JP7315302B2 - Composition for external use on the skin - Google Patents

Description

The present invention relates to an external skin composition.

Ultraviolet rays include ultraviolet A rays (UV-A, 315-400 nm) and ultraviolet B rays (UV-B, 280-315 nm), and others. Of these, UV-A is less likely to cause sunburn, but recent studies have shown that UV-A is greatly involved in the generation of spots and wrinkles. That is, UV-A has a long wavelength, reaches deep into the skin, and exerts effects such as denaturation of collagen, for example.

UV-B has a short wavelength and is blocked by the ozone layer and clouds compared to UV-A. However, UV-B has a high energy and damages cells on the surface of the skin and causes inflammation, so it can cause skin cancer and blemishes.

As the effects of ultraviolet rays on the skin have become clearer, the demand for sunscreen compositions with a high ultraviolet-blocking effect has increased, and various sunscreen compositions have been proposed (Patent Document 1).

Japanese Unexamined Patent Application Publication No. 2015-17080

An object of the present invention is to provide a composition for external use on the skin that has an ultraviolet absorbing ability.

The present inventors have made intensive studies to solve the present problem, and as a result, found that an external skin composition having a high ability to enhance the ultraviolet absorption spectrum can be obtained by using (A) a polyether-modified silicone wax, (B) an ultraviolet absorber, and (C) a water-soluble thickener, and completed the present invention.

That is, the present invention provides the following external skin composition.
Section 1. An external skin composition comprising (A) a polyether-modified silicone wax, (B) an ultraviolet absorber, and (C) a water-soluble thickener.

Section 2. Item 2. The composition for external use on skin according to Item 1, wherein the polyether-modified silicone wax (A) is a water-soluble polyether-modified silicone wax.

Item 3. Item 3. The external skin composition according to item 1 or 2, wherein the water-soluble polyether-modified silicone wax is at least one selected from the group consisting of bisPEG-18 methyl ether dimethylsilane, bis PEG-15 methyl ether dimethicone, PEG-32 methyl ether dimethicone, and PEG-17 dimethicone.

Section 4. Item 4. The composition for external use on skin according to any one of Items 1 to 3, wherein the (B) UV absorber is an oil-soluble UV absorber.

Item 5. Item 5. The external composition for skin according to any one of Items 1 to 4, wherein the (B) ultraviolet absorber is contained in an amount of 0.5 w/w% or more relative to the total amount of the external composition for skin.

Item 6. Item 6. The external skin composition according to any one of Items 1 to 5, wherein the water-soluble thickener (C) is at least one selected from the group consisting of an acrylic acid-based thickener, a cellulose-based thickener, a mucopolysaccharide-based thickener, an amino acid-based thickener, a seaweed-based thickener, a microorganism-derived thickener, a polyethylene glycol-based thickener, and a starch-based thickener.

Item 7. Item 7. The external composition for skin according to any one of Items 1 to 6, wherein the water-soluble thickener (C) is an acrylic thickener, and the acrylic thickener is an acrylic acid/alkyl methacrylate copolymer.

Item 8. Item 8. The external composition for skin according to any one of items 1 to 7, which is a sunscreen composition.

Item 9. The present invention also provides
(A) polyether-modified silicone wax,
Provided is a sunscreen gel formulation containing (B) an ultraviolet absorber and (C) a water-soluble thickener.

Item 10. The present invention also provides
(A) polyether-modified silicone wax,
Provided is an oil-in-water sunscreen composition comprising (B) an ultraviolet absorber and (C) a water-soluble thickener.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide an external composition for skin that has a high ability to enhance the ultraviolet absorption spectrum.

1a to 1c are graphs showing the results of an ultraviolet protection effect test of the external skin composition of the present invention (Examples 1 to 3) and the external skin compositions of Comparative Examples 1 to 3. FIG. FIG. 2 is a graph showing the results of an ultraviolet protection effect test of the external skin composition of the present invention (Example 4 and Comparative Examples 4 and 5). 3a to 3c are graphs showing the results of an ultraviolet protection effect test of the external skin composition of the present invention (Examples 5 to 7) and the external skin compositions of Comparative Examples 6 to 8. FIG.

In this specification, the content unit "w/w%" is synonymous with w/w% of "g/100g".

As used herein, "oil-soluble" means that the solubility in water is 1 w/w% or less, and "water-soluble" means that the solubility in water is greater than 1 w/w%.

As used herein, the term "composition for external use on the skin" refers to a composition for external use that can be applied to the skin. The composition for external use on the skin includes, but is not particularly limited to, a sunscreen composition having ultraviolet absorption ability. Here, the "sunscreen composition" includes, for example, a form in which the sunscreen is specified in the product, but even if there is no specification, any composition for external use on the skin having such a function is included in the "sunscreen composition" as used herein.

The composition for external use on skin of the present invention contains (A) a polyether-modified silicone wax, (B) an ultraviolet absorber, and (C) a water-soluble thickener.

As used herein, (A) polyether-modified silicone wax refers to a polyether-modified silicone that is waxy at room temperature and melts upon heating, and more specifically refers to a polyether-modified silicone having a melting point of room temperature (e.g., 20° C.) or higher.

[(A) Polyether-modified silicone wax]
In the present invention, the polyether-modified silicone wax (A) is not particularly limited, but is preferably a water-soluble polyether-modified silicone wax. As such a water-soluble polyether-modified silicone wax, it is particularly preferable to use one or more selected from the group consisting of, but not limited to, bis-PEG-18 methyl ether dimethylsilane, bis-PEG-15 methyl ether dimethicone, PEG-32 methyl ether dimethicone, and PEG-17 dimethicone. Although not limited, the use of these waxes is preferable when the composition for external use on the skin of the present invention is a non-sticky emulsion having good emulsion stability and a refreshing feel. Component (A) can be used after being synthesized, or a commercially available product can be used as it is.

Specifically, as the water-soluble polyether-modified silicone wax, 2501 CosmeticWax (manufactured by Dow Toray Co., bis PEG-18 methyl ether dimethylsilane, melting point 36 to 42° C.), DMC 6038 (manufactured by Wacker, bis PEG-15 methyl ether dimethicone, melting point about 30° C.), KF-6004 (manufactured by Shin-Etsu Chemical Co., PEG-32 methyl ether dimethicone, melting point 45° C.), or Silsoft. (registered trademark) 895 (manufactured by MOMENTIVE, PEG-17 dimethicone) and the like.

