JP7322895B2 - 温度応答性イオン液体を含む医薬組成物 - Google Patents

温度応答性イオン液体を含む医薬組成物 Download PDF

Info

Publication number
JP7322895B2
JP7322895B2 JP2020558988A JP2020558988A JP7322895B2 JP 7322895 B2 JP7322895 B2 JP 7322895B2 JP 2020558988 A JP2020558988 A JP 2020558988A JP 2020558988 A JP2020558988 A JP 2020558988A JP 7322895 B2 JP7322895 B2 JP 7322895B2
Authority
JP
Japan
Prior art keywords
temperature
ion
ionic liquid
synthesis example
tetrabutylphosphonium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020558988A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2021070893A1 (https=
Inventor
崇光 本白水
真史 須藤
卓 高木
美樹人 平形
由里 梶原
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of JPWO2021070893A1 publication Critical patent/JPWO2021070893A1/ja
Application granted granted Critical
Publication of JP7322895B2 publication Critical patent/JP7322895B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020558988A 2019-10-11 2020-10-08 温度応答性イオン液体を含む医薬組成物 Active JP7322895B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019187274 2019-10-11
JP2019187274 2019-10-11
PCT/JP2020/038097 WO2021070893A1 (ja) 2019-10-11 2020-10-08 温度応答性イオン液体を含む医薬組成物

Publications (2)

Publication Number Publication Date
JPWO2021070893A1 JPWO2021070893A1 (https=) 2021-04-15
JP7322895B2 true JP7322895B2 (ja) 2023-08-08

Family

ID=75437270

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020558988A Active JP7322895B2 (ja) 2019-10-11 2020-10-08 温度応答性イオン液体を含む医薬組成物

Country Status (9)

Country Link
US (1) US20240058452A1 (https=)
EP (1) EP4043007A4 (https=)
JP (1) JP7322895B2 (https=)
KR (1) KR20220080076A (https=)
CN (1) CN114502142B (https=)
AU (1) AU2020362643B2 (https=)
BR (1) BR112022005324A2 (https=)
CA (1) CA3157143A1 (https=)
WO (1) WO2021070893A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2024106024A1 (https=) * 2022-11-14 2024-05-23

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008044849A (ja) 2006-08-10 2008-02-28 Tokyo Univ Of Agriculture & Technology 温度制御により水と可逆的に相溶／相分離を示すイオン液体
WO2008093686A1 (ja) 2007-01-29 2008-08-07 Medrx Co., Ltd. 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途
WO2009066457A1 (ja) 2007-11-22 2009-05-28 Medrx Co., Ltd. 脂肪酸系イオン液体を有効成分とする外用剤組成物
WO2009075094A1 (ja) 2007-12-11 2009-06-18 Medrx Co., Ltd. イオン液体化したエトドラクのテープ剤
WO2009119836A1 (ja) 2008-03-28 2009-10-01 アンジェスＭｇ株式会社 転写因子デコイを有効成分とする外用剤組成物
WO2015129527A1 (ja) 2014-02-27 2015-09-03 株式会社メドレックス プラミペキソールを含有する神経変性疾患の治療用貼付剤
WO2016121753A1 (ja) 2015-01-27 2016-08-04 味の素株式会社 皮膚浸透調節方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1705640A (zh) * 2002-08-16 2005-12-07 塞克姆公司 包含磺酸根阴离子的离子液体
US20060094616A1 (en) * 2004-11-01 2006-05-04 Hecht Stacie E Ionic liquids derived from surfactants
JP4969065B2 (ja) 2005-07-13 2012-07-04 株式会社 メドレックス 常温性イオン性液体を含有する医薬組成物
JP2009178617A (ja) * 2008-01-29 2009-08-13 Sanyo Chem Ind Ltd 熱応答性液体組成物
WO2010078300A1 (en) * 2008-12-29 2010-07-08 The Board Of Trustees Of The University Of Alabama Dual functioning ionic liquids and salts thereof
EP2744335B1 (en) * 2011-08-16 2018-10-10 Basf Se Composition comprising active ingredient, oil and ionic liquid
WO2014024896A1 (ja) * 2012-08-08 2014-02-13 株式会社メドレックス アゴメラチンを含有する貼付剤組成物
CN105363360A (zh) * 2014-08-26 2016-03-02 中国科学院大连化学物理研究所 一种温度刺激响应智能化的微乳液体系及其应用
EP3395368A1 (en) 2014-10-30 2018-10-31 Asahi Kasei Kabushiki Kaisha Transdermal absorption enhancer and transdermal absorption enhancement aid
CN106420610B (zh) * 2016-10-21 2019-06-11 昆明理工大学 一种离子液体微乳及其应用
CN109896992A (zh) * 2017-12-08 2019-06-18 武汉软件工程职业学院 制备离子液体的方法及其应用

