JP7369693B2 - てんかん性の疾患、障害、または病態の処置に使用するためのプロベネシド - Google Patents

てんかん性の疾患、障害、または病態の処置に使用するためのプロベネシド Download PDF

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JP7369693B2
JP7369693B2 JP2020523047A JP2020523047A JP7369693B2 JP 7369693 B2 JP7369693 B2 JP 7369693B2 JP 2020523047 A JP2020523047 A JP 2020523047A JP 2020523047 A JP2020523047 A JP 2020523047A JP 7369693 B2 JP7369693 B2 JP 7369693B2
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acid
epilepsy
day
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probenecid
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JP2020527172A (ja
JP2020527172A5 (enExample
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ロウチ,ナタリー
ドッシ,エレナ
フバーフェルド,ギレ
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Universite Paris Cite
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2020523047A 2017-07-13 2018-07-13 てんかん性の疾患、障害、または病態の処置に使用するためのプロベネシド Active JP7369693B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17305934.6 2017-07-13
EP17305934.6A EP3427729A1 (en) 2017-07-13 2017-07-13 Probenecid for use in treating epileptic diseases, disorders or conditions
PCT/EP2018/069092 WO2019012109A1 (en) 2017-07-13 2018-07-13 PROBENECID FOR USE IN THE TREATMENT OF EPILEPTIC DISEASES, DISORDERS OR DISORDERS

Publications (3)

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JP2020527172A JP2020527172A (ja) 2020-09-03
JP2020527172A5 JP2020527172A5 (enExample) 2021-08-12
JP7369693B2 true JP7369693B2 (ja) 2023-10-26

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JP2020523047A Active JP7369693B2 (ja) 2017-07-13 2018-07-13 てんかん性の疾患、障害、または病態の処置に使用するためのプロベネシド

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US (2) US12318358B2 (enExample)
EP (2) EP3427729A1 (enExample)
JP (1) JP7369693B2 (enExample)
CN (2) CN111386107A (enExample)
CA (1) CA3070178A1 (enExample)
WO (1) WO2019012109A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12128034B2 (en) 2020-03-11 2024-10-29 Iterum Therapeutics International Limited Combinations of beta-lactam compounds, probenecid, and valproic acid and uses thereof
TWI804037B (zh) * 2021-11-02 2023-06-01 長庚醫療財團法人高雄長庚紀念醫院 生酮飲食之評估系統及其運作方法
EP4505999A1 (en) 2023-08-07 2025-02-12 Panntherapi Probenecid formulations