In the composition for external use on skin of the present invention, the total content of component (A) relative to the total amount of the composition for external use on skin is appropriately set according to the balance with other components. The total content of component (A) is preferably 0.001 w/w% or more, more preferably 0.01 w/w% or more, still more preferably 0.1 w/w% or more, and most preferably 0.2 w/w% or more, relative to the total amount of the external composition for skin. The total content of component (A) is preferably 20 w/w% or less, more preferably 10 w/w% or less, even more preferably 5 w/w% or less, and most preferably 3 w/w% or less, relative to the total amount of the external composition for skin. The total content of component (A) is preferably 0.001 w/w% to 20 w/w%, more preferably 0.01 w/w% to 10 w/w%, still more preferably 0.1 w/w% to 5 w/w%, and most preferably 0.2 w/w% to 3 w/w%, relative to the total amount of the external composition for skin.

[(B) UV absorber]
In the present specification, (B) an ultraviolet absorber refers to a compound (component) having the property of absorbing ultraviolet rays.

Examples of the ultraviolet absorber include:
(a) 2-ethylhexyl paramethoxycinnamate (also known as ethylhexyl methoxycinnamate), isopropyl methoxycinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrylene), diisopropyl methylcinnamate, methylbis(trimethylsiloxy)silylisopentyl trimethoxycinnamate, methyl 2,5-diisopropylcinnamate, glyceryl di-paramethoxycinnamate mono-2-ethylhexanoate, cinoxate , DEA methoxycinnamate, ferulic acid and cinnamic acid derivatives such as isoamyl methoxycinnamate;
(b) para-aminobenzoic acid (hereinafter abbreviated as “PABA”), ethyl PABA, ethyl-dihydroxypropyl PABA, ethylhexyl-dimethyl PABA, glyceryl PABA, PEG-25PABA, amyl paradimethylaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, and 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester (also known as diethylaminohydroxybenzoic acid benzoic acid derivatives such as (also referred to as hexyl ylbenzoate, etc.);
(c) salicylic acid derivatives such as homosalate, ethylhexyl salicylate, TEA salicylate, ethylene glycol salicylate, and dipropylene glycol salicylate;
(d) dihydroxybenzophenone (benzophenone-1), tetrahydroxybenzophenone (benzophenone-2), 2-hydroxy-4-methoxybenzophenone (benzophenone-3), hydroxymethoxybenzophenone sulfonic acid (benzophenone-4), dihydroxydimethoxybenzophenone (benzophenone-5), dihydroxydimethoxybenzophenone (benzophenone-6), 2,2′-dihydroxy-4-methoxybenzophenone (benzophenone-8), and 3,3′-carbonyl Benzophenone derivatives such as bis[4-hydroxy-6-methoxybenzenesulfonic acid] disodium (benzophenone-9);
(e) benzylidene camphor derivatives such as 3-benzylidene camphor, 4-methylbenzylidene camphor, benzylidene camphor sulfonic acid, terephthalylidene dicamphor sulfonic acid, benzalkonium methosulfate camphor, and polyacrylamidemethylbenzylidene camphor;
(f) anisotriazine, diethylhexylbutamide triazone, 2,4,6-tris(diisobutyl-4′-aminobenzalmalonate)-s-triazine, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine (also referred to as bisethylhexyloxyphenolmethoxyphenyltriazine, etc.), and 2,4,6-triazine triazine derivatives such as su[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine;
(g) phenylbenzimidazole sulfonic acid and phenylbenzimidazole derivatives such as disodium phenyldibenzimidazole tetrasulfonate;
(h) Drometrizole trisiloxane and phenylbenzotriazole derivatives such as 2,2′-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol];
(i) anthranyl derivatives such as menthyl anthranilate;
(j) imidazolidine derivatives such as 2-ethylhexyl dimethoxybenzylidene oxoimidazolidinepropionate;
(k) benzalmalonate derivatives such as dimethicodiethylbenzalmalonate;
(l) 4,4-diarylbutadiene derivatives such as 1,1-dicarboxy(2,2′-dimethylpropyl)-4,4-diphenylbutadiene; and (m) dibenzoylmethane derivatives such as 4-tert-butyl-4′-methoxydibenzoylmethane;

In the present invention, (B) the UV absorber is preferably an oil-soluble UV absorber. By using an oil-soluble ultraviolet absorber, the composition for external use on the skin of the present invention becomes resistant to sweat and water, suppresses removal after application, and, together with other ingredients, exhibits an excellent effect of easily forming a uniform film that is compatible with sebum.

Here, as the oil-soluble ultraviolet absorber,
(a) 2-ethylhexyl paramethoxycinnamate, isopropyl methoxycinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrylene), diisopropyl methylcinnamate, methylbis(trimethylsiloxy)silylisopentyl trimethoxycinnamate, methyl 2,5-diisopropylcinnamate, glyceryl mono-2-ethyldiparamethoxycinnamate, cinoxate, DEA methoxycinnamate, ferulic acid, and , isoamyl methoxycinnamate;
(b) PABA, ethyl PABA, ethyl-dihydroxypropyl PABA, ethylhexyl-dimethyl PABA, glyceryl PABA, PEG-25PABA, amyl paradimethylaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, and 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester;
(c) ethylhexyl salicylate, TEA salicylate, and dipropylene glycol salicylate;
(d) dihydroxydimethoxybenzophenone (benzophenone-6);
(e) polyacrylamide methylbenzylidene camphor;
(f) anisotriazine, diethylhexylbutamide triazone, 2,4,6-tris(diisobutyl-4′-aminobenzalmalonate)-s-triazine, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, and 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino] -1,3,5-triazine;
(h) Drometrizol trisiloxane;
(i) menthyl anthranilate;
(j) 2-ethylhexyl dimethoxybenzylidene oxoimidazolidinepropionate;
(k) dimethicodiethylbenzalmalonate;
(l) 1,1-dicarboxy(2,2′-dimethylpropyl)-4,4-diphenylbutadiene; and (m) 4-tert-butyl-4′-methoxydibenzoylmethane;

These (B) UV absorbers may be used alone or in combination of two or more. The ultraviolet absorber can be synthesized and used, or a commercially available product can be used as it is.

