JP7149851B2 - Composition for external use on the skin - Google Patents

Description

The present invention relates to an external skin composition.

Ultraviolet rays include ultraviolet A rays (UV-A, 315-400 nm) and ultraviolet B rays (UV-B, 280-315 nm), among others. Of these, UV-A is less likely to cause sunburn, but recent studies have shown that UV-A is greatly involved in the generation of spots and wrinkles. That is, UV-A has a long wavelength, reaches deep into the skin, and exerts effects such as denaturation of collagen, for example.

UV-B has a short wavelength and is blocked by the ozone layer and clouds compared to UV-A. However, UV-B has a high energy and damages cells on the surface of the skin and causes inflammation, so it can cause skin cancer and blemishes.

As the effects of ultraviolet rays on the skin become clearer, there is an increasing demand for sunscreen compositions with a high ultraviolet-blocking effect, and various compositions for external use on the skin have been proposed (Patent Document 1).

JP 2015-17080 A

An object of the present invention is to provide a composition for external use on the skin that has an ultraviolet absorbing ability.

As a result of intensive studies to solve the present problem, the present inventors have found that (A) at least one selected from the group consisting of an alkyl-modified silicone and an alkyl-modified silicone resin and (B) an ultraviolet absorber and an ultraviolet scattering agent. By using at least one selected from the group consisting of agents, it was found that an external composition for skin with a high ability to enhance the ultraviolet absorption spectrum can be obtained, leading to the completion of the present invention.

That is, the present invention provides the following external skin composition.
Section 1.
(A) at least one selected from the group consisting of alkyl-modified silicones and alkyl-modified silicone resins;
(B) an oil-in-water composition for external use on the skin, containing at least one selected from the group consisting of an ultraviolet absorber and an ultraviolet scattering agent.
Section 2.
Item 1. The composition for external use on skin according to Item 1, further comprising (C) a thickening agent.
Item 3.
Item 3. The external skin composition according to Item 1 or 2, wherein the component (A) is at least one selected from the group consisting of alkyldimethicone, alkoxydimethicone, alkylmethicone, and silsesquioxane.
Section 4.
4. The composition for external use on skin according to any one of Items 1 to 3, wherein the (B) UV absorber is an oil-soluble UV absorber.
Item 5.
Item 5. The composition for external use on skin according to any one of items 1 to 4, wherein the content of component (B) is 0.01 to 50 w/w% relative to the total amount of the composition.
Item 6.
The external composition for skin according to any one of claims 1 to 5, wherein the weight ratio of (A):(B) is 1:0.5-50.
Item 7.
Item 7. The composition for external use on skin according to any one of Items 1 to 6, which is used as a sunscreen.
Item 8.
Item 8. The composition for external use on skin according to any one of Items 1 to 7, which is for water resistance and/or for sustained UV protection effect.

The present invention also provides the following methods.
Item 9.
(A) at least one selected from the group consisting of alkyl-modified silicones and alkyl-modified silicone resins, and (B) at least one selected from the group consisting of UV absorbers and UV scattering agents, A method for imparting water resistance and/or UV protection effect persistence to the composition for external use on the skin by incorporating and.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a composition for external use on the skin that has the ability to enhance the ultraviolet absorption spectrum and is comfortable to use.

FIG. 1 is a graph showing the results of an ultraviolet protection effect test of the external skin composition of the present invention and the external skin composition of the comparative example. FIG. 2 shows the measurement results of the ultraviolet absorption spectra of the external skin composition of the present invention and the external skin composition of the comparative example. The unit on the vertical axis is Absorbance (Abs.). FIG. 3 is a graph showing the results of the residual test after water treatment for the external skin composition of the present invention and the external skin composition of the comparative example. FIG. 4 is a graph showing the results of a residual test after treatment with chloride-containing water for the external skin composition of the present invention and the external skin composition of the comparative example. FIG. 5 is a graph showing the results of an ultraviolet protection effect test of the external skin composition of the present invention and the external skin composition of the comparative example. FIG. 6 shows the measurement results of the ultraviolet absorption spectra of the external skin composition of the present invention and the external skin composition of the comparative example. The unit on the vertical axis is Absorbance (Abs.). FIG. 7 is a graph showing the results of a secondary adhesion evaluation test for the external skin composition of the present invention and the external skin composition of the comparative example.

In this specification, the content unit "w/w%" is synonymous with w/w% of "g/100g".

As used herein, "oil-soluble" means that the solubility in water is 1 w/w% or less, and "water-soluble" means that the solubility in water is greater than 1 w/w%.

As used herein, the term "composition for external use on the skin" refers to a composition for external use that can be applied to the skin. The composition for external use on the skin includes, but is not particularly limited to, a sunscreen composition having ultraviolet absorption ability. Here, the "sunscreen composition" includes, for example, a form in which the sunscreen is specified in the product, but even if there is no specification, if it is a composition for external use on the skin that has such a function, it is referred to in this specification. Included in "sunscreen composition".

The external composition for skin of the present invention comprises (A) at least one selected from the group consisting of alkyl-modified silicones and alkyl-modified silicone resins and (B) at least one selected from the group consisting of ultraviolet absorbers and ultraviolet scattering agents. It is an oil-in-water (O/W) composition containing seeds. Here, the oil-in-water composition means an emulsified composition in which the aqueous component is the continuous phase and the oil component is the dispersed phase.

In a composition containing components (A) and (B), a composite structure is formed in which the alkyl groups of component (A) and component (B) are in close proximity. As a result, the component (B) is efficiently and stably dispersed, and when the composition is applied to the skin, it is believed that the UV protection effect is further improved. However, the above is a presumed mechanism, and does not limit the mechanism of the external composition for skin of the present invention.

[(A) Alkyl-modified silicone or alkyl-modified silicone resin]
As used herein, (A) alkyl-modified silicone or alkyl-modified silicone resin refers to a silicone or silicone resin modified by introducing an alkyl group (e.g., MQ resin, silsesquioxane resin), which is semi-solid at room temperature. Alternatively, it refers to an alkyl-modified silicone or an alkyl-modified silicone resin that is solid, preferably waxy, flaky or pasty at normal temperature, particularly preferably waxy or flaky at normal temperature, and melts by heating. More specifically, it refers to an alkyl-modified silicone or an alkyl-modified silicone resin having a melting point of room temperature (for example, 20° C.) or higher.

In the present invention, the alkyl-modified silicone or alkyl-modified silicone resin of component (A) is not limited, but is preferably an oil-soluble alkyl-modified silicone or an oil-soluble alkyl-modified silicone resin. Examples of such alkyl-modified silicones or alkyl-modified silicone resins include, but are not limited to, alkyldimethicone, alkoxydimethicone, alkylmethicone, and silsesquioxane resins. The silsesquioxane resin preferably has an alkyl group. The number of carbon atoms in the alkyl group here is not particularly limited, and is, for example, about 3 to 70, preferably about 10 to 60, more preferably about 16 to 50, still more preferably about 16 to 45. be. Here, the alkyl groups or the alkyl group moieties of the alkoxy groups to be introduced into the silicone or silicone resin need not all be alkyl groups having the same number of carbon atoms, and at least one alkyl group is the preferred range described above. It preferably has a carbon number. The alkyl groups may also be linear or branched, although it may be preferred to include branched alkyl groups.

As component (A), although not limited, alkyl-modified silicone resins can be used, and among them, alkyl-modified silicone resin waxes can be preferably used. Among these, silsesquioxane resin waxes are more preferable, and among them, alkyldimethylsilylpolypropylsilsesquioxane is particularly preferable. In the alkyldimethylsilylpolypropylsilsesquioxane, the number of carbon atoms in the "alkyl" other than the methyl group and the propyl group is not particularly limited, and is, for example, about 10-60, preferably about 18-50, more preferably 30-45 (ie, alkyl (C30-45) dimethylsilylpolypropylsilsesquioxane).

As component (A), paste-like polypropyl silsesquioxane, alkyl (C26-28) dimethicone; wax-like alkyl (C30-45) methicone, stearyl dimethicone, cetearyl methicone, alkyl (C30-45) ) dimethicone, alkyl (C26-28) methicone, behenoxy dimethicone, etc. can also be used.

These (A) components can be synthesized and used, or commercially available products can be used as they are.

When a commercially available product is used and listed in a catalog, it is also possible to select component (A) based on the melting point. Depending on the selection, component (A) can be used at a temperature of 20° C. to 40° C., 40° C. to 80° C., or 80° C. to 100° C., respectively.

