JP7369693B2 - てんかん性の疾患、障害、または病態の処置に使用するためのプロベネシド - Google Patents
てんかん性の疾患、障害、または病態の処置に使用するためのプロベネシド Download PDFInfo
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- JP7369693B2 JP7369693B2 JP2020523047A JP2020523047A JP7369693B2 JP 7369693 B2 JP7369693 B2 JP 7369693B2 JP 2020523047 A JP2020523047 A JP 2020523047A JP 2020523047 A JP2020523047 A JP 2020523047A JP 7369693 B2 JP7369693 B2 JP 7369693B2
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- Prior art keywords
- acid
- epilepsy
- day
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- probenecid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305934.6 | 2017-07-13 | ||
| EP17305934.6A EP3427729A1 (en) | 2017-07-13 | 2017-07-13 | Probenecid for use in treating epileptic diseases, disorders or conditions |
| PCT/EP2018/069092 WO2019012109A1 (en) | 2017-07-13 | 2018-07-13 | PROBENECID FOR USE IN THE TREATMENT OF EPILEPTIC DISEASES, DISORDERS OR DISORDERS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527172A JP2020527172A (ja) | 2020-09-03 |
| JP2020527172A5 JP2020527172A5 (enExample) | 2021-08-12 |
| JP7369693B2 true JP7369693B2 (ja) | 2023-10-26 |
Family
ID=59384111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020523047A Active JP7369693B2 (ja) | 2017-07-13 | 2018-07-13 | てんかん性の疾患、障害、または病態の処置に使用するためのプロベネシド |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12318358B2 (enExample) |
| EP (2) | EP3427729A1 (enExample) |
| JP (1) | JP7369693B2 (enExample) |
| CN (2) | CN111386107A (enExample) |
| CA (1) | CA3070178A1 (enExample) |
| WO (1) | WO2019012109A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12128034B2 (en) | 2020-03-11 | 2024-10-29 | Iterum Therapeutics International Limited | Combinations of beta-lactam compounds, probenecid, and valproic acid and uses thereof |
| TWI804037B (zh) * | 2021-11-02 | 2023-06-01 | 長庚醫療財團法人高雄長庚紀念醫院 | 生酮飲食之評估系統及其運作方法 |
| EP4505999A1 (en) | 2023-08-07 | 2025-02-12 | Panntherapi | Probenecid formulations |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US902695A (en) | 1907-12-31 | 1908-11-03 | Stasia B Staley | Package-tie. |
| JPS586027A (ja) | 1981-07-01 | 1983-01-13 | 住友電気工業株式会社 | 高圧ケ−ブルの接続部 |
| GB2104078B (en) | 1981-08-14 | 1985-01-23 | London Polytech | New aminoacid isomers, their production and their medicinal use |
| HUT40447A (en) | 1984-03-29 | 1986-12-28 | Sandoz Ag | Process for preparing substituted alpha-amino acids and pharmaceutical compositions containing such compounds |
| CA1248531A (en) | 1984-04-17 | 1989-01-10 | Jeffrey C. Watkins | 4-substituted piperazine-2-carboxylic acids |
| US4906621A (en) | 1985-05-24 | 1990-03-06 | Ciba-Geigy Corporation | Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade |
| US4746653A (en) | 1986-02-28 | 1988-05-24 | Ciba-Geigy Corporation | Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals |
| US4657899A (en) | 1986-04-09 | 1987-04-14 | Nova Pharmaceutical Corporation | Antagonists of specific excitatory amino acid neurotransmitter receptors |
| IE66149B1 (en) | 1986-09-16 | 1995-12-13 | Novo Nordisk As | Quinoxaline compounds and their preparation and use |
| US4812458A (en) | 1986-09-16 | 1989-03-14 | A/S Ferrosan | 6,7-disubstituted-2,3-dihydroxyquinoxaline compounds, pharmaceutical compositions thereof, and their use as neuroleptics |
| US4705781A (en) | 1986-10-08 | 1987-11-10 | Giba-Geigy Corporation | Method of treating cerebral ischemia using 4-(phosphono substituted lower alkyl or lower alkenyl)piperazine-2-carboxylic acids and salts, esters and amides thereof |
| GB8625941D0 (en) | 1986-10-30 | 1986-12-03 | Sandoz Ltd | Substituted alpha-amino acids |
| IL84492A0 (en) | 1986-11-21 | 1988-04-29 | Ciba Geigy Ag | Unsaturated phosphonic acids and derivatives |
| GB8703749D0 (en) | 1987-02-18 | 1987-03-25 | Sandoz Ltd | Piperazinecarboxylic acid |
| US4761405A (en) | 1987-03-04 | 1988-08-02 | Nova Pharmaceutical Corporation | Antagonists of specific excitatory amino acid neurotransmitter receptors having increased potency |
| DK146787A (da) | 1987-03-23 | 1988-09-24 | Ferrosan | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| PH27591A (en) | 1987-08-04 | 1993-08-31 | Ciba Geigy Ag | A process for the manufacture of novel unsaturated amino acid compound |
| GB8719102D0 (en) | 1987-08-12 | 1987-09-16 | Merck Sharp & Dohme | Therapeutic agents |
