JP7281470B2 - Ｃ５ａ受容体調節剤 - Google Patents
Ｃ５ａ受容体調節剤 Download PDFInfo
- Publication number
- JP7281470B2 JP7281470B2 JP2020539797A JP2020539797A JP7281470B2 JP 7281470 B2 JP7281470 B2 JP 7281470B2 JP 2020539797 A JP2020539797 A JP 2020539797A JP 2020539797 A JP2020539797 A JP 2020539797A JP 7281470 B2 JP7281470 B2 JP 7281470B2
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- dihydro
- benzyl
- methyl
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2018/051283 | 2018-01-19 | ||
| EP2018051283 | 2018-01-19 | ||
| PCT/EP2019/051245 WO2019141808A1 (en) | 2018-01-19 | 2019-01-18 | C5a receptor modulators |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021511327A JP2021511327A (ja) | 2021-05-06 |
| JP2021511327A5 JP2021511327A5 (https=) | 2022-01-21 |
| JPWO2019141808A5 JPWO2019141808A5 (https=) | 2022-01-21 |
| JP7281470B2 true JP7281470B2 (ja) | 2023-05-25 |
Family
ID=65023915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020539797A Active JP7281470B2 (ja) | 2018-01-19 | 2019-01-18 | Ｃ５ａ受容体調節剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11685729B2 (https=) |
| EP (1) | EP3740477A1 (https=) |
| JP (1) | JP7281470B2 (https=) |
| CN (1) | CN111683937A (https=) |
| CA (1) | CA3087784A1 (https=) |
| WO (1) | WO2019141808A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3737684B1 (en) | 2018-01-10 | 2022-11-16 | Idorsia Pharmaceuticals Ltd | 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-one derivatives and related compounds as c5a receptor modulators for treating vasculitis and inflammatory diseases |
| US11685729B2 (en) | 2018-01-19 | 2023-06-27 | Idorsia Pharmaceuticals Ltd. | C5a receptor modulators |
| CA3087886A1 (en) | 2018-01-19 | 2019-07-25 | Idorsia Pharmaceuticals Ltd | C5a receptor modulators |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023436A1 (en) | 1998-10-16 | 2000-04-27 | Sumitomo Pharmaceuticals Co., Ltd. | Quinazolinone derivatives |
| JP2002528455A (ja) | 1998-10-23 | 2002-09-03 | エフ．ホフマン−ラ ロシュ アーゲー | 二環式窒素複素環化合物 |
| WO2008011032A1 (en) | 2006-07-17 | 2008-01-24 | Amgen Inc. | Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors |
| JP2014511898A (ja) | 2011-04-21 | 2014-05-19 | アステックス、セラピューティックス、リミテッド | 二環式複素環化合物および治療法におけるその使用 |
| JP2021510373A (ja) | 2018-01-10 | 2021-04-22 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 血管炎及び炎症性疾患を治療するためのｃ５ａ受容体調節剤としての２，４，６，７−テトラヒドロ−ピラゾロ［４，３−ｄ］ピリミジン−５−オン誘導体及び関連化合物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624926A (en) | 1993-02-18 | 1997-04-29 | Kyowa Hakko Kogyo Co., Ltd. | Piperidinyl-dioxoquinazolines as adenosine reuptake inhibitors |
| JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| CA2529196A1 (en) | 2003-06-26 | 2005-02-17 | Merck & Co., Inc. | Benzodiazepine cgrp receptor antagonists |
| EP1657238A4 (en) | 2003-08-22 | 2008-12-03 | Takeda Pharmaceutical | CONDENSATE PYRIMIDINE DERIVATIVE AND ITS USE |
| AU2004308712A1 (en) | 2003-12-23 | 2005-07-14 | Tibotec Pharmaceuticals Ltd. | Self-microemulsifying drug delivery systems of a HIV protease inhibitor |
| US20070292421A1 (en) * | 2005-07-28 | 2007-12-20 | Feinberg Bruce B | Method for treating preeclampsia |