A specific commercially available product is SW-8005 C30 Resin Wax (alkyl (C30-45) dimethylsilylpolypropylsilsesquioxane; manufactured by Dow Corning Toray Co., Ltd.; melting point 63 to 71° C. listed in the catalog) as an alkyl-modified silicone resin wax. 670 Fluid (polypropyl silsesquioxane using cyclopentasiloxane as a diluent oil; manufactured by Dow Corning Toray Co., viscosity 200 mm ² /s), 680 Fluid (polypropylene using isododecane as a diluent oil); lucylsesquioxane; manufactured by Dow Corning Toray Co., viscosity 900 mm ² /s); AMS-C30 Cosmetic Wax (alkyl (C30-45) methicone; manufactured by Dow Corning Toray Co., Ltd., melting point 73 to 77) as alkyl-modified silicone wax ° C.), 2503 Cosmetic Wax (stearyl dimethicone; Dow Corning Toray Co., melting point 28-35° C.), BELSIL CM 7026 VP (alkyl (C26-28) methicone; Asahi Kasei Wacker Silicone Co., melting point 70° C.), BELSIL SDM 5055 VP (stearyl dimethicone; manufactured by Asahi Kasei Wacker Silicone Co., Ltd., melting point 30° C.), SF1632 (alkyl (C16-18) dimethicone; manufactured by Momentive Performance Materials, melting point 25-35° C.), SF1642 (alkyl (C30-45 ) Dimethicone; manufactured by Momentive Performance Materials, melting point 60 to 70 ° C.); as alkyl-modified silicone, BELSIL CDM 3526 VP (alkyl (C26-28) dimethicone; manufactured by Asahi Kasei Wacker Silicone Co., melting point 35 ° C.), ABIL Wax 2434 (stearoxydimethicone; manufactured by Evonik Japan, melting point 25°C), ABIL Wax 2440 (behenoxydimethicone; manufactured by Evonik Japan, melting point 40°C), and the like.

In the composition for external use on skin of the present invention, the total content of component (A) relative to the total amount of the composition for external use on skin is appropriately set according to the balance with other components. The total content of component (A) is preferably 0.001 w/w% or more, more preferably 0.01 w/w% or more, still more preferably 0.1 w/w, relative to the total amount of the external composition for skin. /w% or more, most preferably 0.2 w/w% or more. The total content of component (A) is preferably 20 w/w% or less, more preferably 10 w/w% or less, still more preferably 5 w/w% or less, most preferably 5 w/w% or less, relative to the total amount of the external composition for skin. is 3 w/w% or less. The total content of component (A) is preferably 0.001 w/w% to 20 w/w%, more preferably 0.01 w/w% to 10 w/w%, based on the total amount of the external composition for skin, More preferably 0.1 w/w% to 5 w/w%, most preferably 0.2 w/w% to 3 w/w%.

[(B) UV absorber or UV scattering agent]
As used herein, the term "ultraviolet absorber" refers to a compound (component) having the property of absorbing ultraviolet rays.

Examples of the ultraviolet absorber include:
(a) 2-ethylhexyl paramethoxycinnamate (also known as ethylhexyl methoxycinnamate), isopropyl methoxycinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrylene), diisopropyl methylcinnamate, trimethoxycinnamate Methylbis(trimethylsiloxy)silyl isopentyl formate, methyl 2,5-diisopropyl cinnamate, glyceryl mono-2-ethylhexanoate di-paramethoxycinnamate, cinoxate, DEA methoxycinnamate, ferulic acid, and methoxy cinnamon cinnamic acid derivatives such as isoamyl acids;
(b) para-aminobenzoic acid (hereinafter abbreviated as "PABA"), ethyl PABA, ethyl-dihydroxypropyl PABA, ethylhexyl-dimethyl PABA, glyceryl PABA, PEG-25PABA, amyl paradimethylaminobenzoate, paradimethylamino Benzoic acid derivatives such as 2-ethylhexyl benzoate and 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester (also known as diethylaminohydroxybenzoyl hexyl benzoate);
(c) salicylic acid derivatives such as homosalate, ethylhexyl salicylate, TEA salicylate, ethylene glycol salicylate, and dipropylene glycol salicylate;
(d) dihydroxybenzophenone (benzophenone-1), tetrahydroxybenzophenone (benzophenone-2), 2-hydroxy-4-methoxybenzophenone (benzophenone-3), hydroxymethoxybenzophenone sulfonic acid (benzophenone-4), dihydroxydimethoxybenzophenone (benzophenone -5), dihydroxydimethoxybenzophenone (benzophenone-6), 2,2′-dihydroxy-4-methoxybenzophenone (benzophenone-8), and 3,3′-carbonylbis[4-hydroxy-6-methoxybenzenesulfonic acid ] benzophenone derivatives such as disodium (benzophenone-9);
(e) benzylidene camphor derivatives such as 3-benzylidene camphor, 4-methylbenzylidene camphor, benzylidene camphor sulfonic acid, terephthalylidene dicamphor sulfonic acid, benzalkonium methosulfate camphor, and polyacrylamidemethylbenzylidene camphor;
(f) anisotriazine, diethylhexylbutamide triazone, 2,4,6-tris(diisobutyl-4′-aminobenzalmalonate)-s-triazine, 2,4-bis-[{4-(2- ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine (also called bisethylhexyloxyphenolmethoxyphenyltriazine, etc.), and 2,4,6 - triazine derivatives such as tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine;
(g) phenylbenzimidazole sulfonic acid and phenylbenzimidazole derivatives such as disodium phenyldibenzimidazole tetrasulfonate;
(h) Drometrizol trisiloxane and 2,2′-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] phenylbenzotriazole derivatives;
(i) anthranyl derivatives such as menthyl anthranilate;
(j) imidazolidine derivatives such as 2-ethylhexyl dimethoxybenzylidene oxoimidazolidinepropionate;
(k) benzalmalonate derivatives such as dimethicodiethylbenzalmalonate;
(l) 4,4-diarylbutadiene derivatives such as 1,1-dicarboxy(2,2′-dimethylpropyl)-4,4-diphenylbutadiene; and (m) 4-tert-butyl-4′-methoxydiene. dibenzoylmethane derivatives such as benzoylmethane; and the like.

In the present invention, the ultraviolet absorber is preferably an oil-soluble ultraviolet absorber. By using an oil-soluble ultraviolet absorber, the composition for external use on the skin of the present invention is resistant to sweat and water, suppresses the removal of sunscreen after application, and is well compatible with sebum together with other ingredients. It becomes the composition which exhibits the outstanding effect which is easy to form a uniform film.

Here, as the oil-soluble ultraviolet absorber,
(a) 2-ethylhexyl paramethoxycinnamate, isopropyl methoxycinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrylene), diisopropyl methylcinnamate, methylbis(trimethylsiloxy)silylisopentyl trimethoxycinnamate, methyl 2,5-diisopropylcinnamate, glyceryl mono-2-ethylhexanoate dip-paramethoxycinnamate, cinoxate, DEA methoxycinnamate, ferulic acid and isoamyl methoxycinnamate;
(b) PABA, ethyl PABA, ethyl-dihydroxypropyl PABA, ethylhexyl-dimethyl PABA, glyceryl PABA, PEG-25PABA, amyl paradimethylaminobenzoate, 2-ethylhexyl paradimethylaminobenzoate, and 2-[4-( diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester;
(c) ethylhexyl salicylate, TEA salicylate, and dipropylene glycol salicylate;
(d) dihydroxydimethoxybenzophenone (benzophenone-6),
(e) polyacrylamide methylbenzylidene camphor;
(f) anisotriazine, diethylhexylbutamide triazone, 2,4,6-tris(diisobutyl-4′-aminobenzalmalonate)-s-triazine, 2,4-bis-[{4-(2- ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine and 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino] -1,3,5-triazine;
(h) Drometrizol trisiloxane;
(i) menthyl anthranilate;
(j) 2-ethylhexyl dimethoxybenzylidene oxoimidazolidinepropionate;
(k) dimethicodiethylbenzalmalonate;
(l) 1,1-dicarboxy(2,2′-dimethylpropyl)-4,4-diphenylbutadiene; and (m) 4-tert-butyl-4′-methoxydibenzoylmethane; .

These ultraviolet absorbers may be used alone or in combination of two or more. The ultraviolet absorber can be synthesized and used, or a commercially available product can be used as it is.

In the composition for external use on the skin of the present invention, one or two or more of the above ultraviolet absorbers are used as ultraviolet absorbers in order to reduce irritation and odor, and to improve usability and solubility. It is also possible to use raw materials that have undergone formulation modification such as encapsulation. Specifically, a shell substantially composed of a polymer component made of poly(ethylene glycol dimethacrylate), ethylene glycol dimethacrylate/divinylbenzene copolymer, or poly(divinylbenzene) contains an ultraviolet absorber, Microcapsules with an average particle size of 0.4 to 10 μm (ultraviolet absorber-encapsulated capsules), and microcapsules in which t-butyl methoxydibenzoylmethane is encapsulated in sol-gel silica glass and dispersed in water (for example, Eusolex UV-Pearls OB-S (trade name), Eusolex UV-Pearls OB-S2 (trade name); manufactured by Merck), and similarly ethylhexyl methoxycinnamate is encapsulated in sol-gel silica glass and dispersed in water. Capsules (for example, Eusolex UV-Pearls 2292 (trade name), Eusolex UV-Pearls OMC (trade name); manufactured by Merck), and UV absorbers (octocrylene, diethylaminohydroxybenzoylbenzoate, ethylhexyl methoxycinnamate, para 2-ethylhexyl methoxycinnamate, t-butyl-methoxydibenzoylmethane, etc.) is encapsulated with silicone-resinized hydrolyzed silk (polysilicone-14), formed into microcapsules with an average particle size of 2 μm, and dispersed in water. (For example, Silasoma (registered trademark) ME, Silasoma MEA, Silasoma MEA (S), Silasoma MEA (V), Silasoma MEA (L), Silasoma MFA (S), Silasoma MFA (LS), Silasoma EP (S), Silasoma Silasoma series (trade name) such as REA(S); manufactured by Seiwa Kasei Co., Ltd.) can be exemplified.

