JP7279067B2 - 複素環化合物及びその用途 - Google Patents

複素環化合物及びその用途 Download PDF

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JP7279067B2
JP7279067B2 JP2020551599A JP2020551599A JP7279067B2 JP 7279067 B2 JP7279067 B2 JP 7279067B2 JP 2020551599 A JP2020551599 A JP 2020551599A JP 2020551599 A JP2020551599 A JP 2020551599A JP 7279067 B2 JP7279067 B2 JP 7279067B2
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methyl
group
difluoromethoxy
fluoro
benzamide
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JP2020551599A
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Japanese (ja)
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JP2021519294A5 (https=
JPWO2019189945A5 (https=
JP2021519294A (ja
Inventor
裕哉 大黒
重充 松本
健志 若林
礼仁 ▲徳▼永
▲琢▼ 亀井
光博 伊藤
達 味上
雅樹 瀬戸
真二 森本
信二 中村
幸恵 ▲高▼嶋
正鷹 村上
將揮 大仁
信 鎌田
実 中村
康史 和田
広行 筧
和明 ▲高▼見
泰輔 俵石
淳平 会田
幸一 岩永
哲史 山本
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication of JPWO2019189945A5 publication Critical patent/JPWO2019189945A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020551599A 2018-03-28 2019-03-27 複素環化合物及びその用途 Active JP7279067B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018062939 2018-03-28
JP2018062939 2018-03-28
PCT/JP2019/014901 WO2019189945A1 (en) 2018-03-28 2019-03-27 Heterocyclic compound and use thereof

Publications (4)

Publication Number Publication Date
JP2021519294A JP2021519294A (ja) 2021-08-10
JP2021519294A5 JP2021519294A5 (https=) 2022-04-01
JPWO2019189945A5 JPWO2019189945A5 (https=) 2022-04-01
JP7279067B2 true JP7279067B2 (ja) 2023-05-22

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JP2020551599A Active JP7279067B2 (ja) 2018-03-28 2019-03-27 複素環化合物及びその用途

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US (2) US10807987B2 (https=)
EP (1) EP3774800B1 (https=)
JP (1) JP7279067B2 (https=)
KR (1) KR20200136957A (https=)
CN (1) CN111936495A (https=)
AR (1) AR115020A1 (https=)
AU (1) AU2019241765B2 (https=)
BR (1) BR112020018238A2 (https=)
CA (1) CA3100133A1 (https=)
EA (1) EA202092294A1 (https=)
ES (1) ES3006012T3 (https=)
IL (1) IL276912A (https=)
MA (1) MA52214A (https=)
MX (1) MX2020010148A (https=)
SG (1) SG11202008519RA (https=)
TW (1) TW202003519A (https=)
WO (1) WO2019189945A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3660003B1 (en) 2017-07-28 2024-01-24 Takeda Pharmaceutical Company Limited Heterocyclic compound
US10807987B2 (en) * 2018-03-28 2020-10-20 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
JP2021050161A (ja) 2019-09-25 2021-04-01 武田薬品工業株式会社 複素環化合物及びその用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016502555A (ja) 2012-12-04 2016-01-28 ピエール、ファーブル、メディカマン アミノシクロブタン誘導体、それらの製造方法およびそれらの薬物としての使用
WO2016104434A1 (ja) 2014-12-24 2016-06-30 武田薬品工業株式会社 複素環化合物
WO2019022179A1 (ja) 2017-07-28 2019-01-31 武田薬品工業株式会社 複素環化合物
WO2020153414A1 (ja) 2019-01-24 2020-07-30 武田薬品工業株式会社 複素環化合物及びその用途
WO2020196828A1 (ja) 2019-03-28 2020-10-01 武田薬品工業株式会社 含窒素複素環化合物

