JP7349046B2 - Ｓａｒｍ１の阻害剤 - Google Patents

Ｓａｒｍ１の阻害剤 Download PDF

Info

Publication number
JP7349046B2
JP7349046B2 JP2023513172A JP2023513172A JP7349046B2 JP 7349046 B2 JP7349046 B2 JP 7349046B2 JP 2023513172 A JP2023513172 A JP 2023513172A JP 2023513172 A JP2023513172 A JP 2023513172A JP 7349046 B2 JP7349046 B2 JP 7349046B2
Authority
JP
Japan
Prior art keywords
compound
pharmaceutically acceptable
chiral
ring
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2023513172A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023535236A (ja
Inventor
ボサナック，トッド
サイモン ブリアリー，アンドリュー
デブラジ，ラジェシュ
オーウェン ヒューズ，ロバート
アンドリュー ジャージェス－パイク，リチャード
アン パロット，シェリー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Disarm Therapeutics Inc
Original Assignee
Disarm Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Disarm Therapeutics Inc filed Critical Disarm Therapeutics Inc
Publication of JP2023535236A publication Critical patent/JP2023535236A/ja
Priority to JP2023145779A priority Critical patent/JP7756130B2/ja
Application granted granted Critical
Publication of JP7349046B2 publication Critical patent/JP7349046B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023513172A 2020-08-24 2021-08-23 Ｓａｒｍ１の阻害剤 Active JP7349046B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023145779A JP7756130B2 (ja) 2020-08-24 2023-09-08 Ｓａｒｍ１の阻害剤

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063069408P 2020-08-24 2020-08-24
US63/069,408 2020-08-24
US202163142398P 2021-01-27 2021-01-27
US63/142,398 2021-01-27
PCT/US2021/047093 WO2022046606A1 (en) 2020-08-24 2021-08-23 Inhibitors of sarm1

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023145779A Division JP7756130B2 (ja) 2020-08-24 2023-09-08 Ｓａｒｍ１の阻害剤

Publications (2)

Publication Number Publication Date
JP2023535236A JP2023535236A (ja) 2023-08-16
JP7349046B2 true JP7349046B2 (ja) 2023-09-21

Family

ID=77775005

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2023513172A Active JP7349046B2 (ja) 2020-08-24 2021-08-23 Ｓａｒｍ１の阻害剤
JP2023145779A Active JP7756130B2 (ja) 2020-08-24 2023-09-08 Ｓａｒｍ１の阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023145779A Active JP7756130B2 (ja) 2020-08-24 2023-09-08 Ｓａｒｍ１の阻害剤

Country Status (18)