In the composition for external use on skin of the present invention, the total content of the ultraviolet absorber with respect to the total amount of the composition for external use on skin is appropriately set according to the balance with other ingredients. The total content of the ultraviolet absorber is preferably 0.01 w/w% or more, more preferably 0.1 w/w% or more, still more preferably 0.5 w/w, relative to the total amount of the external composition for skin. % or more, even more preferably 1.0 w/w % or more, most preferably 3.0 w/w % or more. In addition, the total content of component (B) is preferably 25 w/w% or less, more preferably 20 w/w% or less, still more preferably 15 w/w% or less, relative to the total amount of the external composition for skin. . The total content of component (B) is preferably 0.01 w/w% to 25 w/w%, more preferably 0.1 w/w% to 20 w/w%, relative to the total amount of the external composition for skin, More preferably, it ranges from 0.5 w/w% to 15 w/w%.

The ultraviolet scattering agent in the present invention refers to a compound (component) having a property of scattering ultraviolet rays, and includes both an oil-dispersed ultraviolet scattering agent and a water-dispersed ultraviolet scattering agent. Examples of the ultraviolet scattering agent include metal oxide powder and clay particles. For example, metal oxides such as zinc oxide, titanium oxide, iron oxide, cerium oxide, and zirconium oxide; metal silicates such as titanium silicate, zinc silicate, and cerium silicate; silicic anhydride, and hydrous silicic acid; silicic acid such as acid; inorganic compounds such as metals such as titanium, zinc and iron; In addition, those inorganic compounds coated with inorganic powder such as hydrated silicic acid, aluminum hydroxide, mica, or talc, and those inorganic compounds coated with resin powder such as polyamide, polyethylene, polyester, polystyrene, or nylon Examples include those that are composited with a body or have their surfaces coated with these, and those whose inorganic compounds have been treated with silicone oil, fatty acid aluminum salts, or the like, or whose surfaces have been coated with these. Although not limited, the ultraviolet scattering agent is preferably a fine particle inorganic powder, more preferably a fine particle metal oxide, and still more preferably a fine particle titanium oxide or a fine particle zinc oxide. Furthermore, the surface of these fine particle inorganic powders is coated with inorganic powder such as hydrous silicic acid, aluminum hydroxide, mica, or talc, or those fine particle inorganic powders are coated with silicone oil, fatty acid aluminum salt, or the like. It is preferable to treat or coat the surface to make it hydrophobic.
Although the average particle size of the ultraviolet scattering agent is not particularly limited, it is preferably about 1 to 500 nm. Among them, the average particle size of the ultraviolet scattering agent is preferably about 2 to 200 nm, more preferably about 3 to 100 nm, even more preferably about 5 to 50 nm, which is fine particles.

These ultraviolet scattering agents may be used alone or in combination of two or more. The UV scattering agent can be synthesized and used, or a commercially available product can be used as it is.

In the composition for external use on skin of the present invention, the total content of the ultraviolet scattering agent with respect to the total amount of the composition for external use on skin can be, for example, 0.1 w/w% or more and 40 w/w% or less. It may be 5 w/w% or more and 35 w/w% or less, 1.0 w/w% or more and 30 w/w% or less, or 1.5 w/w% or more and 25 w/w% or less. good.

In the present invention, it is also possible to use both an ultraviolet absorber and an ultraviolet scattering agent.

In the external composition for skin of the present invention, the total content of component (B) with respect to the total amount of the external composition for skin can be, for example, 0.01 w/w% or more and 50 w/w% or less. .It may be 1 w/w% or more and 45 w/w% or less, 0.5 w/w% or more and 42 w/w% or less, or 1 w/w% or more and 40 w/w% or less. , 1.5 w/w% or more and 35 w/w% or less.

In the composition for external use on the skin of the present invention, the ratio of the amount of component (B) to component (A) is
The total content of component (B) is preferably 0.0005 to 25000 parts by weight, more preferably 0.01 to 2000 parts by weight, more preferably 0.05 to 1000 parts by weight with respect to 1 part by weight of the total content of component (A). Parts by weight are more preferred, 0.1 to 150 parts by weight are particularly preferred, and 0.5 to 50 parts by weight are most preferred.

When the component (B) is an oil-soluble ultraviolet absorber, the ratio of the amount of the component (B) to the component (A) in the composition for external use on the skin of the present invention is such that the total content of the component (A) is 1 weight. parts, the total content of component (B) is preferably 0.0005 to 25000 parts by weight, more preferably 0.01 to 2000 parts by weight, even more preferably 0.05 to 1000 parts by weight, and 0.1 to 150 parts by weight is particularly preferred, and 0.5 to 50 parts by weight is most preferred.

When the component (B) is an oil-dispersed ultraviolet scattering agent, the ratio of the amount of the component (B) to the component (A) in the composition for external use on the skin of the present invention is the total content of the component (A) of 1 The total content of component (B) is preferably 0.01 to 1000 parts by weight, more preferably 0.05 to 800 parts by weight, still more preferably 0.1 to 500 parts by weight, and 0.1 ∼100 parts by weight is particularly preferred, and 0.5 to 50 parts by weight is most preferred.

When the component (B) is a water-dispersible ultraviolet scattering agent, the ratio of the amount of the component (B) to the component (A) in the composition for external use on the skin of the present invention is the total content of the component (A) of 1 The total content of component (B) is preferably 0.01 to 1000 parts by weight, more preferably 0.05 to 800 parts by weight, still more preferably 0.1 to 500 parts by weight, and 0.1 ∼100 parts by weight is particularly preferred, and 0.5 to 50 parts by weight is most preferred.

By containing the components (A) and (B), the external composition for skin of the present invention can exhibit a high UV absorbing function and/or a UV scattering function, and particularly can exhibit a high UV absorbing function. The ultraviolet absorption ability can be evaluated by measuring the ultraviolet absorption spectrum by the method described in the test examples below. That is, specifically, the composition for external use on skin of the present invention can have a UV absorbing power that is enhanced over the value exhibited by (B) the UV absorber and/or the UV scattering agent alone. Furthermore, the composition for external use on the skin of the present invention can be retained well even in water such as sweat or seawater with a high salt concentration. Here, salts are, but are not limited to, chlorides or sulfates. Chlorides or sulfates include, for example, sodium chloride, magnesium chloride, potassium chloride, calcium chloride, magnesium sulfate, calcium sulfate, and the like. In addition, since the composition for external use on the skin of the present invention effectively suppresses secondary adhesion, even if moisture such as sweat is wiped with tissue paper, a handkerchief, a towel, or the like, or if it is rubbed with clothes. Even so, it can remain on the skin and retain its UV absorbing ability well.

The composition for external use on skin of the present invention may optionally contain other components other than the above components (A) and (B). Examples of such components preferably include (C) a thickener.

[(C) Thickener]
The composition for external use on skin of the present invention preferably contains a thickening agent as an additional component. By including a thickener, the stability of the oil-in-water emulsified composition is enhanced, so that the components (A) and (B) of the present invention can be maintained in a state in which they are more likely to exhibit their effects. As used herein, (C) a thickener refers to an agent (ingredient) that has the property of increasing the viscosity of the composition to which it is added. Preferably, the thickening agent is a water-soluble thickening agent that is soluble in water.

In a composition containing components (A) and (B), the alkyl group of component (A) and component (B) form a composite structure in which component (B) is efficiently and stably dispersed. As described above, it is presumed that the UV protection effect is further improved by applying the composition to the skin. In an oil-in-water type composition containing component (A) and component (B) and further containing component (C), component (A) is contained in the aqueous phase by containing component (C) A composite structure in which the alkyl group of (B) is in close proximity to the component (B) is dispersed more efficiently and stably, and when the composition is applied to the skin, the UV protection effect is further improved.

Water-soluble thickeners include acrylic acid-based thickeners, polysaccharide-based thickeners, amino acid-based thickeners, polyethylene glycol-based thickeners, water-soluble anionic polymer-based thickeners, and other highly water-soluble thickeners. Molecular adhesives are preferred.

Specific examples of water-soluble thickeners include (a) acrylic acid/alkyl methacrylate copolymer, hydroxyethyl acrylate/acryloyldimethyltaurate salt copolymer, polyacrylic acid, salts thereof, and the like. acrylic thickener;
(b) polysaccharide-based thickeners such as cellulose-based thickeners, mucopolysaccharide-based thickeners, seaweed-based thickeners, microbial-derived thickeners, or starch-based thickeners;
(c) amino acid thickeners such as collagen;
(d) polyethylene glycol-based thickening agents such as polyethylene glycol, polyethylene glycol distearate, (PEG-240/decyltetredeceth-20/HDI) copolymer, glyceryl behenate/polyglyceryl-6 octastearate;
(e) a water-soluble anionic polymer (including copolymers, homopolymers, and crosspolymers) thickeners containing monomers having anionic groups such as carboxyl groups, sulfonic acid groups, and phosphoric acid groups as structural units; or (f) Other water-soluble polymers such as ethylene glycol triisostearate, polyoxyethylene (20) methyl glucoside triisostearate, bentonite, macrogol, sodium caseinate, and polyvinyl alcohol.

