JP7289311B2 - 新規t細胞受容体 - Google Patents

新規t細胞受容体 Download PDF

Info

Publication number
JP7289311B2
JP7289311B2 JP2020543406A JP2020543406A JP7289311B2 JP 7289311 B2 JP7289311 B2 JP 7289311B2 JP 2020543406 A JP2020543406 A JP 2020543406A JP 2020543406 A JP2020543406 A JP 2020543406A JP 7289311 B2 JP7289311 B2 JP 7289311B2
Authority
JP
Japan
Prior art keywords
tcr
cancer
cells
cell
clone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020543406A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021500406A (ja
JP2021500406A5 (https=
Inventor
セウェル アンドリュー
ドルトン ギャリー
Original Assignee
ユニバーシティ カレッジ カーディフ コンサルタンツ エルティーディー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニバーシティ カレッジ カーディフ コンサルタンツ エルティーディー filed Critical ユニバーシティ カレッジ カーディフ コンサルタンツ エルティーディー
Publication of JP2021500406A publication Critical patent/JP2021500406A/ja
Publication of JP2021500406A5 publication Critical patent/JP2021500406A5/ja
Application granted granted Critical
Publication of JP7289311B2 publication Critical patent/JP7289311B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32T-cell receptors [TCR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/15011Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2020543406A 2017-10-26 2018-10-22 新規t細胞受容体 Active JP7289311B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1717578.7A GB201717578D0 (en) 2017-10-26 2017-10-26 Novel T-cell receptor
GB1717578.7 2017-10-26
GBGB1806155.6A GB201806155D0 (en) 2017-10-26 2018-04-16 Novel t-cell receptor
GB1806155.6 2018-04-16
PCT/GB2018/053045 WO2019081902A1 (en) 2017-10-26 2018-10-22 NEW LYMPHOCYTE RECEPTOR T

Publications (3)

Publication Number Publication Date
JP2021500406A JP2021500406A (ja) 2021-01-07
JP2021500406A5 JP2021500406A5 (https=) 2021-11-25
JP7289311B2 true JP7289311B2 (ja) 2023-06-09

Family

ID=60580240

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020543406A Active JP7289311B2 (ja) 2017-10-26 2018-10-22 新規t細胞受容体

Country Status (17)

Country Link
US (2) US11725039B2 (https=)
EP (2) EP3700925B8 (https=)
JP (1) JP7289311B2 (https=)
KR (1) KR20200078497A (https=)
CN (1) CN111278855B (https=)
AU (2) AU2018356944A1 (https=)
BR (1) BR112020007880A2 (https=)
CA (1) CA3077635A1 (https=)
DK (1) DK3700925T3 (https=)
EA (1) EA202091015A1 (https=)
ES (1) ES2907819T3 (https=)
GB (2) GB201717578D0 (https=)
IL (1) IL274025A (https=)
MX (1) MX2020004334A (https=)
PL (1) PL3700925T3 (https=)
SG (1) SG11202002537WA (https=)
WO (1) WO2019081902A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201717578D0 (en) * 2017-10-26 2017-12-13 Univ College Cardiff Consultants Ltd Novel T-cell receptor
KR20220147583A (ko) * 2020-01-09 2022-11-03 바이오뮤넥스 파마슈티컬스 Mait 및 종양 세포 둘 모두에 결합하는 다중특이적 항체
AU2021208955A1 (en) * 2020-01-16 2022-07-21 Universität Basel MR1 ligands and pharmaceutical compositions for immunomodulation
US20240016837A1 (en) * 2020-06-10 2024-01-18 Eutilex Co., Ltd. T-cell receptor binding to mr1, and use thereof
JP2023549098A (ja) * 2020-11-04 2023-11-22 フェイト セラピューティクス,インコーポレイティド 固形腫瘍を標的とする多重操作されたiPSC及び免疫エフェクター細胞
WO2022118043A1 (en) 2020-12-03 2022-06-09 Enara Bio Limited Novel protein-ligand complex
JPWO2022244876A1 (https=) * 2021-05-20 2022-11-24
WO2022248881A1 (en) 2021-05-28 2022-12-01 Enara Bio Limited Novel protein-ligand complex
CA3225252A1 (en) 2021-07-14 2023-01-19 Jordan JARJOUR Engineered t cell receptors fused to binding domains from antibodies
WO2023002204A1 (en) 2021-07-21 2023-01-26 Enara Bio Limited T-cell receptor
KR20230088292A (ko) * 2021-12-10 2023-06-19 주식회사 유틸렉스 MR1 제한적 Panck T 세포 및 이의 제조방법
WO2023148494A1 (en) 2022-02-03 2023-08-10 University College Cardiff Consultants Limited Novel t-cell receptor
CN119546328A (zh) 2022-04-08 2025-02-28 再生元制药公司 多部分受体和信号传导复合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015075939A1 (ja) 2013-11-21 2015-05-28 Repertoire Genesis株式会社 T細胞受容体およびb細胞受容体レパトアの解析システムならびにその治療および診断への利用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI775117B (zh) * 2013-08-05 2022-08-21 德商伊瑪提克斯生物科技有限公司 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(二)
WO2018162563A1 (en) * 2017-03-07 2018-09-13 Universität Basel Mr1 restricted t cell receptors for cancer immunotherapy
GB201717578D0 (en) * 2017-10-26 2017-12-13 Univ College Cardiff Consultants Ltd Novel T-cell receptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015075939A1 (ja) 2013-11-21 2015-05-28 Repertoire Genesis株式会社 T細胞受容体およびb細胞受容体レパトアの解析システムならびにその治療および診断への利用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Gold MC, et al.,MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage,J Exp Med,211(8),2014年07月28日,pp.1601-10
Won EJ, et al.,Clinical relevance of circulating mucosal-associated invariant T cell levels and their anti-cancer activity in patients with mucosal-associated cancer,Oncotarget,7(46),2016年11月15日,pp.76274-76290

