JP7352284B2 - ＬＳＤ－１インヒビターとしてのピロロ〔２，３－ｃ〕ピリジン及び関連類似体 - Google Patents

ＬＳＤ－１インヒビターとしてのピロロ〔２，３－ｃ〕ピリジン及び関連類似体 Download PDF

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JP7352284B2
JP7352284B2 JP2019563164A JP2019563164A JP7352284B2 JP 7352284 B2 JP7352284 B2 JP 7352284B2 JP 2019563164 A JP2019563164 A JP 2019563164A JP 2019563164 A JP2019563164 A JP 2019563164A JP 7352284 B2 JP7352284 B2 JP 7352284B2
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cancer
hydrogen
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JP2020519667A5 (enExample
JP2020519667A (ja
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ワン シャオメン
チャン トンヨウ
チェン ツァンホイ
チェン チュオ
リウ リウ
ホアン リーユエ
ヤン チャオ－イエ
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University of Michigan System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2019563164A 2017-05-15 2018-05-15 ＬＳＤ－１インヒビターとしてのピロロ〔２，３－ｃ〕ピリジン及び関連類似体 Active JP7352284B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762506349P 2017-05-15 2017-05-15
US62/506,349 2017-05-15
PCT/US2018/032619 WO2018213211A1 (en) 2017-05-15 2018-05-15 Pyrrolo[2,3-c]pyridines and related analogs as lsd-1 inhibitors

Publications (3)

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JP2020519667A JP2020519667A (ja) 2020-07-02
JP2020519667A5 JP2020519667A5 (enExample) 2021-07-26
JP7352284B2 true JP7352284B2 (ja) 2023-09-28

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JP2019563164A Active JP7352284B2 (ja) 2017-05-15 2018-05-15 ＬＳＤ－１インヒビターとしてのピロロ〔２，３－ｃ〕ピリジン及び関連類似体

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US (1) US11168082B2 (enExample)
EP (1) EP3628044B1 (enExample)
JP (1) JP7352284B2 (enExample)
CN (1) CN110914265B (enExample)
AU (2) AU2018269947B2 (enExample)
WO (1) WO2018213211A1 (enExample)

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US11944614B2 (en) * 2018-05-15 2024-04-02 Regents Of The University Of Michigan Imidazo[4,5-c]pyridine compounds as LSD-1 inhibitors
US20220151998A1 (en) 2019-03-20 2022-05-19 Oryzon Genomics, S.A. Methods of treating borderline personality disorder
US20220151999A1 (en) 2019-03-20 2022-05-19 Oryzon Genomics, S.A. Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat
US20220227763A1 (en) 2019-05-29 2022-07-21 Syngenta Crop Protection Ag Microbiocidal derivatives
CN112451671B (zh) * 2020-12-02 2021-11-02 武汉大学 KDM1A在抑制RNA病毒刺激下干扰素IFNβ表达中的应用
CA3231846A1 (en) 2021-04-08 2022-10-13 Tamara Maes Combinations of lsd1 inhibitors for treating myeloid cancers
CN116102533A (zh) * 2021-11-11 2023-05-12 中国科学院上海药物研究所 一种芳杂环类化合物及其应用
JP2025503099A (ja) * 2022-01-25 2025-01-30 成都苑▲東▼生物制▲薬▼股▲ふん▼有限公司 ピリジン系誘導体、その製造方法及び使用
EP4522136A1 (en) 2022-05-09 2025-03-19 Oryzon Genomics, S.A. Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors
CN119497613A (zh) 2022-05-09 2025-02-21 奥莱松基因组股份有限公司 使用lsd1抑制剂治疗nf1-突变肿瘤的方法
IL318791A (en) * 2022-08-22 2025-04-01 Redx Pharma Ltd Pyridopyrazoles as DDR'S inhibitors for the treatment of lipid disorders and cancer
WO2024110649A1 (en) 2022-11-24 2024-05-30 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors and menin inhibitors for treating cancer
WO2024208187A1 (zh) * 2023-04-03 2024-10-10 上海复星医药（集团）股份有限公司 氮杂芳基化合物及其作为lsd1抑制剂的用途
WO2025072637A1 (en) * 2023-09-28 2025-04-03 The Regents Of The University Of Michigan Oxygenated heterocyclic lsd-1 inhibitors and related methods of use

