JP2021165314A - Skin topical composition - Google Patents

Abstract

To provide a skin topical composition having exceptional UV absorbing ability and feel on use.SOLUTION: A skin topical composition contains (A) polyether-modified silicone wax, (B) an ultraviolet absorber, and (C) a water-soluble thickener.SELECTED DRAWING: None

Description

The present invention relates to an external composition for skin.

Ultraviolet rays include ultraviolet A wave (UV-A, 315-400 nm), ultraviolet B wave (UV-B, 280 to 315 nm), and others. Of these, UV-A is less likely to cause sunburn, but recent studies have shown that it is significantly involved in the occurrence of spots and wrinkles. That is, UV-A has a long wavelength and reaches deep into the skin, and has an effect such as denatured collagen.

UV-B has a short wavelength, and compared to UV-A, it is blocked by the ozone layer and clouds, and the amount that reaches the ground is as small as about 10% of the total amount of ultraviolet rays. However, UV-B has strong energy and damages cells on the surface of the skin and causes inflammation, which may cause skin cancer and spots.

As the influence of ultraviolet rays on the skin becomes clear, there is an increasing demand for sunscreen compositions having a high ultraviolet blocking effect, and various sunscreen compositions have been proposed (Patent Document 1).

Japanese Unexamined Patent Publication No. 2015-17080

An object of the present invention is to provide a composition for external use on the skin having an ultraviolet absorbing ability.

As a result of diligent studies to solve this problem, the present inventors have obtained ultraviolet rays by using (A) a polyether-modified silicone wax, (B) an ultraviolet absorber, and (C) a water-soluble thickener. They have found that a composition for external use on the skin having a high absorption spectrum enhancing ability can be obtained, and have completed the present invention.

That is, the present invention provides the following external composition for skin.
Item 1. An external composition for skin containing (A) a polyether-modified silicone wax, (B) an ultraviolet absorber, and (C) a water-soluble thickener.

Item 2. Item 2. The composition for external use on the skin according to Item 1, wherein the (A) polyether-modified silicone wax is a water-soluble polyether-modified silicone wax.

Item 3. The water-soluble polyether-modified silicone wax is selected from the group consisting of bisPEG-18 methyl ether dimethylsilane, bisPEG-15 methyl ether dimethicone, PEG-32 methyl ether dimethicone, and PEG-17 dimethicone. Item 3. The composition for external use on the skin according to Item 1 or 2.

Item 4. Item 2. The composition for external use on the skin according to any one of Items 1 to 3, wherein the (B) ultraviolet absorber is an oil-soluble ultraviolet absorber.

Item 5. Item 2. The external composition for skin according to any one of Items 1 to 4, wherein the ultraviolet absorber (B) is contained in an amount of 0.5 w / w% or more based on the total amount of the external composition for skin.

Item 6. The water-soluble thickener (C) is an acrylic acid-based thickener, a cellulose-based thickener, a mucopolysaccharide-based thickener, an amino acid-based thickener, a seaweed-based thickener, a microorganism-derived thickener, and polyethylene. Item 2. The external composition for skin according to any one of Items 1 to 5, which is at least one selected from the group consisting of a glycol-based thickener and a starch-based thickener.

Item 7. Item 6. The item 1 to 6, wherein the (C) water-soluble thickener is an acrylic acid-based thickener, and the acrylic acid-based thickener is an acrylic acid / methacrylic acid alkyl copolymer. Skin external composition.

Item 8. Item 2. The composition for external use on the skin according to any one of Items 1 to 7, which is a sunscreen composition.

Item 9. The present invention also
(A) Polyether-modified silicone wax,
Provided is a sunscreen gel preparation containing (B) an ultraviolet absorber and (C) a water-soluble thickener.

Item 10. The present invention also
(A) Polyether-modified silicone wax,
Provided is an oil-in-water sunscreen composition containing (B) an ultraviolet absorber and (C) a water-soluble thickener.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a composition for external use on the skin having a high ability to enhance the ultraviolet absorption spectrum.

1a to 1c are graphs showing the results of the ultraviolet protection effect test of the external composition for skin of the present invention (Examples 1 to 3) and the external composition for skin of Comparative Examples 1 to 3. FIG. 2 is a graph showing the results of the ultraviolet protection effect test of the external composition for skin of the present invention (the external composition for skin of Examples 4 and Comparative Examples 4 to 5). 3a to 3c are graphs showing the results of the ultraviolet protection effect test of the external composition for skin of the present invention (Examples 5 to 7) and the external composition for skin of Comparative Examples 6 to 8.

In the present specification, the unit of content "w / w%" is synonymous with w / w% of "g / 100g".

In the present specification, "oil-soluble" means that the solubility in water is 1 w / w% or less, and "water-soluble" means that the solubility in water is larger than 1 w / w%.

As used herein, the term "external composition for skin" refers to an external composition that can be applied to the skin. Although not particularly limited, the composition for external use on the skin includes a sunscreen composition having an ultraviolet absorbing ability. Here, the "sunscreen composition" includes, for example, a form in which the sunscreen is specified in the product, but even if it is not specified, any composition for external use on the skin having such a function is referred to in the present specification. Included in "sunscreen composition".

The external composition for skin of the present invention contains (A) a polyether-modified silicone wax, (B) an ultraviolet absorber, and (C) a water-soluble thickener.

In the present specification, the (A) polyether-modified silicone wax refers to a polyether-modified silicone that is waxy at room temperature and dissolves by heating, and more specifically, a polyether-modified having a melting point of room temperature (for example, 20 ° C.) or higher. Refers to silicone.

[(A) Polyether-modified silicone wax]
In the present invention, the (A) polyether-modified silicone wax is not limited, but a water-soluble polyether-modified silicone wax is preferable. Such water-soluble polyether-modified silicone wax includes, but is not limited to, for example, bisPEG-18 methyl ether dimethylsilane, bisPEG-15 methyl ether dimethicone, PEG-32 methyl ether dimethicone, and PEG-17 dimethicone. It is particularly preferable to use one or more selected from the group. The use of these waxes, but not limited to, is preferred when the external composition for skin of the present invention is made into a refreshing emulsion that is not sticky and has good emulsion stability. As the component (A), it can be synthesized and used, or a commercially available product can be used as it is.

Specifically, as water-soluble polyether-modified silicone wax, 2501 CosmeticWax (manufactured by Toray Dau, bis PEG-18 methyl ether dimethylsilane, melting point 36 to 42 ° C.), DMC 6038 (manufactured by Wacker, bis PEG-15 methyl ether). Examples thereof include dimethicone (melting point about 30 ° C.), KF-6004 (made by Shinetsu Chemical Co., Ltd., PEG-32 methyl ether dimethicone, melting point 45 ° C.), or Silicon® 895 (manufactured by MOMENTIVE, PEG-17 dimethicone). NS.