Here, as the above (a) acrylic acid-based thickener,
(sodium acrylate/sodium acryloyldimethyltaurate) copolymer, (hydroxyethyl acrylate/sodium acryloyldimethyltaurate) copolymer, (acryloyldimethyltaurate ammonium/vinylpyrrolidone) copolymer, (acryloyldimethyltaurate ammonium methacrylate beheneth-25) crosspolymer, (acryloyldimethyltaurate ammonium/steareth-25 methacrylate) crosspolymer, (acryloyldimethyltaurate ammonium/carboxyethylammonium acrylate) crosspolymer, acrylamide/ammonium acrylate copolymer, polyacrylate crosspolymer-6, polyacrylate crosspolymer-11 , polyacrylate-13, (acrylic acid/acryloyldimethyltaurine/dimethylacrylamide) crosspolymer, and (sodium acrylate/acryloyldimethyltaurine/dimethylacrylamide) crosspolymer. or (Acrylates/C10-30 alkyl acrylate) crosspolymer, (Acrylates/Steareth-20 methacrylate) copolymer, (Acrylates/Beheneth-25 methacrylate) copolymer, (Acrylates/Steareth-20 itaconate) one or more non-neutralized thickeners selected from the group consisting of copolymers, steareth-10 allyl ether acrylates copolymers, carboxyvinyl polymers, and polyacrylamides;

Here, as the (b) polysaccharide-based thickener,
Cellulosic thickeners such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxyethylcellulose, stearoxyhydroxypropylmethylcellulose;
Hyaluronic acid, hyaluronic acid derivatives, and salts thereof, mucopolysaccharide thickeners such as sodium chondroitin sulfate;
seaweed-based thickeners such as carrageenan, alginate, propylene glycol alginate, agar;
Microorganism-derived thickeners such as xanthan gum, hydroxypropylxanthan gum, dextran, sclerotium gum and gellan gum; or starch-based thickeners such as hydroxypropyl starch phosphate and corn starch;

The (C) thickener that is preferably used in the present invention is not particularly limited, but typically includes an acrylic acid-based thickener and/or a water-soluble anionic polymer. Particularly preferred acrylic thickeners and/or water-soluble anionic polymers are (acrylates/alkyl acrylate (C10-30)) crosspolymers, (hydroxyethyl acrylate/sodium acryloyldimethyltaurate) copolymers, acrylamide /ammonium acrylate copolymer, (acrylates/beheneth-25 methacrylate) crosspolymer sodium, polyacrylate crosspolymer-6, polyacrylate-13, (acrylic acid/acryloyldimethyltaurine/dimethylacrylamide) crosspolymer, (acrylates/itaconic acid Steareth-20) copolymer, (acryloyldimethyltaurate ammonium/vinylpyrrolidone) copolymer, (sodium acrylate/acryloyldimethyltaurate/dimethylacrylamide) crosspolymer, steareth-10 allyl ether acrylates copolymer, carboxyvinyl polymer and polyacrylamide One or more selected from the group. Among them, the (C) thickener used in the present invention is preferably a water-soluble anionic thickener and an acrylic acid-based thickener.

These (C) thickeners may be used alone or in combination of two or more. When these thickeners are used, it is possible to create a gel formulation with a particularly high watery feel, and it is possible to create a light gel formulation that has an appropriate film feeling and formulation stability, and is comfortable to use. can.

(C) Among thickeners, commercially available acrylic acid-based thickeners include PEMULEN™ TR-1 and TR-2 (manufactured by Lubrizol Advanced Materials); Ultraz10 Polymer (manufactured by Lubrizol Advanced Materials), STRUCTURE (trademark) 2001 (manufactured by Akzo Nobel), Aristoflex (trademark) AVC, HMB (manufactured by Clariant Japan) and the like can be used. Moreover, you may use it as a mixture mixed with oils, such as squalane, a nonionic surfactant, and water. Specific examples of such a mixture include, for example, SIMULGEL (trademark) FL, NS (manufactured by Seppic), which are commercially available products containing hydroxyethyl acrylate/acryloyl dimethyl taurate sodium copolymer; sodium acrylate/acryloyl SIMULGEL (trademark) EG (manufactured by Sepik), SIMULGEL (trademark) EPG (manufactured by Sepik), which are commercial products containing dimethyl taurine copolymer; Commercial products containing steareth-10 allyl ether acrylates copolymer SALCARE™ SC80 (manufactured by Ciba Specialty Chemicals, Inc.); SALCARE™ SC91 (Ciba Specialty Chemicals, Inc.), a commercial product containing sodium acrylate/sodium methacrylate/sodium methacrylate alkyl methacrylate copolymer Chemicals Co., Ltd.); SEPINOV (trademark) P88 (manufactured by Seppic), which is a commercial product containing (Na acrylate/acryloyldimethyltaurine/dimethylacrylamide) crosspolymer, Adekanol (trademark) GT-700 (Asahi Denka Kogyo Co., Ltd.) and SEPIGEL (trademark) 305 (Seiwa Kasei Co., Ltd.), which is a commercially available product containing polyacrylamide. As the polyacrylic acid amide, for example, commercially available SEPIGEL (trademark) 305 (manufactured by Seiwa Kasei Co., Ltd.) can be used. Examples of the carboxyvinyl polymer include Carbopol (trademark) 940, 941, 980, 981, ETD2050, Ultraz10 Polymer (manufactured by Lubrizol Advanced Materials); Syntaren K Syntaren L (manufactured by 3V SIGMA); AQUPEC (trademark) HV-501E , HV-504E, HV-505E (manufactured by Sumitomo Seika Co., Ltd.); Hivis Wako 103, 104, 105 (manufactured by Wako Pure Chemical Industries, Ltd.); Junron PW-110 (manufactured by Nippon Junyaku Co., Ltd.).

In addition, as a polyethylene glycol-based thickener, Adekanol (trademark) GT-700 (manufactured by Asahi Denka Kogyo Co., Ltd.), which is a commercial product containing (PEG-240/decyltetradeceth-20/HDI) copolymer, and the starch-based Examples of the thickener include STRUCTURE™ XL (manufactured by Akzo Nobel), a commercial product containing hydroxypropyl starch phosphate, and examples of the polyvinyl alcohol include Gosenol™ EG-05, a commercial product. , and EG-40 (manufactured by Nippon Synthetic Chemical Industry Co., Ltd.).

In the external composition for skin of the present invention, the content of the (C) thickening component with respect to the total amount of the external composition for skin is preferably 0.00001 w/w% or more, more preferably 0.0001 w/w%. Above, more preferably 0.001 w/w% or more, most preferably 0.1 w/w% or more. The total content of component (C) is preferably 20 w/w% or less, more preferably 10 w/w% or less, still more preferably 5 w/w% or less, relative to the total amount of the external composition for skin. . The total content of component (C) is preferably 0.00001 w/w% to 20 w/w%, more preferably 0.0001 w/w% to 10 w/w%, relative to the total amount of the external composition for skin. , more preferably 0.001 w/w% to 5 w/w%, most preferably 0.1 w/w% to 5 w/w%.

In the composition for external use on the skin of the present invention, the ratio of the amount of component (C) to component (A) is such that the total content of component (C) is 0 per 1 part by weight of the total content of component (A). 0.0000005 to 20000 parts by weight is preferred, 0.00002 to 100 parts by weight is more preferred, 0.0005 to 25 parts by weight is even more preferred, 0.01 to 10 parts by weight is even more preferred, and 0.1 to 1 part by weight is preferred. is particularly preferred, and 0.1 to 0.6 parts by weight is most preferred.

The composition for external use on the skin of the present invention exhibits a higher ultraviolet absorption ability by containing the components (A), (B) and (C).

The external composition for skin of the present invention contains, in addition to the above components (A) and (B), for example, antioxidants, whitening active ingredients, various pharmacologically active ingredients and physiologically active ingredients, as long as the effects of the present invention are not impaired. may be contained in an appropriate amount in combination.

[Antioxidant]
As the antioxidant (antioxidant component) in the present invention, known antioxidants can be used as long as they do not impair the effects of the present invention. In the present invention, an antioxidant (antioxidant component, antioxidant component) refers to a drug (component) that inhibits, reduces, or suppresses oxidation caused by reactive oxygen species and the like.

Examples of the antioxidant include:
(a) tocopherols and their derivatives or their salts (e.g., α-tocopherol, δ-tocopherol, acetate-α-tocopherol, tocotrienol), pyrroloquinoline quinones and their derivatives or their salts, ubiquinones and their derivatives or their vitamin antioxidants such as salts of, retinols and derivatives thereof or salts thereof, pantothenic acid and derivatives thereof or salts thereof, erythorbic acid or salts thereof;
(b) thiotaurine, cysteine, homocysteine, acetylcysteine, methionine, thioglycerol, sodium sulfite, sodium metabisulfite, sodium thiosulfate, sodium pyrosulfite, thioredoxin, dithiothreitol, alpha lipoic acid, ergothioneine, glutathione, glutathione peroxidase, sulfur-containing antioxidants such as glutathione-S-transferase;
(c) phenols such as dibutylhydroxytoluene, dibutylhydroxyanisole, bisethylhexylhydroxydimethoxybenzyl malonate, diethylhexylsyringylidene malonate, gallic acid and its derivatives or their salts, chlorogenic acid and its derivatives or their salts, etc. system antioxidants;
(d) components derived from plants (e.g., grape, ginseng, comfrey, etc.) (e.g., grape seed extract, grape leaf extract, ginseng extract, comfrey leaf extract, etc.); proanthocyanidins, hesperidin, glucosyl hesperidin, flavonoids and polyphenol antioxidants such as These may be used alone or in combination of two or more.