Country Link
US (2) US12043613B2 (cg-RX-API-DMAC7.html)
EP (1) EP4200293A1 (cg-RX-API-DMAC7.html)
JP (2) JP7349046B2 (cg-RX-API-DMAC7.html)
KR (1) KR20230057396A (cg-RX-API-DMAC7.html)
AU (2) AU2021333558C1 (cg-RX-API-DMAC7.html)
BR (1) BR112023002575A2 (cg-RX-API-DMAC7.html)
CA (1) CA3189181A1 (cg-RX-API-DMAC7.html)
CL (1) CL2023000525A1 (cg-RX-API-DMAC7.html)
CO (1) CO2023001975A2 (cg-RX-API-DMAC7.html)
CR (1) CR20230113A (cg-RX-API-DMAC7.html)
DO (1) DOP2023000038A (cg-RX-API-DMAC7.html)
EC (1) ECSP23012981A (cg-RX-API-DMAC7.html)
IL (1) IL300586A (cg-RX-API-DMAC7.html)
MX (1) MX2023002256A (cg-RX-API-DMAC7.html)
PE (1) PE20230737A1 (cg-RX-API-DMAC7.html)
TW (2) TWI786777B (cg-RX-API-DMAC7.html)
WO (1) WO2022046606A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA202301801B (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3897670A4 (en) 2018-12-19 2022-09-07 Disarm Therapeutics, Inc. MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS
US12404265B2 (en) 2020-08-04 2025-09-02 Nura Bio, Inc. Substituted pyridine derivatives as SARM1 inhibitors
CN116438171A (zh) 2020-09-16 2023-07-14 努拉生物公司 作为sarm1抑制剂的取代的吡啶衍生物
CA3226869A1 (en) 2021-07-28 2023-02-02 Rao Kolluri Substituted pyridine derivatives as sarm1 inhibitors
KR20250040698A (ko) * 2022-07-21 2025-03-24 아밀릭스 파마슈티컬스, 인코포레이티드 올리고뉴클레오티드 조성물 및 이의 방법
IL321043A (en) * 2022-12-15 2025-07-01 Sironax Ltd SARM1 modulators, their preparations and uses
EP4655069A1 (en) 2023-01-24 2025-12-03 Disarm Therapeutics, Inc. Pyridazines as sarm1 inhibitors
WO2024222835A1 (en) * 2023-04-27 2024-10-31 Sironax Ltd. Sarm1 modulators, preparations, and uses thereof
CN119219603A (zh) * 2023-06-28 2024-12-31 科辉智药(深圳)新药研究中心有限公司 Sarm1酶活性抑制剂及其用途
WO2025049184A1 (en) 2023-08-25 2025-03-06 Eli Lilly And Company (s)-3-((6-fluoropyridin-3-yl)methyl)-1-(5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl)piperidin-2-one benzenesulfonate
WO2025045746A1 (en) * 2023-08-25 2025-03-06 F. Hoffmann-La Roche Ag Pyrazole derivatives as sarm1 inhibitors useful for the treatment of neurodegenerative disorders
WO2025076017A1 (en) * 2023-10-05 2025-04-10 Genentech, Inc. Carbamates for use as sarm1 inhibitors
WO2025076088A1 (en) * 2023-10-05 2025-04-10 Genentech, Inc. Lactams for use as sarm1 inhibitors
WO2025157895A1 (en) 2024-01-25 2025-07-31 UCB Biopharma SRL Pyrrolidinone derivatives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020158762A1 (ja) 2019-01-30 2020-08-06 武田薬品工業株式会社 複素環化合物
JP2021506979A (ja) 2017-12-22 2021-02-22 ラヴェンナ ファーマシューティカルズ，インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアリール−ビピリジンアミン誘導体
JP2021528488A (ja) 2018-06-07 2021-10-21 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１阻害剤
WO2022031736A1 (en) 2020-08-04 2022-02-10 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436966B1 (en) 1997-10-27 2002-08-20 Takeda Chemical Ind., Ltd. Adenosine A3 receptor antagonists
US6787555B2 (en) 2001-04-30 2004-09-07 The Procter & Gamble Company Triazole compounds useful in treating diseases associated with unwanted cytokine activity
CA2504320A1 (en) 2002-10-30 2004-05-21 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of rock and other protein kinases
AU2003300099A1 (en) 2003-01-02 2004-07-29 Millennium Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR INHIBITING TGF-Beta
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
US7585881B2 (en) 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
WO2005105780A2 (en) 2004-04-28 2005-11-10 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of rock and other protein kinases
KR20070095952A (ko) 2004-12-16 2007-10-01 버텍스 파마슈티칼스 인코포레이티드 염증성 질환, 증식성 질환 및 면역학적으로 매개된 질환치료용 Ｔｅｃ 계열 단백질 키나제의 억제제로서 유용한피리드-2-온
AU2007265965B2 (en) 2006-06-28 2012-03-08 Aska Pharmaceutical Co., Ltd. Pyridylisoxazole derivative
EP2069333A1 (en) 2006-09-21 2009-06-17 Novartis Ag Pyrrole derivatives useful for the treatment of cytokine-mediated diseases
WO2009080705A2 (en) 2007-12-20 2009-07-02 Novartis Ag Bis-thiazole derivatives, process for their preparation and their use as medicaments
KR20100093129A (ko) 2007-12-20 2010-08-24 노파르티스 아게 Ｐｉ ３ 키나제 억제제로서 사용되는 티아졸 유도체
TW201004941A (en) 2008-07-16 2010-02-01 Wyeth Corp Alpha7 nicotinic acetylcholine receptor inhibitors
US8785468B2 (en) 2009-02-13 2014-07-22 Amgen Inc. Phenylalanine amide derivatives useful for treating insulin-related diseases and conditions
US20120328629A1 (en) 2011-06-24 2012-12-27 University Of Miami Therapeutic Applications Targeting SARM1
JP6482466B2 (ja) 2012-11-03 2019-03-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング サイトメガロウイルスの阻害剤
WO2014099694A1 (en) 2012-12-19 2014-06-26 Merck Sharp & Dohme Corp. FACTOR IXa INHIBITORS
RU2570907C2 (ru) 2013-10-21 2015-12-20 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Производные 3-ациламинопиридин-2(1h)-она, применимые как ингибиторы серин-треониновой протеинкиназы gsk3b в качестве лекарственных препаратов для лечения диабета ii типа.
EP3076789A4 (en) 2013-12-04 2017-11-22 The Scripps Research Institute Novel compounds as jnk kinase inhibitors
EP3500285B1 (en) 2016-08-16 2022-04-20 Henry Ford Health System Compositions for the treatment of chemotherapy-induced neuropathic pain
WO2018057989A1 (en) 2016-09-24 2018-03-29 Washington University INHIBITORS OF SARM1 NADase ACTIVITY AND USES THEREOF
US20180251431A1 (en) 2016-12-09 2018-09-06 Vertex Pharmaceuticals Incorporated 1,3-substituted pyrazole compounds useful for reduction of very long chain fatty acid levels
BR112019012822A2 (pt) * 2016-12-22 2019-11-26 Bayer Ag 1,2,4-tiadiazolilpirrolonas e 1,2,4-tiadiazolil-hidantoínas e sais das mesmas e uso das mesmas como herbicidas
JP2020504115A (ja) 2016-12-22 2020-02-06 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 置換アゾリルピロロンおよびアゾリルヒダントインならびにその塩ならびに除草活性物質としてのその使用
EP3801500B1 (en) 2018-06-07 2025-03-05 Disarm Therapeutics, Inc. Inhibitors of sarm1
US20210261537A1 (en) * 2018-06-07 2021-08-26 Disarm Therapeutics, Inc. Inhibitors of sarm1
JP7289375B2 (ja) 2019-06-06 2023-06-09 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１の阻害剤
WO2020252229A2 (en) 2019-06-14 2020-12-17 Disarm Therapeutics, Inc. Inhibitors of sarm1
BR112022000354A2 (pt) 2019-07-22 2022-05-10 Bayer Ag Pirazóis e trizóis substituídos com amino na posição 5 como pesticidas
US12441719B2 (en) 2019-09-12 2025-10-14 Disarm Therapeutics, Inc. Inhibitors of SARM1
CN114845709B (zh) 2019-11-05 2024-10-01 德米拉公司 用于治疗炎性病症的mrgprx2拮抗剂
CR20220375A (es) 2020-01-07 2022-09-22 Disarm Therapeutics Inc Inhibidores de sarm1
JP7478252B2 (ja) 2020-04-09 2024-05-02 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１の阻害剤
JP7477642B2 (ja) 2020-04-09 2024-05-01 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１の阻害剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021506979A (ja) 2017-12-22 2021-02-22 ラヴェンナ ファーマシューティカルズ，インコーポレイテッド ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアリール−ビピリジンアミン誘導体
JP2021528488A (ja) 2018-06-07 2021-10-21 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１阻害剤
WO2020158762A1 (ja) 2019-01-30 2020-08-06 武田薬品工業株式会社 複素環化合物
WO2022031736A1 (en) 2020-08-04 2022-02-10 Nura Bio, Inc. Substituted pyridine derivatives as sarm1 inhibitors