In the external composition for skin of the present invention, the total content of the component (A) with respect to the total amount of the external composition for skin is appropriately set depending on the balance with other components. The total content of the component (A) is preferably 0.001 w / w% or more, more preferably 0.01 w / w% or more, still more preferably 0.1 w, based on the total amount of the external composition for skin. / W% or more, most preferably 0.2 w / w% or more. The total content of the component (A) is preferably 20 w / w% or less, more preferably 10 w / w% or less, still more preferably 5 w / w% or less, most preferably 5 w / w% or less, based on the total amount of the external composition for skin. Is 3 w / w% or less. The total content of the component (A) is preferably 0.001 w / w% to 20 w / w%, more preferably 0.01 w / w% to 10 w / w%, based on the total amount of the external composition for skin. More preferably, it is 0.1 w / w% to 5 w / w%, and most preferably 0.2 w / w% to 3 w / w%.

[(B) UV absorber]
In the present specification, the (B) ultraviolet absorber refers to a compound (component) having a property of absorbing ultraviolet rays.

Examples of the ultraviolet absorber include
(A) 2-Ethylhexyl paramethoxycinnamic acid (also known as ethylhexyl methoxycinnamate), isopropyl methoxycinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamic acid (octocrylene), diisopropyl methylsilicate, trimethoxykei Methyl bis (trimethylsiloxy) silylisopentyl, methyl 2,5-diisopropylcinnamic acid, diparamethoxycinnamic acid mono-2-ethylhexanate glyceryl, synoxate, DEA methoxycinnamate, ferulic acid, and methoxycinnamic acid Cinnamic acid derivatives such as isoamyl acid;
(B) Para-aminobenzoic acid (hereinafter abbreviated as "PABA"), ethyl PABA, ethyl-dihydroxypropyl PABA, ethylhexyl-dimethyl PABA, glyceryl PABA, PEG-25 PABA, amyl paradimethylaminobenzoate, paradimethylamino 2-Ethylhexyl benzoate and benzoic acid derivatives such as 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester (also known as diethylaminohydroxybenzoyl hexyl benzoate);
(C) Salicylic acid derivatives such as homosalate, ethylhexyl salicylate, TEA salicylate, ethylene glycol salicylate, and dipropylene glycol salicylate;
(D) Dihydroxybenzophenone (benzophenone-1), tetrahydroxybenzophenone (benzophenone-2), 2-hydroxy-4-methoxybenzophenone (benzophenone-3), hydroxymethoxybenzophenone sulfonic acid (benzophenone-4), dihydroxydimethoxybenzophenone (benzophenone-4) -5), dihydroxydimethoxybenzophenone (benzophenone-6), 2,2'-dihydroxy-4-methoxybenzophenone (benzophenone-8), and 3,3'-carbonylbis [4-hydroxy-6-methoxybenzenesulfonic acid] ] Benzophenone derivatives such as disodium (benzophenone-9);
(E) Benzylidene sulphonic acid, benzylidene sulphonic acid, terephthalilidene sulphonic acid, sulphonic acid sulphate, and polyacrylamide methylbenzylidene sulphonic acid, and benzylidene sulphate derivatives such as 4-methylbenzylidenes.
(F) Anisotriazine, diethylhexylbutamidotriazine, 2,4,6-tris (diisobutyl-4'-aminobenzalmaronate) -s-triazine, 2,4-bis-[{4- (2-) Ethylhexyloxy) -2-hydroxy} -phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine (also known as bisethylhexyloxyphenol methoxyphenyltriazine, etc.), and 2,4,6 -Triazine [4- (2-ethylhexyloxycarbonyl) anilino] -Triazine derivatives such as 1,3,5-triazine;
(G) phenylbenzimidazole sulfonic acid and phenylbenzoimidazole derivatives such as phenyldibenzoimidazole tetrasulfonate disodium;
(H) Drometrizole trisiloxane and 2,2'-methylenebis [6- (2H-benzotriazole-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol] and the like. Phenylbenzotriazole derivative;
(I) Anthranilic derivatives such as menthyl anthranilate;
(J) Imidazolidine derivatives such as 2-ethylhexyl dimethoxybenzylideneoxoimidazolidine propionate;
(K) A benzalmalonate derivative such as dimethicodiethylbenzalmalonate;
(L) 4,4-Diarylbutadiene derivatives such as 1,1-dicarboxy (2,2'-dimethylpropyl) -4,4-diphenylbutadiene; and (m) 4-tert-butyl-4'-methoxydi Dibenzoylmethane derivatives such as benzoylmethane; etc. can be mentioned.

In the present invention, the (B) ultraviolet absorber is preferably an oil-soluble ultraviolet absorber. By using an oil-soluble UV absorber, the external composition for skin of the present invention becomes resistant to sweat water, suppresses falling off after application, and in combination with other components, forms a uniform film that is well-adapted to sebum. It is a composition that is easy to form and exhibits an excellent effect.

Here, as an oil-soluble ultraviolet absorber,
(A) 2-Ethylhexyl paramethoxycinnamate, isopropyl methoxycinnamate, 2-ethylhexyl α-cyano-β-phenyl cinnamate (octocrylene), diisopropyl methylsilicate, methylbis (trimethylsiloxy) trimethoxycinnamate, silylisopentyl, Methyl 2,5-diisopropylcinnamic acid, mono-2-ethylhexanate diparamethoxycinnamic acid, glyceryl, synoxate, DEA methoxycinnamate, ferulic acid, and isoamyl methoxycinnamate;
(B) PABA, ethyl PABA, ethyl-dihydroxypropyl PABA, ethylhexyl-dimethyl PABA, glyceryl PABA, PEG-25 PABA, amyl para-dimethylaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, and 2- [4-( Diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester;
(C) Ethylhexyl salicylate, TEA salicylate, and dipropylene glycol salicylate;
(D) Dihydroxydimethoxybenzophenone (benzophenone-6);
(E) Polyacrylamide methylbenzyl camphor;
(F) Anisotriazine, diethylhexylbutamidotriazine, 2,4,6-tris (diisobutyl-4'-aminobenzalmaronate) -s-triazine, 2,4-bis-[{4- (2-) Ethylhexyloxy) -2-hydroxy} -phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine, and 2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine;
(H) Drometrizole trisiloxane;
(I) Menthyl anthranilate;
(J) 2-Ethylhexyl dimethoxybenzylideneoxoimidazolidine propionate;
(K) Dimethicodiethylbenzalmalonate;
(L) 1,1-dicarboxy (2,2'-dimethylpropyl) -4,4-diphenylbutadiene; and (m) 4-tert-butyl-4'-methoxydibenzoylmethane; and the like can be mentioned. ..

These (B) ultraviolet absorbers may be used alone or in combination of two or more. The ultraviolet absorber can be used synthetically or a commercially available product can be used as it is.

