JP7278257B2 - 老化細胞を排除する薬学的作用物質を用いる、黄斑変性症、緑内障、および糖尿病性網膜症などの眼病態の治療 - Google Patents

老化細胞を排除する薬学的作用物質を用いる、黄斑変性症、緑内障、および糖尿病性網膜症などの眼病態の治療 Download PDF

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JP7278257B2
JP7278257B2 JP2020507573A JP2020507573A JP7278257B2 JP 7278257 B2 JP7278257 B2 JP 7278257B2 JP 2020507573 A JP2020507573 A JP 2020507573A JP 2020507573 A JP2020507573 A JP 2020507573A JP 7278257 B2 JP7278257 B2 JP 7278257B2
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eye
cells
disease
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ジル ホプキンス
パム ツルダ
クロード チャップマン
ハリー スウェイガード
ヤン プーン
ダニエル マーキス
ナサニエル デビッド
ジェイミー ダナンバーグ
レミ-マーティン ラバージ
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ユニティ バイオテクノロジー インコーポレイテッド
バック インスティテュート フォー リサーチ オン エイジング
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2020507573A 2017-08-11 2018-08-13 老化細胞を排除する薬学的作用物質を用いる、黄斑変性症、緑内障、および糖尿病性網膜症などの眼病態の治療 Active JP7278257B2 (ja)

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US15/675,171 2017-08-11
US15/675,171 US20180000816A1 (en) 2015-02-06 2017-08-11 Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions
US201762579793P 2017-10-31 2017-10-31
US62/579,793 2017-10-31
PCT/US2018/046553 WO2019033119A1 (en) 2017-08-11 2018-08-13 TREATMENT OF OPHTHALMIC CONDITIONS SUCH AS MACULAR DEGENERATION, GLAUCOMA AND DIABETIC RETINOPATHY USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS

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JP2023076763A Pending JP2023100864A (ja) 2017-08-11 2023-05-08 老化細胞を排除する薬学的作用物質を用いる、黄斑変性症、緑内障、および糖尿病性網膜症などの眼病態の治療

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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200354336A9 (en) 2017-08-11 2020-11-12 Unity Biotechnology, Inc. Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells
US10588916B2 (en) 2017-10-31 2020-03-17 Unity Biotechnology, Inc. Technology to inhibit vascular changes that lead to vision loss in the eye
JP7080346B2 (ja) 2018-04-30 2022-06-03 ユニティ バイオテクノロジー インコーポレイテッド 老化細胞によって引き起こされるかまたは媒介される状態の臨床管理における使用のためおよびがんを治療するための、Bclファミリーアンタゴニストであるホスホノアミダート
US10717722B2 (en) 2018-06-13 2020-07-21 Unity Biotechnology, Inc. Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
KR20240014102A (ko) 2018-06-29 2024-01-31 우한 뉴로프스 바이오테크놀로지 리미티드 컴퍼니 레버 유전성 시신경병증의 치료를 위한 조성물 및 방법
CA3109432A1 (en) * 2018-08-20 2020-02-27 Wuhan Neurophth Biotechnology Limited Company Compositions and methods for treating leber's hereditary optic neuropathy
JP2022548071A (ja) * 2019-09-13 2022-11-16 アメリカ合衆国 網膜変性を治療するための新薬の開発につながる標的
CN113025633B (zh) 2019-12-09 2024-08-27 武汉纽福斯生物科技有限公司 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用
US20230078120A1 (en) * 2020-05-04 2023-03-16 Ascentage Pharma (Suzhou) Co.,Ltd. Methods for Treating Coronavirus Infections
JP2024501033A (ja) * 2020-12-28 2024-01-10 エムディー ヘルスケア インコーポレイテッド ミクロコッカス・ルテウス由来細胞外小胞を含む眼疾患の予防または治療用組成物
CN117222414A (zh) 2021-03-01 2023-12-12 脱落性治疗公司 用于激活恒定自然杀伤t-细胞的化合物和用于消除炎性衰老细胞的方法
JP2024516367A (ja) * 2021-04-13 2024-04-15 ユニティ バイオテクノロジー インコーポレイテッド 網膜血管症を治療する方法
KR102625248B1 (ko) * 2021-05-04 2024-01-16 주식회사 퓨전바이오텍 이미다졸린 유도체 화합물을 유효성분으로 포함하는 황반 변성 치료용 약학적 조성물
WO2024051741A1 (zh) * 2022-09-06 2024-03-14 西藏海思科制药有限公司 一种抑制Bcl-2或Bcl-xL的化合物及其在医药上的应用
DE112024002866T5 (de) * 2023-07-06 2026-04-23 Jichi Medical University Konzentrationsregulator für In-vivo-Substanzen oder Medikamente in einem halbgeschlossenen In-vivo-System
CN119925379B (zh) * 2025-03-05 2025-09-05 中南大学湘雅医院 Bcl3抑制剂在制备治疗青光眼的药物中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014507421A (ja) 2011-01-25 2014-03-27 ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン Bcl−2/bcl−xl阻害剤およびそれを使用する治療方法
WO2015116740A1 (en) 2014-01-28 2015-08-06 Buck Institute For Research On Aging Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
JP2016506916A (ja) 2013-01-16 2016-03-07 ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン Bcl−2/Bcl−xL阻害薬およびそれを使用した治療方法
WO2016127135A1 (en) 2015-02-06 2016-08-11 Unity Biotechnology, Inc. Compounds and uses in treatment of senescence-associated conditons

