JP7365238B2 - ５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用 - Google Patents

５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用 Download PDF

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JP7365238B2
JP7365238B2 JP2019552238A JP2019552238A JP7365238B2 JP 7365238 B2 JP7365238 B2 JP 7365238B2 JP 2019552238 A JP2019552238 A JP 2019552238A JP 2019552238 A JP2019552238 A JP 2019552238A JP 7365238 B2 JP7365238 B2 JP 7365238B2
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ethyl
hexahydropyrrolo
pyrrol
diethyl
dihydrofuran
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ベンジャミン イー． ブラス，
ダニエル ジェイ． キャニー，
ケビン エム． ブラットナー，
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Temple Univ School of Medicine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019552238A 2017-03-21 2018-03-15 ５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用 Active JP7365238B2 (ja)

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JP2023174457A JP7705909B2 (ja) 2017-03-21 2023-10-06 ５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用

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US201762474280P 2017-03-21 2017-03-21
US62/474,280 2017-03-21
PCT/US2018/022581 WO2018175190A1 (en) 2017-03-21 2018-03-15 5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents

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JP2020511515A5 JP2020511515A5 (https=) 2021-04-22
JP7365238B2 true JP7365238B2 (ja) 2023-10-19

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JP2023174457A Active JP7705909B2 (ja) 2017-03-21 2023-10-06 ５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用

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US (3) US11220505B2 (https=)
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Publication number Priority date Publication date Assignee Title
JP2023168623A (ja) * 2017-03-21 2023-11-24 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション シグマ－２受容体の新規調節物質およびその使用方法

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EP2970223B1 (en) 2013-03-11 2020-04-15 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
US10544117B2 (en) 2014-09-10 2020-01-28 Temple University—Of the Commonwealth System of Higher Education 5-hydroxytryptamine receptor 7 activity modulators and their method of use
AU2017361078B2 (en) 2016-11-15 2022-01-06 Praeventix, Llc Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use
MA49017A (fr) * 2017-03-21 2020-02-05 Univ Temple Modulateurs du récepteur 7 de la 5-hydroxytryptamine et utilisation de ces derniers en tant qu'agents thérapeutiques
EA202092328A1 (ru) 2018-05-11 2021-04-08 Темпл Юниверсити-Оф Зэ Коммонвелс Систем Оф Хаер Эдьюкейшн Новые функционализированные лактамы в качестве модуляторов 5-гидрокситриптаминового рецептора 7 и способ их применения
GB201809295D0 (en) * 2018-06-06 2018-07-25 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
CN112010859B (zh) * 2019-05-30 2022-07-19 中国科学院上海药物研究所 一种并环化合物、其制备方法和用途
WO2021097117A2 (en) * 2019-11-13 2021-05-20 Temple University-Of The Commonwealth System Of Higher Education Novel functionalized lactones as modulators of the 5-hydroxytryptamine receptor 7 and their method of use
JP7730811B2 (ja) * 2019-11-13 2025-08-28 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション ５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクタムおよびその使用方法

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WO2016183150A1 (en) 2015-05-12 2016-11-17 Temple University-Of The Commonwealth System Of Higher Education Novel sigma-2 receptor binders and their method of use
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JP2019535825A (ja) 2016-11-15 2019-12-12 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイションＴｅｍｐｌｅ Ｕｎｉｖｅｒｓｉｔｙ−Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ ５−ヒドロキシトリプタミン受容体７の新規調節因子およびその使用方法
JP2020511506A (ja) 2017-03-21 2020-04-16 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイションＴｅｍｐｌｅ Ｕｎｉｖｅｒｓｉｔｙ−Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ シグマ−２受容体の新規調節物質およびその使用方法

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EA202092328A1 (ru) 2018-05-11 2021-04-08 Темпл Юниверсити-Оф Зэ Коммонвелс Систем Оф Хаер Эдьюкейшн Новые функционализированные лактамы в качестве модуляторов 5-гидрокситриптаминового рецептора 7 и способ их применения

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JP2010509402A (ja) 2006-11-13 2010-03-25 キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド Ａ１アデノシン受容体のアロステリック調節剤
JP2011519936A (ja) 2008-05-09 2011-07-14 アボット・ラボラトリーズ ニューロンニコチン受容体のための選択的リガンドおよびこれらの使用
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WO2014164756A1 (en) 2013-03-11 2014-10-09 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
JP2016540792A (ja) 2013-12-20 2016-12-28 ラボラトリオス・デル・デエレ・エステベ・エセ・ア 疼痛に対して多重モードの活性を有するピペラジン誘導体
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WO2016183150A1 (en) 2015-05-12 2016-11-17 Temple University-Of The Commonwealth System Of Higher Education Novel sigma-2 receptor binders and their method of use
JP2019535825A (ja) 2016-11-15 2019-12-12 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイションＴｅｍｐｌｅ Ｕｎｉｖｅｒｓｉｔｙ−Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ ５−ヒドロキシトリプタミン受容体７の新規調節因子およびその使用方法
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2023168623A (ja) * 2017-03-21 2023-11-24 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション シグマ－２受容体の新規調節物質およびその使用方法
JP7781122B2 (ja) 2017-03-21 2025-12-05 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション シグマ－２受容体の新規調節物質およびその使用方法

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Publication number Publication date
EP3600289A4 (en) 2020-08-05
JP7705909B2 (ja) 2025-07-10
JP2023168626A (ja) 2023-11-24
EP3600289A1 (en) 2020-02-05
US20220348581A1 (en) 2022-11-03
US20200331915A1 (en) 2020-10-22
US12338245B2 (en) 2025-06-24
US11807642B2 (en) 2023-11-07
US11220505B2 (en) 2022-01-11
WO2018175190A1 (en) 2018-09-27
JP2020511515A (ja) 2020-04-16
US20240300953A1 (en) 2024-09-12
MA49017A (fr) 2020-02-05

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