| WO2007028789A1 (en) | 2005-09-07 | 2007-03-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Quinazoline derivatives as antiviral agents |
| WO2007146349A2 (en) | 2006-06-13 | 2007-12-21 | Vertex Pharmaceuticals Incorporated | Cgrp receptor antagonists |
| US7834000B2 (en) | 2006-06-13 | 2010-11-16 | Vertex Pharmaceuticals Incorporated | CGRP receptor antagonists |
| SA08280783B1 (ar) | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
| PT2585064T (pt) * | 2010-06-24 | 2017-08-08 | Chemocentryx Inc | Antagonistas do c5ar |
| US20120143725A1 (en) | 2010-12-02 | 2012-06-07 | Vinimaya Inc. | Methods and systems for influencing search and shopping decisions in electronic procurement |
| JP6417419B2 (ja) | 2013-09-04 | 2018-11-07 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 免疫調節剤として有用な化合物 |
| HRP20181052T1 (hr) | 2013-09-06 | 2018-09-07 | Aurigene Discovery Technologies Limited | Derivati 1,2,4-oksadiazola kao imunomodulatori |
| WO2015044900A1 (en) | 2013-09-27 | 2015-04-02 | Aurigene Discovery Technologies Limited | Therapeutic immunomodulating compounds |
| JO3789B1 (ar) * | 2015-03-13 | 2021-01-31 | Resverlogix Corp | التراكيب والوسائل العلاجية المعتمدة لمعالجة الامراض المتعلقة بالمتممة |
| CA3087886A1 (en) | 2018-01-19 | 2019-07-25 | Idorsia Pharmaceuticals Ltd | C5a receptor modulators |
| US11685729B2 (en) | 2018-01-19 | 2023-06-27 | Idorsia Pharmaceuticals Ltd. | C5a receptor modulators |
-
2019
- 2019-01-18 US US16/963,143 patent/US11685729B2/en active Active
- 2019-01-18 WO PCT/EP2019/051245 patent/WO2019141808A1/en not_active Ceased
- 2019-01-18 CN CN201980009036.7A patent/CN111683937A/zh active Pending
- 2019-01-18 JP JP2020539797A patent/JP7281470B2/ja active Active
- 2019-01-18 EP EP19700614.1A patent/EP3740477A1/en not_active Withdrawn
- 2019-01-18 CA CA3087784A patent/CA3087784A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023436A1 (en) | 1998-10-16 | 2000-04-27 | Sumitomo Pharmaceuticals Co., Ltd. | Quinazolinone derivatives |
| JP2002528455A (ja) | 1998-10-23 | 2002-09-03 | エフ．ホフマン−ラ ロシュ アーゲー | 二環式窒素複素環化合物 |
| WO2008011032A1 (en) | 2006-07-17 | 2008-01-24 | Amgen Inc. | Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors |
| JP2014511898A (ja) | 2011-04-21 | 2014-05-19 | アステックス、セラピューティックス、リミテッド | 二環式複素環化合物および治療法におけるその使用 |
| JP2021510373A (ja) | 2018-01-10 | 2021-04-22 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 血管炎及び炎症性疾患を治療するためのｃ５ａ受容体調節剤としての２，４，６，７−テトラヒドロ−ピラゾロ［４，３−ｄ］ピリミジン−５−オン誘導体及び関連化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20210122736A1 (en) | 2021-04-29 |
| CN111683937A (zh) | 2020-09-18 |
| CA3087784A1 (en) | 2019-07-25 |
| EP3740477A1 (en) | 2020-11-25 |
| US11685729B2 (en) | 2023-06-27 |
| WO2019141808A1 (en) | 2019-07-25 |
| JP2021511327A (ja) | 2021-05-06 |
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| JP7014914B2 (ja) | 血管炎及び炎症性疾患を治療するためのｃ５ａ受容体調節剤としての２，４，６，７－テトラヒドロ－ピラゾロ［４，３－ｄ］ピリミジン－５－オン誘導体及び関連化合物 | |
| JP7281470B2 (ja) | Ｃ５ａ受容体調節剤 | |
| HK40035648B (en) | 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-one derivatives and related compounds for treating vasculitis and inflammatory diseases | |
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