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FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
US5252563A (en) * 1991-12-19 1993-10-12 G. D. Searle & Company 5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine compounds for treatment of neurotoxic injury
JP3439551B2 (ja) * 1994-11-08 2003-08-25 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
EP0815134B1 (en) 1995-03-14 2002-06-05 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
PT929574E (pt) 1996-08-27 2005-11-30 Praecis Pharm Inc Moduladores da agregacao de peptidos beta-amiloides compreendendo d-aminoacidos
US6331640B1 (en) 1998-10-13 2001-12-18 Hoffmann-La Roche Inc. Diaminopropionic acid derivatives
EP1196609A2 (en) 1999-06-28 2002-04-17 Oklahoma Medical Research Foundation Catalytically active recombinant memapsin and methods of use thereof
WO2002080928A1 (en) * 2001-04-03 2002-10-17 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
JP2004161716A (ja) * 2002-11-15 2004-06-10 Takeda Chem Ind Ltd Ｊｎｋ阻害剤
MXPA05010824A (es) * 2003-04-10 2005-12-05 Pfizer Compuestos biciclicos como antagonistas del receptor nr2b.
EP1919872A4 (en) 2005-08-31 2009-08-05 Smithkline Beecham Corp CHEMICAL COMPOUNDS
MX2011008276A (es) * 2009-02-06 2011-12-14 Elan Pharm Inc Inhibidores de quinasa jun n-terminal.
US8404859B2 (en) 2011-03-16 2013-03-26 Hoffmann-La Roche Inc. Thiazole and thiophene compounds
ES2581848T3 (es) * 2011-04-05 2016-09-07 Pfizer Limited Derivados de pirrolo[2,3-d]pirimidina como inhibidores de quinasas relacionadas con tropomiosina
CA2903572A1 (en) 2013-03-15 2014-10-23 Epizyme, Inc. Substituted benzene compounds
US9243001B2 (en) 2013-03-15 2016-01-26 Epizyme, Inc. Substituted benzene compounds
JP6827757B2 (ja) 2016-10-11 2021-02-10 鬼怒川ゴム工業株式会社 ウエザーストリップ取付用クリップ
US10807987B2 (en) * 2018-03-28 2020-10-20 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
JP2016502555A (ja) 2012-12-04 2016-01-28 ピエール、ファーブル、メディカマン アミノシクロブタン誘導体、それらの製造方法およびそれらの薬物としての使用
WO2016104434A1 (ja) 2014-12-24 2016-06-30 武田薬品工業株式会社 複素環化合物
WO2019022179A1 (ja) 2017-07-28 2019-01-31 武田薬品工業株式会社 複素環化合物
WO2020153414A1 (ja) 2019-01-24 2020-07-30 武田薬品工業株式会社 複素環化合物及びその用途
WO2020196828A1 (ja) 2019-03-28 2020-10-01 武田薬品工業株式会社 含窒素複素環化合物

Also Published As

Publication number Publication date
EP3774800C0 (en) 2024-11-13
WO2019189945A1 (en) 2019-10-03
AU2019241765A8 (en) 2021-02-18
MX2020010148A (es) 2020-12-07
TW202003519A (zh) 2020-01-16
ES3006012T3 (en) 2025-03-17
US20190300536A1 (en) 2019-10-03
KR20200136957A (ko) 2020-12-08
WO2019189945A8 (en) 2020-10-15
EA202092294A1 (ru) 2021-01-15
US10807987B2 (en) 2020-10-20
IL276912A (en) 2020-10-29
US20210332053A1 (en) 2021-10-28
MA52214A (fr) 2021-04-21
JP2021519294A (ja) 2021-08-10
CN111936495A (zh) 2020-11-13
AR115020A1 (es) 2020-11-18
CA3100133A1 (en) 2019-10-03
SG11202008519RA (en) 2020-10-29
AU2019241765A1 (en) 2020-11-12
US11702419B2 (en) 2023-07-18
BR112020018238A2 (pt) 2020-12-29
AU2019241765B2 (en) 2022-07-07
EP3774800A1 (en) 2021-02-17
EP3774800B1 (en) 2024-11-13

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