Also Published As

Publication number Publication date
EP3700925A1 (en) 2020-09-02
AU2018356944A1 (en) 2020-04-16
US11725039B2 (en) 2023-08-15
US20210147506A1 (en) 2021-05-20
EP3700925B1 (en) 2021-12-29
KR20200078497A (ko) 2020-07-01
JP2021500406A (ja) 2021-01-07
EA202091015A1 (ru) 2020-07-17
CN111278855A (zh) 2020-06-12
WO2019081902A1 (en) 2019-05-02
GB201717578D0 (en) 2017-12-13
CA3077635A1 (en) 2019-05-02
DK3700925T3 (en) 2022-04-04
MX2020004334A (es) 2020-08-03
GB201806155D0 (en) 2018-05-30
EP3700925B8 (en) 2022-02-16
US20200369742A1 (en) 2020-11-26
PL3700925T3 (pl) 2022-05-02
BR112020007880A2 (pt) 2020-10-27
CN111278855B (zh) 2024-04-02
IL274025A (en) 2020-06-30
ES2907819T3 (es) 2022-04-26
EP4039700A1 (en) 2022-08-10
AU2024202735A1 (en) 2024-05-30
SG11202002537WA (en) 2020-05-28
US11078252B2 (en) 2021-08-03

Similar Documents

Publication Publication Date Title
JP7289311B2 (ja) 新規t細胞受容体
Klebanoff et al. T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome
AU2021202223B2 (en) Methods of isolating T cells having antigenic specificity for a cancer-specific mutation
US11738047B2 (en) Genetically modified immune cells targeting NY-ESO-1 and methods of use thereof
Robbins et al. Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions
JP7190096B2 (ja) 遺伝子編集t細胞及びその使用
US12221465B2 (en) Signaling and antigen-presenting bifunctional receptors (SABR)
WO2019047932A1 (zh) 基因工程化的t细胞及应用
BR112020001605A2 (pt) métodos para produzir composições de células geneticamente modificadas e composições relacionadas
JP2017522859A (ja) グリピカン3に特異的なt細胞受容体、及び肝細胞癌の免疫療法のためのその使用
Chervin et al. Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses
Tsuji et al. Rapid construction of antitumor T-cell receptor vectors from frozen tumors for engineered T-cell therapy
CN111372944A (zh) 新型γδT细胞受体和其配体
CN109804246B (zh) 用于快速克隆t细胞受体的组合物和方法
US20240009235A1 (en) T cell receptors directed against bob1 and uses thereof
Yang et al. Chimeric immune receptors (CIRs) specific to JC virus for immunotherapy in progressive multifocal leukoencephalopathy (PML)
US12479903B2 (en) CD5 specific T cell receptor cell or gene therapy
EA045252B1 (ru) Новый т-клеточный рецептор
HK40034405B (en) Novel t-cell receptor
HK40034405A (en) Novel t-cell receptor
Wheeler Identifying a novel γδ T-cell stress ligand: Potential for cancer immunotherapy
Rosenberger Comparing the therapeutic potential of T cell receptors from tumors and healthy donors for adoptive T cell therapy in cancer
EP4472742A1 (en) Novel t-cell receptor
HK40099489A (zh) 用於癌症免疫治疗的转染t细胞和t细胞受体
JP2023550154A (ja) サイトケラチンに対する抗腫瘍応答

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200730

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200625

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211005

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20211005

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220823

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20221116

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230222

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230509

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230530

R150 Certificate of patent or registration of utility model

Ref document number: 7289311

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150