Also Published As

Publication number Publication date
TW202334117A (zh) 2023-09-01
MX2023002256A (es) 2023-03-17
KR20230057396A (ko) 2023-04-28
PE20230737A1 (es) 2023-05-03
JP2023535236A (ja) 2023-08-16
TW202214597A (zh) 2022-04-16
JP2024016014A (ja) 2024-02-06
TW202530197A (zh) 2025-08-01
AU2024203373A1 (en) 2024-06-13
DOP2023000038A (es) 2023-03-15
AU2021333558C1 (en) 2024-06-20
BR112023002575A2 (pt) 2023-03-07
ECSP23012981A (es) 2023-03-31
CO2023001975A2 (es) 2023-03-07
JP7756130B2 (ja) 2025-10-17
US20220056013A1 (en) 2022-02-24
CA3189181A1 (en) 2022-03-03
CR20230113A (es) 2023-04-14
CL2023000525A1 (es) 2023-09-15
IL300586A (en) 2023-04-01
EP4200293A1 (en) 2023-06-28
AU2021333558B2 (en) 2024-02-22
WO2022046606A1 (en) 2022-03-03
ZA202301801B (en) 2024-09-25
TWI786777B (zh) 2022-12-11
US12043613B2 (en) 2024-07-23
US20240376083A1 (en) 2024-11-14
AU2021333558A1 (en) 2023-03-02

Similar Documents

Publication Publication Date Title
JP7349046B2 (ja) Ｓａｒｍ１の阻害剤
JP7319395B2 (ja) Ｓａｒｍ１の阻害剤
JP7659110B2 (ja) Ｓａｒｍ１の阻害剤
JP7478142B2 (ja) Ｓａｒｍ１阻害剤
JP7478252B2 (ja) Ｓａｒｍ１の阻害剤
JP7289375B2 (ja) Ｓａｒｍ１の阻害剤
JP7534390B2 (ja) Ｓａｒｍ１の阻害剤
JP7477642B2 (ja) Ｓａｒｍ１の阻害剤
JP7746384B2 (ja) Ｓａｒｍ１のベンゾピラゾール阻害剤
EA048703B1 (ru) Ингибиторы sarm1
CN116940569A (zh) Sarm1抑制剂
BR122025022748A2 (pt) Inibidores de sarm1, composições que os compreendem, usos dos mesmos, métodos para inibir sarm1, e combinações

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230324

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230324

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20230324

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230816

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230908

R150 Certificate of patent or registration of utility model

Ref document number: 7349046

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150