In the composition for external use on the skin of the present invention, one or two or more of the above ultraviolet absorbers may be used as the ultraviolet absorber in order to reduce irritation and odor, and to improve usability and solubility. Specifically, microcapsules (ultraviolet absorber-encapsulated capsules) having an average particle size of 0.4 to 10 μm, encapsulating an ultraviolet absorber in a shell substantially composed of a polymer component composed of poly(ethylene glycol dimethacrylate), ethylene glycol dimethacrylate/divinylbenzene copolymer, or poly(divinylbenzene), and microcapsules in which t-butyl methoxydibenzoylmethane is encapsulated in sol-gel silica glass and dispersed in water (for example, Eusolex UV-Pearls). OB-S (trade name), Eusolex UV-Pearls OB-S2 (trade name); manufactured by Merck) and similarly ethylhexyl methoxycinnamate encapsulated in sol-gel silica glass and dispersed in water microcapsules (e.g., Eusolex UV-Pearls 2292 (trade name), Eusolex UV-Pearls OMC (trade name); manufactured by Merck), An ultraviolet absorber (octocrylene, diethylaminohydroxybenzoylbenzoic acid, ethylhexyl methoxycinnamate, 2-ethylhexyl paramethoxycinnamate, t-butyl-methoxydibenzoylmethane, etc.) is encapsulated with silicone-resinized hydrolyzed silk (polysilicone-14), formed into microcapsules with an average particle size of 2 μm, and dispersed in water (for example, Silasoma (registered trademark) ME, Silasoma MEA, Silasoma ME). A (S), Silasoma MEA (V), Silasoma MEA (L), Silasoma MFA (S), Silasoma MFA (LS), Silasoma EP (S), Silasoma series (trade names) such as Silasoma REA (S); manufactured by Seiwa Kasei Co., Ltd.).

In the composition for external use on skin of the present invention, the total content of component (B) with respect to the total amount of the composition for external use on skin is appropriately set according to the balance with other components. The total content of component (B) is preferably 0.01 w/w% or more, more preferably 0.1 w/w% or more, still more preferably 0.5 w/w% or more, even more preferably 1.0 w/w% or more, and most preferably 3.0 w/w% or more, relative to the total amount of the external composition for skin. In addition, the total content of component (B) is preferably 25 w/w% or less, more preferably 20 w/w% or less, even more preferably 15 w/w% or less, and most preferably 10 w/w% or less, relative to the total amount of the external composition for skin. The total content of component (B) is preferably 0.01 w/w% to 25 w/w%, more preferably 0.1 w/w% to 20 w/w%, still more preferably 0.5 w/w% to 15 w/w%, and most preferably 1.0 w/w% to 10 w/w%, relative to the total amount of the external composition for skin.

In the composition for external use on skin of the present invention, the ratio of the amount of component (B) to component (A) is preferably 0.0005 to 25000 parts by weight, more preferably 0.01 to 2000 parts by weight, more preferably 0.1 to 150 parts by weight, and most preferably 0.34 to 50 parts by weight, per 1 part by weight of total component (A).

[(C) Water-soluble thickener]
As used herein, (C) a water-soluble thickener refers to an agent (ingredient) that dissolves in water and has the property of increasing viscosity.

In the composition for external use on the skin of the present invention, (C) the water-soluble thickener is preferably an acrylic acid-based thickener, a cellulose-based thickener, a mucopolysaccharide-based thickener, an amino acid-based thickener, a seaweed-based thickener, a microorganism-derived thickener, a polyethylene glycol-based thickener, or a starch-based thickener.

Specific examples of water-soluble thickeners include (a) acrylic acid-based thickeners such as acrylic acid/alkyl methacrylate copolymer, hydroxyethyl acrylate/acryloyldimethyltaurate salt copolymer, polyacrylic acid, or salts thereof;
(b) Cellulosic thickeners such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxyethylcellulose, stearoxyhydroxypropylmethylcellulose;
(c) Hyaluronic acid, hyaluronic acid derivatives, and salts thereof, mucopolysaccharide thickeners such as sodium chondroitin sulfate;
(d) amino acid thickeners such as collagen;
(e) seaweed-based thickeners such as carrageenan, alginate, propylene glycol alginate, agar;
(f) microbial thickeners such as xanthan gum, hydroxypropyl xanthan gum, dextran, sclerotium gum, gellan gum;
(g) polyethylene glycol-based thickeners such as polyethylene glycol, polyethylene glycol distearate, (PEG-240/decyltetredeceth-20/HDI) copolymer, glyceryl behenate/polyglyceryl-6 octastearate; and
(h) starch-based thickeners such as hydroxypropyl starch phosphate, corn starch;
are exemplified.

In addition, other water-soluble polymers such as ethylene glycol triisostearate, polyoxyethylene (20) methyl glucoside triisostearate, bentonite, macrogol, and sodium caseinate can be used.

In the present invention, an acrylic acid-based thickener is particularly preferred as (C) the water-soluble thickener. In the present invention, particularly preferred acrylic thickeners include (acrylates/alkyl (C10-30) acrylate) crosspolymer, (hydroxyethyl acrylate/sodium acryloyldimethyltaurate) copolymer, acrylamide/ammonium acrylate copolymer, (acrylates/beheneth-25 methacrylate) crosspolymer sodium, polyacrylate-6, polyacrylate-13, (acrylic acid/acryloyldimethyltaurine/dimethylacrylamide) crosspolymer, and (acrylates/itacon). acid steareth-20) copolymer, (acryloyldimethyltaurate ammonium/VP) copolymer, (sodium acrylate/acryloyldimethyltaurate/dimethylacrylamide) crosspolymer, steareth-10 allyl ether acrylates copolymer, carboxyvinyl polymer, and polyacrylamide.

In addition, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyethylene glycol, polyvinyl alcohol, xanthan gum, hydroxypropyl starch phosphate, sodium hyaluronate, hyaluronic acid derivatives or salts thereof, collagen, agar, xanthan gum, hydroxypropyl starch phosphate, macrogol, etc. are also preferably used.

These (C) water-soluble thickeners may be used alone or in combination of two or more. When these water-soluble thickeners are used, it is possible to prepare a gel preparation with a particularly high watery feel, and it is possible to prepare a light gel preparation that has an appropriate film feeling and formulation stability, and is comfortable to use.

