20 2012-05-24 Collegium Pharmaceutical, Inc. Pharmaceutical compositions for sleep disorders
CA2825309C (en) * 2011-01-28 2019-10-01 Pfantastic Medical Research Institute, Llc Pyridostigmine for the treatment of obstructive sleep apnea
CR20190546A (es) * 2017-04-28 2020-04-08 Brigham & Womens Hospital Inc Métodos y composiciones para tratar la apnea del sueño
CA3089712A1 (en) * 2018-01-30 2019-08-08 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea

Also Published As

Publication number Publication date
ECSP19084058A (es) 2020-01-31
NI201900110A (es) 2020-03-18
MX2019012729A (es) 2019-12-19
NZ758564A (en) 2023-12-22
US20240189261A1 (en) 2024-06-13
ZA201907158B (en) 2021-09-29
AU2022241471A1 (en) 2022-10-27
WO2018200775A1 (en) 2018-11-01
KR20240042261A (ko) 2024-04-01
CA3061468A1 (en) 2018-11-01
PH12019502427A1 (en) 2020-10-05
US20240261239A1 (en) 2024-08-08
KR102682159B1 (ko) 2024-07-08
DOP2019000274A (es) 2019-12-30
SG10202111623TA (en) 2021-12-30
GEP20247617B (en) 2024-04-25
JP7373997B2 (ja) 2023-11-06
US11123313B2 (en) 2021-09-21
KR20190140019A (ko) 2019-12-18
SG11201909973UA (en) 2019-11-28
GEP20227387B (en) 2022-06-10
EP3615016A4 (en) 2021-02-24
US20210401777A1 (en) 2021-12-30
UA127759C2 (uk) 2023-12-27
CR20190546A (es) 2020-04-08
EP3615016A1 (en) 2020-03-04
BR112019022483A2 (pt) 2020-05-12
AU2018260666B2 (en) 2022-07-21
JP2020517719A (ja) 2020-06-18
US20200054583A1 (en) 2020-02-20
MY200172A (en) 2023-12-12
CN110799181A (zh) 2020-02-14
AU2018260666A1 (en) 2019-11-14
MA49069A (fr) 2020-03-04
JP2023139000A (ja) 2023-10-03
CO2019013180A2 (es) 2020-02-07

Similar Documents

Publication Publication Date Title
PH12019502427A1 (en) Methods and compositions for treating sleep apnea
MX2021009407A (es) Métodos y composiciones para el tratamiento de la apnea del sueño.
GEP20227366B (en) Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
PH12018501235A1 (en) 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders
MX2024001713A (es) Metodos y composiciones para tratar la apnea del sue?o.
PH12019501408A1 (en) Pharmaceutical dosage forms containing task-1 and task-3 channel inhibitors, and the use of same in breathing disorder therapy
WO2014120936A3 (en) Treatments for depression and other diseases with a low dose agent
PH12019501458A1 (en) Pharmaceutical dosage forms containing task-1 and task-3 channel inhibitors, and the use of same in breathing disorder therapy
MX2021004883A (es) Metodos y composiciones para tratar apnea del sue?o.
MX2021003428A (es) Antagonistas del receptor adrenérgico a2 subtipo c (alfa-2c) para el tratamiento de la apnea del sueño.
AU2012334804A8 (en) Modulators of C3a receptors
MX2016008027A (es) Uso de laquinimod para retrasar la evolucion de la enfermedad de huntington.
WO2016025671A3 (en) Treatment of sleep apnea with a combination of a carbonic anhydrase inhibitor and an aldosterone antagonist
MX2021006081A (es) Proceso para la produccion de formas farmaceuticas que contienen inhibidores de los canales task-1 y task-3 y su uso para la terapia de trastornos respiratorios.
MX2021001845A (es) Un medicamento combinado que comprende fenilefrina y paracetamol.
EA201992569A1 (ru) Способы и композиции для лечения апноэ во сне
NZ758564B2 (en) Methods and compositions for treating sleep apnea
JOP20210113A1 (ar) مناهضات لمستقبلات ألفا 2 الأدرينالية من النمط الثانوي سي (ألفا-2سي) لمعالجة انقطاع النفس أثناء النوم
PH12014501390A1 (en) Novel therapeutic use of p75 receptor antagonists
EA201991538A1 (ru) Фармацевтические лекарственные формы, содержащие ингибиторы каналов task-1 и task-3, и их применение для лечения нарушений дыхания
EA201991540A1 (ru) Фармацевтические лекарственные формы, содержащие ингибиторы каналов task-1 и task-3 и их применение для лечения нарушений дыхания
AU2017902725A0 (en) Alleviation of Snoring and Sleep Apnoea by Elastic Tension-Induced mandibular Advancement
EA201990341A1 (ru) Замещенные диазагетеробициклические соединения и их применение
UA72830U (ru) Способ лечения синдрома раздраженного кишечника в сочетании с хроническим обструктивным заболеванием легких