In the composition for external use on the skin of the present invention, as an ultraviolet absorber, one or more of the above ultraviolet absorbers are microencapsulated in order to reduce irritation and odor and improve usability and solubility. It is also possible to use a raw material with a formulation modification such as encapsulation in a capsule. Specifically, an ultraviolet absorber is encapsulated in a shell substantially composed of a polymer component composed of poly (ethylene glycol dimethacrylate), ethylene glycol dimethacrylate / divinylbenzene copolymer, or poly (divinylbenzene). Microcapsules with an average particle size of 0.4 to 10 μm (ultraviolet absorber-encapsulating capsules) and microcapsules containing t-butylmethoxydibenzoylmethane in sol-gel silica glass and dispersed in water (for example, Eusolex) UV-Pearls OB-S (trade name), Eusolex UV-Pearls OB-S2 (trade name); manufactured by Merck) and similarly, ethylhexyl methoxycinnamate was encapsulated in sol-gel silica glass and dispersed in water. Capsules (eg, Eusolex UV-Pearls 2292 (trade name), Eusolex UV-Pearls OMC (trade name); manufactured by Merck), and UV absorbers (octocrylene, diethylaminohydroxybenzoylbenzoic acid, ethylhexyl methoxycinnamate, para). 2-Ethylhexyl methoxycinnamate, t-butyl-methoxydibenzoylmethane, etc.) was encapsulated in silicone-resinylated hydrolyzed silk (polysilicone-14) to form microcapsules with an average particle size of 2 μm, which were dispersed in water. (For example, Silasoma® ME, Silasoma MEA, Silasoma MEA (S), Silasoma MEA (V), Silasoma MEA (L), Silasoma MFA (S), Silasoma MFA (LS), Silasoma Examples thereof include the Silasoma series (trade name) such as REA (S); manufactured by Seiwa Kasei Co., Ltd.).

In the external composition for skin of the present invention, the total content of the component (B) with respect to the total amount of the external composition for skin is appropriately set depending on the balance with other components. The total content of the component (B) is preferably 0.01 w / w% or more, more preferably 0.1 w / w% or more, still more preferably 0.5 w / w /, based on the total amount of the external composition for skin. It is w% or more, more preferably 1.0 w / w% or more, and most preferably 3.0 w / w% or more. The total content of the component (B) is preferably 25 w / w% or less, more preferably 20 w / w% or less, still more preferably 15 w / w% or less, most preferably 15 w / w% or less, based on the total amount of the external composition for skin. It is preferably 10 w / w% or less. The total content of the component (B) is preferably 0.01 w / w% to 25 w / w%, more preferably 0.1 w / w% to 20 w / w%, based on the total amount of the external composition for skin. More preferably, it is 0.5 w / w% to 15 w / w%, and most preferably 1.0 w / w% to 10 w / w%.

In the external composition for skin of the present invention, the ratio of the blending amount of the component (B) to the component (A) is such that the total content of the component (B) is 0 with respect to 1 part by weight of the total content of the component (A). It is preferably 0005 to 25,000 parts by weight, more preferably 0.01 to 2000 parts by weight, further preferably 0.1 to 150 parts by weight, and most preferably 0.34 to 50 parts by weight.

[(C) Water-soluble thickener]
As used herein, the (C) water-soluble thickener refers to a drug (ingredient) that is soluble in water and has the property of increasing viscosity.

In the external composition for skin of the present invention, the (C) water-soluble thickener is an acrylic acid-based thickener, a cellulose-based thickener, a mucopolysaccharide-based thickener, an amino acid-based thickener, and a seaweed-based thickener. Agents, microbial-derived thickeners, polyethylene glycol-based thickeners, or starch-based thickeners are preferred.

Specific examples of the water-soluble thickener include (a) acrylic acid / alkyl methacrylate copolymer, hydroxyethyl acrylate / acryloyldimethyltaurine salt copolymer, polyacrylic acid, and salts thereof. Acrylic acid-based thickener;
(B) Cellulose-based thickeners such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, and stearoxy hydroxypropyl methyl cellulose;
(C) Hyaluronic acid, hyaluronic acid derivatives, and mucopolysaccharide-based thickeners such as salts thereof and sodium chondroitin sulfate;
(D) Amino acid-based thickeners such as collagen;
(E) Seaweed-based thickeners such as carrageenan, alginate, propylene glycol alginate, and agar;
(F) Microorganism-derived thickeners such as xanthan gum, hydroxypropyl xanthan gum, dextran, sclerothium gum, and gellan gum;
(G) Polyethylene glycol-based thickeners such as polyethylene glycol, polyethylene glycol distearate, (PEG-240 / decyl tetredeceth-20 / HDI) copolymer, glyceryl behenate and polyglyceryl octastearate-6; and
(H) Starch-based thickeners such as hydroxypropyl starch phosphoric acid and cornstarch;
Is exemplified.

In addition, other water-soluble polymers such as ethylene glycol triisostearate, polyoxyethylene (20) methylglucoside triisostearate, bentonite, macrogol, and sodium gazein can be mentioned.

In the present invention, as the (C) water-soluble thickener, an acrylic acid-based thickener is particularly preferable. In the present invention, particularly preferable as the acrylic acid-based thickener are (Acrylate / alkyl acrylate (C10-30)) crosspolymer, (hydroxyethyl acrylate / sodium acryloyldimethyltaurine) copolymer, and acrylamide / ammonium acrylate. Copolymer, (Acrylate / Behenes methacrylate-25) Crosspolymer Sodium, Polyacrylate-6, Polyacrylate-13, (Acrylic Acid / Acryloyldimethyltaurin / Dimethylacrylamide) Crosspolymer, (Acrylate / Steareth itaconate-20) Copolymer, One selected from the group consisting of (acryloyldimethyltaurinammonium / VP) copolymer, (sodium acrylate / acryloyldimethyltaurin / dimethylacrylamide) crosspolymer, steareth-10 allyl ether acrylates copolymer, carboxyvinyl polymer and polyacrylamide. That is all.

In addition, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyethylene glycol, polyvinyl alcohol, xanthan gum, hydroxypropyl starch phosphate, sodium hyaluronate, hyaluronic acid derivatives or salts thereof, collagen, canten, xanthan gum, hydroxypropyl starch phosphate, macrogol. , Etc. are also preferable.

These (C) water-soluble thickeners may be used alone or in combination of two or more. When these water-soluble thickeners are used, it is possible to prepare a gel preparation with a lot of water feeling, and to make a light gel preparation with an appropriate film feeling and preparation stability, which is comfortable to use. be able to.

