JP7272794B2 - ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法 - Google Patents

ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法 Download PDF

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JP7272794B2
JP7272794B2 JP2018543040A JP2018543040A JP7272794B2 JP 7272794 B2 JP7272794 B2 JP 7272794B2 JP 2018543040 A JP2018543040 A JP 2018543040A JP 2018543040 A JP2018543040 A JP 2018543040A JP 7272794 B2 JP7272794 B2 JP 7272794B2
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uveitis
antibody
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JP2018532804A (ja
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サンダラム アヴァリ・プリーシ・スリダラ
ロナルド・ブガジェ
キャレン・ダブリュー・チュウ
ディ ジェンティ ヴァレリー・コープ
クリスティーン・エー・エリックソン
ドミニーク・メリー－ミグナード
ラファエル・ヴァロナ
ロバート・エル・ヴィティ
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Regeneron Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018543040A 2015-11-03 2016-11-03 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法 Active JP7272794B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021147378A JP2021193120A (ja) 2015-11-03 2021-09-10 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法
JP2023021270A JP7581399B2 (ja) 2015-11-03 2023-02-15 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法
JP2024189424A JP2025020227A (ja) 2015-11-03 2024-10-29 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562250269P 2015-11-03 2015-11-03
US62/250,269 2015-11-03
EP16306166.6 2016-09-14
EP16306166 2016-09-14
US201662408391P 2016-10-14 2016-10-14
US62/408,391 2016-10-14
PCT/US2016/060344 WO2017079443A1 (en) 2015-11-03 2016-11-03 Compositions comprising il6r antibodies for the treatment of uveitis and macular edema and methods of using same

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JP2021147378A Division JP2021193120A (ja) 2015-11-03 2021-09-10 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法

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JP2018532804A JP2018532804A (ja) 2018-11-08
JP2018532804A5 JP2018532804A5 (https=) 2019-12-05
JP7272794B2 true JP7272794B2 (ja) 2023-05-12

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JP2018543040A Active JP7272794B2 (ja) 2015-11-03 2016-11-03 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法
JP2021147378A Pending JP2021193120A (ja) 2015-11-03 2021-09-10 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法
JP2023021270A Active JP7581399B2 (ja) 2015-11-03 2023-02-15 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法
JP2024189424A Pending JP2025020227A (ja) 2015-11-03 2024-10-29 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法

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JP2021147378A Pending JP2021193120A (ja) 2015-11-03 2021-09-10 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法
JP2023021270A Active JP7581399B2 (ja) 2015-11-03 2023-02-15 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法
JP2024189424A Pending JP2025020227A (ja) 2015-11-03 2024-10-29 ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法

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US (2) US10968278B2 (https=)
EP (1) EP3371224B1 (https=)
JP (4) JP7272794B2 (https=)
KR (2) KR102930886B1 (https=)
CN (1) CN108473583A (https=)
AU (2) AU2016348418B8 (https=)
BR (1) BR112018008900A8 (https=)
CA (1) CA3003874A1 (https=)
IL (1) IL319993A (https=)
MX (2) MX2018005589A (https=)
SG (1) SG11201803654TA (https=)
TW (3) TWI786636B (https=)
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JP2023062062A (ja) * 2015-11-03 2023-05-02 サノフィ・バイオテクノロジー ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法

