JP7329503B2 - 重篤患者用の療法モニタリングマーカーとしてのpro-adm - Google Patents
重篤患者用の療法モニタリングマーカーとしてのpro-adm Download PDFInfo
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- JP7329503B2 JP7329503B2 JP2020515677A JP2020515677A JP7329503B2 JP 7329503 B2 JP7329503 B2 JP 7329503B2 JP 2020515677 A JP2020515677 A JP 2020515677A JP 2020515677 A JP2020515677 A JP 2020515677A JP 7329503 B2 JP7329503 B2 JP 7329503B2
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/26—Infectious diseases, e.g. generalised sepsis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023006500A JP7544879B2 (ja) | 2017-09-13 | 2023-01-19 | 重篤患者用の療法モニタリングマーカーとしてのpro-adm |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17190912.0 | 2017-09-13 | ||
| EP17190912 | 2017-09-13 | ||
| PCT/EP2018/074722 WO2019053115A1 (en) | 2017-09-13 | 2018-09-13 | USE OF PROADM AS A THERAPEUTIC SURVEILLANCE MARKER FOR CRITICALLY PHASE PATIENTS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023006500A Division JP7544879B2 (ja) | 2017-09-13 | 2023-01-19 | 重篤患者用の療法モニタリングマーカーとしてのpro-adm |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020533604A JP2020533604A (ja) | 2020-11-19 |
| JP2020533604A5 JP2020533604A5 (https=) | 2021-03-25 |
| JP7329503B2 true JP7329503B2 (ja) | 2023-08-18 |
Family
ID=59887050
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020515677A Active JP7329503B2 (ja) | 2017-09-13 | 2018-09-13 | 重篤患者用の療法モニタリングマーカーとしてのpro-adm |
| JP2020515760A Active JP7366007B2 (ja) | 2017-09-13 | 2018-09-13 | プロアドレノメジュリンに基づく輸液療法のガイダンスのための方法 |
| JP2023006500A Active JP7544879B2 (ja) | 2017-09-13 | 2023-01-19 | 重篤患者用の療法モニタリングマーカーとしてのpro-adm |
| JP2023175415A Abandoned JP2023181226A (ja) | 2017-09-13 | 2023-10-10 | プロアドレノメジュリンに基づく輸液療法のガイダンスのための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020515760A Active JP7366007B2 (ja) | 2017-09-13 | 2018-09-13 | プロアドレノメジュリンに基づく輸液療法のガイダンスのための方法 |
| JP2023006500A Active JP7544879B2 (ja) | 2017-09-13 | 2023-01-19 | 重篤患者用の療法モニタリングマーカーとしてのpro-adm |
| JP2023175415A Abandoned JP2023181226A (ja) | 2017-09-13 | 2023-10-10 | プロアドレノメジュリンに基づく輸液療法のガイダンスのための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20200300864A1 (https=) |
| EP (2) | EP3682245A1 (https=) |
| JP (4) | JP7329503B2 (https=) |
| CN (2) | CN111065927B (https=) |
| BR (1) | BR112020004138A2 (https=) |
| CA (1) | CA3075440A1 (https=) |
| WO (2) | WO2019053116A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2026013199A1 (en) | 2024-07-12 | 2026-01-15 | Cezanne S.A.S. | Clinical immunoassay with early signal measurement |
| CN118976116B (zh) * | 2024-10-22 | 2025-01-24 | 四川大学华西医院 | 琥珀酰明胶在制备腹膜透析液中的用途以及一种含琥珀酰明胶、枸橼酸钠的腹膜透析液 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008012019A2 (de) | 2006-07-24 | 2008-01-31 | B.R.A.H.M.S. Aktiengesellschaft | Verfahren zur steuerung der therapie von patienten mit herzinsuffizienz anhand der in vitro bestimmung von schwellenwerten von vasoaktiven peptiden |
| US20080213746A1 (en) | 2006-11-09 | 2008-09-04 | Leong Loke Ng | Methods of Diagnosis and Risk Stratification of Adverse Events in Post Myocardial Infarction Patients Using Pro-adrenomedullin |