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
KR0185215B1 (ko) 1990-11-30 1999-05-01 요시다 쇼오지 서방성 안구삽입용 약제
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
BR0208856B1 (pt) 2001-04-11 2013-02-05 processo para o tratamento de superfÍcie de uma junta com rosca e junta com rosca para tubos de aÇo.
US9804295B2 (en) 2005-05-05 2017-10-31 Novartis Ag Ophthalmic devices for sustained delivery of active compounds
WO2009094466A2 (en) 2008-01-22 2009-07-30 University Of Florida Research Foundation, Inc. Contact lenses for extended release of bioactive agents containing diffusion attenuators
US8353856B2 (en) 2008-11-05 2013-01-15 Abbott Medical Optics Inc. Glaucoma drainage shunts and methods of use
EP2922544B1 (en) 2012-11-21 2018-08-01 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
CN105377289A (zh) * 2013-04-21 2016-03-02 耶达研究及发展有限公司 用于下调Bcl-xL和/或Bcl-w的活性和/或量的试剂
US20150038140A1 (en) 2013-07-31 2015-02-05 Qualcomm Incorporated Predictive mobility in cellular networks
WO2015017536A1 (en) 2013-07-31 2015-02-05 The Board Of Trustees Of The Leland Stanford Junior University Method and system for evaluating progression of age-related macular degeneration
US20180000816A1 (en) * 2015-02-06 2018-01-04 Unity Biotechnology, Inc. Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions
WO2017008060A1 (en) * 2015-07-08 2017-01-12 Unity Biotechnology, Inc. Compositions and methods for treating senescence-associated diseases and disorders
US11111259B2 (en) * 2015-12-18 2021-09-07 Unity Biotechnology, Inc. Acylsulfonamide derivatives for treating senescence-associated diseases and disorders

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014507421A (ja) 2011-01-25 2014-03-27 ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン Bcl−2/bcl−xl阻害剤およびそれを使用する治療方法
JP2016506916A (ja) 2013-01-16 2016-03-07 ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン Bcl−2/Bcl−xL阻害薬およびそれを使用した治療方法
WO2015116740A1 (en) 2014-01-28 2015-08-06 Buck Institute For Research On Aging Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
WO2016127135A1 (en) 2015-02-06 2016-08-11 Unity Biotechnology, Inc. Compounds and uses in treatment of senescence-associated conditons

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Longchuan Bai et.al.,BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo,PLOS ONE,2014年,9(6),e99404

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MX2025004366A (es) 2025-05-02
EP3441069A1 (en) 2019-02-13
JP2023100864A (ja) 2023-07-19
MX2020001644A (es) 2020-07-13
WO2019033119A1 (en) 2019-02-14
AU2018314280B2 (en) 2023-07-20
AU2023251388A1 (en) 2023-11-02
CN111372598A (zh) 2020-07-03
AU2018314280A1 (en) 2020-02-27
EP4234025A3 (en) 2024-04-24
RU2020109987A (ru) 2021-09-13
JP2020530470A (ja) 2020-10-22
EP3441069B1 (en) 2023-04-05
EP4234025A2 (en) 2023-08-30
CA3072673A1 (en) 2019-02-14
AU2023251388B2 (en) 2024-12-12

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