JP7331322B2 - 新規の送達系 - Google Patents

新規の送達系 Download PDF

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Publication number
JP7331322B2
JP7331322B2 JP2020518603A JP2020518603A JP7331322B2 JP 7331322 B2 JP7331322 B2 JP 7331322B2 JP 2020518603 A JP2020518603 A JP 2020518603A JP 2020518603 A JP2020518603 A JP 2020518603A JP 7331322 B2 JP7331322 B2 JP 7331322B2
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JP
Japan
Prior art keywords
delivery system
coating
inner coating
solid core
weight
Prior art date
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JP2020518603A
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English (en)
Japanese (ja)
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JP2021501676A (ja
Inventor
エルガー フンダ，
オディール クラインツ，
ロベルト シュタイネール，
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DSM IP Assets BV
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DSM IP Assets BV
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A23P20/105—Coating with compositions containing vegetable or microbial fermentation gums, e.g. cellulose or derivatives; Coating with edible polymers, e.g. polyvinyalcohol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/70—Vitamins
    • A23V2250/704—Vitamin B
    • A23V2250/7044—Vitamin B2

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Fodder In General (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020518603A 2017-11-03 2018-10-30 新規の送達系 Active JP7331322B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17199806.5 2017-11-03
EP17199806 2017-11-03
PCT/EP2018/079662 WO2019086425A1 (en) 2017-11-03 2018-10-30 New delivery system

Publications (2)

Publication Number Publication Date
JP2021501676A JP2021501676A (ja) 2021-01-21
JP7331322B2 true JP7331322B2 (ja) 2023-08-23

Family

ID=60473269

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020518603A Active JP7331322B2 (ja) 2017-11-03 2018-10-30 新規の送達系
JP2020518607A Active JP7331323B2 (ja) 2017-11-03 2018-10-30 新規の送達系

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020518607A Active JP7331323B2 (ja) 2017-11-03 2018-10-30 新規の送達系

Country Status (7)

Country Link
US (2) US11872316B2 (enExample)
EP (2) EP3703514B1 (enExample)
JP (2) JP7331322B2 (enExample)
KR (4) KR102790073B1 (enExample)
CN (2) CN111315236A (enExample)
ES (2) ES3034026T3 (enExample)
WO (2) WO2019086427A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220193033A1 (en) * 2019-04-30 2022-06-23 Dsm Ip Assets B.V. New delivery system for specific water-soluble vitamins
EP3962462A1 (en) * 2019-04-30 2022-03-09 DSM IP Assets B.V. New delivery system for polyunsaturated fatty acids
CN114760992A (zh) * 2019-11-27 2022-07-15 帝斯曼知识产权资产管理有限公司 包含核黄素的mups片剂
CN114727966A (zh) * 2019-11-27 2022-07-08 帝斯曼知识产权资产管理有限公司 包含核黄素的多单位丸粒系统片剂

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004018443A (ja) 2002-06-14 2004-01-22 Pigeon Corp 腸溶性カプセル剤
JP2004123636A (ja) 2002-10-03 2004-04-22 Nof Corp 二重被覆造粒物およびその製造方法
JP2014058502A (ja) 2012-08-23 2014-04-03 Nisshin Pharma Inc キトサン含有組成物及びキトサンコーティング組成物
JP2014139200A (ja) 2012-12-21 2014-07-31 Nisshin Pharma Inc 大腸送達カプセル及びその製造方法
JP2017532050A (ja) 2014-12-09 2017-11-02 インターコンチネンタル グレート ブランズ エルエルシー 腸溶性被覆機能性食品成分及び腸溶性被覆機能性食品成分の製造方法

Family Cites Families (7)

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US11744803B2 (en) 2005-07-29 2023-09-05 Stichting Groningen Centre for Drug Rese PH-controlled pulsatile delivery system, methods for preparation and use thereof
CN101677958A (zh) 2007-03-26 2010-03-24 帝国制药株式会社 用于结肠-特异性递送的口服药物制剂
PL2200588T3 (pl) * 2007-09-25 2019-09-30 Solubest Ltd. Kompozycje zawierające lipofilowe związki aktywne i sposób ich wytwarzania
WO2009064429A1 (en) 2007-11-13 2009-05-22 Hercules Incorporated Water dispersible enteric coating formulation for nutraceutical and pharmaceutical dosage forms
EP2616051A1 (en) * 2010-07-29 2013-07-24 Cosmo Technologies Ltd. Pharmaceutical and/or dietary compositions based on short chain fatty acids
US20150283144A1 (en) 2012-11-01 2015-10-08 Rijksuniversiteit Groningen Methods and compositions for stimulating beneficial bacteria in the gastrointestinal tract
CN106572979B (zh) 2014-08-07 2021-03-12 雀巢产品有限公司 递送体系

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004018443A (ja) 2002-06-14 2004-01-22 Pigeon Corp 腸溶性カプセル剤
JP2004123636A (ja) 2002-10-03 2004-04-22 Nof Corp 二重被覆造粒物およびその製造方法
JP2014058502A (ja) 2012-08-23 2014-04-03 Nisshin Pharma Inc キトサン含有組成物及びキトサンコーティング組成物
JP2014139200A (ja) 2012-12-21 2014-07-31 Nisshin Pharma Inc 大腸送達カプセル及びその製造方法
JP2017532050A (ja) 2014-12-09 2017-11-02 インターコンチネンタル グレート ブランズ エルエルシー 腸溶性被覆機能性食品成分及び腸溶性被覆機能性食品成分の製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MESSAOUD, G. B. et al.，PHYSICO-CHEMICAL PROPERTIES OF ALGINATE/SHELLAC AQUEOUS-CORE CAPSULES: INFLUENCE OF MEMBRANE ARCHITECTURE ON RIBOFLAVIN RELEASE，CARBOHYDRATE POLYMERS，(2016), vol.144，pp.428-437，http://dx.doi.org/10.1016/j.carbpol.2016.02.081
MOHAMMAD A. K. Z. et al.，MICROENCAPSULATION OF PROBIOTICS BY CALCIUM ALGINATE-GELATINIZED STARCH WITH CHITOSAN COATING AND EVALUATION OF SURVIVAL IN SIMULATED HUMAN GASTRO-INTESTINAL CONDITION，IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH，2014年，(2014), vol.13，pp.843，https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177644/pdf/ijpr-13-843.pdf

Also Published As

Publication number Publication date
JP2021501676A (ja) 2021-01-21
US11872316B2 (en) 2024-01-16
ES3035248T3 (en) 2025-09-01
BR112020008194A2 (pt) 2020-10-06
KR20250025501A (ko) 2025-02-21
CN111315236A (zh) 2020-06-19
BR112020008587A2 (pt) 2020-10-20
KR20250025502A (ko) 2025-02-21
EP3703514A1 (en) 2020-09-09
KR102790073B1 (ko) 2025-04-04
KR20200084330A (ko) 2020-07-10
US11602503B2 (en) 2023-03-14
KR102790067B1 (ko) 2025-04-04
EP3703514B1 (en) 2025-04-09
US20210177766A1 (en) 2021-06-17
WO2019086425A1 (en) 2019-05-09
JP7331323B2 (ja) 2023-08-23
KR20200084329A (ko) 2020-07-10
CN111315237A (zh) 2020-06-19
EP3703515A1 (en) 2020-09-09
US20200352866A1 (en) 2020-11-12
ES3034026T3 (en) 2025-08-12
EP3703515B1 (en) 2025-04-09
WO2019086427A1 (en) 2019-05-09
JP2021501565A (ja) 2021-01-21

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