In addition, these are commercially available products such as PEMULEN (trademark) TR-1, TR-2 (manufactured by Lubrizol Advanced Materials); Carbopol (trademark) ETD2020, Ultrez20Polymer, ), STRUCTURE (trademark) 2001 (manufactured by Akzo Nobel), Aristoflex (trademark) AVC, HMB (manufactured by Clariant Japan) and the like can be used. As the polyvinyl alcohol, commercially available products such as Gohsenol™ EG-05 and EG-40 (manufactured by Nippon Synthetic Chemical Industry Co., Ltd.) can be used. Moreover, you may use it as a mixture mixed with oils, such as squalane, a nonionic surfactant, and water. Specific examples of such a mixture include, for example, SIMULGEL (trademark) FL and NS (manufactured by Sepik), which are commercially available products containing hydroxyethyl acrylate/sodium acryloyldimethyltaurate taurate copolymer; SIMULGEL (trademark) EG (manufactured by Seppic) and SIMULGEL (trademark) EPG (manufactured by Sepik), which are commercially available products containing sodium acrylate/acryloyldimethyltaurate copolymer; SALCARE™ SC80 (manufactured by Ciba Specialty Chemicals), a commercial product containing an ether acrylates copolymer; SALCARE™ SC91 (manufactured by Ciba Specialty Chemicals), a commercial product containing a sodium acrylate/sodium methacrylate/sodium methacrylate alkyl methacrylate copolymer; SEPINO, a commercially available product containing a (sodium acrylate/acryloyldimethyltaurine/dimethylacrylamide) crosspolymer. V (trademark) P88 (manufactured by Seppic), Adekanol (trademark) GT-700 (manufactured by Asahi Denka Kogyo Co., Ltd.); and SEPIGEL (trademark) 305 (Seiwa Kasei), which is a commercially available product containing polyacrylamide. As the polyacrylic acid amide, for example, commercially available SEPIGEL (trademark) 305 (manufactured by Seiwa Kasei Co., Ltd.) can be used. Carbopol (trademark) 940, 941, 980, 981, ETD2050, Ultraz10 Polymer (manufactured by Lubrizol Advanced Materials); Syntaren K Syntaren L (manufactured by 3V SIGMA); AQUPEC (trademark) HV-501E, HV-504E, HV-50 5E (manufactured by Sumitomo Seika Co., Ltd.); Hivis Wako 103, 104, 105 (manufactured by Wako Pure Chemical Industries, Ltd.);

In addition, Adekanol (trademark) GT-700 (manufactured by Asahi Denka Kogyo Co., Ltd.), which is a commercially available product containing a (PEG-240/decyltetradeceth-20/HDI) copolymer, and the starch-based thickener include, for example, STRUCTURE (trademark) XL (manufactured by Akzo Nobel), which is a commercially available product containing hydroxypropyl starch phosphate.

In the external composition for skin of the present invention, the content of (C) the water-soluble thickening component with respect to the total amount of the external composition for skin is preferably 0.00001 w/w% or more, more preferably 0.0001 w/w% or more, still more preferably 0.001 w/w% or more, and most preferably 0.1 w/w% or more. The total content of component (C) is preferably 20 w/w% or less, more preferably 10 w/w% or less, still more preferably 5 w/w% or less, relative to the total amount of the external composition for skin. The total content of component (C) is preferably 0.00001 w/w% to 20 w/w%, more preferably 0.0001 w/w% to 10 w/w%, still more preferably 0.001 w/w% to 5 w/w%, and most preferably 0.1 w/w% to 5 w/w%, relative to the total amount of the external composition for skin.

In the external composition for skin of the present invention, the ratio of the amount of component (C) to component (A) is preferably 0.0000005 to 20000 parts by weight, more preferably 0.000001 to 2000 parts by weight, more preferably 0.00002 to 100 parts by weight, and most preferably 0.00034 to 25 parts by weight, per 1 part by weight of total component (A).

The composition for external use on the skin of the present invention exhibits a high ultraviolet absorption ability and is excellent in use feeling by containing the (A) component, the (B) component and the (C) component. That is, specifically, the composition for external use on the skin of the present invention can have an ultraviolet absorbing power that is enhanced compared to the value exhibited by (B) the ultraviolet absorber alone, and is comfortable to use with a reduced feeling of sliminess.

The composition for external use on the skin of the present invention may contain, in addition to the above components (A) to (C), for example, an ultraviolet diffuse reflecting agent, an antioxidant, a whitening active ingredient, various pharmacologically active ingredients and physiologically active ingredients in combination in an appropriate amount, as long as the effects of the present invention are not hindered.

[UV diffuse reflection agent]
As the UV irregularly reflecting agent in the present invention, any known UV irregularly reflecting agent can be used as long as the effect of the present invention is not impaired. Metal oxide powder and clay particles can be exemplified as the UV diffuse reflection agent. For example, titanium oxide, zinc oxide, cerium oxide, kaolin, or talc.

In the composition for external use on skin of the present invention, the content of the ultraviolet diffuse reflection agent in the total amount of the composition for external use on skin may be, for example, 0.1 w/w% or more and 20 w/w% or less, may be 0.5 w/w% or more and 15 w/w% or less, or may be 1.0 w/w% or more and 10 w/w% or less.

[Antioxidant]
As the antioxidant (antioxidant component) in the present invention, known antioxidants can be used as long as they do not impair the effects of the present invention. In the present invention, an antioxidant (antioxidant component, antioxidant component) refers to a drug (component) that inhibits, reduces, or suppresses oxidation caused by reactive oxygen species and the like.

Examples of the antioxidant include:
(a) vitamin antioxidants such as tocopherols and their derivatives or their salts (e.g., α-tocopherol, δ-tocopherol, acetate-α-tocopherol, tocotrienols), pyrroloquinoline quinones and their derivatives or their salts, ubiquinones and their derivatives or their salts, retinols and their derivatives or their salts, pantothenic acid and its derivatives or their salts, erythorbic acid or their salts;
(b) sulfur-containing antioxidants such as thiotaurine, cysteine, homocysteine, acetylcysteine, methionine, thioglycerol, sodium sulfite, sodium metabisulfite, sodium thiosulfate sodium pyrosulfite, thioredoxin, dithiothreitol, α-lipoic acid, ergothioneine, glutathione, glutathione peroxidase, glutathione-S-transferase;
(c) phenolic antioxidants such as dibutylhydroxytoluene, dibutylhydroxyanisole, bisethylhexylhydroxydimethoxybenzyl malonate, diethylhexylsyringylidene malonate, gallic acid and its derivatives or their salts, chlorogenic acid and its derivatives or their salts;
(d) components derived from plants (e.g., grape, ginseng, comfrey, etc.) (e.g., grape seed extract, grape leaf extract, ginseng extract, comfrey leaf extract, etc.); These may be used alone or in combination of two or more.

