JP7315466B2 - 生体試料中において改善した性能を有する、ｔｉｍｐ２に関するアッセイ - Google Patents
生体試料中において改善した性能を有する、ｔｉｍｐ２に関するアッセイ Download PDFInfo
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| WO2010048346A1 (en) | 2008-10-21 | 2010-04-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| ES2818138T3 (es) | 2009-12-20 | 2021-04-09 | Astute Medical Inc | Métodos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal |
| EP2585827A4 (en) | 2010-06-23 | 2013-12-04 | Astute Medical Inc | METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING kidney injury and kidney insufficiency |
| EP3540440B1 (en) | 2011-12-08 | 2022-09-28 | Astute Medical, Inc. | Methods and uses for evaluating renal injury and renal status |
| JP6681195B2 (ja) | 2013-01-17 | 2020-04-15 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| JP2016540759A (ja) | 2013-12-03 | 2016-12-28 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後のための方法および組成物 |
| US11243202B2 (en) | 2015-04-09 | 2022-02-08 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP3465201A4 (en) | 2016-06-06 | 2020-08-26 | Astute Medical, Inc. | MANAGEMENT OF ACUTE KIDNEY DAMAGE USING INSULINOMIMETIC GROWTH FACTOR BINDING PROTEIN 7 AND TISSUE METALLOPROTEINASE 2 INHIBITOR |
| CN110431422A (zh) | 2017-02-06 | 2019-11-08 | 机敏医药股份有限公司 | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 |
| US11718682B2 (en) | 2017-04-05 | 2023-08-08 | Astute Medical, Inc. | Assays for TIMP2 having improved performance in biological samples |
| WO2023225626A2 (en) * | 2022-05-20 | 2023-11-23 | Adanate, Inc. | Multi-targeting lilrb antibodies and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008508502A (ja) | 2004-07-28 | 2008-03-21 | エフ．ホフマン−ラ ロシュ アーゲー | β細胞不全の標的／マーカーとしてのＴＩＭＰ−２ |
| JP2016528236A (ja) | 2013-08-07 | 2016-09-15 | アスチュート メディカル，インコーポレイテッド | 生物学的試料において改善された性能を有するｔｉｍｐ２のためのアッセイ |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5698671A (en) | 1989-03-21 | 1997-12-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metalloproteinase peptides |
| DE69033982T2 (de) * | 1989-03-21 | 2002-10-24 | The United States Of America, Represented By The Secretary | Matrizenmetalloproteinase-inhibitor-peptide |
| US6797492B2 (en) | 1991-05-17 | 2004-09-28 | Merck & Co., Inc. | Method for reducing the immunogenicity of antibody variable domains |
| DE122004000008I1 (de) | 1991-06-14 | 2005-06-09 | Genentech Inc | Humanisierter Heregulin Antikörper. |
| JP3017591B2 (ja) | 1992-01-17 | 2000-03-13 | 富士薬品工業株式会社 | 抗ヒトｔｉｍｐ−２モノクローナル抗体の製法およびその利用 |
| US6562596B1 (en) | 1993-10-06 | 2003-05-13 | Amgen Inc. | Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods |
| ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
| AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6391265B1 (en) | 1996-08-26 | 2002-05-21 | Biosite Diagnostics, Inc. | Devices incorporating filters for filtering fluid samples |
| EP2314625B1 (en) | 1996-12-03 | 2014-05-07 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| US6045899A (en) | 1996-12-12 | 2000-04-04 | Usf Filtration & Separations Group, Inc. | Highly assymetric, hydrophilic, microfiltration membranes having large pore diameters |
| ES2284210T3 (es) | 1997-07-16 | 2007-11-01 | Charm Sciences Inc. | Un dispositivo de ensayo y un metodo para detectar la presencia de un analito residual en una muestra. |
| WO1999047930A1 (en) | 1998-03-16 | 1999-09-23 | Quidel Corporation | Immunoassay device and method |
| US7214542B2 (en) | 2003-01-30 | 2007-05-08 | Michael Hutchinson | Method of processing assay test results |
| WO2004096832A2 (en) | 2003-04-29 | 2004-11-11 | Children's Medical Center Corporation | Novel antiangiogenic peptides |