| JP2012526271A (ja) | 2009-05-05 | 2012-10-25 | ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 内皮性機能/機能不全に関連した疾患に罹患している患者の血管作動性ホルモンに基づいた層化 |
| JP2013541015A (ja) | 2010-11-01 | 2013-11-07 | ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非特異的症状を有する患者の予後及びリスク評価 |
| JP2016521315A (ja) | 2013-04-19 | 2016-07-21 | ユナイテッド テクノロジーズ コーポレイションUnited Technologies Corporation | 付加製造のためのビルドプレート及び装置 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2570703B1 (fr) | 1984-09-26 | 1988-07-08 | Commissariat Energie Atomique | Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents |
| US4882733A (en) | 1987-03-13 | 1989-11-21 | Ford Aerospace Corporation | Method and apparatus for combining encoding and modulation |
| FR2664699B1 (fr) | 1990-07-13 | 1995-08-18 | Cis Bio Int | Procede d'amplification du signal d'emission d'un compose luminescent. |
| DE69602756T2 (de) | 1995-08-18 | 2000-02-10 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville | Funktionelle rolle von adrenomedullin(am) und dem gen-verwandten produkt(pamp) in der menschlichen pathologie und physiologie |
| KR100425525B1 (ko) | 2000-11-21 | 2004-03-30 | 재단법인서울대학교산학협력재단 | 조산과 태아감염 및 태아손상을 산전 진단하기 위한진단시약 및 진단키트 |
| US6864237B2 (en) * | 2002-05-17 | 2005-03-08 | Ping Wang | Treatment of shock using adrenomedullin and adrenomedullin binding protein-1 |
| DE10316583A1 (de) | 2003-04-10 | 2004-10-28 | B.R.A.H.M.S Aktiengesellschaft | Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung |
| CN101208602A (zh) * | 2005-04-15 | 2008-06-25 | 贝克顿迪金森公司 | 脓毒症的诊断 |
| DE102006060112A1 (de) | 2006-12-20 | 2008-06-26 | Brahms Aktiengesellschaft | Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM |
| US8298774B2 (en) | 2007-03-12 | 2012-10-30 | Biomedica Medizinprodukte Gmbh & Co Kg | Diagnosis of septic complications |
| PL2185937T5 (pl) | 2007-09-07 | 2014-12-31 | Univ Zuerich | Sposób wykrywania posocznicy u ludzi |
| ES2486268T3 (es) | 2007-11-16 | 2014-08-18 | Biocartis Nv | Biomarcadores y procedimientos de diagnóstico, predicción y/o pronóstico de septicemia y usos de los mismos |
| JP5989965B2 (ja) * | 2008-01-08 | 2016-09-07 | メルク シャープ エンド ドーム リミテッド | 2−{4−[(3s)−ピペリジン−3−イル]フェニル}−2h−インダゾール−7−カルボキサミドの薬学的に許容される塩 |
| EP2131200A1 (en) * | 2008-06-04 | 2009-12-09 | BRAHMS Aktiengesellschaft | A marker for graft failure and mortality |
| JP5702371B2 (ja) * | 2009-05-27 | 2015-04-15 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Muc1のアンタゴニストを使用した、炎症の阻害 |
| EP2438447B1 (en) | 2009-06-05 | 2015-02-18 | B.R.A.H.M.S GmbH | Detection of bacterial infections in subjects suffering from dyspnea. |
| US8383332B2 (en) | 2009-10-13 | 2013-02-26 | B.R.A.H.M.S. Gmbh | Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack |
| EP2545379B1 (en) | 2010-03-08 | 2015-09-30 | B.R.A.H.M.S GmbH | Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with non-specific complaints |