In the external skin composition of the present invention, the antioxidant is bisethylhexylhydroxydimethoxybenzyl malonate and its derivatives, malonic acid and its derivatives, pyrroloquinoline quinone and its derivatives, tocopherols and its derivatives, thiotaurine and its derivatives, dibutylhydroxytoluene and its derivatives, gallic acid or its derivatives, chlorogenic acid and its derivatives, hesperidin and its derivatives, glucosylhesperidin and its derivatives, ergothioneine and its derivatives, flavonoids. and derivatives thereof, or dibutylhydroxyanisole and derivatives thereof, and when they can take the form of salts, salts of any of the above compounds and salts of any of the above derivatives are preferred. Among them, bisethylhexylhydroxydimethoxybenzyl malonate, pyrroloquinoline quinone and its derivatives or their salts, tocopherols and their derivatives or their salts, thiotaurine, dibutylhydroxytoluene, gallic acid and its derivatives or their salts, chlorogenic acid and its derivatives or their salts, or dibutylhydroxyanisole are more preferable. Bisethylhexylhydroxydimethoxybenzyl malonate, diethylhexylsyringylidene malonate, pyrroloquinoline quinone and its derivatives or salts thereof, tocopherol and its derivatives or salts thereof, thiotaurine, dibutylhydroxytoluene, or gallic acid and its derivatives or salts thereof are even more preferred.

In the external composition for skin of the present invention, the content of the antioxidant with respect to the total amount of the external composition for skin may be 0.00001 w/w% or more and 20 w/w% or less, may be 0.0001 w/w% or more and 10 w/w% or less, may be 0.001 w/w% or more and 7 w/w% or less, may be 0.05 w/w% or more and 5 w/w% or less, or may be 0.03 w/w. % or more and 3 w/w% or less, 0.02 w/w% or more and 1 w/w% or less, or 0.01 w/w% or more and 0.5 w/w% or less.

[Whitening active ingredient]
As the whitening active ingredient (whitening agent) in the present invention, known whitening active ingredients can be used as long as the effects of the present invention are not impaired. In the present invention, the active whitening ingredient (whitening agent) refers to an agent (ingredient) that has the property of improving, suppressing, reducing, preventing, preventing, or delaying skin pigmentation caused by melanin pigments, etc., which is particularly related to skin dullness, blemishes, chloasma, and the like.

Examples of the whitening active ingredients include:
(a) Hydroquinone and its derivatives or salts thereof (eg α-arbutin, β-arbutin); kojic acid; ellagic acid; phytic acid; rucinol; tyrosinase inhibitors such as 4-methoxysalicylic acid potassium salt, tranexamic acid and its derivatives or salts thereof;
(b) endothelin-1 receptor inhibitors such as chamomilla ET;
(c) a tyrosinase proteolytic agent such as free linoleic acid;
(d) melanin efflux agents such as adenosine monophosphate disodium salt;
(e) melanin transport inhibitors such as niacinamide;
(f) In addition, plant components (for example, plant extracts and essential oils) having a whitening effect can be mentioned. These may be used alone or in combination of two or more.

In the external composition for skin of the present invention, the active whitening ingredient is hydroquinone and its derivatives or their salts, ascorbic acid and its derivatives or their salts, tranexamic acid and its derivatives or their salts, ellagic acid, niacinamide and the like. Among them, hydroquinone, arbutin, sodium ascorbate phosphate, ascorbic acid, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), 3-O-ethylascorbic acid, glucoside ascorbate, tranexamic acid and the like are more preferable.

In the external composition for skin of the present invention, the content of the whitening active ingredient with respect to the total amount of the external composition for skin may be 0.00001 w/w% or more and 20 w/w% or less, may be 0.00001 w/w% or more and 10 w/w% or less, may be 0.001 w/w% or more and 7 w/w% or less, may be 0.05 w/w% or more and 5 w/w% or less, or may be 0.03w. /w% or more and 3 w/w% or less, 0.02 w/w% or more and 1 w/w% or less, or 0.01 w/w% or more and 0.5 w/w% or less.

[Anti-inflammatory ingredient]
As the anti-inflammatory component (anti-inflammatory agent) in the present invention, known anti-inflammatory components can be used as long as they do not impair the effects of the present invention. In the present invention, an anti-inflammatory component (anti-inflammatory agent) refers to a drug (component) that inhibits, reduces, or suppresses inflammation of cells such as epidermis.

Examples of the anti-inflammatory ingredients include ingredients derived from plants (e.g., comfrey leaf extract, etc.); Examples include methacin, salicylic acid and derivatives thereof. These may be used alone or in combination of two or more.

In the external composition for skin of the present invention, the anti-inflammatory component is preferably allantoin, glycyrrhizic acid and its derivatives or their salts, glycyrrhizic acid and its derivatives or their salts, zinc oxide, guaiazulene, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin, salicylic acid and its derivatives or their salts, and the like. Among them, allantoin, glycyrrhizic acid, dipotassium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate, zinc oxide, menthol, camphor, indomethacin, and salicylic acid are more preferable.

Further, in the external composition for skin of the present invention, the content of the anti-inflammatory ingredient in the total amount of the external composition for skin may be 0.00001 w/w% or more and 20 w/w% or less, may be 0.0001 w/w% or more and 10 w/w% or less, may be 0.001 w/w% or more and 5 w/w% or less, may be 0.05 w/w% or more and 3 w/w% or less, or may be 0.03 w/w/%. w % or more and 1 w/w % or less, 0.02 w/w % or more and 0.5 w/w % or less, or 0.01 w/w % or more and 0.1 w/w % or less.

[Other Bases or Carriers]
The external composition for skin of the present invention can contain known bases or carriers used in cosmetics and quasi-drugs to the extent that the effects of the present invention are not impaired. The base or carrier can be used singly or in combination of two or more.

As bases or carriers, hydrocarbons such as paraffin, liquid paraffin, squalane, white wax, gelling hydrocarbons (plastibase etc.), ozokerite, ceresin, vaseline, hard fat, microcrystalline wax, α-olefin oligomers, light liquid paraffin; fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid and isostearic acid; higher alcohols such as cetanol, stearyl alcohol, behenyl alcohol; silicones such as methylpolysiloxane, diddecamethylcyclopentasiloxane, methylsiloxane network polymer, methylhydrogenpolysiloxane; polysaccharides such as dextrin and maltodextrin; lower alcohols such as ethanol and isopropanol; glycol ethers such as ethylene glycol monoethyl ether; and aqueous bases such as water.