In addition, these are commercially available products such as PEMULEN ™ TR-1, TR-2 (manufactured by Lubrizol Advanced Materials); Carbopol ™ ETD2020, Ultrez20Polymer, Ultrez21Polymer, Ultrez10Polymer (manufactured by Ultremer) ) 2001 (manufactured by AkzoNobel), Aristoflex (trademark) AVC, HMB (manufactured by Clariant Japan) and the like can be used. As the polyvinyl alcohol, for example, commercially available Gosenol ™ EG-05, EG-40 (manufactured by Nippon Synthetic Chemical Industry Co., Ltd.) and the like can be used. Further, it may be used as a mixture mixed with an oil agent such as squalane, a nonionic surfactant, and water. As such a mixture, specifically, for example, SIMULGEL ™ FL, NS (manufactured by Sepic), which is a commercially available product containing a hydroxyethyl acrylate-acryloyldimethyltaurine sodium copolymer; sodium acrylate-acryloyl. SIMULGEL (trademark) EG (manufactured by Sepic), SIMULGEL (trademark) EPG (manufactured by Sepic), which are commercially available products containing a dimethyltaurine copolymer; SALCARE ™ SC80 (manufactured by Ciba Specialty Chemicals); SALCARE ™ SC91 (Ciba Specialty), which is a commercial product containing an alkyl copolymer of sodium acrylate, sodium methacrylic acid, and sodium methacrylate. (Chemicals Co., Ltd.); (Na acrylate / acryloyldimethyltaurine / dimethylacrylamide) Commercially available products containing a cross polymer, SEPINOV (trademark) P88 (manufactured by Sepic), Adecanol (trademark) GT-700 (Asahi Denka Kogyo Co., Ltd.) (Manufactured by); and SEPIGEL ™ 305 (Seiwa Kasei), which is a commercially available product containing polyacrylamide, and the like can be mentioned. As the polyacrylic acid amide, for example, a commercially available SEPIGEL ™ 305 (manufactured by Seiwa Kasei Co., Ltd.) can be used. Examples of the carboxyvinyl polymer include Carbopol ™ 940, 941, 980, 981, ETD2050, Ultraz10 Polymer, (Brizol Advanced Materials); Syntalen K Syntaren L (3V SIGMA); AQUAPEC ™ HV-50. , HV-504E, HV-505E (manufactured by Sumitomo Seika Chemical Industries, Ltd.); Hibiswaco 103, 104, 105 (manufactured by Wako Pure Chemical Industries, Ltd.); Junron PW-110 (manufactured by Nippon Pure Chemical Industries, Ltd.) and the like can be used.

In addition, Adecanol (trademark) GT-700 (manufactured by Asahi Denka Kogyo Co., Ltd.), which is a commercially available product containing a (PEG-240 / decyltetradeceth-20 / HDI) copolymer, and the starch-based thickener include, for example. Examples thereof include STRUCTURE (trademark) XL (manufactured by AkzoNobel), which is a commercially available product containing hydroxypropyl starch phosphoric acid.

Further, in the external composition for skin of the present invention, the content of the (C) water-soluble thickening component with respect to the total amount of the external composition for skin is preferably 0.00001 w / w% or more, more preferably 0.0001 w /. It is w% or more, more preferably 0.001 w / w% or more, and most preferably 0.1 w / w% or more. The total content of the component (C) is preferably 20 w / w% or less, more preferably 10 w / w% or less, still more preferably 5 w / w% or less, based on the total amount of the external composition for skin. .. The total content of the component (C) is preferably 0.00001 w / w% to 20 w / w%, more preferably 0.0001 w / w% to 10 w / w%, based on the total amount of the external composition for skin. More preferably, it is 0.001 w / w% to 5 w / w%, and most preferably 0.1 w / w% to 5 w / w%.

In the external composition for skin of the present invention, the ratio of the blending amount of the component (C) to the component (A) is such that the total content of the component (C) is 0 with respect to 1 part by weight of the total content of the component (A). It is preferably 0.000005 to 20000 parts by weight, more preferably 0.000001 to 2000 parts by weight, further preferably 0.00002 to 100 parts by weight, and most preferably 0.00034 to 25 parts by weight.

The composition for external use on the skin of the present invention exhibits high ultraviolet absorption ability and is excellent in usability by containing the component (A), the component (B) and the component (C). That is, specifically, the composition for external use on the skin of the present invention can have an ultraviolet absorbing ability enhanced more than the value produced by (B) the ultraviolet absorber alone, and the slimy feeling and the like are alleviated. It is comfortable to use.

In addition to the above components (A) to (C), the external composition for skin of the present invention may contain, for example, an ultraviolet diffuser, an antioxidant, a whitening active ingredient, and various pharmacologically active ingredients, as long as the effects of the present invention are not impaired. Or a physiologically active ingredient may be combined and contained in an appropriate amount.

[UV diffuse reflector]
As the ultraviolet diffuser in the present invention, a known ultraviolet diffuser can be used as long as the effect of the present invention is not impaired. Examples of the ultraviolet diffuse reflector include metal oxide powder and clay particles. For example, titanium oxide, zinc oxide, cerium oxide, kaolin, or talc.

In the external composition for skin of the present invention, the content of the ultraviolet diffuser with respect to the total amount of the external composition for skin can be, for example, 0.1 w / w% or more and 20 w / w% or less, 0.5 w. It may be / w% or more and 15 w / w% or less, and may be 1.0 w / w% or more and 10 w / w% or less.

[Antioxidant]
As the antioxidant (antioxidant component) in the present invention, a known antioxidant can be used as long as the effect of the present invention is not impaired. In the present invention, the antioxidant (antioxidant component, antioxidant component) refers to a drug (component) having a property of inhibiting, reducing, or suppressing oxidation by active oxygen species or the like.

Examples of the antioxidant include
(A) Tocopherols and derivatives thereof or salts thereof (for example, α-tocopherol, δ-tocopherol, acetate-α-tocopherol, tocotrienol), pyrroloquinolinquinone and its derivatives or salts thereof, ubiquinones and derivatives thereof or them. Vitamin antioxidants such as salts of, retinols and derivatives thereof or salts thereof, pantothenic acid and derivatives thereof or salts thereof, erythorbic acid or salts thereof;
(B) Thiotaurine, cysteine, homocysteine, acetylcysteine, methionine, thioglycerol, sodium sulfite, sodium metabisulfite, sodium thiosulfite, sodium pyrosulfite, thioredoxin, dithiothreitol, α-lipoic acid, ergothioneine, glutathione, glutathione peroxidase, Sulfur-containing antioxidants such as glutathione-S-transferase;
(C) Phenols such as dibutylhydroxytoluene, dibutylhydroxyanisole, bisethylhexyl hydroxydimethoxybenzyl malonate, diethylhexyl syringidene malonic acid, gallic acid and its derivatives or salts thereof, chlorogenic acid and its derivatives or salts thereof. Antioxidants;
(D) Ingredients derived from plants (eg grapes, otane carrots, comfrey, etc.) (eg grape seed extract, grape leaf extract, otane carrot extract, confrey leaf extract, etc.); proanthocyanidins, hesperidins, glucosyl hesperidins, flavonoids, etc. , And other polyphenolic antioxidants can be mentioned. These may be used alone, or two or more kinds may be mixed and used.

