JP7355730B2 - ゲノムを修飾するための組成物及び方法 - Google Patents
ゲノムを修飾するための組成物及び方法 Download PDFInfo
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- JP7355730B2 JP7355730B2 JP2020507102A JP2020507102A JP7355730B2 JP 7355730 B2 JP7355730 B2 JP 7355730B2 JP 2020507102 A JP2020507102 A JP 2020507102A JP 2020507102 A JP2020507102 A JP 2020507102A JP 7355730 B2 JP7355730 B2 JP 7355730B2
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/825—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving pigment biosynthesis
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8262—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield involving plant development
- C12N15/8269—Photosynthesis
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
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- C07K2319/00—Fusion polypeptide
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2510/00—Genetically modified cells
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- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
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- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023155533A JP2023169897A (ja) | 2017-08-09 | 2023-09-21 | ゲノムを修飾するための組成物及び方法 |
| JP2025152643A JP2025185269A (ja) | 2017-08-09 | 2025-09-12 | ゲノムを修飾するための組成物及び方法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762542983P | 2017-08-09 | 2017-08-09 | |
| US62/542,983 | 2017-08-09 | ||
| US201762551958P | 2017-08-30 | 2017-08-30 | |
| US62/551,958 | 2017-08-30 | ||
| US201762565255P | 2017-09-29 | 2017-09-29 | |
| US62/565,255 | 2017-09-29 | ||
| US201762599226P | 2017-12-15 | 2017-12-15 | |
| US62/599,226 | 2017-12-15 | ||
| PCT/IB2018/055972 WO2019030695A1 (en) | 2017-08-09 | 2018-08-08 | Compositions and methods for modifying genomes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023155533A Division JP2023169897A (ja) | 2017-08-09 | 2023-09-21 | ゲノムを修飾するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020533963A JP2020533963A (ja) | 2020-11-26 |
| JP2020533963A5 JP2020533963A5 (https=) | 2021-09-16 |
| JP7355730B2 true JP7355730B2 (ja) | 2023-10-03 |
Family
ID=63592761
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020507102A Active JP7355730B2 (ja) | 2017-08-09 | 2018-08-08 | ゲノムを修飾するための組成物及び方法 |
| JP2023155533A Pending JP2023169897A (ja) | 2017-08-09 | 2023-09-21 | ゲノムを修飾するための組成物及び方法 |
| JP2025152643A Pending JP2025185269A (ja) | 2017-08-09 | 2025-09-12 | ゲノムを修飾するための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023155533A Pending JP2023169897A (ja) | 2017-08-09 | 2023-09-21 | ゲノムを修飾するための組成物及び方法 |
| JP2025152643A Pending JP2025185269A (ja) | 2017-08-09 | 2025-09-12 | ゲノムを修飾するための組成物及び方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US10316324B2 (https=) |
| EP (3) | EP3665279B1 (https=) |
| JP (3) | JP7355730B2 (https=) |
| KR (3) | KR20250050118A (https=) |
| CN (2) | CN111373040B (https=) |
| AU (2) | AU2018315731B2 (https=) |
| BR (1) | BR112020002647A2 (https=) |
| CA (2) | CA3072312C (https=) |
| ES (1) | ES2960390T3 (https=) |
| IL (2) | IL310452A (https=) |
| WO (1) | WO2019030695A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| CA3038960A1 (en) | 2016-09-30 | 2018-04-05 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
| JP7306696B2 (ja) | 2016-09-30 | 2023-07-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Rna誘導型核酸修飾酵素及びその使用方法 |