Among them, hydrocarbons (especially α-olefin oligomers, squalane, light liquid paraffin, liquid paraffin), tri-fatty acid glycerides (especially glyceryl tri-2-ethylhexanoate, tri(caprylic/capric acid) glyceride), higher alcohols (especially cetanol, stearyl alcohol, behenyl alcohol), silicone oils (especially methylpolysiloxane, decamethylcyclopentasiloxane, ethyltrisiloxane, methyltrimethicone, methylsiloxane network polymer, polyoxyethylene-methylpolysiloxane co- Polymers, methylhydrogenpolysiloxane, triethoxysilylethylpolydimethylsiloxyethylhexyl dimethicone, dimethylpolysiloxane), esters (especially isononyl isononanoate, pentaerythrityl tetra-2-ethylhexanoate), polysaccharides (especially dextrin, maltodextrin), glycol ethers (especially diethylene glycol monoethyl ether), and water are preferred.

When the composition for external use on skin of the present invention contains water as a base, the content of water relative to the total amount of the composition for external use on skin is preferably 30 w/w% or more and 99 w/w% or less, more preferably 40 w/w% or more and 95 w/w% or less, and further preferably 50 w/w% or more and 90 w/w% or less. The skin care composition of the present invention is most preferably an O/W emulsified composition containing 50 w/w% or more of water.

[Additive]
Known additives added to cosmetics and quasi-drugs, such as surfactants, preservatives, pH adjusters, chelating agents, stabilizers, irritation reducers, preservatives, colorants, etc., can be added to the external composition for skin of the present invention within a range that does not impair the effects of the present invention. An additive can be used individually by 1 type or in combination of 2 or more types.

Surfactants include, for example, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; glyceryl fatty acids such as glyceryl monostearate and glyceryl monostearate malic acid; polyglycerol fatty acids such as polyglyceryl acid and polyglyceryl diisostearate; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80 (HCO-80); Oxyethylene (20) sorbitan (polysorbate 20), polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan isostearate; polyoxyethylene monococonut fatty acid glyceryl; glycerol alkyl ether; alkyl glucoside; Alkylene alkyl ethers; amines such as stearylamine and oleylamine; silicone surfactants such as polyoxyethylene/methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and PEG-9 polydimethylsiloxyethyl dimethicone.

Among them, glycerin fatty acids (especially glyceryl monostearate), polyglycerin fatty acids (especially polyglyceryl monostearate), hydrogenated castor oil derivatives (especially polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60)), polyoxyethylene sorbitan fatty acid esters (especially polyoxyethylene (20) sorbitan isostearate, polyoxyethylene monostearate (2 0) Sorbitan (polysorbate 60)), polyoxyalkylene alkyl ether (especially polyoxyethylene cetyl ether), silicone surfactant (especially polyoxyethylene/methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone) are preferred.

Preservatives and antiseptics include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, phenoxyethanol and the like. Among them, methyl parahydroxybenzoate, propyl parahydroxybenzoate, and phenoxyethanol are preferable.

pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, phosphoric acid, polyphosphoric acid, boric acid, etc.), organic acids (lactic acid, acetic acid, citric acid, sodium citrate, tartaric acid, malic acid, succinic acid, sodium succinate, oxalic acid, gluconic acid, fumaric acid, propionic acid, acetic acid, aspartic acid, ε-aminocaproic acid, glutamic acid, aminoethylsulfonic acid, etc.), gluconolactone, ammonium acetate, inorganic bases (sodium bicarbonate, sodium carbonate, potassium hydroxide). , sodium hydroxide, calcium hydroxide, magnesium hydroxide, etc.), organic bases (monoethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, lysine, etc.). Among them, succinic acid, sodium succinate, citric acid, sodium citrate, triethanolamine, potassium hydroxide and sodium hydroxide are preferred.

Chelating agents include ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetate (sodium salt (edetate sodium: Japanese Pharmacopoeia, EDTA-2Na, etc.), potassium salt, etc.), phytic acid, gluconic acid, polyphosphoric acid, metaphosphoric acid, and the like. Among them, sodium edetate is preferred.

Examples of stabilizers include butylhydroxyanisole and the like.

Examples of irritation reducing agents include licorice extract, sodium alginate, 2-methacryloyloxyethylphosphorylcholine and the like.

Examples of coloring agents include inorganic pigments and natural pigments.

[Other active ingredients]
In the present invention, the composition for external use on the skin may contain other active ingredients that can be added to cosmetics and quasi-drugs, such as anti-wrinkle/anti-aging ingredients, keratin softening ingredients, cell activating ingredients, vitamins, moisturizing ingredients, ingredients that prevent and/or repair DNA damage, antibacterial ingredients, and astringent ingredients, as long as the effects of the present invention are not impaired. Other active ingredients can be used singly or in combination of two or more.

Examples of anti-wrinkle and anti-aging ingredients include hydrolyzed soy protein, retinoids (retinol and its derivatives, retinoic acid, retinal, etc.), pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, and mevalonolactone. Among them, artemia extract, hydrolyzed soybean protein, retinol, retinol acetate, and retinol palmitate are preferable.

Examples of keratin softening ingredients include lanolin, urea, α-hydroxy acids (phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, etc.), citric acid, and the like. Among them, lactic acid, sodium lactate, glycolic acid, salicylic acid, and phytic acid are preferred.

Examples of cell activating components include components derived from plants (for example, bilberry); amino acids such as γ-aminobutyric acid and ε-aminoproic acid; α-hydroxy acids such as glycolic acid and lactic acid; Among them, bilberry leaf extract is preferred.

Vitamins include retinol, retinol acetate, retinol palmitate and other retinol derivatives, retinal, retinoic acid, methyl retinoate, ethyl retinoate, retinol retinoate, d-δ-tocopheryl retinoate, α-tocopheryl retinoate, β-tocopheryl retinoate and other vitamin A groups; β-carotene, α-carotene, γ-carotene, δ - provitamin A compounds such as carotene, lycopene, zeaxanthin, cryptoxanthin, echinenone; vitamin E compounds such as δ-tocopherol, α-tocopherol, β-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate, δ-tocopherol, tocopherol nicotinate; riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate , riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinic acid ester; nicotinic acids such as methyl nicotinate, nicotinic acid and nicotinamide; vitamin Cs such as ascorbyl stearate, L-ascorbyl dipalmitate, ascorbyl tetraisopalmitate (tetra-2-hexyldecanoate ascorbyl); vitamin Ds such as phylloquinone and farnoquinone; vitamin Ks such as phylloquinone and farnoquinone; vitamin B1s such as amine triphosphate monophosphate; vitamin B6s such as pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, pyridoxal 5'-phosphate, pyridoxamine hydrochloride; vitamin B12s such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin; panthenol), D-pantethein, D-pantethine, coenzyme A, pantothenic acids such as pantothenyl ethyl ether; biotins such as biotin and biocytin; and vitamin-like acting factors such as carnitine, ferulic acid, α-lipoic acid, orotic acid, and γ-oryzanol.