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MA54861A (fr) 2019-01-31 2021-12-08 Regeneron Pharma Anticorps anti-récepteur de l'il6 pour traiter l'arthrite idiopathique juvénile
SG11202111742QA (en) 2019-04-24 2021-11-29 Sanofi Biotechnology Methods of diagnosis and treatment of rheumatoid arthritis
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CA3195967A1 (en) * 2020-10-28 2022-05-05 Xu Wang Vectorized anti-tnf-? antibodies for ocular indications
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２０１４ ＡＣＲ／ＡＲＨＰ Ａｎｎｕａｌ Ｍｅｅｔｉｎｇ Ａｂｓｔｒａｃｔ ｎｕｍｂｅｒ：１２４９， ［ｏｎｌｉｎｅ］， ２０１４， ［ｒｅｔｒｉｅｖｅｄ ｏｎ ２０２０－０９－１４］， ＜ＵＲＬ：ｈｔｔｐｓ：／／ａｃｒａｂｓｔｒａｃｔｓ．ｏｒｇ／ａｂｓｔｒａｃｔ／ｅｆｆｉｃａｃｙ－ｏｆ－ｔｏｃｉｌｉｚｕｍａｂ－ｉｎ－ｐａｔｉｅｎｔｓ－ｗｉｔｈ－ｕｖｅｉｔｉｓ－ｒｅｆｒａｃｔｏｒｙ－ｔｏ－ｏｔｈｅｒ－ｂｉｏｌｏｇｉｃ－ｄｒｕｇｓ－ａ－ｍｕｌｔｉｃｅｎｔｅｒ－ｓｔｕｄｙ－ｏｎ－３１－ｃａｓｅｓ／＞
Ｇｒａｅｆｅｓ Ａｒｃｈ． Ｃｌｉｎ． Ｅｘｐ． Ｏｐｈｔｈａｌｍｏｌ． （２０１３） ｖｏｌ．２５１， ｉｓｓｕｅ １１， ｐ．２６２７－２６３２
Ｉｎｖｅｓｔ． Ｏｐｈｔｈａｌｍｏｌ． Ｖｉｓ． Ｓｃｉ． （Ｊｕｎ ２０１５） ｖｏｌ．５６， ｎｏ．７， ３１１６
ＮＣＴ０１９００４３１ Ｐｈａｓｅ ＩＩ Ｓｔｕｄｙ ｔｏ Ａｎａｌｙｚｅ Ｓａｒｉｌｕｍａｂ ｉｎ Ｎｏｎ－Ｉｎｆｅｃｔｉｏｕｓ Ｕｖｅｉｔｉｓ （ＳＡＲＩＬＮＩＵＳＡＴＵＲＮ）， ＣｌｉｎｉｃａｌＴｒｉａｌｓ．ｇｏｖ， ［ｏｎｌｉｎｅ］， ２０１５－０４－１３， ［ｒｅｔｒｉｅｖｅｄ ｏｎ ２０２０－０９－１４］， ＜ＵＲＬ：ｈｔｔｐｓ：／／ｃｌｉｎｉｃａｌｔｒｉａｌｓ．ｇｏｖ／ｃｔ２／ｈｉｓｔｏｒｙ／ＮＣＴ０１９００４３１？Ｖ＿３２＝Ｖｉｅｗ＃ＳｔｕｄｙＰａｇｅＴｏｐ＞
Ｏｐｈｔｈａｌｍｏｌｏｇｙ （２０１４） ｖｏｌ．１２１， ｉｓｓｕｅ １２， ｐ．２３８０－２３８６

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023062062A (ja) * 2015-11-03 2023-05-02 サノフィ・バイオテクノロジー ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法
JP7581399B2 (ja) 2015-11-03 2024-11-12 サノフィ・バイオテクノロジー ブドウ膜炎および黄斑浮腫の処置のためのｉｌ６ｒ抗体を含む組成物およびそれを使用する方法

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TW202138001A (zh) 2021-10-16
KR20260036589A (ko) 2026-03-17
US20170166646A1 (en) 2017-06-15
AU2016348418B2 (en) 2023-10-12
BR112018008900A8 (pt) 2019-02-26
BR112018008900A2 (pt) 2018-11-06
TWI729022B (zh) 2021-06-01
MX2022011972A (es) 2022-10-20
JP7581399B2 (ja) 2024-11-12
KR20180073680A (ko) 2018-07-02
JP2018532804A (ja) 2018-11-08
EP3371224B1 (en) 2026-04-29
US20210301027A1 (en) 2021-09-30
AU2016348418A1 (en) 2018-06-21
JP2023062062A (ja) 2023-05-02
CA3003874A1 (en) 2017-05-11
US10968278B2 (en) 2021-04-06
SG11201803654TA (en) 2018-05-30
WO2017079443A8 (en) 2017-07-06
TWI786636B (zh) 2022-12-11
WO2017079443A1 (en) 2017-05-11
AU2016348418A8 (en) 2023-10-19
TW201729828A (zh) 2017-09-01
KR102930886B1 (ko) 2026-02-25
EP3371224A1 (en) 2018-09-12
MX2018005589A (es) 2018-11-09
JP2025020227A (ja) 2025-02-12
AU2016348418B8 (en) 2023-10-19
TW202339795A (zh) 2023-10-16
JP2021193120A (ja) 2021-12-23
AU2023233110A1 (en) 2023-10-05
IL319993A (en) 2025-06-01
CN108473583A (zh) 2018-08-31

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