In the skin external composition of the present invention, the antioxidant is bisethylhexylhydroxydimethoxybenzyl malonate and its derivatives, malonic acid and its derivatives, pyrroloquinoline quinone and its derivatives, tocopherols and its derivatives, thiotaurine and its derivatives, dibutylhydroxytoluene and its derivatives, gallic acid and its derivatives, chlorogenic acid and its derivatives, hesperidin and its derivatives, glucosylhesperidin and its derivatives, ergothioneine and its derivatives, flavonoids and its derivatives, or dibutylhydroxyanisole and its derivatives, And when it can take the form of a salt, it is preferably a salt of any of the above compounds, a salt of any of the above derivatives, and the like. Among others, bisethylhexylhydroxydimethoxybenzyl malonate, pyrroloquinoline quinone and its derivatives or their salts, tocopherols and their derivatives or their salts, thiotaurine, dibutylhydroxytoluene, gallic acid and its derivatives or their salts, chlorogenic acid and derivatives or salts thereof, or dibutylhydroxyanisole are more preferred. Also, bisethylhexylhydroxydimethoxybenzyl malonate, diethylhexylsyringylidene malonate, pyrroloquinoline quinone and its derivatives or their salts, tocopherol and its derivatives or their salts, thiotaurine, dibutylhydroxytoluene, or gallic acid and its Derivatives or salts thereof are even more preferred.

Further, in the external composition for skin of the present invention, the content of the antioxidant with respect to the total amount of the external composition for skin can be 0.00001 w/w% or more and 20 w/w% or less. /w% or more and 10 w/w% or less, 0.001 w/w% or more and 7 w/w% or less, or 0.05 w/w% or more and 5 w/w% or less. , may be 0.03 w/w% or more and 3 w/w% or less, may be 0.02 w/w% or more and 1 w/w% or less, or may be 0.01 w/w% or more and 0.5 w/w% It may be below.

[Whitening active ingredient]
As the whitening active ingredient (whitening agent) in the present invention, known whitening active ingredients can be used as long as the effects of the present invention are not impaired. In the present invention, the effective whitening ingredient (whitening agent) is used to improve, suppress, reduce, prevent, prevent, and prevent skin pigmentation caused by melanin pigments, etc., which is particularly related to skin dullness, blemishes, melasma, and the like. or a drug (ingredient) that has the property of delaying

Examples of the whitening active ingredients include:
(a) hydroquinone and its derivatives or salts thereof (eg α-arbutin, β-arbutin); kojic acid; ellagic acid; phytic acid; rucinol; sodium, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (tetra-2-hexyldecanoate ascorbyl), 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbyl glucoside, etc.), potassium 4-methoxysalicylate tyrosinase inhibitors such as salts, tranexamic acid and its derivatives or salts thereof;
(b) endothelin-1 receptor inhibitors such as chamomilla ET;
(c) a tyrosinase proteolytic agent such as free linoleic acid;
(d) melanin efflux agents such as adenosine monophosphate disodium salt;
(e) melanin transport inhibitors such as niacinamide;
(f) In addition, plant components (for example, plant extracts and essential oils) having a whitening effect can be mentioned. These may be used alone or in combination of two or more.

In the external composition for skin of the present invention, the whitening active ingredients include hydroquinone and derivatives thereof or salts thereof, ascorbic acid and derivatives thereof or salts thereof, tranexamic acid and derivatives thereof or salts thereof, ellagic acid, niacinamide and the like. is preferably Among them, hydroquinone, arbutin, sodium ascorbate phosphate, ascorbic acid, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (ascorbyl tetra-2-hexyldecanoate), 3-O-ethylascorbic acid, ascorbyl glucoside, Tranexamic acid and the like are more preferable.

Further, in the external composition for skin of the present invention, the content of the whitening active ingredient with respect to the total amount of the external composition for skin can be 0.00001 w/w% or more and 20 w/w% or less. /w% or more and 10 w/w% or less, 0.001 w/w% or more and 7 w/w% or less, or 0.05 w/w% or more and 5 w/w% or less. , may be 0.03 w/w% or more and 3 w/w% or less, may be 0.02 w/w% or more and 1 w/w% or less, or may be 0.01 w/w% or more and 0.5 w/w% It may be below.

[Anti-inflammatory ingredient]
As the anti-inflammatory component (anti-inflammatory agent) in the present invention, known anti-inflammatory components can be used as long as they do not impair the effects of the present invention. In the present invention, an anti-inflammatory component (anti-inflammatory agent) refers to a drug (component) that inhibits, reduces, or suppresses inflammation of cells such as epidermis.

Examples of the anti-inflammatory ingredients include ingredients derived from plants (e.g., comfrey leaf extract, etc.); and derivatives or salts thereof (stearyl glycyrrhetinate, 18α-hydroxyglycyrrhetinic acid, etc.), guaiazulene, pyridoxine hydrochloride, menthol, camphor, turpentine oil, indomethacin, salicylic acid and derivatives thereof. These may be used alone or in combination of two or more.

In the external skin composition of the present invention, the anti-inflammatory component is allantoin, glycyrrhizic acid and its derivatives or their salts, glycyrrhetinic acid and its derivatives or their salts, guaiazulene, pyridoxine hydrochloride, menthol, camphor, turpentine oil, and indomethacin. , or salicylic acid and its derivatives or salts thereof. Among them, allantoin, glycyrrhizic acid, dipotassium glycyrrhizinate, glycyrrhetinic acid, stearyl glycyrrhetinate, menthol, camphor, indomethacin, and salicylic acid are more preferred.

Further, in the external composition for skin of the present invention, the content of the anti-inflammatory component with respect to the total amount of the external composition for skin can be 0.00001 w/w% or more and 20 w/w% or less. 0001 w/w% or more and 10 w/w% or less, 0.001 w/w% or more and 5 w/w% or less, or 0.05 w/w% or more and 3 w/w% or less It may be 0.03 w/w% or more and 1 w/w% or less, 0.02 w/w% or more and 0.5 w/w% or less, or 0.01 w/w% or more and 0.1 w/w% or more. /w% or less.

[Other Bases or Carriers]
The external composition for skin of the present invention can contain known bases or carriers used in cosmetics and quasi-drugs to the extent that the effects of the present invention are not impaired. The base or carrier can be used singly or in combination of two or more.

Bases or carriers include paraffin, liquid paraffin, squalane, white wax, gelling hydrocarbons (plastibase, etc.), ozokerite, ceresin, vaseline, hard fat, microcrystalline wax, α-olefin oligomer, light liquid paraffin, etc. Hydrocarbons; Fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid; Glyceryl tri-2-ethylhexanoate (trioctanoin), Glyceryl tri(caprylic/capric) Tri-fatty acid glycerides; higher alcohols such as cetanol, stearyl alcohol and behenyl alcohol; silicones such as methylpolysiloxane, didecamethylcyclopentasiloxane, methylsiloxane network polymer, methylhydrogenpolysiloxane and dimethicone; Esters such as octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythyl tetra-2-ethylhexanoate, triethylhexyl trimellitate; polysaccharides such as dextrin and maltodextrin; ethanol, isopropanol Glycol ethers such as ethylene glycol monoethyl ether; Aqueous bases such as water.

Above all, the external composition for skin of the present invention preferably contains water and/or a lower alcohol, and more preferably contains water. The composition for external use on skin of the present invention is not limited, but the content of water with respect to the total amount of the composition for external use on skin is preferably 30 w/w% or more and 99 w/w% or less, and 40 w/w% or more and 95 w/w% or less. is more preferable, and 50 w/w% or more and 90 w/w% or less is even more preferable. The external skin composition of the present invention is most preferably an oil-in-water composition containing 50 w/w% or more water.

[Additive]
The external composition for skin of the present invention may contain known additives added to cosmetics and quasi-drugs, such as surfactants, preservatives, pH adjusters, and chelating agents, as long as they do not impair the effects of the present invention. , stabilizers, irritants, preservatives, colorants, texture modifiers and the like can be added. An additive can be used individually by 1 type or in combination of 2 or more types.

Examples of surfactants include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate. sorbitan fatty acid esters; glycerin fatty acids such as glyceryl monostearate, glyceryl monostearate malic acid; polyglycerin fatty acids such as polyglyceryl monostearate, polyglyceryl monoisostearate, polyglyceryl diisostearate; propylene glycol monostearate Propylene glycol fatty acid esters such as; Polyoxyethylene hydrogenated castor oil 40 (PEG-40 hydrogenated castor oil, HCO-40), Polyoxyethylene hydrogenated castor oil 50 (PEG-50 hydrogenated castor oil, HCO-50) , hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 60 (PEG-60 hydrogenated castor oil, HCO-60), polyoxyethylene hydrogenated castor oil 80 (PEG-80 hydrogenated castor oil, HCO-80); Polyoxyethylene (20) sorbitan laurate (polysorbate 20), polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), polyoxyethylene isostearate ( 20) polyoxyethylene sorbitan fatty acid esters such as sorbitan; polyoxyethylene monococonut oil fatty acid glyceryl; glycerin alkyl ether; alkyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether; amines; silicone surfactants such as polyoxyethylene/methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, and dimethylsilicone oil. can.

