JP7313019B2 - 医薬組成物 - Google Patents

医薬組成物 Download PDF

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Publication number
JP7313019B2
JP7313019B2 JP2021546977A JP2021546977A JP7313019B2 JP 7313019 B2 JP7313019 B2 JP 7313019B2 JP 2021546977 A JP2021546977 A JP 2021546977A JP 2021546977 A JP2021546977 A JP 2021546977A JP 7313019 B2 JP7313019 B2 JP 7313019B2
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JP
Japan
Prior art keywords
sulfate
nasal
chondroitin
polysaccharide
sulfated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021546977A
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English (en)
Japanese (ja)
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JPWO2021054440A1 (https=
Inventor
重治 藤枝
哲司 高林
加奈子 吉田
英基 渡部
昂樹 藤川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maruho Co Ltd
University of Fukui NUC
Original Assignee
Maruho Co Ltd
University of Fukui NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of JPWO2021054440A1 publication Critical patent/JPWO2021054440A1/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733—Fructosans, e.g. inulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2021546977A 2019-09-20 2020-09-18 医薬組成物 Active JP7313019B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019170955 2019-09-20
JP2019170955 2019-09-20
PCT/JP2020/035438 WO2021054440A1 (ja) 2019-09-20 2020-09-18 医薬組成物

Publications (2)

Publication Number Publication Date
JPWO2021054440A1 JPWO2021054440A1 (https=) 2021-03-25
JP7313019B2 true JP7313019B2 (ja) 2023-07-24

Family

ID=74883058

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021546977A Active JP7313019B2 (ja) 2019-09-20 2020-09-18 医薬組成物

Country Status (10)

Country Link
US (1) US20220347093A1 (https=)
EP (1) EP4032535A4 (https=)
JP (1) JP7313019B2 (https=)
CN (3) CN114650828B (https=)
AU (1) AU2020349263B2 (https=)
BR (1) BR112022003464A2 (https=)
CA (1) CA3154360C (https=)
MY (1) MY206715A (https=)
PH (1) PH12022550661A1 (https=)
WO (1) WO2021054440A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3144752A1 (fr) * 2023-01-10 2024-07-12 Song Huang Utilisation de polysulfate de pentosane pour le traitement de la toux seche

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009503090A (ja) 2005-08-03 2009-01-29 モリア・バイオファーマシューティカルズ 嚢胞性線維症における脂質複合体の使用及びその適用
JP2013521300A (ja) 2010-03-03 2013-06-10 ネオキュティス エスアー 抗菌ペプチド隔離化合物を用いた皮膚疾患および皮膚障害の処置のための組成物および方法
JP2014534214A (ja) 2011-10-27 2014-12-18 イッサム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム・リミテッド 慢性副鼻腔炎の処置における脂質コンジュゲート

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3497209B2 (ja) 1993-08-24 2004-02-16 生化学工業株式会社 硫酸化糖の脱硫酸化方法
JP3512277B2 (ja) 1995-10-05 2004-03-29 有限会社ジーオーメディカルサービス 鼻茸治療・予防剤
JPH10203988A (ja) 1997-01-27 1998-08-04 Meiji Milk Prod Co Ltd 鼻茸および鼻粘膜の浮腫性病変の治療剤
JPH11335288A (ja) * 1998-05-20 1999-12-07 Maruho Co Ltd アレルギー性疾患の予防または治療薬
WO2000069917A1 (fr) * 1999-05-18 2000-11-23 Maruho Kabushikikaisha Compositions medicinales destinees a inhiber le systeme kallikreine-kinine ou la phospholipase a¿2?
US20140005115A1 (en) * 2005-11-17 2014-01-02 Yissum Research Development Company Lipid conjugates in the treatment of bronchitis
CN111437387B (zh) 2013-06-21 2024-10-01 赛诺菲生物技术公司 通过施用il-4r拮抗剂治疗鼻息肉症的方法
JP6637587B2 (ja) * 2015-08-04 2020-01-29 ズートツッカー アーゲー 副鼻腔炎に対するイヌリンの予防的使用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009503090A (ja) 2005-08-03 2009-01-29 モリア・バイオファーマシューティカルズ 嚢胞性線維症における脂質複合体の使用及びその適用
JP2013521300A (ja) 2010-03-03 2013-06-10 ネオキュティス エスアー 抗菌ペプチド隔離化合物を用いた皮膚疾患および皮膚障害の処置のための組成物および方法
JP2014534214A (ja) 2011-10-27 2014-12-18 イッサム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム・リミテッド 慢性副鼻腔炎の処置における脂質コンジュゲート

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
SAKAI Shinobu et al.，Chondroitin Sulfate Intake Inhibits the IgE-mediated Allergic Response by Down-regulating Th2 Respon，J Biol Chem.，2006年，vol.281(29)，p.19872-19880，Abstract
SANDEN Caroline et al.，Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental，Immun Inflamm Dis.，2017年，vol.5(3)，p.300-309，Abstract
TAKABAYASHI Tetsuji et al.，Excessive Fibrin Deposition in Nasal Polyps Caused by Fibrinolytic Impairment through Reduction of T，Am J Respir Crit Care Med.，2013年，vol.187(1)，p.49-57，Abstract, p.49右欄7-12行目, p.56左欄34-64行目, Figure7
大西伸和ほか，NC/Ngaマウスの掻破行動及び皮膚局所Th2応答に対する微粉砕コンニャクグルコマンナンの抑制効果，アレルギー，vol.55 No.8/9，2006年，p.1124，p.1124左上欄
藤枝重治ほか，疾患研究から次世代の治療に III.アレルギー性鼻炎 2.好酸球性副鼻腔炎，実験医学，vol.37 No.10，2019年06月15日，p.1697-1704，p.1697-1698

Also Published As

Publication number Publication date
EP4032535A1 (en) 2022-07-27
CN114650828A (zh) 2022-06-21
CA3154360C (en) 2024-01-23
WO2021054440A1 (ja) 2021-03-25
AU2020349263B2 (en) 2023-08-17
CA3154360A1 (en) 2021-03-25
BR112022003464A2 (pt) 2022-05-24
CN118976045A (zh) 2024-11-19
CN118416094A (zh) 2024-08-02
JPWO2021054440A1 (https=) 2021-03-25
US20220347093A1 (en) 2022-11-03
MY206715A (en) 2025-01-03
EP4032535A4 (en) 2023-10-25
AU2020349263A1 (en) 2022-04-14
PH12022550661A1 (en) 2023-03-27
CN114650828B (zh) 2024-08-06

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