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WO2000001697A1 (en) 1998-07-02 2000-01-13 Du Pont Pharmaceuticals Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
JP2002507996A (ja) 1997-07-03 2002-03-12 デュポン ファーマシューティカルズ カンパニー 神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類
JP2008540664A (ja) 2005-05-16 2008-11-20 アイアールエム・リミテッド・ライアビリティ・カンパニー タンパク質キナーゼ阻害剤としてのピロロピリジン誘導体
JP2009523812A (ja) 2006-01-19 2009-06-25 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド 融合へテロ二環式キナーゼ阻害剤
JP2010508363A (ja) 2006-11-01 2010-03-18 バーテックス ファーマシューティカルズ インコーポレイテッド ヤヌスキナーゼの阻害剤として有用な三環系ヘテロアリール化合物
JP2010528026A (ja) 2007-05-18 2010-08-19 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｐｉ３キナーゼ阻害物質としてのキノリン誘導体
JP2010537998A (ja) 2007-08-27 2010-12-09 ワイス・エルエルシー イミダゾピリジン類似体、およびＷｎｔ−βカテニン細胞メッセージ伝達系のアゴニストとしてのその使用
JP2013529196A (ja) 2010-05-14 2013-07-18 メディカル リサーチ カウンシル テクノロジー キナーゼｌｒｒｋ２の阻害剤としてのピラゾロピリジン
WO2015153683A1 (en) 2014-04-02 2015-10-08 Intermune, Inc. Anti-fibrotic pyridinones
JP2017502940A (ja) 2013-12-11 2017-01-26 セルジーン クオンティセル リサーチ，インク． リジン特異的デメチラーゼ−１の阻害剤
JP2020506197A (ja) 2017-02-07 2020-02-27 デウン ファーマシューティカル カンパニー リミテッド 新規なヘテロ環化合物、その製造方法およびこれを含む薬学的組成物

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CA2444882A1 (en) * 2001-04-30 2002-11-07 Vertex Pharmaceuticals Incorporated Inhibitors of gsk-3 and crystal structures of gsk-3.beta. protein and protein complexes
MX2009010886A (es) * 2007-04-12 2009-12-14 Hoffmann La Roche Derivados de pirimidina como inhibidores de fosfatidilinositol-3-c inasa.
WO2008138184A1 (fr) * 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co.Ltd. Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases
KR101789129B1 (ko) * 2010-06-30 2017-11-20 후지필름 가부시키가이샤 신규 니코틴아미드 유도체 또는 그 염
KR20150024669A (ko) 2013-08-27 2015-03-09 제일모직주식회사 화합물, 이를 포함하는 유기발광소자 및 상기 유기발광소자를 포함하는 표시장치
KR102421235B1 (ko) 2014-02-13 2022-07-15 인사이트 코포레이션 Lsd1 저해제로서 사이클로프로필아민
NZ723203A (en) 2014-02-13 2020-08-28 Incyte Corp Cyclopropylamines as lsd1 inhibitors
EP3392244A1 (en) 2014-02-13 2018-10-24 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
UA122688C2 (uk) 2015-04-03 2020-12-28 Інсайт Корпорейшн Гетероциклічні сполуки як інгібітори lsd1
WO2016201266A1 (en) 2015-06-11 2016-12-15 Usher Iii Initiative, Inc. Methods of treating or preventing a proteopathy

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002507996A (ja) 1997-07-03 2002-03-12 デュポン ファーマシューティカルズ カンパニー 神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類
WO2000001697A1 (en) 1998-07-02 2000-01-13 Du Pont Pharmaceuticals Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
JP2008540664A (ja) 2005-05-16 2008-11-20 アイアールエム・リミテッド・ライアビリティ・カンパニー タンパク質キナーゼ阻害剤としてのピロロピリジン誘導体
JP2009523812A (ja) 2006-01-19 2009-06-25 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド 融合へテロ二環式キナーゼ阻害剤
JP2010508363A (ja) 2006-11-01 2010-03-18 バーテックス ファーマシューティカルズ インコーポレイテッド ヤヌスキナーゼの阻害剤として有用な三環系ヘテロアリール化合物
JP2010528026A (ja) 2007-05-18 2010-08-19 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｐｉ３キナーゼ阻害物質としてのキノリン誘導体
JP2010537998A (ja) 2007-08-27 2010-12-09 ワイス・エルエルシー イミダゾピリジン類似体、およびＷｎｔ−βカテニン細胞メッセージ伝達系のアゴニストとしてのその使用
JP2013529196A (ja) 2010-05-14 2013-07-18 メディカル リサーチ カウンシル テクノロジー キナーゼｌｒｒｋ２の阻害剤としてのピラゾロピリジン
JP2017502940A (ja) 2013-12-11 2017-01-26 セルジーン クオンティセル リサーチ，インク． リジン特異的デメチラーゼ−１の阻害剤
WO2015153683A1 (en) 2014-04-02 2015-10-08 Intermune, Inc. Anti-fibrotic pyridinones
JP2020506197A (ja) 2017-02-07 2020-02-27 デウン ファーマシューティカル カンパニー リミテッド 新規なヘテロ環化合物、その製造方法およびこれを含む薬学的組成物

Also Published As

Publication number Publication date
WO2018213211A1 (en) 2018-11-22
US20200157091A1 (en) 2020-05-21
AU2022200197A1 (en) 2022-02-10
AU2018269947A1 (en) 2019-12-19
CN110914265B (zh) 2022-12-23
EP3628044A1 (en) 2020-04-01
CN110914265A (zh) 2020-03-24
JP2020519667A (ja) 2020-07-02
US11168082B2 (en) 2021-11-09
AU2018269947B2 (en) 2021-10-14
EP3628044B1 (en) 2023-11-22

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