Among them, glycerin fatty acids (especially glyceryl monostearate), polyglycerin fatty acids (especially polyglyceryl monostearate, polyglyceryl pentaisostearate), hydrogenated castor oil derivatives (especially polyoxyethylene hydrogenated castor oil 50 (PEG- 50 hydrogenated castor oil, HCO-50), polyoxyethylene hydrogenated castor oil 60 (PEG-60 hydrogenated castor oil, HCO-60)), polyoxyethylene sorbitan fatty acid esters (in particular, polyoxyethylene isostearate (20 ) Sorbitan, polyoxyethylene monostearate (20) sorbitan (polysorbate 60)), polyoxyalkylene alkyl ether (especially polyoxyethylene cetyl ether), silicone surfactant (especially polyoxyethylene-methylpolysiloxane co- Polymers, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, PEG-9 Polydimethylsiloxyethyl Dimethicone, Dimethyl Silicone Oil) are preferred.

Benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, parahydroxybenzoic acid Benzyl, methyl p-hydroxybenzoate, phenoxyethanol and the like can be mentioned. Among them, methyl parahydroxybenzoate, propyl parahydroxybenzoate and phenoxyethanol are preferable.

Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, phosphoric acid, polyphosphoric acid, boric acid, etc.), organic acids (lactic acid, acetic acid, citric acid, sodium citrate, tartaric acid, malic acid, succinic acid, sodium succinate, oxalic acid, gluconic acid, fumaric acid, propionic acid, acetic acid, aspartic acid, ε-aminocaproic acid, glutamic acid, aminoethylsulfonic acid, etc.), gluconolactone, ammonium acetate, inorganic bases (sodium bicarbonate, sodium carbonate, hydroxide potassium, sodium hydroxide, calcium hydroxide, magnesium hydroxide, etc.), organic bases (monoethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, lysine, etc.). Among them, succinic acid, sodium succinate, citric acid, sodium citrate, triethanolamine, potassium hydroxide and sodium hydroxide are preferred.

Chelating agents include ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetate (sodium salt (edetate sodium: Japanese Pharmacopoeia, EDTA-2Na, etc.), potassium salt, etc.), phytic acid, gluconic acid, polyphosphoric acid, metalin Acid can be given. Among them, sodium edetate is preferred.

Examples of stabilizers include butylhydroxyanisole and the like.

Examples of irritation reducing agents include licorice extract, sodium alginate, 2-methacryloyloxyethylphosphorylcholine and the like.

Examples of coloring agents include inorganic pigments and natural pigments.

Usability modifiers include polystyrene, polymethyl methacrylate, acrylates copolymer, acrylates crosspolymer, (butyl acrylate/glycol dimethacrylate) crosspolymer, methyl methacrylate crosspolymer, (methyl methacrylate/dimethacrylic acid glycol) crosspolymer, (styrene/divinylbenzene) crosspolymer, lauroyllysine, nylon-12.

[Other active ingredients]
In the present invention, the composition for external use on the skin includes anti-wrinkle/anti-aging ingredients, keratin softening ingredients, cell activating ingredients, vitamins, moisturizing ingredients, prevention of DNA damage, and / Or other active ingredients that can be added to cosmetics and quasi-drugs, such as restorative ingredients, antibacterial ingredients, astringent ingredients, etc., can be blended. Other active ingredients can be used singly or in combination of two or more.

Anti-wrinkle and anti-aging ingredients include hydrolyzed soy protein, retinoids (retinol and its derivatives, retinoic acid, retinal, etc.), pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl -L-serine, mevalonolactone, and the like. Among them, artemia extract, hydrolyzed soybean protein, retinol, retinol acetate, and retinol palmitate are preferable.

Examples of keratin softening ingredients include lanolin, urea, α-hydroxy acids (phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, etc.), citric acid, and the like. Among them, lactic acid, sodium lactate, glycolic acid, salicylic acid, and phytic acid are preferred.

Examples of cell activating components include components derived from plants (for example, bilberry); amino acids such as γ-aminobutyric acid and ε-aminoproic acid; α-hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponins, and allantoin. , Photosensitive element No. 301, and the like. Among them, bilberry leaf extract is preferred.

Vitamins include retinol, retinol acetate, retinol derivatives such as retinol palmitate, retinal, retinoic acid, methyl retinoate, ethyl retinoate, retinol retinoate, d-δ-tocopheryl retinoate, α-tocopheryl retinoate , β-tocopheryl retinoate and other vitamin A compounds; β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, echinenone and other provitamin A compounds; δ-tocopherol, α- Vitamin E compounds such as tocopherol, β-tocopherol, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate, δ-tocopherol, tocopherol nicotinate; riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate , riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinic acid ester; vitamin B2s; methyl nicotinate, nicotinic acid, nicotinic acid such as nicotinamide; ascorbyl stearate, dipalmitate L- vitamin Cs such as ascorbyl and ascorbyl tetraisopalmitate (tetra-2-hexyldecanoate ascorbyl); vitamin Ds such as methylhesperidin, ergocalciferol and cholecalciferol; vitamin Ks such as phylloquinone and farnoquinone; dibenzoylthiamine , dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate , thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, vitamin B1 such as thiamine triphosphate monophosphate; pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5'-phosphoric acid vitamin B6 such as pyridoxal and pyridoxamine hydrochloride; vitamin B12 such as cyanocobalamin, hydroxocobalamin and deoxyadenosylcobalamin; folic acids such as folic acid and pteroylglutamic acid; pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D- pantetheine, D - pantothenic acids such as pantethine, coenzyme A, pantothenyl ethyl ether; biotins such as biotin and biocytin; I can give

Among them, vitamin A such as retinol, retinol acetate, and retinol palmitate; sodium ascorbate phosphate, magnesium ascorbate phosphate, ascorbyl tetraisopalmitate (tetra-2-hexyldecanoate ascorbyl), 2-O-ethyl Vitamin Cs such as ascorbic acid and 3-O-ethylascorbic acid; vitamins E such as δ-tocopherol and tocopherol nicotinate; and nicotinic acids such as nicotinic acid amide are preferred.

Moisturizing ingredients include ingredients derived from plants (for example, cinnabar sphagnum); amino acids and their derivatives such as alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, glucosamine, and theanine; collagen, gelatin, and elastin; proteins, peptides, and hydrolysates thereof; polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol and diglycerin; sugar alcohols such as sorbitol; Phospholipids; NMF-derived components such as lactic acid, sodium pyrrolidonecarboxylate, urea; Polyglutamic acid; -10 methyl glucose (e.g., Macbiobride MG (trademark) series (manufactured by NOF Corporation), etc.), PEG/PPG/polybutylene glycol-8/5/3 glycerin (e.g., Willbride (trademark) S-753 (manufactured by NOF Corporation)); trimethylglycine (betaine); hydroxyethylurea; acrylic acid/acrylamide/dimethyldiallylammonium chloride copolymer; Hydrolyzed collagen, hydrolyzed elastin, MPC polymer glycerin, 1,3-butylene glycol, dipropylene glycol, diglycerin, polyoxypropylene methyl glucoside, trimethylglycine (betaine), hydroxyethyl urea, hydrogenated lecithin, sorbitol, among others. is preferred.

Examples of components having an action to prevent and/or repair DNA damage include components derived from animals (e.g., Artemia); components derived from plants (e.g., cat's claw); DNA, DNA salts, RNA, RNA salts, etc. can include the nucleic acid component of Among them, Artemia extract and DNA-Na are preferable.

Antibacterial ingredients include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer No. 101. , Photosensitizer No. 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, and the like. Among them, benzalkonium chloride, benzethonium chloride, gluconic acid and its derivatives, isopropylmethylphenol, triclocarban, triclosan, photosensitizer No. 101, photosensitizer No. 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiamino hydrochloride Glycine is preferred, and benzalkonium chloride, gluconic acid and its derivatives, benzethonium chloride, isopropylmethylphenol are more preferred.

Examples of astringent components include metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc sulfate, and aluminum potassium sulfate; and organic acids such as tannic acid, citric acid, lactic acid, and succinic acid. Among them, alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, aluminum potassium sulfate, and tannic acid are preferred.

[Formulation]
In addition, the composition for external use on the skin of the present invention can be prepared by mixing and stirring each component according to a conventional method.

The composition for external use on the skin in the present invention is not particularly limited in the form of drug, and can take a form known as cosmetics or quasi-drugs. Among such known forms, for example, sheets such as liquids, suspensions, emulsions, creams, gels, liniments, lotions, aerosols, powders, poultices, and non-woven fabrics are impregnated with a chemical solution. Examples include sheet agents and lip emulsions. Among them, liquid formulations, suspensions, emulsions, creams, gels, and lotions are preferable in terms of good feeling in use. The external composition for skin of the present invention is an oil-in-water (O/W) composition, and is preferably in the form of an aqueous emulsion, an aqueous gel, or an aqueous lotion.

The external composition for skin of the present invention can preferably be used in the form of basic cosmetics such as lip emulsions, milky lotions, emulsified lotions, and body lotions. The composition for external use on skin of the present invention can also be used in the form of makeup cosmetics such as foundation, lipstick, blusher, eye makeup, face powder, body powder, manicure and pedicure.