In the external composition for skin of the present invention, the antioxidant is bisethylhexyl hydroxydimethoxybenzyl malonate and its derivatives, malonic acid and its derivatives, pyrroloquinolinquinone and its derivatives, tocopherols and its derivatives, thiotaurine and its derivatives. Dibutylhydroxytoluene and its derivatives, gallic acid or its derivatives, chlorogenic acid and its derivatives, hesperidin and its derivatives, glucosyl hesperidin and its derivatives, ergothioneine and its derivatives, flavonoids and its derivatives, or dibutylhydroxyanisole and its derivatives, In addition, when it can take the form of a salt, it is preferably a salt of any of the above compounds and a salt of any of the above derivatives. Among them, bisethylhexyl hydroxydimethoxybenzyl malonate, pyroquinolinquinone and its derivatives or their salts, tocopherols and their derivatives or their salts, thiotaurine, dibutylhydroxytoluene, gallic acid and its derivatives or their salts, chlorogenic acid. And derivatives thereof or salts thereof, or dibutylhydroxyanisole is more preferable. Also, bisethylhexyl hydroxydimethoxybenzyl malonate, diethylhexyl syringylidene malonic acid, pyrroloquinoline quinone and its derivatives or their salts, tocopherol and its derivatives or their salts, thiotaurine, dibutylhydroxytoluene, or gallic acid and its salts. Derivatives or salts thereof are even more preferred.

Further, in the external composition for skin of the present invention, the content of the antioxidant with respect to the total amount of the external composition for skin can be 0.00001w / w% or more and 20w / w% or less, and 0.0001w. It may be / w% or more and 10 w / w% or less, 0.001 w / w% or more and 7 w / w% or less, or 0.05 w / w% or more and 5 w / w% or less. , 0.03 w / w% or more and 3 w / w% or less, 0.02 w / w% or more and 1 w / w% or less, 0.01 w / w% or more and 0.5 w / w% or less. It may be as follows.

[Whitening active ingredient]
As the whitening active ingredient (whitening agent) in the present invention, a known whitening active ingredient can be used as long as the effect of the present invention is not impaired. In the present invention, the whitening active ingredient (whitening agent) is used to improve, suppress / reduce / prevent, prevent, and prevent skin pigmentation caused by melanin pigment, which is particularly related to dullness, darkening, and chloasma of the skin. Or a drug (ingredient) that has the property of delaying.

Examples of the whitening active ingredient include
(A) Hydroquinone and its derivatives or salts thereof (eg α-arbutin, β-arbutin); kodic acid; ellagic acid; phytic acid; lucinol; ascorbic acid and its derivatives or salts thereof (eg ascorbic acid phosphate ester) Sodium, magnesium ascorbic acid phosphate, ascorbic tetraisopalmitate (ascorbic tetra2-hexyldecanoate), 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid glucoside, etc.), potassium 4-methoxysalicylate Tyrosinase inhibitors such as salts, tranexamic acid and derivatives thereof or salts thereof;
(B) Endothelin-1 receptor inhibitors such as chamomile ET;
(C) Tyrosinase proteolysis promoters such as free linoleic acid;
(D) Melanin excretion enhancer such as adenosine monophosphate disodium salt;
(E) Melanin transport inhibitors such as niacinamide;
(F) In addition, plant components having a whitening effect (for example, plant extracts and essential oils); can be mentioned. These may be used alone, or two or more kinds may be mixed and used.

In the external composition for skin of the present invention, the whitening active ingredient is hydroquinone and its derivative or its salt, ascorbic acid and its derivative or its salt, tranexamic acid and its derivative or its salt, ellagic acid, niacinamide and the like. Is preferable. Among them, hydroquinone, albutin, sodium ascorbic acid ester, ascorbic acid, magnesium ascorbic acid phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra2-hexyldecanoate), 3-O-ethylascorbic acid, glucoside ascorbic acid, More preferably, tranexamic acid or the like.

Further, in the external composition for skin of the present invention, the content of the whitening active ingredient with respect to the total amount of the external composition for skin can be 0.00001w / w% or more and 20w / w% or less, and 0.00001w. It may be / w% or more and 10 w / w% or less, 0.001 w / w% or more and 7 w / w% or less, or 0.05 w / w% or more and 5 w / w% or less. , 0.03 w / w% or more and 3 w / w% or less, 0.02 w / w% or more and 1 w / w% or less, 0.01 w / w% or more and 0.5 w / w% or less. It may be as follows.

[Anti-inflammatory ingredient]
As the anti-inflammatory component (anti-inflammatory agent) in the present invention, a known anti-inflammatory component can be used as long as the effect of the present invention is not impaired. In the present invention, the anti-inflammatory component (anti-inflammatory agent) refers to a drug (component) having a property of inhibiting, reducing, or suppressing inflammation of cells such as the epidermis.

Examples of the anti-inflammatory component include components derived from plants (for example, comfrey leaf extract); allantoin, caramine, glycyrrhizic acid and derivatives thereof or salts thereof (dipotassium glycyrrhizinate, sodium glycyrrhizinate, etc.), glycyrrhetinic acid. And derivatives thereof or salts thereof (stearyl glycyrrhetinate, 18α-hydroxyglycyrrhetinic acid, etc.), zinc oxide, guaiazulene, pyridoxin hydrochloride, menthol, camphor, terepine oil, indomethacin, salicylic acid and derivatives thereof. These may be used alone, or two or more kinds may be mixed and used.

In the external composition for skin of the present invention, the anti-inflammatory component is allantoin, glycyrrhizic acid and its derivatives or salts thereof, glycyrrhetinic acid and its derivatives or salts thereof, zinc oxide, guaiazulene, pyridoxin hydrochloride, menthol, camphor, terepine. It is preferably oil, indomethacin, or salicylic acid and its derivatives or salts thereof. Of these, allantoin, glycyrrhizinic acid, dipotassium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate, zinc oxide, menthol, camphor, indomethacin, and salicylic acid are more preferable.

Further, in the external composition for skin of the present invention, the content of the anti-inflammatory component with respect to the total amount of the external composition for skin can be 0.00001 w / w% or more and 20 w / w% or less. It may be 0001w / w% or more and 10w / w% or less, 0.001w / w% or more and 5w / w% or less, or 0.05w / w% or more and 3w / w% or less. Often, it may be 0.03 w / w% or more and 1 w / w% or less, 0.02 w / w% or more and 0.5 w / w% or less, and 0.01 w / w% or more and 0.1 w. It may be less than / w%.

[Other bases or carriers]
The external composition for skin of the present invention may contain a known base or carrier used in cosmetics and quasi-drugs as long as the effects of the present invention are not impaired. The base or carrier may be used alone or in combination of two or more.

