JP7350713B2 - ベンゾチアゾールルシフェリンアナログを安定化させるための組成物及び方法 - Google Patents

ベンゾチアゾールルシフェリンアナログを安定化させるための組成物及び方法 Download PDF

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JP7350713B2
JP7350713B2 JP2020506187A JP2020506187A JP7350713B2 JP 7350713 B2 JP7350713 B2 JP 7350713B2 JP 2020506187 A JP2020506187 A JP 2020506187A JP 2020506187 A JP2020506187 A JP 2020506187A JP 7350713 B2 JP7350713 B2 JP 7350713B2
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composition
benzothiazole luciferin
formula
benzothiazole
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JP2020529442A (ja
JP2020529442A5 (enExample
Inventor
ツェー シー
メアリー ピー ホール
トーマス エイ カークランド
ランス ピー エンセル
ポンチョ マイセンハイマー
ウェンフイ チョウ
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Promega Corp
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Promega Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2020506187A 2017-08-04 2018-08-02 ベンゾチアゾールルシフェリンアナログを安定化させるための組成物及び方法 Active JP7350713B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762541350P 2017-08-04 2017-08-04
US62/541,350 2017-08-04
PCT/US2018/045040 WO2019028272A1 (en) 2017-08-04 2018-08-02 COMPOSITIONS AND METHODS FOR STABILIZING LUCIFERIN BENZOTHIAZOLE ANALOGS

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JP2020529442A JP2020529442A (ja) 2020-10-08
JP2020529442A5 JP2020529442A5 (enExample) 2021-09-09
JP7350713B2 true JP7350713B2 (ja) 2023-09-26

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US (1) US11136615B2 (enExample)
EP (1) EP3661932B1 (enExample)
JP (1) JP7350713B2 (enExample)
WO (1) WO2019028272A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3548470B1 (en) 2016-12-01 2023-11-01 Promega Corporation 5,5-disubstituted luciferins and their use in luciferase-based assays

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017519977A (ja) 2014-05-23 2017-07-20 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 発光源基質を安定させる組成物及び方法

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
DE3537877A1 (de) 1985-10-24 1987-04-30 Geiger Reinhard Luciferin-derivate und immunoassays unter einsatz derartiger luciferin-derivate
US6602677B1 (en) 1997-09-19 2003-08-05 Promega Corporation Thermostable luciferases and methods of production
JP4478231B2 (ja) 1998-12-09 2010-06-09 栄研化学株式会社 生物発光試薬の安定化方法
JP4379644B2 (ja) 1999-03-08 2009-12-09 栄研化学株式会社 ホタルルシフェリンの安定化方法
JP4503724B2 (ja) 1999-05-10 2010-07-14 栄研化学株式会社 ホタルルシフェリンの安定化方法
US7118878B1 (en) 2000-06-09 2006-10-10 Promega Corporation Method for increasing luminescence assay sensitivity
EP1546162B1 (en) 2002-09-20 2011-06-22 Promega Corporation Luminescence-based methods and probes for measuring cytochrome p450 activity
JPWO2006013837A1 (ja) 2004-08-05 2008-05-29 東洋ビーネット株式会社 ルシフェラーゼ発光方法および発光試薬
EP2778234B1 (en) 2005-05-31 2017-09-27 Promega Corporation Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
WO2008109459A1 (en) 2007-03-02 2008-09-12 University Of Massachusetts Luciferins
JP6075723B2 (ja) 2012-08-21 2017-02-08 栄研化学株式会社 Ｎ−（２−アセトアミド）イミノ二酢酸を用いる発光増強方法
EP2959010B1 (en) 2013-02-22 2020-07-29 Promega Corporation Stabilized formulation for luminescent detection of luciferase and nucleoside phosphates
WO2014159044A1 (en) 2013-03-12 2014-10-02 Promega Corporation Red-shifted luciferins and methods of using same
US9732373B2 (en) * 2014-09-11 2017-08-15 Promega Corporation Luciferase sequences utilizing infrared-emitting substrates to produce enhanced luminescence
WO2017057672A1 (ja) 2015-09-30 2017-04-06 栄研化学株式会社 ルシフェリンの安定化方法及び生物発光の測定方法
EP3548470B1 (en) 2016-12-01 2023-11-01 Promega Corporation 5,5-disubstituted luciferins and their use in luciferase-based assays

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017519977A (ja) 2014-05-23 2017-07-20 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 発光源基質を安定させる組成物及び方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Angew. Chem. Int. Ed., 2012, Vol.51, pp.8428-8430

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JP2020529442A (ja) 2020-10-08
EP3661932B1 (en) 2021-10-06
US11136615B2 (en) 2021-10-05
WO2019028272A1 (en) 2019-02-07
EP3661932A1 (en) 2020-06-10
US20190040449A1 (en) 2019-02-07

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