JP7278257B2 - 老化細胞を排除する薬学的作用物質を用いる、黄斑変性症、緑内障、および糖尿病性網膜症などの眼病態の治療 - Google Patents
老化細胞を排除する薬学的作用物質を用いる、黄斑変性症、緑内障、および糖尿病性網膜症などの眼病態の治療 Download PDFInfo
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Citations (4)
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| WO2015116740A1 (en) | 2014-01-28 | 2015-08-06 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
| JP2016506916A (ja) | 2013-01-16 | 2016-03-07 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | Ｂｃｌ−２／Ｂｃｌ−ｘＬ阻害薬およびそれを使用した治療方法 |
| WO2016127135A1 (en) | 2015-02-06 | 2016-08-11 | Unity Biotechnology, Inc. | Compounds and uses in treatment of senescence-associated conditons |
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| US8353856B2 (en) | 2008-11-05 | 2013-01-15 | Abbott Medical Optics Inc. | Glaucoma drainage shunts and methods of use |
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| CN105377289A (zh) * | 2013-04-21 | 2016-03-02 | 耶达研究及发展有限公司 | 用于下调Bcl-xL和/或Bcl-w的活性和/或量的试剂 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014507421A (ja) | 2011-01-25 | 2014-03-27 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | Ｂｃｌ−２／ｂｃｌ−ｘｌ阻害剤およびそれを使用する治療方法 |
| JP2016506916A (ja) | 2013-01-16 | 2016-03-07 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | Ｂｃｌ−２／Ｂｃｌ−ｘＬ阻害薬およびそれを使用した治療方法 |
| WO2015116740A1 (en) | 2014-01-28 | 2015-08-06 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
| WO2016127135A1 (en) | 2015-02-06 | 2016-08-11 | Unity Biotechnology, Inc. | Compounds and uses in treatment of senescence-associated conditons |
Non-Patent Citations (1)
| Title |
|---|
| Longchuan Bai et.al.，BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo，PLOS ONE，2014年，9(6)，e99404 |
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| EP4234025A3 (en) | 2024-04-24 |
| CA3072673A1 (en) | 2019-02-14 |
| RU2020109987A (ru) | 2021-09-13 |
| JP2023100864A (ja) | 2023-07-19 |
| MX2025004366A (es) | 2025-05-02 |
| EP4234025A2 (en) | 2023-08-30 |
| MX2020001644A (es) | 2020-07-13 |
| AU2018314280A1 (en) | 2020-02-27 |
| JP2020530470A (ja) | 2020-10-22 |
| CN111372598A (zh) | 2020-07-03 |
| EP3441069A1 (en) | 2019-02-13 |
| AU2023251388B2 (en) | 2024-12-12 |
| AU2018314280B2 (en) | 2023-07-20 |
| AU2023251388A1 (en) | 2023-11-02 |
| EP3441069B1 (en) | 2023-04-05 |
| WO2019033119A1 (en) | 2019-02-14 |
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