CA3134852A1 - Amphiphilic compound, and medical resin composition and pharmaceutical additive using the same - Google Patents

Amphiphilic compound, and medical resin composition and pharmaceutical additive using the same Download PDF

Info

Publication number
CA3134852A1
CA3134852A1 CA3134852A CA3134852A CA3134852A1 CA 3134852 A1 CA3134852 A1 CA 3134852A1 CA 3134852 A CA3134852 A CA 3134852A CA 3134852 A CA3134852 A CA 3134852A CA 3134852 A1 CA3134852 A1 CA 3134852A1
Authority
CA
Canada
Prior art keywords
amphiphilic compound
group
carbon atoms
polymer
monomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3134852A
Other languages
English (en)
French (fr)
Inventor
Masato IMASE
Akane Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shokubai Co Ltd
Original Assignee
Nippon Shokubai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shokubai Co Ltd filed Critical Nippon Shokubai Co Ltd
Publication of CA3134852A1 publication Critical patent/CA3134852A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/10—Esters
    • C08F20/20—Esters of polyhydric alcohols or polyhydric phenols, e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F120/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F120/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F120/10—Esters
    • C08F120/20—Esters of polyhydric alcohols or polyhydric phenols, e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F126/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F126/06—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • C08F126/08—N-Vinyl-pyrrolidine
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
CA3134852A 2019-03-29 2020-03-30 Amphiphilic compound, and medical resin composition and pharmaceutical additive using the same Pending CA3134852A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019067826 2019-03-29
JP2019-067826 2019-03-29
PCT/JP2020/014668 WO2020203998A1 (ja) 2019-03-29 2020-03-30 両親媒性化合物、並びにこれを用いた医療用樹脂組成物および医薬品添加剤

Publications (1)

Publication Number Publication Date
CA3134852A1 true CA3134852A1 (en) 2020-10-08

Family

ID=72668997

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3134852A Pending CA3134852A1 (en) 2019-03-29 2020-03-30 Amphiphilic compound, and medical resin composition and pharmaceutical additive using the same

Country Status (6)

Country Link
US (1) US12297302B2 (https=)
EP (1) EP3950735A4 (https=)
JP (2) JP7250907B2 (https=)
CN (3) CN116606393A (https=)
CA (1) CA3134852A1 (https=)
WO (1) WO2020203998A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022161408A (ja) * 2021-04-09 2022-10-21 株式会社日本触媒 血液または血小板保存容器
JP7778816B2 (ja) * 2021-12-15 2025-12-02 株式会社日本触媒 コンジュゲート化合物およびコンジュゲート化合物の製造方法
WO2025022920A1 (ja) * 2023-07-26 2025-01-30 株式会社日本触媒 脂質ナノ粒子

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
US4529786A (en) * 1981-03-30 1985-07-16 Celanese Corporation Acrylate and methacrylate monoesters of pentaerythritol and pentaerythritol orthoesters and polymers and copolymers derived therefrom
US4855369A (en) * 1985-12-11 1989-08-08 Exxon Chemical Patents Inc. High solids acrylic-based coatings
DE19525031A1 (de) * 1995-07-10 1997-01-16 Heraeus Kulzer Gmbh Derivate aromatischer Carbonsäuren, aromatische Carbonsäureanhydride und Hydroxy(meth)acrylaten sowie Adhäsive, enthaltend diese Verbindungen
PT1208393E (pt) 1999-09-02 2008-10-24 Alcon Inc Composições de revestimento hidrofílicas, ligadas covalentemente, para implantes
US6632905B2 (en) 1999-09-02 2003-10-14 Alcon Universal Ltd. Covalently-bound, hydrophilic coating compositions for surgical implants
AU2002353485B2 (en) * 2001-12-04 2009-01-15 Ben Gurion University Of The Negev Research And Development Authority Amphiphilic compounds and vesicles/liposomes for organ-specific drug targeting
US20080019918A1 (en) * 2004-09-10 2008-01-24 Takao Aoki Medicinal Preparation
TW200835662A (en) 2006-12-22 2008-09-01 Sekisui Chemical Co Ltd Glass paste
US20080314767A1 (en) * 2007-06-22 2008-12-25 Bausch & Lomb Incorporated Ophthalmic Solutions
EP2128180A1 (en) * 2008-05-29 2009-12-02 Unilever N.V. Amphiphilic branched polymers and their use as emulsifiers
GB201003970D0 (en) * 2010-03-10 2010-04-21 Univ Sheffield Polymer synthesis
JP5854998B2 (ja) * 2010-07-24 2016-02-09 株式会社日本触媒 親水化処理剤
JP5538315B2 (ja) 2011-07-20 2014-07-02 桜宮化学株式会社 エマルジョン燃料
JP6887713B2 (ja) * 2016-06-16 2021-06-16 エルジー・ケム・リミテッド 両親媒性高分子
US20190218323A1 (en) * 2016-08-08 2019-07-18 The University Of Liverpool Branched polymers
JP7076971B2 (ja) 2017-09-28 2022-05-30 キヤノン株式会社 撮像装置およびその製造方法ならびに機器

