JP7250907B2 - 両親媒性化合物、並びにこれを用いた医療用樹脂組成物および医薬品添加剤 - Google Patents

両親媒性化合物、並びにこれを用いた医療用樹脂組成物および医薬品添加剤 Download PDF

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JP7250907B2
JP7250907B2 JP2021512133A JP2021512133A JP7250907B2 JP 7250907 B2 JP7250907 B2 JP 7250907B2 JP 2021512133 A JP2021512133 A JP 2021512133A JP 2021512133 A JP2021512133 A JP 2021512133A JP 7250907 B2 JP7250907 B2 JP 7250907B2
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将人 今瀬
あかね 佐藤
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Nippon Shokubai Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/10—Esters
    • C08F20/20—Esters of polyhydric alcohols or polyhydric phenols, e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F120/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F120/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F120/10—Esters
    • C08F120/20—Esters of polyhydric alcohols or polyhydric phenols, e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F126/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F126/06—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • C08F126/08—N-Vinyl-pyrrolidine
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
JP2021512133A 2019-03-29 2020-03-30 両親媒性化合物、並びにこれを用いた医療用樹脂組成物および医薬品添加剤 Active JP7250907B2 (ja)

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JP2023045195A JP7684343B2 (ja) 2019-03-29 2023-03-22 両親媒性化合物、並びにこれを用いた医療用樹脂組成物および医薬品添加剤

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JP2019067826 2019-03-29
JP2019067826 2019-03-29
PCT/JP2020/014668 WO2020203998A1 (ja) 2019-03-29 2020-03-30 両親媒性化合物、並びにこれを用いた医療用樹脂組成物および医薬品添加剤

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JP7250907B2 true JP7250907B2 (ja) 2023-04-03

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JP2023045195A Active JP7684343B2 (ja) 2019-03-29 2023-03-22 両親媒性化合物、並びにこれを用いた医療用樹脂組成物および医薬品添加剤

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US (1) US12297302B2 (https=)
EP (1) EP3950735A4 (https=)
JP (2) JP7250907B2 (https=)
CN (3) CN116606393A (https=)
CA (1) CA3134852A1 (https=)
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JP2022161408A (ja) * 2021-04-09 2022-10-21 株式会社日本触媒 血液または血小板保存容器
JP7778816B2 (ja) * 2021-12-15 2025-12-02 株式会社日本触媒 コンジュゲート化合物およびコンジュゲート化合物の製造方法
WO2025022920A1 (ja) * 2023-07-26 2025-01-30 株式会社日本触媒 脂質ナノ粒子

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508125A (ja) 1999-09-02 2003-03-04 アルコン，インコーポレイテッド 移植片用の共有結合した親水性塗装組成物
WO2008084656A1 (ja) 2006-12-22 2008-07-17 Sekisui Chemical Co., Ltd. ガラスペースト
JP2010531166A (ja) 2007-06-22 2010-09-24 ボーシュ アンド ローム インコーポレイティド 眼科用溶液

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
US4529786A (en) * 1981-03-30 1985-07-16 Celanese Corporation Acrylate and methacrylate monoesters of pentaerythritol and pentaerythritol orthoesters and polymers and copolymers derived therefrom
US4855369A (en) * 1985-12-11 1989-08-08 Exxon Chemical Patents Inc. High solids acrylic-based coatings
DE19525031A1 (de) * 1995-07-10 1997-01-16 Heraeus Kulzer Gmbh Derivate aromatischer Carbonsäuren, aromatische Carbonsäureanhydride und Hydroxy(meth)acrylaten sowie Adhäsive, enthaltend diese Verbindungen
US6632905B2 (en) 1999-09-02 2003-10-14 Alcon Universal Ltd. Covalently-bound, hydrophilic coating compositions for surgical implants
AU2002353485B2 (en) * 2001-12-04 2009-01-15 Ben Gurion University Of The Negev Research And Development Authority Amphiphilic compounds and vesicles/liposomes for organ-specific drug targeting
US20080019918A1 (en) * 2004-09-10 2008-01-24 Takao Aoki Medicinal Preparation
EP2128180A1 (en) * 2008-05-29 2009-12-02 Unilever N.V. Amphiphilic branched polymers and their use as emulsifiers
GB201003970D0 (en) * 2010-03-10 2010-04-21 Univ Sheffield Polymer synthesis
JP5854998B2 (ja) * 2010-07-24 2016-02-09 株式会社日本触媒 親水化処理剤
JP5538315B2 (ja) 2011-07-20 2014-07-02 桜宮化学株式会社 エマルジョン燃料
JP6887713B2 (ja) * 2016-06-16 2021-06-16 エルジー・ケム・リミテッド 両親媒性高分子
US20190218323A1 (en) * 2016-08-08 2019-07-18 The University Of Liverpool Branched polymers
JP7076971B2 (ja) 2017-09-28 2022-05-30 キヤノン株式会社 撮像装置およびその製造方法ならびに機器

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508125A (ja) 1999-09-02 2003-03-04 アルコン，インコーポレイテッド 移植片用の共有結合した親水性塗装組成物
WO2008084656A1 (ja) 2006-12-22 2008-07-17 Sekisui Chemical Co., Ltd. ガラスペースト
JP2010531166A (ja) 2007-06-22 2010-09-24 ボーシュ アンド ローム インコーポレイティド 眼科用溶液

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JP7684343B2 (ja) 2025-05-27
CA3134852A1 (en) 2020-10-08
EP3950735A4 (en) 2023-01-04
US12297302B2 (en) 2025-05-13
CN113646341A (zh) 2021-11-12
CN116606393A (zh) 2023-08-18
US20220185918A1 (en) 2022-06-16
WO2020203998A1 (ja) 2020-10-08
JPWO2020203998A1 (https=) 2020-10-08
CN116589702A (zh) 2023-08-15
JP2023076520A (ja) 2023-06-01
EP3950735A1 (en) 2022-02-09
CN113646341B (zh) 2023-04-18

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