JP7299889B2 - 緑内障を治療するためのWnt5aの調節 - Google Patents
緑内障を治療するためのWnt5aの調節 Download PDFInfo
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- JP7299889B2 JP7299889B2 JP2020531558A JP2020531558A JP7299889B2 JP 7299889 B2 JP7299889 B2 JP 7299889B2 JP 2020531558 A JP2020531558 A JP 2020531558A JP 2020531558 A JP2020531558 A JP 2020531558A JP 7299889 B2 JP7299889 B2 JP 7299889B2
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
緑内障は、米国国内で300万人を超える人々、世界全体では6000万人が罹患している大きな健康問題の1つである。2040年には、世界全体で1億1180万人が緑内障に罹患すると推定されている。緑内障の主要な危険因子の1つとして、眼圧上昇(IOP)が挙げられる。眼圧上昇は視神経に障害を与える可能性があり、治療を行わなければ、永久的に失明することもある。現在、緑内障を治癒させる方法はない。既存の点眼薬または経口薬は、効果が限られており、多くの副作用を伴う。また、手術は、瘢痕化や線維化が生じて奏功しないことも多い。
Claims (6)
- Wnt5a特異的阻害薬を含み、単位剤形の形態である、緑内障を治療するための眼科用製剤であって、該Wnt5a特異的阻害薬が、抗Wnt5a特異的抗体、またはWnt5a特異的siRNAである、眼科用製剤。
- 外用眼科用のゲル剤、軟膏剤、懸濁剤または液剤の形態である、請求項1の製剤。
- 前記剤形が、前記阻害薬を含有するコンタクトレンズ、点眼剤、デポ剤またはボーラス剤である、請求項1または2の製剤。
- 点眼剤ディスペンサーに充填されている、請求項1、2または3の製剤。
- 前房内注射用、結膜下注射用または硝子体内注射用のシリンジに充填されている、請求項1、2、3または4の製剤。
- 眼への直接的な外用による送達に適した添加剤および特性をさらに含み、該添加剤および該特性が、眼科用に適した透明性、pH緩衝性、等張性、粘性、安定性および無菌性からなる群から選択される、請求項1、2、3、4または5の製剤。
Priority Applications (1)
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JP2023076047A JP2023099171A (ja) | 2017-08-20 | 2023-05-02 | 緑内障を治療するためのWnt5aの調節 |
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US201762547854P | 2017-08-20 | 2017-08-20 | |
US62/547,854 | 2017-08-20 | ||
PCT/US2018/046578 WO2019040311A1 (en) | 2017-08-20 | 2018-08-14 | MODULATION OF WNT5A TO TREAT GLAUCOMA |
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JP2023076047A Division JP2023099171A (ja) | 2017-08-20 | 2023-05-02 | 緑内障を治療するためのWnt5aの調節 |
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JP2020531581A JP2020531581A (ja) | 2020-11-05 |
JP7299889B2 true JP7299889B2 (ja) | 2023-06-28 |
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JP2020531558A Active JP7299889B2 (ja) | 2017-08-20 | 2018-08-14 | 緑内障を治療するためのWnt5aの調節 |
JP2023076047A Pending JP2023099171A (ja) | 2017-08-20 | 2023-05-02 | 緑内障を治療するためのWnt5aの調節 |
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Country Status (6)
Country | Link |
---|---|
US (2) | US20200157158A1 (ja) |
EP (1) | EP3668487A4 (ja) |
JP (2) | JP7299889B2 (ja) |
KR (1) | KR20200042912A (ja) |
CN (4) | CN117159718A (ja) |
WO (1) | WO2019040311A1 (ja) |
Families Citing this family (1)
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WO2022266270A1 (en) * | 2021-06-18 | 2022-12-22 | The Regents Of The University Of California | Treatment of Glaucoma by Neuroprotection |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2003086334A1 (fr) | 2002-04-17 | 2003-10-23 | Taisho Pharmaceutical Co., Ltd. | Produit tonique pour la pousse de cheveux |
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---|---|---|---|---|
CA2729889A1 (en) * | 2000-02-29 | 2001-09-07 | Alcon, Inc. | Screening method for frizzled related proteins agonists and antagonists |
KR100881058B1 (ko) * | 2007-07-06 | 2009-01-30 | 부산대학교 산학협력단 | Wnt5a 단백질의 억제제를 포함하는 신경교아종 치료및 예방용 조성물 |
WO2012158910A2 (en) * | 2011-05-18 | 2012-11-22 | The Regents Of The University Of California | Compositions and methods for treating retinal diseases |
EP2554662A1 (en) * | 2011-08-05 | 2013-02-06 | M Maria Pia Cosma | Methods of treatment of retinal degeneration diseases |
-
2018
- 2018-08-14 KR KR1020207007598A patent/KR20200042912A/ko not_active Application Discontinuation
- 2018-08-14 CN CN202311355500.2A patent/CN117159718A/zh active Pending
- 2018-08-14 WO PCT/US2018/046578 patent/WO2019040311A1/en active Application Filing
- 2018-08-14 EP EP18847365.6A patent/EP3668487A4/en active Pending
- 2018-08-14 JP JP2020531558A patent/JP7299889B2/ja active Active
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2020
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2023
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2003086334A1 (fr) | 2002-04-17 | 2003-10-23 | Taisho Pharmaceutical Co., Ltd. | Produit tonique pour la pousse de cheveux |
Non-Patent Citations (1)
Title |
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Invest Ophthalmol Vis Sci, 2013, Vol. 54, pp. 6502-9509 |
Also Published As
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EP3668487A1 (en) | 2020-06-24 |
CN117379543A (zh) | 2024-01-12 |
EP3668487A4 (en) | 2020-08-26 |
US20240124538A1 (en) | 2024-04-18 |
JP2020531581A (ja) | 2020-11-05 |
CN117159718A (zh) | 2023-12-05 |
US20200157158A1 (en) | 2020-05-21 |
JP2023099171A (ja) | 2023-07-11 |
KR20200042912A (ko) | 2020-04-24 |
CN111132664A (zh) | 2020-05-08 |
WO2019040311A1 (en) | 2019-02-28 |
CN117159463A (zh) | 2023-12-05 |
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