Bases or carriers include paraffins, liquid paraffins, squalanes, white waxes, gelled hydrocarbons (such as plastic bases), ozokelite, selecin, vaseline, hard fats, microcrystallin waxes, α-olefin oligomers, light liquid paraffins, etc. Hydrocarbons; fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid; glyceryl tri2-ethylhexaneate (trioctanoin), tri (caprylic acid / capric acid) glyceryl Tri-fatty acid glycerides; higher alcohols such as cetanol, stearyl alcohol, behenyl alcohol; silicones such as methylpolysiloxane, didecamethylcyclopentasiloxane, methylsiloxane reticulated polymer, methylhydrogenpolysiloxane, ;;; myristic acid Esters such as isopropyl, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythrite tetra2-ethylhexanoate; polysaccharides such as dextrin, maltodextrin; polysaccharides such as ethanol, isopropanol Lower alcohols; glycol ethers such as ethylene glycol monoethyl ether; aqueous bases such as water can be mentioned.

Among them, hydrocarbons (particularly α-olefin oligomers, squalanes, light liquid paraffins, liquid paraffins), trifatty acid glycerides (particularly glyceryl tri2-ethylhexaneate, tri (caprylic acid / capric acid) glyceryl), higher alcohols. (Especially cetanol, stearyl alcohol, behenyl alcohol), silicone oil (especially methylpolysiloxane, decamethylcyclopentasiloxane, ethyltrisiloxane, methyltrimethicone, methylsiloxane reticulated polymer, polyoxyethylene / methylpolysiloxane copolymer) , Methylhydrogenpolysiloxane, triethoxysilylethylpolydimethylsiloxyethylhexyl dimethicone, dimethylpolysiloxane), esters (particularly isononyl isononanoate, pentaerythlit tetra2-ethylhexaneate), polysaccharides (particularly dextrin, malt) Dextrin), glycol ether (particularly diethylene glycol monoethyl ether), and water are preferred.

When the external composition for skin of the present invention contains water as a base, the content of water with respect to the total amount of the external composition for skin is preferably 30 w / w% or more and 99 w / w% or less, preferably 40 w / w. % Or more and 95 w / w% or less is more preferable, and 50 w / w% or more and 90 w / w% or less is further preferable. The external composition for skin of the present invention is most preferably an O / W emulsified composition containing 50 w / w% or more of water.

[Additive]
The external composition for skin of the present invention includes known additives to be added to cosmetics and quasi-drugs, for example, surfactants, preservatives, pH adjusters, chelating agents, as long as the effects of the present invention are not impaired. , Stabilizers, irritation reducers, preservatives, colorants and the like can be added. As the additive, one type can be used alone, or two or more types can be used in combination.

Examples of the surfactant include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, penta-2-ethylhexylate diglycerol sorbitan, and tetra-2-ethylhexylate diglycerol sorbitan. Sorbitane fatty acid esters; glyceryl monostearate, glycerin monostearate glycerin fatty acids such as malic acid; polyglyceryl monostearate, polyglyceryl monoisostearate, polyglycerin fatty acids such as polyglyceryl diisostearate; propylene glycol monostearate Polyethylene glycol fatty acid esters such as: Polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxy Hardened castor oil derivatives such as ethylene-cured castor oil 80 (HCO-80); polyoxyethylene monolaurylate (20) sorbitan (polysorbate 20), polyoxyethylene monostearate (20) sorbitan (polysorbate 60), monooleic acid Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan (polysolvate 80), polyoxyethylene (20) sorbitan isostearate; polyoxyethylene monopalm oil fatty acid glyceryl; glycerin alkyl ether; alkyl glucoside; polyoxy Polyoxyalkylene alkyl ethers such as ethylene cetyl ethers; amines such as stearylamine and oleylamine; polyoxyethylene / methylpolysiloxane copolymers, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl Examples include silicone-based surfactants such as dimethicone.

Among them, glycerin fatty acids (particularly glyceryl monostearate), polyglycerin fatty acids (particularly polyglyceryl monostearate), hardened castor oil derivatives (particularly polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxy). Polyethylene hydrogenated castor oil 60 (HCO-60)), polyoxyethylene sorbitan fatty acid esters (particularly polyoxyethylene (20) sorbitan isostearate, polyoxyethylene monostearate (20) sorbitan (polysorbate 60)), polyoxy Alkylene alkyl ethers (particularly polyoxyethylene cetyl ethers), silicone surfactants (particularly polyoxyethylene / methylpolysiloxane copolymers, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone) ) Is preferable.

Preservatives and preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxybenzoic acid. Examples thereof include benzyl, methyl paraoxybenzoate, and phenoxyethanol. Of these, methyl paraoxybenzoate, propyl paraoxybenzoate, and phenoxyethanol are preferable.

As pH adjusters, inorganic acids (hydrochloride, sulfuric acid, phosphoric acid, polyphosphate, boric acid, etc.), organic acids (lactic acid, acetic acid, citric acid, sodium citrate, tartrate acid, malic acid, succinic acid, sodium succinate, etc. Shuic acid, gluconic acid, fumaric acid, propionic acid, acetic acid, aspartic acid, ε-aminocaproic acid, glutamate, aminoethylsulfonic acid, etc.), gluconolactone, ammonium acetate, inorganic base (sodium hydrogencarbonate, sodium carbonate, hydroxide) Examples include potassium, sodium hydroxide, calcium hydroxide, magnesium hydroxide, etc.), organic bases (monoethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, lysine, etc.). Of these, succinic acid, sodium succinate, citric acid, sodium citrate, triethanolamine, potassium hydroxide and sodium hydroxide are preferable.

Chelating agents include ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetic acid salt (sodium salt (sodium edetate: Japanese Pharmacy, EDTA-2Na, etc.), potassium salt, etc.), phytic acid, gluconic acid, polyphosphate, and metallin. You can give acid and so on. Of these, sodium edetate is preferable.

Examples of the stabilizer include butylhydroxyanisole and the like.

Examples of the irritation reducing agent include licorice extract, sodium alginate, 2-methacryloyloxyethyl phosphorylcholine and the like.

Examples of the colorant include inorganic pigments and natural pigments.

[Other active ingredients]
In the present invention, the composition for external use on the skin includes anti-wrinkle / anti-aging ingredients, keratin softening ingredients, cell activating ingredients, vitamins, moisturizing ingredients, prevention of DNA damage, and prevention of DNA damage, as long as the effects of the present invention are not impaired. / Or other active ingredients that can be added to cosmetics and quasi-drugs, such as restorative ingredients, antibacterial ingredients, and astringent ingredients, can be added. Other active ingredients may be used alone or in combination of two or more.

Anti-wrinkle and anti-aging ingredients include hydrolyzed soybean protein, retinoids (retinol and its derivatives, retinoic acid, retinal, etc.), pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl. -L-serine, mevalonolactone and the like can be mentioned. Of these, artemia extract, hydrolyzed soybean protein, retinol, retinol acetate, and retinol palmitate are preferable.

