JP7270630B2 - 抗癌剤として有用なテトラヒドロキナゾリン誘導体 - Google Patents

抗癌剤として有用なテトラヒドロキナゾリン誘導体 Download PDF

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JP7270630B2
JP7270630B2 JP2020542790A JP2020542790A JP7270630B2 JP 7270630 B2 JP7270630 B2 JP 7270630B2 JP 2020542790 A JP2020542790 A JP 2020542790A JP 2020542790 A JP2020542790 A JP 2020542790A JP 7270630 B2 JP7270630 B2 JP 7270630B2
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alkyl
methyl
group
indazol
compound
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JP2021513534A (ja
JPWO2019155399A5 (https=
JP2021513534A5 (https=
Inventor
ブルーン，アレクセイ
チェン，ピン
チェン，ヘンミャオ
コリンズ，マイケル・レイモンド
リントン，マリア・アンジェリカ
マデルナ，アンドレアス
麻子 永田
パルマー，シンシア
プランケン，サイモン
スパングラー，ジリアン・エリス
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ファイザー・インク
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020542790A 2018-02-09 2019-02-07 抗癌剤として有用なテトラヒドロキナゾリン誘導体 Active JP7270630B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862628350P 2018-02-09 2018-02-09
US62/628,350 2018-02-09
US201862651796P 2018-04-03 2018-04-03
US62/651,796 2018-04-03
US201862782408P 2018-12-20 2018-12-20
US62/782,408 2018-12-20
PCT/IB2019/050993 WO2019155399A1 (en) 2018-02-09 2019-02-07 Tetrahydroquinazoline derivatives useful as anticancer agents

Publications (4)

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JP2021513534A JP2021513534A (ja) 2021-05-27
JPWO2019155399A5 JPWO2019155399A5 (https=) 2022-02-10
JP2021513534A5 JP2021513534A5 (https=) 2022-02-10
JP7270630B2 true JP7270630B2 (ja) 2023-05-10

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US (1) US10590115B2 (https=)
EP (1) EP3749665A1 (https=)
JP (1) JP7270630B2 (https=)
CA (1) CA3090482C (https=)
PY (1) PY1909256A (https=)
TW (1) TW201942116A (https=)
UY (1) UY38076A (https=)
WO (1) WO2019155399A1 (https=)

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UY38076A (es) 2019-10-01
US10590115B2 (en) 2020-03-17
US20190248767A1 (en) 2019-08-15
JP2021513534A (ja) 2021-05-27
WO2019155399A1 (en) 2019-08-15
PY1909256A (es) 2020-07-16
CA3090482C (en) 2023-01-31
TW201942116A (zh) 2019-11-01
CA3090482A1 (en) 2019-08-15
EP3749665A1 (en) 2020-12-16

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