Since the ultraviolet absorption function can be enhanced by the present invention, the composition for external use on the skin of the present invention has an SPF (Sun Protection Factor) value, which is a protective factor against ultraviolet B waves (UV-B), and an ultraviolet A wave ( A composition for external use on the skin can have a high PA (Protection Grade of UVA) value against UV-A). For example, the external composition for skin of the present invention may have an SPF value of SPF 10 or higher, preferably SPF 20 or higher, more preferably SPF 30 or higher, even more preferably SPF 40 or higher, and particularly preferably SPF 50 or higher. Further, for example, the composition for external use on skin of the present invention may have a PA value of PA+, preferably PA++, more preferably PA+++, still more preferably PA++++.

The composition for external use on the skin of the present invention can be used as a sunscreen regardless of the content of the product. In addition, the composition for external use on skin of the present invention can be used for applications requiring water resistance. Furthermore, the composition for external use on skin of the present invention can be used for applications that require a sustained UV protection effect.

The present invention can also have the following aspects.
(A) at least one selected from the group consisting of alkyl-modified silicones and alkyl-modified silicone resins, and (B) at least one selected from the group consisting of ultraviolet absorbers and ultraviolet scattering agents, A composition for external use on the skin, which is an oil type;
Furthermore, the composition for external use on the skin, which further contains (C) a thickening agent;
The (C) thickener is a water-soluble thickener, and includes an acrylic acid-based thickener, a polysaccharide-based thickener, an amino acid-based thickener, a polyethylene glycol-based thickener, and a water-soluble anionic polymer system. The composition for external use on the skin, which is at least one selected from the group consisting of thickeners and other water-soluble polymer adhesives;
The skin external composition, wherein the component (A) is at least one selected from the group consisting of alkyldimethicone, alkoxydimethicone, alkylmethicone, and silsesquioxane;
Any of the above skin external compositions, wherein the component (B) is at least one selected from the group consisting of an oil-soluble ultraviolet absorber, a water-dispersible ultraviolet scattering agent, and an oil-dispersible ultraviolet scattering agent;
Any of the above skin care compositions, wherein the content of component (B) is 0.01 to 50 w/w% relative to the total amount of the composition;
Any of the above skin care compositions, wherein the weight ratio of (A):(B) is 1:0.5 to 50;
Any of the above skin external compositions, wherein (B) is an oil-soluble ultraviolet absorber and the weight ratio of (A):(B) is 1:0.5 to 50;
Any of the above skin care compositions, wherein (B) is a water-dispersible UV scattering agent, and the weight ratio of (A):(B) is 0.5 to 50;
Any one of the above skin external compositions, wherein (B) is an oil-dispersed ultraviolet scattering agent, and the weight ratio of (A):(B) is 0.5-50.

The present invention also provides (A) at least one selected from the group consisting of alkyl-modified silicones and alkyl-modified silicone resins, and (B) an ultraviolet absorber and an ultraviolet scattering agent for producing a sunscreen external skin preparation. at least one selected from the group consisting of

The present invention also provides (A) at least one selected from the group consisting of alkyl-modified silicones and alkyl-modified silicone resins, and (B) an ultraviolet absorber and an ultraviolet scattering agent for producing a sunscreen composition for external use on the skin. at least one selected from the group consisting of

The present invention also provides (A) at least one selected from the group consisting of alkyl-modified silicones and alkyl-modified silicone resins, and (B) an ultraviolet absorber and an ultraviolet scattering agent for producing a water-resistant composition for external use on the skin. at least one selected from the group consisting of

The present invention also provides (A) at least one selected from the group consisting of an alkyl-modified silicone and an alkyl-modified silicone resin, and (B) an ultraviolet absorber and an ultraviolet at least one selected from the group consisting of scattering agents.

Any of the above uses, further comprising (C) a thickening agent;
The (C) thickener is a water-soluble thickener, and includes an acrylic acid-based thickener, a polysaccharide-based thickener, an amino acid-based thickener, a polyethylene glycol-based thickener, and a water-soluble anionic polymer system. Use of any one of the above, which is at least one selected from the group consisting of thickeners and other water-soluble polymer adhesives;
Any of the above uses, wherein the component (A) is at least one selected from the group consisting of alkyldimethicone, alkoxydimethicone, alkylmethicone, and silsesquioxane;
Any one of the above uses, wherein the component (B) is at least one selected from the group consisting of oil-soluble ultraviolet absorbers, water-dispersible ultraviolet scattering agents, and oil-dispersible ultraviolet scattering agents;
Any of the above uses, wherein the content of component (B) is 0.01 to 50 w/w% relative to the total amount of the composition;
Any of the above uses, wherein the weight ratio of (A):(B) is 1:0.5-50;
Any of the above uses, wherein (B) is an oil-soluble ultraviolet absorber, and the weight ratio of (A):(B) is 1:0.5 to 50;
Any of the above uses, wherein the (B) is a water-dispersible ultraviolet scattering agent, and the weight ratio of (A):(B) is 0.5 to 50;
(B) is an oil-dispersed ultraviolet scattering agent, and the weight ratio of (A):(B) is 0.5-50.

The present invention also provides an external composition for skin, (A) at least one selected from the group consisting of alkyl-modified silicones and alkyl-modified silicone resins, and (B) selected from the group consisting of ultraviolet absorbers and ultraviolet scattering agents. and a method for imparting water resistance and/or UV protection effect persistence to the external composition for skin by preparing an oil-in-water composition containing at least one of

EXAMPLES Next, the present invention will be specifically described with reference to examples, but the present invention is not limited to the following examples.
The unit of each component amount in Tables 1 to 4 is w/w%.

External skin compositions having compositions shown in Tables 1 and 2 were prepared according to a conventional method. Specifically, the oil phase component and the water phase component were weighed and dissolved by heating as necessary. Thereafter, the oil phase was added to the aqueous phase, and the mixture was stirred with a homomixer to prepare a uniform oil-in-water composition. If necessary, a neutralizing agent was added after stirring to prepare a uniform oil-in-water composition.

(Test Example 1) Ultraviolet protection effect test Each composition for external use for skin shown in Table 1 was evenly applied to a polymethyl methacrylate (PMMA) plate at a concentration of 1.3 mg/cm ² , and dried in a dark place for 15 minutes. After leaving it to dry for a minute, the ultraviolet absorption spectrum was measured using an ultraviolet-visible spectrophotometer (UV-2450: manufactured by Shimadzu Corporation). By comparing the area under the absorbance curve (AUC) at 290 to 400 nm with that of a blank formulation (a formulation containing no component (A)), the rate of increase (enhancing effect) of the UV absorption spectrum was calculated. The calculation formula is as follows.
Increase rate of ultraviolet absorption spectrum = [(Each AUC of Examples)/(Each AUC of Comparative Examples)] x 100 (%) The ultraviolet absorption spectrum was measured at five different points in the same PMMA plate, and their An average value was taken.

なお、表１中＊１の原料名は、ＳＷ－８００５ Ｃ３０ Ｒｅｓｉｎ Ｗａｘであり、＊２の原料名は、Ａｒｉｓｔｏｆｌｅｘ ＡＶＣである。

In addition, the raw material name of *1 in Table 1 is SW-8005 C30 Resin Wax, and the raw material name of *2 is Aristoflex AVC.

The results of Test Example 1 are shown in FIGS. 1 and 2. FIG. Examples 1 and 2 containing the component (A) have increased UV absorption spectra compared to the comparative examples containing only the component (B).

(Test Example 2) Residual test after water treatment For the external composition for skin shown in Table 1, after measuring the ultraviolet absorption spectrum in Test Example 1, water treatment was performed, and the ultraviolet absorption spectrum was again obtained by the same method. was measured, and the area under the absorbance curve (AUC) at 290-400 nm before and after water treatment was compared to calculate the residual rate. The calculation formula is as shown below.
Residual rate by water treatment = [(AUC after water treatment) / (AUC before water treatment)]
×100 (%)
In this test example, the water treatment means that the PMMA plate coated with the composition is attached to one end of the stirring blade of a water bath, and the stirring blade is immersed in a water bath (tap water) at 20 to 25 ° C. for 5 minutes. After that, the PMMA plate is slowly removed and left to dry in a dark place for 30 minutes.

Also, the ultraviolet absorption spectrum was measured at five different points within the same PMMA plate, and the average value thereof was taken.

This test corresponds to the severe conditions of actual use when the external skin composition of the present invention comes into contact with tap water, rain, pool water, etc. after being applied. , it can be seen that the compositions of Examples are excellent in water resistance and durability of UV protection effect.

The results of Test Example 2 are shown in FIG. Examples 1 and 2 containing component (A) had good residual rates of 124.8% and 102.2%, respectively, compared to the comparative example containing only component (B).

(Test Example 3) Residual test after calcium chloride aqueous solution treatment A test was performed in the same manner as in Test Example 2, except that the water bath (tap water) in Test Example 2 was changed to a 0.28% anhydrous calcium chloride aqueous solution.

The results are shown in FIG. Compared to the comparative examples containing only the component (B), Examples 1 and 2 containing the component (A) had good residual rates of 96.0% and 107.1%, respectively, after treatment with an aqueous solution of calcium chloride. .