Examples of the keratin softening component include lanolin, urea, α-hydroxy acids (phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, etc.), citric acid and the like. Of these, lactic acid, sodium lactate, glycolic acid, salicylic acid, and phytic acid are preferable.

The cell activating components include components derived from plants (for example, bilberry); amino acids such as γ-aminobutyric acid and ε-aminoproic acid; α-hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponins and allantoins. , Photosensitizer No. 301, etc. can be mentioned. Of these, bilberry leaf extract is preferable.

Examples of vitamins include retinol derivatives such as retinol, retinol acetate, and retinol palmitate, retinal, retinoic acid, methyl retinoate, ethyl retinoate, retinol retinoate, d-δ-tocopheryl retinoate, and α-tocopheryl retinoate. , Β-tocopheryl retinoate and other vitamin A; β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, ekinenone and other provitamin A; δ-tocopherol, α- Vitamin Es such as tocopherol, β-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol succinate, δ-tocopherol, tocopherol nicotinate; riboflavin, flavin mononucleotide, flavin adenin dinucleotide, riboflavin butyrate , Vitamin B2s such as riboflavin tetrabutyric acid ester, riboflavin 5'-phosphate sodium, riboflavin tetranicotinic acid ester; nicotinic acids such as methyl nicotinate, nicotinic acid, nicotinic acid amide; ascorbyl stearate, L-dipalmitate Vitamin Cs such as ascorbyl, ascorbyl tetraisopalmitate (ascorbyl tetra2-hexyldecanoate); Vitamin Ds such as methylhesperidine, ergocalciferol, cholecalciferol; Vitamin Ks such as phylloquinone, farnoquinone; dibenzoylthiamine , Dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate ester phosphate , Thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate and other vitamin B1s; pyridoxin hydrochloride, pyridoxin acetate, pyridoxal hydrochloride, 5'-phosphate Vitamin B6s such as pyridoxal and pyridoxamine hydrochloride, vitamin B12s such as cyanocobalamine, hydroxocobalamine, deoxyadenosylcobalamine; folic acids such as folic acid and pteroylglutamic acid; pantothenic acid, calcium pantothenate, pantothenyl alcohol (pantenol), D-Pantatein, D -Pantothenic acids such as pantetin, coenzyme A, and pantothenyl ethyl ether; biotins such as biotin and biositin; and other vitamin-like agents such as carnitine, ferulic acid, α-lipoic acid, ollotic acid, and γ-oryzanol. I can give it.

Among them, vitamin As such as retinol, retinol acetate, and retinol palmitate; sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra2-hexyldecanoate), 2-O-ethyl Vitamin Cs such as ascorbic acid and 3-O-ethylascorbic acid; Vitamin Es such as δ-tocopherol and tocopherol nicotinate; nicotinic acids such as nicotinic acid amide are preferred.

Moisturizing ingredients include those derived from plants (eg, chigaya); amino acids such as alanine, serine, leucine, isoleucine, threonine, glycerin, proline, hydroxyproline, glucosamine, theanine and their derivatives; collagen, gelatin, elastin Such proteins and peptides, their hydrolysates; polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, diglycerin; sugar alcohols such as sorbitol; lecithin, hydrogenated lecithin, etc. Phosphorlipids; NMF-derived components such as lactic acid, sodium pyrrolidone carboxylate, urea; polyglutamic acid; polymers with phospholipid polar groups such as MPC polymers (eg, LIPIDURE ™); polyoxypropylene methyl glucoside; PPG -10 Methylglucose (eg, McBiobride MG ™ series (manufactured by Nichiyu Co., Ltd.), etc.), PEG / PPG / Polybutylene glycol-8 / 5/3 glycerin (eg, Wilbride ™ S-753) (Manufactured by Nichiyu Co., Ltd.)); trimethylglycerin (betaine); hydroxyethylurea; acrylate / acrylamide / dimethyldiallylammonium chloride copolymer; sorbitol and the like. Among them, hydrolyzed collagen, hydrolyzed elastin, MPC polymer glycerin, 1,3-butylene glycol, dipropylene glycol, diglycerin, polyoxypropylene methyl glucoside, trimethylglycine (betaine), hydroxyethylurea, hydrogenated lecithin, sorbitol. Is preferable.

Ingredients that prevent and / or repair DNA damage include components derived from animals (eg, artemia); components derived from plants (eg, cat's claw); DNA, DNA salts, RNA, RNA salts, etc. Nucleic acid components can be given. Of these, Artemia extract and DNA-Na are preferable.

Antibacterial components include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclosan, triclosan, photosensitizer No. 101. , Photosensitizer No. 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride and the like. Among them, benzalkonium chloride, benzethonium chloride, gluconic acid and its derivatives, isopropylmethylphenol, triclocarvan, triclosan, photosensitizer 101, photosensitizer 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiamino hydrochloride. Glycin is preferred, with benzalkonium chloride, gluconic acid and its derivatives, benzethonium chloride, and isopropylmethylphenol being more preferred.

Examples of the astringent component include metal salts such as myoban, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc sulfate and potassium aluminum sulfate; and organic acids such as tannic acid, citric acid, lactic acid and succinic acid. Of these, alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, potassium aluminum sulfate, and tannic acid are preferable.

[Formation form]
In addition, the external composition for skin in the present invention can be prepared by mixing and stirring each component according to a conventional method, for example.

The form of the drug for external use on the skin in the present invention is not particularly limited, and a form known as a form of a cosmetic or a quasi-drug can be taken. Among such known forms, for example, sheets such as liquids, suspensions, emulsions, creams, gels, liniments, lotions, aerosols, powders, poultices, and non-woven fabrics are impregnated with the chemicals. Examples include sheet preparations and stick preparations such as lipsticks. Among them, liquids, suspensions, emulsions, creams, gels and lotions are preferable, and gels are more preferable, in terms of good usability. The skin external composition of the present invention is preferably in the form of an aqueous solution, an aqueous suspension, an aqueous emulsion, an aqueous gel, or an aqueous lotion. Further, the oil-in-water type (O / W), the water-in-oil type (W / O), and the like can be appropriately selected according to the purpose of use and the desired feeling of use depending on the formulation, but in particular, the oil-in-water type (O / O). / W) composition is preferable.

The external composition for skin of the present invention can be used in the form of basic cosmetics such as emulsions, creams, cosmetics, body lotions and body creams. The external composition for skin of the present invention can also be used in the form of make-up cosmetics such as foundation, lipstick, blusher, eye makeup, face powder, manicure, and pedicure.

Since the ultraviolet absorbing function can be enhanced by the present invention, the external composition for skin of the present invention has an SPF (Sun Protection Factor) value, which is a protection index against ultraviolet B waves (UV-B), and ultraviolet A waves (UV-B). A composition for external use on the skin having a high value of PA (Protection Grade of UVA), which is a protection index against UV-A), can be obtained. For example, the external composition for skin of the present invention may have an SPF value of SPF 10 or more, preferably SPF 20 or more, more preferably SPF 30 or more, still more preferably SPF 40 or more, and particularly preferably SPF 50 or more. Further, for example, the external composition for skin of the present invention may have a PA value of PA +, preferably PA ++, more preferably PA ++++, and even more preferably PA ++++.