| SG11201402362VA (en) * | 2011-11-16 | 2014-06-27 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for reducing the risk of mortality in a patient having a chronic or acute disease or acute condition |
| CA2856150A1 (en) * | 2011-11-16 | 2013-05-23 | Adrenomed Ag | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease |
| US11067586B2 (en) * | 2011-11-16 | 2021-07-20 | Sphingotec Gmbh | Adrenomedullin assays and methods for determining mature adrenomedullin |
| DK2780717T3 (en) * | 2011-11-16 | 2017-02-13 | Sphingotec Gmbh | ADRENOMEDULLINASSAYS AND METHODS FOR DETERMINING MODERN ADRENOMEDULLIN |
| US10935548B2 (en) | 2011-12-08 | 2021-03-02 | Astute Medical, Inc. | Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2 |
| EP2637023A1 (en) * | 2012-03-08 | 2013-09-11 | B.R.A.H.M.S GmbH | Prediction of outcome in patients with chronic obstructive pulmonary disease |
| EP2976646B1 (en) * | 2013-03-20 | 2020-08-19 | sphingotec GmbH | Adrenomedullin to guide therapy of blood pressure decline |
| US20180348235A1 (en) | 2015-11-27 | 2018-12-06 | B.R.A.H.M.S Gmbh | MR-proADM as marker for the extracellular volume status of a subject |
| EP4231018A3 (en) | 2016-07-08 | 2023-11-15 | SphingoTec GmbH | Adrenomedullin for assessing congestion in a subject with acute heart failure |
| CA3033094A1 (en) | 2016-08-09 | 2018-02-15 | B.R.A.H.M.S Gmbh | Histones and/or proadm as markers indicating an adverse event |
-
2018
- 2018-09-13 WO PCT/EP2018/074723 patent/WO2019053116A1/en not_active Ceased
- 2018-09-13 BR BR112020004138-6A patent/BR112020004138A2/pt unknown
- 2018-09-13 WO PCT/EP2018/074722 patent/WO2019053115A1/en not_active Ceased
- 2018-09-13 JP JP2020515677A patent/JP7329503B2/ja active Active
- 2018-09-13 JP JP2020515760A patent/JP7366007B2/ja active Active
- 2018-09-13 EP EP18765656.6A patent/EP3682245A1/en active Pending
- 2018-09-13 US US16/646,637 patent/US20200300864A1/en active Pending
- 2018-09-13 CN CN201880059136.6A patent/CN111065927B/zh active Active
- 2018-09-13 US US16/646,639 patent/US12517138B2/en active Active
- 2018-09-13 EP EP18765657.4A patent/EP3682246A1/en active Pending
- 2018-09-13 CA CA3075440A patent/CA3075440A1/en active Pending
- 2018-09-13 CN CN201880059366.2A patent/CN111094986B/zh active Active
-
2023
- 2023-01-19 JP JP2023006500A patent/JP7544879B2/ja active Active
- 2023-10-10 JP JP2023175415A patent/JP2023181226A/ja not_active Abandoned
-
2025
- 2025-01-17 US US19/027,967 patent/US20250189539A1/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008012019A2 (de) | 2006-07-24 | 2008-01-31 | B.R.A.H.M.S. Aktiengesellschaft | Verfahren zur steuerung der therapie von patienten mit herzinsuffizienz anhand der in vitro bestimmung von schwellenwerten von vasoaktiven peptiden |
| JP2009544951A (ja) | 2006-07-24 | 2009-12-17 | ベー・エル・アー・ハー・エム・エス・アクティエンゲゼルシャフト | 血管作動性ペプチドの閾値をインビトロで測定することによって心機能不全を患う患者の治療を管理する方法 |
| US20080213746A1 (en) | 2006-11-09 | 2008-09-04 | Leong Loke Ng | Methods of Diagnosis and Risk Stratification of Adverse Events in Post Myocardial Infarction Patients Using Pro-adrenomedullin |
