CN114502142B - 包含温度响应性离子液体的医药组合物 - Google Patents

包含温度响应性离子液体的医药组合物 Download PDF

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Publication number
CN114502142B
CN114502142B CN202080070860.6A CN202080070860A CN114502142B CN 114502142 B CN114502142 B CN 114502142B CN 202080070860 A CN202080070860 A CN 202080070860A CN 114502142 B CN114502142 B CN 114502142B
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temperature
ion
ionic liquid
synthesis example
tetrabutylphosphonium
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CN114502142A (zh
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本白水崇光
须藤真史
高木卓
平形美树人
梶原由里
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Toray Industries Inc
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Toray Industries Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080070860.6A 2019-10-11 2020-10-08 包含温度响应性离子液体的医药组合物 Active CN114502142B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-187274 2019-10-11
JP2019187274 2019-10-11
PCT/JP2020/038097 WO2021070893A1 (ja) 2019-10-11 2020-10-08 温度応答性イオン液体を含む医薬組成物

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CN114502142A CN114502142A (zh) 2022-05-13
CN114502142B true CN114502142B (zh) 2023-05-09

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Country Link
US (1) US20240058452A1 (https=)
EP (1) EP4043007A4 (https=)
JP (1) JP7322895B2 (https=)
KR (1) KR20220080076A (https=)
CN (1) CN114502142B (https=)
AU (1) AU2020362643B2 (https=)
BR (1) BR112022005324A2 (https=)
CA (1) CA3157143A1 (https=)
WO (1) WO2021070893A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2024106024A1 (https=) * 2022-11-14 2024-05-23

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1705640A (zh) * 2002-08-16 2005-12-07 塞克姆公司 包含磺酸根阴离子的离子液体
JP2009178617A (ja) * 2008-01-29 2009-08-13 Sanyo Chem Ind Ltd 熱応答性液体組成物
US20100256174A1 (en) * 2007-11-22 2010-10-07 Toshikazu Yamaguchi External preparation composition comprising fatty acid-based ionic liquid as active ingredient
CN103929962A (zh) * 2011-08-16 2014-07-16 巴斯夫欧洲公司 包含活性成分、油和离子液体的组合物
CN105363360A (zh) * 2014-08-26 2016-03-02 中国科学院大连化学物理研究所 一种温度刺激响应智能化的微乳液体系及其应用
US20170014353A1 (en) * 2014-02-27 2017-01-19 Medrx Co., Ltd. Pramipexole-Containing Transdermal Patch for Treatment of Neurodegenerative Disease
CN106420610A (zh) * 2016-10-21 2017-02-22 昆明理工大学 一种离子液体微乳及其应用
US20170319545A1 (en) * 2015-01-27 2017-11-09 Ajinomoto Co., Inc. Method for controlling skin penetration

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060094616A1 (en) * 2004-11-01 2006-05-04 Hecht Stacie E Ionic liquids derived from surfactants
JP4969065B2 (ja) 2005-07-13 2012-07-04 株式会社 メドレックス 常温性イオン性液体を含有する医薬組成物
JP2008044849A (ja) * 2006-08-10 2008-02-28 Tokyo Univ Of Agriculture & Technology 温度制御により水と可逆的に相溶／相分離を示すイオン液体
US20100029704A1 (en) * 2007-01-29 2010-02-04 Medrx Co., Ltd. Salt of nonsteroidal anti-inflammatory drug and organic amine compound and use thereof
EP2233138B1 (en) * 2007-12-11 2014-07-23 Medrx Co., Ltd. Tape preparation comprising etodolac in ionic liquid form
WO2009119836A1 (ja) * 2008-03-28 2009-10-01 アンジェスＭｇ株式会社 転写因子デコイを有効成分とする外用剤組成物
WO2010078300A1 (en) * 2008-12-29 2010-07-08 The Board Of Trustees Of The University Of Alabama Dual functioning ionic liquids and salts thereof
WO2014024896A1 (ja) * 2012-08-08 2014-02-13 株式会社メドレックス アゴメラチンを含有する貼付剤組成物
EP3395368A1 (en) 2014-10-30 2018-10-31 Asahi Kasei Kabushiki Kaisha Transdermal absorption enhancer and transdermal absorption enhancement aid
CN109896992A (zh) * 2017-12-08 2019-06-18 武汉软件工程职业学院 制备离子液体的方法及其应用

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1705640A (zh) * 2002-08-16 2005-12-07 塞克姆公司 包含磺酸根阴离子的离子液体
US20100256174A1 (en) * 2007-11-22 2010-10-07 Toshikazu Yamaguchi External preparation composition comprising fatty acid-based ionic liquid as active ingredient
JP2009178617A (ja) * 2008-01-29 2009-08-13 Sanyo Chem Ind Ltd 熱応答性液体組成物
CN103929962A (zh) * 2011-08-16 2014-07-16 巴斯夫欧洲公司 包含活性成分、油和离子液体的组合物
US20170014353A1 (en) * 2014-02-27 2017-01-19 Medrx Co., Ltd. Pramipexole-Containing Transdermal Patch for Treatment of Neurodegenerative Disease
CN105363360A (zh) * 2014-08-26 2016-03-02 中国科学院大连化学物理研究所 一种温度刺激响应智能化的微乳液体系及其应用
US20170319545A1 (en) * 2015-01-27 2017-11-09 Ajinomoto Co., Inc. Method for controlling skin penetration
CN106420610A (zh) * 2016-10-21 2017-02-22 昆明理工大学 一种离子液体微乳及其应用

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Temperature and anion responsive self-assembly of ionic liquid block copolymers coating gold nanoparticles;Junbo LI et al;《Front. Mater. Sci.》;20161231;第1-9页 *

Also Published As

Publication number Publication date
AU2020362643B2 (en) 2024-12-12
EP4043007A4 (en) 2023-11-08
JP7322895B2 (ja) 2023-08-08
CA3157143A1 (en) 2021-04-15
JPWO2021070893A1 (https=) 2021-04-15
WO2021070893A1 (ja) 2021-04-15
BR112022005324A2 (pt) 2022-06-14
US20240058452A1 (en) 2024-02-22
EP4043007A1 (en) 2022-08-17
CN114502142A (zh) 2022-05-13
AU2020362643A1 (en) 2022-05-05
KR20220080076A (ko) 2022-06-14

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