The present invention further relates to the following methods or uses.
That is,

(A) Polyether-modified silicone wax for the production of external skin preparations,
Use of a composition containing (B) an ultraviolet absorber and (C) a water-soluble thickener.

(A) Polyether-modified silicone wax for the manufacture of sunscreen formulations,
Use of a composition containing (B) an ultraviolet absorber and (C) a water-soluble thickener.

In the use of the above composition, preferably, the (A) polyether-modified silicone wax may be a water-soluble polyether-modified silicone wax.

Preferably, the water-soluble polyether-modified silicone wax is selected from the group consisting of bis PEG-18 methyl ether dimethylsilane, bis PEG-15 methyl ether dimethicone, PEG-32 methyl ether dimethicone, and PEG-17 dimethicone. It can be at least one species.

In the use of the composition, the UV absorber (B) may preferably be an oil-soluble UV absorber.

Preferably, the above (B) UV absorber can be contained in an amount of 0.5 w / w% or more based on the total amount of the composition.

In the use of the above composition, the above (C) water-soluble thickener is an acrylic acid-based thickener, a cellulose-based thickener, a mucopolysaccharide-based thickener, an amino acid-based thickener, and a seaweed-based thickener. , At least one selected from the group consisting of microbial-derived thickeners, polyethylene glycol-based thickeners, and starch-based thickeners.

The water-soluble thickener (C) is an acrylic acid-based thickener, and the acrylic acid-based thickener may be an acrylic acid / alkyl methacrylate copolymer.

Preferably, the sunscreen formulation can be a gel formulation.

Preferably, the sunscreen preparation may be an oil-in-water sunscreen composition.

The present invention further relates to the following methods.
That is,

(A) Polyether-modified silicone wax,
A method of preventing sunburn by applying (B) an ultraviolet absorber and (C) a water-soluble thickener to the skin.

In the method for preventing sunburn, preferably, the (A) polyether-modified silicone wax may be a water-soluble polyether-modified silicone wax.

Preferably, the water-soluble polyether-modified silicone wax is selected from the group consisting of bis PEG-18 methyl ether dimethylsilane, bis PEG-15 methyl ether dimethicone, PEG-32 methyl ether dimethicone, and PEG-17 dimethicone. It can be at least one species.

In the method for preventing sunburn, the ultraviolet absorber (B) is preferably an oil-soluble ultraviolet absorber.

In the method for preventing sunburn, preferably, the (A) polyether-modified silicone wax, (B) ultraviolet absorber, and (C) water-soluble thickener are the components (A) and (B). And can be applied to the skin in the form of a composition comprising component (C).

Preferably, the above (B) UV absorber can be contained in an amount of 0.5 w / w% or more based on the total amount of the composition.

In the method for preventing sunburn, the water-soluble thickener (C) is an acrylic acid-based thickener, a cellulose-based thickener, a mucopolysaccharide-based thickener, an amino acid-based thickener, and a seaweed-based thickener. It may be at least one selected from the group consisting of agents, microbial-derived thickeners, polyethylene glycol-based thickeners, and starch-based thickeners.

The water-soluble thickener (C) is an acrylic acid-based thickener, and the acrylic acid-based thickener may be an acrylic acid / alkyl methacrylate copolymer.

Preferably, the composition can be a gel formulation or an oil-in-water composition.

Next, the present invention will be specifically described with reference to Examples, but the present invention is not limited to the following Examples.
The unit of each component amount in Tables 1 to 5 is w / w%.

Sunscreen compositions having the compositions shown in Tables 1 to 3 were prepared according to a conventional method. Specifically, the oil phase component and the aqueous phase component were weighed and dissolved by heating if necessary. Then, the oil phase was added to the aqueous phase, and the mixture was stirred with a homomixer to prepare a uniform O / W type composition. If necessary, a neutralizing agent was added after stirring to prepare a uniform O / W type composition.

Test Example 1: UV protection effect test Each sunscreen composition shown in Tables 1 to 3 is uniformly applied to a plate made of polymethylmethacrylate (HeloplateHD6 manufactured by Sanyo Trading Co., Ltd.) at 1.3 mg / cm ^2. Then, after air-drying, the ultraviolet absorption spectrum was measured using an ultraviolet spectrophotometer (manufactured by JASCO Corporation, V-650).
The results are shown in Figures 1-3.

Examples 1 to 4 have an ultraviolet protection effect (an effect of enhancing an ultraviolet absorption spectrum) as shown in FIG. 1, as compared with Comparative Examples 1 to 4 in which the component (A) bisPEG-18 methyl ether dimethylsilane is removed. Had had. Similarly, Example 4 has an ultraviolet protection effect as shown in FIG. 2, as compared with Comparative Example 5 in which the cross polymer (Acrylate / alkyl acrylate (C10-30)) of the component (C) is removed. Was.

表中＊１の原料名は、ＳＩＭＵＬＧＥＬＮＳであり、＊２の原料名は、ＳＩＭＵＬＧＥＬＥＧである。

In the table, the raw material name of * 1 is SIMULGELNS, and the raw material name of * 2 is SIMULGELEG.

As shown in FIG. 3, Examples 5 to 7 had a remarkable ultraviolet protection effect (effect of enhancing the ultraviolet absorption spectrum) as compared with Comparative Examples 6 to 8 excluding the component (A), respectively.

Similar to Examples 1 to 7, sunscreen compositions having the compositions shown in Table 4 were prepared according to a conventional method, and the UV protection effect was tested.

As a result, Example 8 had an ultraviolet protection effect (effect of enhancing the ultraviolet absorption spectrum) as compared with Comparative Example 9, and had a remarkable ultraviolet protection effect, which was particularly different at the peak top near 350 nm.

Test Example 2 Usability Test The usability was confirmed using the sunscreen compositions of Example 4 and Comparative Example 4 in Table 2. Five panelists were asked to use each sample to evaluate the slimy feeling derived from the thickener. As a result of comparing the lack of sliminess, 4 out of 5 evaluated that there was no sliminess in Example 4 as compared with Comparative Example 4.

In Comparative Example 4 in which a large amount of the ultraviolet absorber as the component (B) was blended with the water-soluble thickener as the component (C), the usability was impaired, while in addition to the components (B) and (C), further It was found that the sunscreen composition of the present invention containing the component (A), a polyether-modified silicone wax, exhibited an excellent usability. As described above, according to the present invention, it is possible to provide a sunscreen composition having an excellent usability and an enhanced ultraviolet absorbing ability.

Preparation example The preparations shown in Table 5 below are prepared. Pharmaceutical examples 1 to 10 are sunscreen compositions of O / W type gels.

Claims (1)

The invention described in the specification.

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