Among them, vitamin A compounds such as retinol, retinol acetate, and retinol palmitate; vitamin C compounds such as sodium ascorbyl phosphate, magnesium ascorbyl phosphate, ascorbyl tetraisopalmitate (tetra-2-hexyldecanoic acid ascorbyl), 2-O-ethylascorbic acid and 3-O-ethylascorbic acid; vitamin E compounds such as δ-tocopherol and tocopherol nicotinate; nicotinic acid compounds such as nicotinamide. is preferred.

Moisturizing ingredients include ingredients derived from plants (for example, cypress); amino acids and their derivatives such as alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, glucosamine and theanine; proteins and peptides such as collagen, gelatin and elastin, and hydrolysates thereof; polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol and diglycerin; sugar alcohols such as sorbitol; Phospholipids such as added lecithin; NMF-derived components such as lactic acid, sodium pyrrolidone carboxylate, urea; polyglutamic acid; (trademark) S-753 (manufactured by NOF Corporation); trimethylglycine (betaine); hydroxyethylurea; acrylic acid/acrylamide/dimethyldiallylammonium chloride copolymer; Among them, hydrolyzed collagen, hydrolyzed elastin, MPC polymer glycerin, 1,3-butylene glycol, dipropylene glycol, diglycerin, polyoxypropylene methyl glucoside, trimethylglycine (betaine), hydroxyethylurea, hydrogenated lecithin, and sorbitol are preferred.

Examples of components having an action to prevent and/or repair DNA damage include components derived from animals (e.g., Artemia); components derived from plants (e.g., cat's claw); and nucleic acid components such as DNA, DNA salts, RNA, and RNA salts. Among them, Artemia extract and DNA-Na are preferable.

Examples of the antibacterial component include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, paraben, phenoxyethanol, 1,2-pentanediol, and alkyldiaminoglycine hydrochloride. Among them, benzalkonium chloride, benzethonium chloride, gluconic acid and its derivatives, isopropylmethylphenol, triclocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, paraben, phenoxyethanol, 1,2-pentanediol, and alkyldiaminoglycine hydrochloride are preferred, and benzalkonium chloride, gluconic acid and its derivatives, benzethonium chloride, and isopropylmethylphenol are more preferred.

Examples of astringent components include metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc sulfate, and aluminum potassium sulfate; and organic acids such as tannic acid, citric acid, lactic acid, and succinic acid. Among them, alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, aluminum potassium sulfate, and tannic acid are preferred.

[Formulation]
In addition, the composition for external use on the skin of the present invention can be prepared by mixing and stirring each component according to a conventional method.

The composition for external use on the skin in the present invention is not particularly limited in the form of drug, and can take a form known as cosmetics or quasi-drugs. Among such known forms, for example, liquids, suspensions, emulsions, creams, gels, liniments, lotions, aerosols, powders, poultices, sheets such as non-woven fabrics impregnated with chemicals, and sticks such as lipsticks can be mentioned. Among them, liquids, suspensions, emulsions, creams, gels, and lotions are preferred, and gels are more preferred, in terms of good feeling during use. The external skin composition of the present invention is preferably in the form of an aqueous solution, aqueous suspension, aqueous emulsion, aqueous gel, or aqueous lotion. In addition, depending on the formulation, an oil-in-water type (O/W), a water-in-oil type (W/O), etc. can be appropriately selected according to the purpose of use and desired feeling of use, but in particular, an oil-in-water type (O/W) composition is preferred.

The composition for external use on skin of the present invention can be used in the form of basic cosmetics such as emulsion, cream, cosmetics, body lotion and body cream. The composition for external use on skin of the present invention can also be used in the form of make-up cosmetics such as foundation, lipstick, blusher, eye makeup, face powder, manicure, and pedicure.

Since the ultraviolet absorption function can be enhanced by the present invention, the external skin composition of the present invention has a high SPF (Sun Protection Factor) value and a high PA (Protection Grade of UVA) value, which are protective factors against ultraviolet B waves (UV-B) and ultraviolet A waves (UV-A). For example, the external composition for skin of the present invention may have an SPF value of SPF 10 or higher, preferably SPF 20 or higher, more preferably SPF 30 or higher, even more preferably SPF 40 or higher, and particularly preferably SPF 50 or higher. Further, for example, the composition for external use on skin of the present invention may have a PA value of PA+, preferably PA++, more preferably PA+++, still more preferably PA++++.

The present invention further relates to the following methods or uses.
i.e.

(A) a polyether-modified silicone wax for the production of an external skin preparation,
Use of a composition containing (B) a UV absorber and (C) a water-soluble thickener.

(A) a polyether-modified silicone wax for the production of sunscreen formulations,
Use of a composition containing (B) a UV absorber and (C) a water-soluble thickener.

In using the above composition, the polyether-modified silicone wax (A) is preferably a water-soluble polyether-modified silicone wax.

Preferably, the water-soluble polyether-modified silicone wax can be at least one selected from the group consisting of bisPEG-18 methylether dimethylsilane, bisPEG-15 methylether dimethicone, PEG-32 methylether dimethicone, and PEG-17 dimethicone.

In the use of the composition, the (B) UV absorber may preferably be an oil-soluble UV absorber.

Preferably, the (B) ultraviolet absorber can be contained in an amount of 0.5 w/w % or more relative to the total amount of the composition.

In the use of the composition, the water-soluble thickener (C) may be at least one selected from the group consisting of acrylic acid-based thickeners, cellulose-based thickeners, mucopolysaccharide-based thickeners, amino acid-based thickeners, seaweed-based thickeners, microorganism-derived thickeners, polyethylene glycol-based thickeners, and starch-based thickeners.

The water-soluble thickener (C) is an acrylic thickener, and the acrylic thickener may be an acrylic acid/alkyl methacrylate copolymer.

Preferably, the sunscreen formulation may be a gel formulation.

Preferably, the sunscreen formulation may be an oil-in-water sunscreen composition.