Also Published As

Publication number Publication date
JP7684343B2 (ja) 2025-05-27
EP3950735A4 (en) 2023-01-04
JP7250907B2 (ja) 2023-04-03
US12297302B2 (en) 2025-05-13
CN113646341A (zh) 2021-11-12
CN116606393A (zh) 2023-08-18
US20220185918A1 (en) 2022-06-16
WO2020203998A1 (ja) 2020-10-08
JPWO2020203998A1 (https=) 2020-10-08
CN116589702A (zh) 2023-08-15
JP2023076520A (ja) 2023-06-01
EP3950735A1 (en) 2022-02-09
CN113646341B (zh) 2023-04-18

Similar Documents

Publication Publication Date Title
JP7684343B2 (ja) 両親媒性化合物、並びにこれを用いた医療用樹脂組成物および医薬品添加剤
EP4291242A1 (en) Polyoxazoline-lipid conjugates and lipid nanoparticles and pharmaceutical compositions including same
JP7513675B2 (ja) 生体適合性医療用材料
CN116867500A (zh) 两性离子脂质纳米颗粒组合物和使用方法
US10182987B2 (en) Lipid membrane structure for intracellular delivery of siRNA
Wei et al. Fabrication of pH-and ultrasound-responsive polymeric micelles: the effect of amphiphilic block copolymers with different hydrophilic/hydrophobic block ratios for self-assembly and controlled drug release
US20150050330A1 (en) Compositions and methods for polymer-caged liposomes
WO2008096904A1 (ja) マンノース６－リン酸－ポリエチレングリコール結合体
CN118217239A (zh) 盐酸米托蒽醌离子配对自组装纳米粒及其制备方法和应用
JPH06178930A (ja) 被膜安定化リポソーム及びその製造方法
ES2640060T3 (es) Proceso para producir una partícula fina revestida
JP6777390B2 (ja) 生体適合性医療用材料
US8809495B2 (en) Peptides imparting cell permeability to lipid membrane structure and/or enhancing cell permeability of lipid membrane structure, and lipid membrane structure comprising lipid bound to such peptide as constituent lipid and having cell permeability or showing enhanced cell permeability
WO2005030835A1 (ja) ポリエチレングリコール誘導体及びこれを膜構成成分とする薬物担体
WO2025022920A1 (ja) 脂質ナノ粒子
CN120187465A (zh) 脂质类似物、包含它们的脂质体及其用途
JP7411371B2 (ja) 糖鎖修飾ポリマーおよびその製造方法、並びにこれを用いた医療用樹脂組成物および医薬品添加剤
US20240374733A1 (en) Ph-responsive lipid derivative
NL2035538B1 (en) Lipid-like copolymers and method of producing these and the use thereof, pharmaceutical compositions comprising said copolymers, and the use of said compositions.
EP4458870A1 (en) Polymer derivatives and their use as lipid nanoparticle modifiers
US20240101733A1 (en) Monoglycerol acrylate based polymer and uses thereof
KR20090013848A (ko) 안트라사이클라인계 항암약물 봉입용 리포솜 및 이의제조방법

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20231116

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20241122

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD

Year of fee payment: 5

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250208

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20250219

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250219

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION

Effective date: 20250317

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250319

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20250714

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20250714

D22 Grant of ip right intended

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D22-D128 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ALLOWANCE REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20260203

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD

Year of fee payment: 6

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20260203

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20260203

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20260205