This test corresponds to the severe conditions of actual use when the composition for external use on skin of the present invention comes into contact with sweat, seawater, etc. after application of the composition for external use on skin of the present invention. It can be seen that the product has particularly long-lasting water resistance and UV protection effect against perspiration.

(Test Example 4) Ultraviolet protection effect test As shown in Table 2, the same test as in Test Example 1 was performed using a composition for external use on the skin containing an ultraviolet scattering agent.

In addition, the raw material name of *1 in Table 2 is SW-8005 C30 Resin Wax, and the raw material name of *2 is Simulgel NS. Example 3 and Comparative Example 2 contain (hydroxyethyl acrylate/Na acryloyldimethyltaurate) copolymer at 0.83 w/w%, squalane at 0.56 w/w% and polysorbate 60 at 0.12 w/w%.

The results of Test Example 1 using the Examples and Comparative Examples in Table 2 are shown in FIGS.

As shown in FIGS. 5 and 6, Example 3 had a higher UV protective effect (enhanced effect of UV absorption spectrum) than Comparative Example 2, which did not contain the component (A).

(Test Example 5) Secondary Adhesion Evaluation Test Each external skin composition (sample) of Example 1 and Comparative Example 1 in Table 1 was uniformly applied to a PMMA plate at 2 mg/cm ² and dried. . After drying the sample, the ultraviolet absorption spectrum of each PMMA plate was measured with an ultraviolet-visible spectrophotometer (UV-2450; manufactured by Shimadzu Corporation) to determine the area under the absorbance curve (AUC) at 290-400 nm. After that, the coated surface of the PMMA plate was placed on the tissue paper, and a load of 500 g was attached to the tissue paper from the top of the PMMA plate for 10 minutes. AUC was determined at 100°C, and the difference in AUC before and after adhesion was compared to calculate the residual rate of UV absorption capacity. The calculation formula is as shown in Formula 2.
[Formula 2]
Remaining rate of ultraviolet absorption capacity = [(Each AUC after adhesion) / (Each AUC before adhesion)] × 100
(%)
The ultraviolet absorption spectrum was measured at 5 different points on the same PMMA plate, and the average value thereof was taken.
This result is shown in FIG. It was confirmed that the composition for external use on the skin of the present invention is resistant to secondary adhesion. When the external composition for skin of the present invention is applied as, for example, a sunscreen formulation, the formulation remains on the skin even after application and can maintain its UV protection effect.

(Test Example 6) Ultraviolet Protection Effect Test As shown in Tables 3 to 6, the same test as in Test Example 1 was performed using the composition for external use on the skin.

表３中、*１の原材料名は、ＡＢＩＬ Ｗａｘ ２４４０である。

In Table 3, *1 raw material name is ABIL Wax 2440.

表４中、＊１の原料名は、ＡＢＩＬ Ｗａｘ ２４４０であり、＊２の原料名は、ＢＥＬＳＩＬ ＣＭ ７０２６ ＶＰであり、＊３の原料名は、ＳＷ－８００５ Ｃ３０ Ｒｅｓｉｎ Ｗａｘである。

In Table 4, the raw material name of *1 is ABIL Wax 2440, the raw material name of *2 is BELSIL CM 7026 VP, and the raw material name of *3 is SW-8005 C30 Resin Wax.

表５中＊１の原料名は、ＡＢＩＬ Ｗａｘ ２４４０であり、＊２の原料名は、ＢＥＬＳＩＬ ＣＭ ７０２６ ＶＰであり、＊３の原料名は、ＳＷ－８００５Ｃ３０ Ｒｅｓｉｎ Ｗａｘである。

In Table 5, the raw material name of *1 is ABIL Wax 2440, the raw material name of *2 is BELSIL CM 7026 VP, and the raw material name of *3 is SW-8005C30 Resin Wax.

表６中*1の原料名は、670 Fluidである。

The raw material name of *1 in Table 6 is 670 Fluid.

(Test Example 7) Residual test after water treatment As shown in Table 3, the same test as in Test Example 2 was performed using the composition for external use on the skin.

Comparing the residual rate of UV protection effect after water treatment in Comparative Example 3 and the residual rate of UV protection effect after water treatment in Example 4, Example 4 shows 111.2% UV protection compared to Comparative Example 3. The defensive effect remained and was good.

(Formulation example)
The formulations described in Tables 7 and 8 below are prepared. Formulation Examples 1, 3 to 9, and 11 to 16 are oil-in-water gel preparations for external use on the skin. Formulation Examples 2 and 10 are both oil-in-water lotions for external use on the skin.

Here, the preparation method of Formulation Example 8 is as follows. That is, hydrophobized fine particles of titanium oxide, ethylhexyl methoxycinnamate, diethylaminohydroxybenzoyl hexyl benzoate, ethylhexyl triazone, neopentyl glycol dicaprate, triethylhexyl trimellitate, mineral oil, polyglyceryl pentaisostearate, alkyl (C30-45 ) Weigh dimethylsilylpolypropylsilsesquioxane (oil phase). Next, sodium edetate, 1,3-butylene glycol, concentrated glycerin, xanthan gum, coated particulate zinc oxide, carboxyvinyl polymer, (ammonium acryloyldimethyltaurate/vinylpyrrolidone) copolymer, triethanolamine, (styrene/divinylbenzene). Weigh out crosspolymer, preservative and purified water (aqueous phase). After heating and dissolving the oil phase, the oil phase is added to the water phase and stirred with a homomixer to prepare a uniform oil-in-water composition.

Furthermore, the preparation method of Formulation Example 16 is as follows. That is, hydrophobized fine particles of titanium oxide, ethylhexyl methoxycinnamate, diethylaminohydroxybenzoyl hexyl benzoate, ethylhexyl triazone, neopentyl glycol dicaprate, triethylhexyl trimellitate, mineral oil, polyglyceryl pentaisostearate, polypropylene silsesquioxane and cyclopentasiloxane (oil phase). Next, sodium edetate, 1,3-butylene glycol, concentrated glycerin, xanthan gum, coated particulate zinc oxide, carboxyvinyl polymer, (ammonium acryloyldimethyltaurate/vinylpyrrolidone) copolymer, triethanolamine, (styrene/divinylbenzene). Weigh out crosspolymer, preservative and purified water (aqueous phase). After heating and dissolving the oil phase, the oil phase is added to the water phase and stirred with a homomixer to prepare a uniform oil-in-water composition.

In Table 7, *1 raw material name is SW-8005 C30 Resin Wax, *2 raw material name is AMS-C30 Cosmetic Wax, *3 raw material name is Simulgel NS, *4. is Aristoflex AVC.

In Table 8, the raw material name of *1 is 670 Fluid, the raw material name of *2 is 680 Fluid, the raw material name of *3 is Simulgel NS, and the raw material name of *4 is Aristoflex AVC. is.

Claims (9)

(A) at least one selected from the group consisting of alkyl(C30-45)dimethylsilylpolypropylsilsesquioxane, polypropylsilsesquioxane, behenoxydimethicone, and alkyl(C26-28)methicone;
(B) at least one selected from the group consisting of ultraviolet absorbers and ultraviolet scattering agents; and (C) (acrylates/alkyl acrylate (C10-30)) crosspolymer, polydimethacrylates, vinylpyrrolidone) copolymer, (hydroxyethyl acrylate/acryloyldimethyltaurate Na) copolymer, methyl methacrylate crosspolymer, carbomer, and (acrylates/beheneth-25 methacrylate) copolymer. A composition for external use on the skin, which contains seeds, is an oil-in-water type, and has a weight ratio of (A):(B) of 1:5.5-24. 2. The composition for external use on skin according to claim 1, wherein the (B) UV absorber is an oil-soluble UV absorber. 3. The composition for external use on skin according to claim 1, wherein the content of component (A) is 0.1 to 10 w/w% of the total amount of the composition. The external composition for skin according to any one of claims 1 to 3, wherein the content of component (B) is 0.01 to 50 w/w% of the total amount of the composition. The external composition for skin according to any one of claims 1 to 4, wherein the content of component (C) is 0.1 to 5 w/w% of the total amount of the composition. The composition for external use on skin according to any one of claims 1 to 5, wherein the weight ratio of (A):(C) is 1:0.1 to 0.6. The external composition for skin according to any one of claims 1 to 6, wherein the water content is 30 to 99 w/w% relative to the total amount of the composition. 8. The composition for external use on skin according to any one of claims 1 to 7, which is for water resistance and/or for sustained UV protection effect. (A) at least selected from the group consisting of alkyl (C30-45) dimethylsilyl polypropyl silsesquioxane, polypropyl silsesquioxane, behenoxydimethicone, and alkyl (C26-28) methicone in the external skin composition and (B) at least one selected from the group consisting of ultraviolet absorbers and ultraviolet scattering agents; and (C) (acrylates/alkyl acrylate (C10-30)) crosspolymer, polydimethacrylates, ( ammonium acryloyldimethyltaurate/vinylpyrrolidone) copolymer, (hydroxyethyl acrylate/Na acryloyldimethyltaurate) copolymer, methyl methacrylate crosspolymer, carbomer, and (acrylates/beheneth-25 methacrylate) copolymer; and at least one viscous agent , and the weight ratio of (A):(B) is 1:5.5 to 24, so that water resistance and/or durability of UV protection effect can be improved. A method of imparting to the composition.

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