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008044849A (ja) 2006-08-10 2008-02-28 Tokyo Univ Of Agriculture & Technology 温度制御により水と可逆的に相溶／相分離を示すイオン液体
WO2008093686A1 (ja) 2007-01-29 2008-08-07 Medrx Co., Ltd. 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途
WO2009066457A1 (ja) 2007-11-22 2009-05-28 Medrx Co., Ltd. 脂肪酸系イオン液体を有効成分とする外用剤組成物
WO2009075094A1 (ja) 2007-12-11 2009-06-18 Medrx Co., Ltd. イオン液体化したエトドラクのテープ剤
WO2009119836A1 (ja) 2008-03-28 2009-10-01 アンジェスＭｇ株式会社 転写因子デコイを有効成分とする外用剤組成物
WO2015129527A1 (ja) 2014-02-27 2015-09-03 株式会社メドレックス プラミペキソールを含有する神経変性疾患の治療用貼付剤
WO2016121753A1 (ja) 2015-01-27 2016-08-04 味の素株式会社 皮膚浸透調節方法

Also Published As

Publication number Publication date
AU2020362643B2 (en) 2024-12-12
EP4043007A4 (en) 2023-11-08
CA3157143A1 (en) 2021-04-15
JPWO2021070893A1 (https=) 2021-04-15
WO2021070893A1 (ja) 2021-04-15
BR112022005324A2 (pt) 2022-06-14
US20240058452A1 (en) 2024-02-22
EP4043007A1 (en) 2022-08-17
CN114502142B (zh) 2023-05-09
CN114502142A (zh) 2022-05-13
AU2020362643A1 (en) 2022-05-05
KR20220080076A (ko) 2022-06-14

Similar Documents

Publication Publication Date Title
JP5345937B2 (ja) 抗真菌組成物
JP5544544B2 (ja) 塩基性薬効成分の脂肪酸塩、安息香酸塩を含有する外用剤とその製造方法
US20110207765A1 (en) Topical composition comprising a combination of at least two penetration enhancing agents
JP5674020B2 (ja) 転写因子デコイを有効成分とする外用剤組成物
JP7788131B2 (ja) 経皮吸収製剤
AU2019274772B2 (en) Pharmaceutical formulation
PT2473475T (pt) Utilização de profármacos de canabidiol na administração tópica e transdérmica com microagulhas
WO2011050728A1 (zh) 一种稳定的雷沙吉兰组合物
JPH0525045A (ja) 経皮吸収製剤
JP7322895B2 (ja) 温度応答性イオン液体を含む医薬組成物
WO2014174564A1 (ja) メマンチン含有経皮吸収型貼付製剤
EP2233138A1 (en) Tape preparation comprising etodolac in ionic liquid form
TW202202129A (zh) 含麻醉藥物活性成分的透皮製劑及其製備方法
CN110386869A (zh) 布洛芬离子液体及其制备方法
US20050158371A1 (en) Novel external agent
US10828265B2 (en) Formulations of propranolol and analogs as an amorphous melt or ionic liquid for transdermal drug delivery
WO2024106024A1 (ja) 温度応答性イオン液体、温度応答性イオン液体を含む経皮吸収促進剤又は経皮吸収促進助剤、及び温度応答性イオン液体を含む医薬組成物
JP2024163413A (ja) 吸収制御剤
JP5301205B2 (ja) ゲル軟膏組成物
JP2024163412A (ja) 含窒素化合物用の可溶化剤
WO2017195897A1 (ja) 経皮製剤
BR122023027784A2 (pt) Preparação medicinal para uso externo
HK1161683A (en) Topical composition comprising a combination of at least two penetration enhancing agents

Legal Events

Date Code Title Description
RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20211215

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220913

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20220913

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20221122

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230116

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230328

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230501

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230627

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230710

R151 Written notification of patent or utility model registration

Ref document number: 7322895

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R151