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US902695A (en) 1907-12-31 1908-11-03 Stasia B Staley Package-tie.
JPS586027A (ja) 1981-07-01 1983-01-13 住友電気工業株式会社 高圧ケ−ブルの接続部
GB2104078B (en) 1981-08-14 1985-01-23 London Polytech New aminoacid isomers, their production and their medicinal use
HUT40447A (en) 1984-03-29 1986-12-28 Sandoz Ag Process for preparing substituted alpha-amino acids and pharmaceutical compositions containing such compounds
CA1248531A (en) 1984-04-17 1989-01-10 Jeffrey C. Watkins 4-substituted piperazine-2-carboxylic acids
US4906621A (en) 1985-05-24 1990-03-06 Ciba-Geigy Corporation Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
US4746653A (en) 1986-02-28 1988-05-24 Ciba-Geigy Corporation Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
US4657899A (en) 1986-04-09 1987-04-14 Nova Pharmaceutical Corporation Antagonists of specific excitatory amino acid neurotransmitter receptors
IE66149B1 (en) 1986-09-16 1995-12-13 Novo Nordisk As Quinoxaline compounds and their preparation and use
US4812458A (en) 1986-09-16 1989-03-14 A/S Ferrosan 6,7-disubstituted-2,3-dihydroxyquinoxaline compounds, pharmaceutical compositions thereof, and their use as neuroleptics
US4705781A (en) 1986-10-08 1987-11-10 Giba-Geigy Corporation Method of treating cerebral ischemia using 4-(phosphono substituted lower alkyl or lower alkenyl)piperazine-2-carboxylic acids and salts, esters and amides thereof
GB8625941D0 (en) 1986-10-30 1986-12-03 Sandoz Ltd Substituted alpha-amino acids
IL84492A0 (en) 1986-11-21 1988-04-29 Ciba Geigy Ag Unsaturated phosphonic acids and derivatives
GB8703749D0 (en) 1987-02-18 1987-03-25 Sandoz Ltd Piperazinecarboxylic acid
US4761405A (en) 1987-03-04 1988-08-02 Nova Pharmaceutical Corporation Antagonists of specific excitatory amino acid neurotransmitter receptors having increased potency
DK146787A (da) 1987-03-23 1988-09-24 Ferrosan Heterocykliske forbindelser, deres fremstilling og anvendelse
PH27591A (en) 1987-08-04 1993-08-31 Ciba Geigy Ag A process for the manufacture of novel unsaturated amino acid compound
GB8719102D0 (en) 1987-08-12 1987-09-16 Merck Sharp & Dohme Therapeutic agents
US4918064A (en) 1987-10-21 1990-04-17 G. D. Searle & Co. Phenyl glycines for use in reducing neurotoxic injury
NO179551C (no) 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
GB8727792D0 (en) 1987-11-27 1987-12-31 Merck Sharp & Dohme Therapeutic agents
US4904681A (en) 1987-12-01 1990-02-27 G. D. Searle & Co. D-cycloserine and its prodrugs as cognitive enhancers
US4968678A (en) 1988-02-19 1990-11-06 Eli Lilly And Company Tetrazole excitatory amino acid receptor antagonists
JPH0210544A (ja) 1988-06-29 1990-01-16 Canon Inc 光磁気記憶装置
EP0342558B1 (en) 1988-05-16 1994-02-02 G.D. Searle & Co. 2-amino-4,5-methyleneadipic acid compounds for treatment of CNS disorders
DK160941C (da) 1988-06-28 1991-10-21 Novo Nordisk As Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar
GB8823605D0 (en) 1988-10-07 1988-11-16 Merck Sharp & Dohme Therapeutic agents
CA2000901A1 (en) 1988-10-21 1990-04-21 Alexis A. Cordi Phosphono-hydroisoquinoline compounds useful in reducing neurotoxic injury
DK715888D0 (da) 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
DK716188D0 (da) 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
US5187171A (en) 1989-01-09 1993-02-16 G. D. Searle & Co. Use of a glycine b partial agonist as an antipsychotic
US4902695A (en) 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
DE69029668T2 (de) 1989-03-08 1997-08-07 Merck Sharp & Dohme Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten
US5061721A (en) 1989-03-15 1991-10-29 G. D. Searle & Co. Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder
US4902687A (en) 1989-03-27 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
ATE112282T1 (de) 1989-04-07 1994-10-15 Ciba Geigy Ag Ungesättigte aminodicarbonsäurederivate.
GB8908529D0 (en) 1989-04-14 1989-06-01 Merck Sharp & Dohme Therapeutic agents
US4960786A (en) 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
JPH0347123A (ja) 1989-05-05 1991-02-28 G D Searle & Co インドール―2―カルボキシレート化合物類を含有するcns疾患治療用組成物
CA2025326C (en) 1989-09-19 2001-04-24 Jeffrey P. Whitten Nmda antagonists
EP0420806B1 (de) 1989-09-26 1995-07-05 Ciba-Geigy Ag Phosphonsäure, Verfahren zur Herstellung und Verwendung als Arzneimittelwirkstoff
DK0501378T3 (da) * 1991-02-28 1995-03-20 Merrell Dow Pharma NMDA-antagonister
ATE162075T1 (de) 1991-09-09 1998-01-15 Warner Lambert Co Pharmazeutisches kombinationspräparat, das ein uricosurisches mittel und einen excitatorischen aminosäure-antagonisten enthält
US5318985A (en) * 1991-12-20 1994-06-07 Merrell Dow Pharmaceuticals Inc. Potentiation of NMDA antagonists

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Brain Research Bulletin,1992年,Vol.28,pp.233-238
CNS & Neurological Disorders-Drug Targets,2013年,vol.12,pp.1050-1065
Neuropharmacology,2004年,vol.47,pp.916-925

Also Published As

Publication number Publication date
RU2020106762A3 (enExample) 2021-11-10
CN120478323A (zh) 2025-08-15
CN111386107A (zh) 2020-07-07
EP3651758A1 (en) 2020-05-20
JP2020527172A (ja) 2020-09-03
US12318358B2 (en) 2025-06-03
EP3427729A1 (en) 2019-01-16
US20250288544A1 (en) 2025-09-18
RU2020106762A (ru) 2021-08-13
WO2019012109A1 (en) 2019-01-17
US20200163916A1 (en) 2020-05-28
CA3070178A1 (en) 2019-01-17

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