JP7349046B2 - Ｓａｒｍ１の阻害剤 - Google Patents

Ｓａｒｍ１の阻害剤 Download PDF

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Publication number
JP7349046B2
JP7349046B2 JP2023513172A JP2023513172A JP7349046B2 JP 7349046 B2 JP7349046 B2 JP 7349046B2 JP 2023513172 A JP2023513172 A JP 2023513172A JP 2023513172 A JP2023513172 A JP 2023513172A JP 7349046 B2 JP7349046 B2 JP 7349046B2
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Japan
Prior art keywords
compound
pharmaceutically acceptable
chiral
ring
mmol
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JP2023513172A
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English (en)
Japanese (ja)
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JP2023535236A (ja
Inventor
ボサナック，トッド
サイモン ブリアリー，アンドリュー
デブラジ，ラジェシュ
オーウェン ヒューズ，ロバート
アンドリュー ジャージェス－パイク，リチャード
アン パロット，シェリー
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Disarm Therapeutics Inc
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Disarm Therapeutics Inc
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Priority to JP2023145779A priority Critical patent/JP7756130B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immunology (AREA)
  • Pyridine Compounds (AREA)
JP2023513172A 2020-08-24 2021-08-23 Ｓａｒｍ１の阻害剤 Active JP7349046B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023145779A JP7756130B2 (ja) 2020-08-24 2023-09-08 Ｓａｒｍ１の阻害剤

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063069408P 2020-08-24 2020-08-24
US63/069,408 2020-08-24
US202163142398P 2021-01-27 2021-01-27
US63/142,398 2021-01-27
PCT/US2021/047093 WO2022046606A1 (en) 2020-08-24 2021-08-23 Inhibitors of sarm1

Related Child Applications (1)

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JP2023145779A Division JP7756130B2 (ja) 2020-08-24 2023-09-08 Ｓａｒｍ１の阻害剤

Publications (2)

Publication Number Publication Date
JP2023535236A JP2023535236A (ja) 2023-08-16
JP7349046B2 true JP7349046B2 (ja) 2023-09-21

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JP2023145779A Active JP7756130B2 (ja) 2020-08-24 2023-09-08 Ｓａｒｍ１の阻害剤

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US (2) US12043613B2 (enExample)
EP (1) EP4200293A1 (enExample)
JP (2) JP7349046B2 (enExample)
KR (2) KR20260016617A (enExample)
CN (1) CN122404291A (enExample)
AU (3) AU2021333558C1 (enExample)
BR (1) BR112023002575A2 (enExample)
CA (2) CA3313757A1 (enExample)
CL (1) CL2023000525A1 (enExample)
CO (1) CO2023001975A2 (enExample)
CR (1) CR20230113A (enExample)
DO (1) DOP2023000038A (enExample)
EC (1) ECSP23012981A (enExample)
IL (1) IL300586A (enExample)
JO (1) JOP20230037A1 (enExample)
MX (1) MX2023002256A (enExample)
NZ (1) NZ797733A (enExample)
PE (1) PE20230737A1 (enExample)
TW (3) TW202334117A (enExample)
UA (1) UA130657C2 (enExample)
WO (1) WO2022046606A1 (enExample)
ZA (1) ZA202301801B (enExample)