| CN1833169A (zh) | 2003-08-11 | 2006-09-13 | 协和梅迪克斯株式会社 | 测量对象物测量器具、测量装置和测量方法 |
| US7485468B2 (en) | 2004-10-15 | 2009-02-03 | Galapagos Bv | Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases |
| WO2007048102A2 (en) | 2005-10-18 | 2007-04-26 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services | Angio-inhibitory peptides derived from human timp-2 |
| WO2010048346A1 (en) | 2008-10-21 | 2010-04-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US8900881B2 (en) | 2008-12-30 | 2014-12-02 | Jin Po Lee | Quantitative analyte assay device and method |
| CN102781471B (zh) | 2009-10-16 | 2016-10-12 | 奥默罗斯公司 | 通过抑制masp-2依赖性补体活化治疗弥散性血管内凝血的方法 |
| ES2818138T3 (es) | 2009-12-20 | 2021-04-09 | Astute Medical Inc | Métodos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal |
| EP2666872B1 (en) | 2010-02-05 | 2016-04-27 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| KR101858765B1 (ko) | 2010-03-31 | 2018-05-16 | 세키스이 메디칼 가부시키가이샤 | 면역 크로마토그래피를 이용한 측정 방법, 면역 크로마토그래피용 테스트 스트립 및 면역 크로마토그래피용 측정 시약 키트 |
| EP2585827A4 (en) | 2010-06-23 | 2013-12-04 | Astute Medical Inc | METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING kidney injury and kidney insufficiency |
| KR20140012943A (ko) | 2010-09-30 | 2014-02-04 | 닛토덴코 가부시키가이샤 | Timp1 및 timp2 발현의 조절 |
| AU2012312907A1 (en) | 2011-08-26 | 2014-03-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP3540440B1 (en) | 2011-12-08 | 2022-09-28 | Astute Medical, Inc. | Methods and uses for evaluating renal injury and renal status |
| CN104603150A (zh) | 2012-04-20 | 2015-05-06 | 中央研究院 | 与CH4和CεmX结构域之间的连接处结合的抗mIgE抗体 |
| AU2013306076B2 (en) * | 2012-08-21 | 2018-01-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mesothelin domain-specific monoclonal antibodies and use thereof |
| JP6681195B2 (ja) | 2013-01-17 | 2020-04-15 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| US20160146832A1 (en) | 2013-06-05 | 2016-05-26 | Lakhmir S. Chawla | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| WO2015069880A1 (en) | 2013-11-06 | 2015-05-14 | Astute Medical, Inc. | Assays for igfbp7 having improved performance in biological samples |
| JP2016540759A (ja) | 2013-12-03 | 2016-12-28 | アスチュート メディカル，インコーポレイテッド | 腎損傷および腎不全の診断および予後のための方法および組成物 |
| KR101605421B1 (ko) * | 2014-03-05 | 2016-03-23 | 국립암센터 | B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도 |
| US11243202B2 (en) | 2015-04-09 | 2022-02-08 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EP3465201A4 (en) | 2016-06-06 | 2020-08-26 | Astute Medical, Inc. | MANAGEMENT OF ACUTE KIDNEY DAMAGE USING INSULINOMIMETIC GROWTH FACTOR BINDING PROTEIN 7 AND TISSUE METALLOPROTEINASE 2 INHIBITOR |
| CN110352073A (zh) | 2016-10-28 | 2019-10-18 | 机敏医药股份有限公司 | 针对timp-2的抗体用于改善肾功能的用途 |
| CN110431422A (zh) | 2017-02-06 | 2019-11-08 | 机敏医药股份有限公司 | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 |
| US11718682B2 (en) | 2017-04-05 | 2023-08-08 | Astute Medical, Inc. | Assays for TIMP2 having improved performance in biological samples |
| US20210025875A1 (en) | 2017-05-07 | 2021-01-28 | Astute Medical, Inc. | Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008508502A (ja) | 2004-07-28 | 2008-03-21 | エフ．ホフマン−ラ ロシュ アーゲー | β細胞不全の標的／マーカーとしてのＴＩＭＰ−２ |
| JP2016528236A (ja) | 2013-08-07 | 2016-09-15 | アスチュート メディカル，インコーポレイテッド | 生物学的試料において改善された性能を有するｔｉｍｐ２のためのアッセイ |
Non-Patent Citations (2)
| Title |
|---|
| Clinica Chimica Acta，1993年，Vol.220, No.1，p.31-45 |
| Journal of Immunological Methods，1995年，Vol.187, No.1，p.33-39 |
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| JP2020516603A (ja) | 2020-06-11 |
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