| JP2012526271A (ja) | 2009-05-05 | 2012-10-25 | ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 内皮性機能/機能不全に関連した疾患に罹患している患者の血管作動性ホルモンに基づいた層化 |
| JP2013541015A (ja) | 2010-11-01 | 2013-11-07 | ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 非特異的症状を有する患者の予後及びリスク評価 |
| US20130302841A1 (en) | 2010-11-01 | 2013-11-14 | B.R.A.H.M.S Gmbh | Prognosis and risk assessment of patients with non-specific complaints |
| JP2016521315A (ja) | 2013-04-19 | 2016-07-21 | ユナイテッド テクノロジーズ コーポレイションUnited Technologies Corporation | 付加製造のためのビルドプレート及び装置 |
Non-Patent Citations (7)
| Title |
|---|
| Darius Cameron Wilson,Early sepsis identification following cytoreductive surgery for peritoneal malignancy,Critical Care,2020年,Vol.24,Page.112 |
| Francesco Travaglino,Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II score,BMC Infectious Diseases,2012年08月08日,Vol.12,Page.184 |
| Jochen Gille,MR-proADM: A New Biomarker for Early Diagnosis of Sepsis in Burned Patients,Journal of Burn Care & Research,2017年09月01日,Vol.38 No.5,Pages 290-298 |
| Munirah Al Shuaibi,Pro-adrenomedullin as a Novel Biomarker for Predicting Infections and Response to Antimicrobials in Febrile Patients With Hematologic Malignancies,Clinical Infectious Diseases,2013年01月03日,Vol.56 No.7,Page.943-950 |
| MUNIRAH AL SHUAIBI; ET AL,PRO-ADRENOMEDULLIN AS A NOVEL BIOMARKER FOR PREDICTING INFECTIONS AND RESPONSE TO ANTIMICROBIALS IN FEBRILE PATIENTS WITH HEMATOLOGIC MALIGNANCIES,CLINICAL INFECTIOUS DISEASES,米国,THE UNIVERSITY OF CHICAGO PRESS,2013年01月03日,VOL:56, NR:7,PAGE(S):943 - 950,http://dx.doi.org/10.1093/cid/cis1029 |
| Oliver Hartm,Time-dependent Cox regression: Serial measurement of the cardiovascular biomarker proadrenomedullin improves survival prediction in patients with lower respiratory tract infection,International Journal of Cardiology,2012年09月24日,Vol.161 No.3,Page.166-173 |
| Pierre-Emmanuel Charles,MR-PROADM ELEVATION UPON ICU ADMISSION PREDICTS THE OUTCOME OF SEPTIC PATIENTS AND IS CORRELATED WITH UPCOMING FLUID OVERLOAD,SHOCK,2017年10月,Vol.48 No.4,Page.418-426 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020004138A2 (pt) | 2020-09-08 |
| RU2020111719A3 (https=) | 2021-12-17 |
| JP2020533604A (ja) | 2020-11-19 |
| US20200300864A1 (en) | 2020-09-24 |
| US20250189539A1 (en) | 2025-06-12 |
| EP3682246A1 (en) | 2020-07-22 |
| CN111094986B (zh) | 2023-11-10 |
| WO2019053116A1 (en) | 2019-03-21 |
| JP7366007B2 (ja) | 2023-10-20 |
| CN111065927B (zh) | 2023-10-17 |
| US20200271667A1 (en) | 2020-08-27 |
| EP3682245A1 (en) | 2020-07-22 |
| CN111094986A (zh) | 2020-05-01 |
| WO2019053116A8 (en) | 2022-03-17 |
| JP2023181226A (ja) | 2023-12-21 |
| WO2019053115A1 (en) | 2019-03-21 |
| JP7544879B2 (ja) | 2024-09-03 |
| CN111065927A (zh) | 2020-04-24 |
| US12517138B2 (en) | 2026-01-06 |
| RU2020111719A (ru) | 2021-10-13 |
| JP2023041741A (ja) | 2023-03-24 |
| JP2020537117A (ja) | 2020-12-17 |
| CA3075440A1 (en) | 2019-03-21 |
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