| JP7355730B2 (ja) * | 2017-08-09 | 2023-10-03 | ベンソン ヒル,インコーポレイティド | ゲノムを修飾するための組成物及び方法 |
| CN111263810A (zh) | 2017-08-22 | 2020-06-09 | 纳匹基因公司 | 使用多核苷酸指导的核酸内切酶的细胞器基因组修饰 |
| JP2021503278A (ja) | 2017-11-01 | 2021-02-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | CasZ組成物及び使用方法 |
| WO2019089808A1 (en) | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Class 2 crispr/cas compositions and methods of use |
| WO2019089804A1 (en) | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Casy compositions and methods of use |
| EP3830301B1 (en) | 2018-08-01 | 2024-05-22 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
| US11407995B1 (en) * | 2018-10-26 | 2022-08-09 | Inari Agriculture Technology, Inc. | RNA-guided nucleases and DNA binding proteins |
| EP3931313A2 (en) | 2019-01-04 | 2022-01-05 | Mammoth Biosciences, Inc. | Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection |
| US20230002761A1 (en) * | 2019-11-19 | 2023-01-05 | Benson Hill, Inc. | Anti-bacterial crispr compositions and methods |
| CN111100868B (zh) * | 2019-12-17 | 2021-05-25 | 南京林业大学 | 美洲黑杨的促雌基因ferr和抑雌基因ferr-r及其应用 |
| EP3878958A1 (en) | 2020-03-11 | 2021-09-15 | B.R.A.I.N. Biotechnology Research And Information Network AG | Crispr-cas nucleases from cpr-enriched metagenome |
| EP4159853A4 (en) * | 2020-05-28 | 2023-11-15 | ShanghaiTech University | GENOME EDITING SYSTEM AND METHOD |
| CN113930413B (zh) * | 2020-06-29 | 2024-12-27 | 中国农业大学 | 新型CRISPR-Cas12j.23酶和系统 |
| CN113930411A (zh) * | 2020-06-29 | 2022-01-14 | 中国农业大学 | 新型CRISPR-Cas12M酶和系统 |
| EP3943600A1 (en) | 2020-07-21 | 2022-01-26 | B.R.A.I.N. Biotechnology Research And Information Network AG | Novel, non-naturally occurring crispr-cas nucleases for genome editing |
| US20240376451A1 (en) * | 2021-01-07 | 2024-11-14 | Inscripta, Inc. | Mad nucleases |
| IL305545A (en) | 2021-03-02 | 2023-10-01 | BRAIN Biotech AG | Novel CRISPR-CAS nucleases from metagenomics |
| US20220389418A1 (en) * | 2021-06-01 | 2022-12-08 | Helmholtz-Institut Für Rna-Basierte Nfektionsforschung (Hzi) | Rna-guided cas nucleases and uses thereof in diagnostics and therapy |
| EP4215611A1 (en) | 2022-01-19 | 2023-07-26 | BRAIN Biotech AG | Modification of the genome of a filamentous fungus |
| EP4466347A1 (en) * | 2022-01-19 | 2024-11-27 | BRAIN Biotech AG | Depletion of cells by crispr nucleases |
| EP4215612A1 (en) * | 2022-01-20 | 2023-07-26 | Sartorius Stedim Cellca GmbH | Genome editing with crispr/cas nucleases comprising collateral activity |
| CN115588463B (zh) * | 2022-10-26 | 2025-08-08 | 杭州师范大学 | 基于深度学习挖掘蛋白质相互作用类型的预测方法 |
| EP4361265A1 (en) * | 2022-10-27 | 2024-05-01 | BRAIN Biotech AG | Optimization of editing efficacy of crispr nucleases with collateral activity |
| EP4646475A1 (en) * | 2023-01-04 | 2025-11-12 | BRAIN Biotech AG | Activated bec nucleases for degrading nucleic acid molecules |
| US20260085302A1 (en) | 2024-09-20 | 2026-03-26 | Confluence Genetics, Llc | Compositions and methods for controlling plant pests |
| CN119246486B (zh) * | 2024-12-06 | 2025-04-01 | 南京师范大学 | 一种Cas蛋白在食用油鉴别中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017141173A2 (en) | 2016-02-15 | 2017-08-24 | Benson Hill Biosystems, Inc. | Compositions and methods for modifying genomes |
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