| US4918064A (en) | 1987-10-21 | 1990-04-17 | G. D. Searle & Co. | Phenyl glycines for use in reducing neurotoxic injury |
| NO179551C (no) | 1987-11-10 | 1996-10-30 | Novo Nordisk As | Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser |
| GB8727792D0 (en) | 1987-11-27 | 1987-12-31 | Merck Sharp & Dohme | Therapeutic agents |
| US4904681A (en) | 1987-12-01 | 1990-02-27 | G. D. Searle & Co. | D-cycloserine and its prodrugs as cognitive enhancers |
| US4968678A (en) | 1988-02-19 | 1990-11-06 | Eli Lilly And Company | Tetrazole excitatory amino acid receptor antagonists |
| JPH0210544A (ja) | 1988-06-29 | 1990-01-16 | Canon Inc | 光磁気記憶装置 |
| EP0342558B1 (en) | 1988-05-16 | 1994-02-02 | G.D. Searle & Co. | 2-amino-4,5-methyleneadipic acid compounds for treatment of CNS disorders |
| DK160941C (da) | 1988-06-28 | 1991-10-21 | Novo Nordisk As | Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar |
| GB8823605D0 (en) | 1988-10-07 | 1988-11-16 | Merck Sharp & Dohme | Therapeutic agents |
| CA2000901A1 (en) | 1988-10-21 | 1990-04-21 | Alexis A. Cordi | Phosphono-hydroisoquinoline compounds useful in reducing neurotoxic injury |
| DK715888D0 (da) | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| DK716188D0 (da) | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| US5187171A (en) | 1989-01-09 | 1993-02-16 | G. D. Searle & Co. | Use of a glycine b partial agonist as an antipsychotic |
| US4902695A (en) | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| DE69029668T2 (de) | 1989-03-08 | 1997-08-07 | Merck Sharp & Dohme | Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten |
| US5061721A (en) | 1989-03-15 | 1991-10-29 | G. D. Searle & Co. | Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
| US4902687A (en) | 1989-03-27 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| ATE112282T1 (de) | 1989-04-07 | 1994-10-15 | Ciba Geigy Ag | Ungesättigte aminodicarbonsäurederivate. |
| GB8908529D0 (en) | 1989-04-14 | 1989-06-01 | Merck Sharp & Dohme | Therapeutic agents |
| US4960786A (en) | 1989-04-24 | 1990-10-02 | Merrell Dow Pharmaceuticals Inc. | Excitatory amino acid antagonists |
| JPH0347123A (ja) | 1989-05-05 | 1991-02-28 | G D Searle & Co | インドール―2―カルボキシレート化合物類を含有するcns疾患治療用組成物 |
| CA2025326C (en) | 1989-09-19 | 2001-04-24 | Jeffrey P. Whitten | Nmda antagonists |
| EP0420806B1 (de) | 1989-09-26 | 1995-07-05 | Ciba-Geigy Ag | Phosphonsäure, Verfahren zur Herstellung und Verwendung als Arzneimittelwirkstoff |
| DK0501378T3 (da) * | 1991-02-28 | 1995-03-20 | Merrell Dow Pharma | NMDA-antagonister |
| ATE162075T1 (de) | 1991-09-09 | 1998-01-15 | Warner Lambert Co | Pharmazeutisches kombinationspräparat, das ein uricosurisches mittel und einen excitatorischen aminosäure-antagonisten enthält |
| US5318985A (en) * | 1991-12-20 | 1994-06-07 | Merrell Dow Pharmaceuticals Inc. | Potentiation of NMDA antagonists |
-
2017
- 2017-07-13 EP EP17305934.6A patent/EP3427729A1/en not_active Withdrawn
-
2018
- 2018-07-13 CN CN201880059798.3A patent/CN111386107A/zh active Pending
- 2018-07-13 CA CA3070178A patent/CA3070178A1/en active Pending
- 2018-07-13 US US16/630,114 patent/US12318358B2/en active Active
- 2018-07-13 CN CN202510416283.6A patent/CN120478323A/zh active Pending
- 2018-07-13 JP JP2020523047A patent/JP7369693B2/ja active Active
- 2018-07-13 EP EP18739857.3A patent/EP3651758A1/en active Pending
- 2018-07-13 WO PCT/EP2018/069092 patent/WO2019012109A1/en not_active Ceased
-
2025
- 2025-05-30 US US19/223,794 patent/US20250288544A1/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| Brain Research Bulletin,1992年,Vol.28,pp.233-238 |
| CNS & Neurological Disorders-Drug Targets,2013年,vol.12,pp.1050-1065 |
| Neuropharmacology,2004年,vol.47,pp.916-925 |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2020106762A3 (enExample) | 2021-11-10 |
| CN120478323A (zh) | 2025-08-15 |
| CN111386107A (zh) | 2020-07-07 |
| EP3651758A1 (en) | 2020-05-20 |
| JP2020527172A (ja) | 2020-09-03 |
| US12318358B2 (en) | 2025-06-03 |
| EP3427729A1 (en) | 2019-01-16 |
| US20250288544A1 (en) | 2025-09-18 |
| RU2020106762A (ru) | 2021-08-13 |
| WO2019012109A1 (en) | 2019-01-17 |
| US20200163916A1 (en) | 2020-05-28 |
| CA3070178A1 (en) | 2019-01-17 |
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