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CA3123215C (en) 2018-12-19 2024-04-02 Disarm Therapeutics, Inc. Inhibitors of sarm1 in combination with neuroprotective agents
EP4192828A1 (en) 2020-08-04 2023-06-14 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors
WO2022060812A1 (en) 2020-09-16 2022-03-24 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors
KR20240041987A (ko) 2021-07-28 2024-04-01 누라 바이오, 인크. Sarm1 억제제로서 치환된 피리딘 유도체
IL318437A (en) * 2022-07-21 2025-03-01 Amylyx Pharmaceuticals Inc Compositions containing oligonucleotides, and methods of using them
IL321043A (en) * 2022-12-15 2025-07-01 Sironax Ltd SARM1 modulators, their preparations and uses
WO2024158775A1 (en) 2023-01-24 2024-08-02 Disarm Therapeutics, Inc. Pyridazines as sarm1 inhibitors
CN121399112A (zh) * 2023-04-27 2026-01-23 维泰瑞隆有限公司 Sarm1调节剂、其制备和用途
CN119219603A (zh) * 2023-06-28 2024-12-31 科辉智药(深圳)新药研究中心有限公司 Sarm1酶活性抑制剂及其用途
WO2025049184A1 (en) 2023-08-25 2025-03-06 Eli Lilly And Company (s)-3-((6-fluoropyridin-3-yl)methyl)-1-(5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl)piperidin-2-one benzenesulfonate
EP4766702A1 (en) * 2023-08-25 2026-07-01 F. Hoffmann-La Roche AG Pyrazole derivatives used as MRSA inhibitors useful for the treatment of neurodegenerative disorders
WO2025076088A1 (en) * 2023-10-05 2025-04-10 Genentech, Inc. Lactams for use as sarm1 inhibitors
WO2025076017A1 (en) * 2023-10-05 2025-04-10 Genentech, Inc. Carbamates for use as sarm1 inhibitors
TW202545928A (zh) 2024-01-25 2025-12-01 比利時商優稀美生物醫藥股份有限公司 吡咯啶酮衍生物
WO2026104394A1 (en) 2024-11-13 2026-05-21 UCB Biopharma SRL Pyrrolidinone derivatives inhibitors of sarm1

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JP2021506979A (ja) 2017-12-22 2021-02-22 ラヴェンナ ファーマシューティカルズ，インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアリール−ビピリジンアミン誘導体
JP2021528488A (ja) 2018-06-07 2021-10-21 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１阻害剤
WO2022031736A1 (en) 2020-08-04 2022-02-10 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors

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JP2021506979A (ja) 2017-12-22 2021-02-22 ラヴェンナ ファーマシューティカルズ，インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアリール−ビピリジンアミン誘導体
JP2021528488A (ja) 2018-06-07 2021-10-21 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１阻害剤
WO2020158762A1 (ja) 2019-01-30 2020-08-06 武田薬品工業株式会社 複素環化合物
WO2022031736A1 (en) 2020-08-04 2022-02-10 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors

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AU2021333558A1 (en) 2023-03-02
TW202214597A (zh) 2022-04-16
TWI786777B (zh) 2022-12-11
KR20260016617A (ko) 2026-02-03
ECSP23012981A (es) 2023-03-31
TW202530197A (zh) 2025-08-01
US20220056013A1 (en) 2022-02-24
AU2021333558B2 (en) 2024-02-22
JOP20230037A1 (ar) 2023-02-23
DOP2023000038A (es) 2023-03-15
JP2023535236A (ja) 2023-08-16
CN122404291A (zh) 2026-07-17
MX2023002256A (es) 2023-03-17
AU2024203373A1 (en) 2024-06-13
TW202334117A (zh) 2023-09-01
ZA202301801B (en) 2024-09-25
AU2024203373B2 (en) 2026-04-02
US12043613B2 (en) 2024-07-23
BR112023002575A2 (pt) 2023-03-07
UA130657C2 (uk) 2026-04-08
CO2023001975A2 (es) 2023-03-07
PE20230737A1 (es) 2023-05-03
IL300586A (en) 2023-04-01
KR102918550B1 (ko) 2026-01-27
EP4200293A1 (en) 2023-06-28
CL2023000525A1 (es) 2023-09-15
CR20230113A (es) 2023-04-14
CA3189181A1 (en) 2022-03-03
WO2022046606A1 (en) 2022-03-03
AU2026205227A1 (en) 2026-07-23
NZ797733A (en) 2026-03-27
JP7756130B2 (ja) 2025-10-17
AU2021333558C1 (en) 2024-06-20
US20240376083A1 (en) 2024-11-14
TWI904906B (zh) 2025-11-11
CA3313757A1 (en) 2026-06-21
JP2024016014A (ja) 2024-02-06
KR20230057396A (ko) 2023-04-28

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