The present invention further relates to the following method.
i.e.

(A) polyether-modified silicone wax,
A method of preventing sunburn by applying (B) a UV absorber and (C) a water-soluble thickening agent to the skin.

In the method for preventing sunburn, the (A) polyether-modified silicone wax is preferably a water-soluble polyether-modified silicone wax.

Preferably, the water-soluble polyether-modified silicone wax can be at least one selected from the group consisting of bisPEG-18 methylether dimethylsilane, bisPEG-15 methylether dimethicone, PEG-32 methylether dimethicone, and PEG-17 dimethicone.

In the method for preventing sunburn, the (B) UV absorber may preferably be an oil-soluble UV absorber.

In the method for preventing sunburn, the (A) polyether-modified silicone wax, (B) the ultraviolet absorber, and (C) the water-soluble thickener are preferably applied to the skin in the form of a composition containing the components (A), (B), and (C).

Preferably, the (B) ultraviolet absorber can be contained in an amount of 0.5 w/w % or more relative to the total amount of the composition.

In the method for preventing sunburn, the (C) water-soluble thickener may be at least one selected from the group consisting of an acrylic acid-based thickener, a cellulose-based thickener, a mucopolysaccharide-based thickener, an amino acid-based thickener, a seaweed-based thickener, a microorganism-derived thickener, a polyethylene glycol-based thickener, and a starch-based thickener.

The water-soluble thickener (C) is an acrylic thickener, and the acrylic thickener may be an acrylic acid/alkyl methacrylate copolymer.

Preferably, the composition may be a gel formulation or an oil-in-water composition.

EXAMPLES Next, the present invention will be specifically described with reference to examples, but the present invention is not limited to the following examples.
The unit of each component amount in Tables 1 to 5 is w/w%.

Sunscreen compositions having compositions shown in Tables 1 to 3 were prepared according to a conventional method. Specifically, the oil phase component and the water phase component were weighed and dissolved by heating as necessary. Thereafter, the oil phase was added to the aqueous phase, and the mixture was stirred with a homomixer to prepare a uniform O/W composition. Further, if necessary, a neutralizing agent was added after stirring to prepare a uniform O/W type composition.

Test Example 1: UV protection effect test Each sunscreen composition described in Tables 1 to 3 was uniformly applied to a polymethyl methacrylate plate (manufactured by Sanyo Trading Co., Ltd., HeloplateHD6) so as to be 1.3 mg / cm ^2. After air drying, the UV absorption spectrum was measured using an ultraviolet spectrophotometer (manufactured by JASCO Corporation, V-650).
The results are shown in Figures 1-3.

As shown in FIG. 1, Examples 1 to 4 had an ultraviolet protection effect (enhanced effect of ultraviolet absorption spectrum) compared to Comparative Examples 1 to 4, in which component (A) bisPEG-18 methyl ether dimethylsilane was omitted. Similarly, Example 4 had a UV protection effect, as shown in FIG. 2, compared to Comparative Example 5 in which the (C) component (acrylates/alkyl acrylate (C10-30)) crosspolymer was omitted.

表中＊１の原料名は、ＳＩＭＵＬＧＥＬＮＳであり、＊２の原料名は、ＳＩＭＵＬＧＥＬＥＧである。

In the table, the raw material name of *1 is SIMULGELNS, and the raw material name of *2 is SIMULGELEG.

As shown in FIG. 3, Examples 5 to 7 had a remarkable UV protective effect (enhanced effect of UV absorption spectrum) compared to Comparative Examples 6 to 8, which did not contain the component (A).

In the same manner as in Examples 1 to 7, sunscreen compositions having the compositions shown in Table 4 were prepared according to a conventional method and tested for UV protection effect.

As a result, Example 8 exhibited a UV protection effect (enhanced effect of UV absorption spectrum) as compared with Comparative Example 9, and had a remarkable UV protection effect with a difference in the peak top around 350 nm in particular.

Test Example 2 Feeling Test Using the sunscreen compositions of Example 4 and Comparative Example 4 in Table 2, feeling during use was confirmed. Five panelists were asked to use each sample, and the sliminess derived from the thickener was evaluated. As a result of comparing the lack of slimy feeling, 4 out of 5 evaluated that Example 4 had no slimy feeling compared to Comparative Example 4.

Comparative Example 4, in which a large amount of the water-soluble thickener (C) was blended with a large amount of the UV absorber (B), exhibited an excellent feeling during use, while the sunscreen composition of the present invention containing the polyether-modified silicone wax (A) in addition to the components (B) and (C) exhibited an excellent feeling during use. As described above, according to the present invention, it is possible to provide a sunscreen composition which is excellent in feeling upon use and has enhanced ultraviolet absorbing ability.

Formulation Examples Formulations shown in Table 5 below are prepared. Formulation Examples 1 to 10 are all O/W gel sunscreen compositions.

Claims (6)

(A) one or two water-soluble polyether-modified silicone waxes selected from the group consisting of bisPEG-18 methyl ether dimethylsilane and bis PEG-15 methyl ether dimethicone;
(B) 1 to 16 w/w% of an ultraviolet absorber relative to the total amount of the composition, and (C) a water-soluble thickening agent for external use on the skin,
The weight ratio of component (A) and component (B) is 0.34 to 50 parts by weight per 1 part by weight of the total content of component (A),
External use of acrylic acid -based adverse aggregates (C) External composition, including acrylic acid -based adverse agent, (but (1) sodium ascorbic acid phosphate, ascorvirrikoside, acuberry extract, palmit leak orgopeptide, palmitopeptide -7, palmitopeptide-7. Except for peptide -5, astaxanthin, and (2) a composition containing a snow -alga (ice snow vessel) extract. A composition for external use on the skin, containing at least two kinds of (B) ultraviolet absorbers. 3. The composition for external use on skin according to claim 1 or 2, further comprising at least one selected from the group consisting of a cellulose-based thickener, a mucopolysaccharide-based thickener, an amino acid-based thickener, a seaweed-based thickener, a microorganism-derived thickener, a polyethylene glycol-based thickener, and a starch-based thickener as the (C) water-soluble thickener. The composition for external use on skin according to any one of claims 1 to 3, wherein the weight ratio of component (A) to component (C) is 0.000034 to 25 parts by weight per 1 part by weight of the total content of component (A). The composition for external use on skin according to any one of claims 1 to 4, which is a sunscreen composition. The composition for external use on skin according to any one of claims 1 to 5, which is an oil-in-water type.

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