JP7249281B2 - 磁気式多ビーズアッセイのための方法および装置 - Google Patents

磁気式多ビーズアッセイのための方法および装置 Download PDF

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JP7249281B2
JP7249281B2 JP2019534665A JP2019534665A JP7249281B2 JP 7249281 B2 JP7249281 B2 JP 7249281B2 JP 2019534665 A JP2019534665 A JP 2019534665A JP 2019534665 A JP2019534665 A JP 2019534665A JP 7249281 B2 JP7249281 B2 JP 7249281B2
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bead
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magnetic
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JP2020514709A (ja
JP2020514709A5 (enExample
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コリン, ビー. コノリー,
ジェフリー, ディー. ランドール,
ジョン, シー. ピーナ,
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Quantum Diamond Technologies (United States)
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326Magnetic particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/10Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553Metal or metal coated
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/24Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/26Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/323Detection of MR without the use of RF or microwaves, e.g. force-detected MR, thermally detected MR, MR detection via electrical conductivity, optically detected MR

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
JP2019534665A 2016-12-23 2017-12-22 磁気式多ビーズアッセイのための方法および装置 Active JP7249281B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662438593P 2016-12-23 2016-12-23
US62/438,593 2016-12-23
PCT/US2017/068126 WO2018119367A1 (en) 2016-12-23 2017-12-22 Methods and apparatus for magnetic multi-bead assays

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JP2020514709A JP2020514709A (ja) 2020-05-21
JP2020514709A5 JP2020514709A5 (enExample) 2021-02-04
JP7249281B2 true JP7249281B2 (ja) 2023-03-30

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US (2) US11513115B2 (enExample)
EP (1) EP3559668B1 (enExample)
JP (1) JP7249281B2 (enExample)
CA (1) CA3046849A1 (enExample)
WO (1) WO2018119367A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10845449B2 (en) 2016-10-20 2020-11-24 Quantum Diamond Technologies Inc. Methods and apparatus for magnetic particle analysis using diamond magnetic imaging
WO2018119367A1 (en) 2016-12-23 2018-06-28 Quantum Diamond Technologies Inc. Methods and apparatus for magnetic multi-bead assays
WO2019027917A1 (en) 2017-07-31 2019-02-07 Quantum Diamond Technologies, Inc METHODS AND APPARATUS FOR SAMPLE MEASUREMENT
JP7417220B2 (ja) * 2019-05-24 2024-01-18 国立大学法人大阪大学 撮像装置および撮像方法
JP7392336B2 (ja) * 2019-09-06 2023-12-06 株式会社島津製作所 磁気共鳴分光装置および磁気共鳴分光の測定方法
JP2023500413A (ja) * 2019-11-12 2023-01-05 クアンタム ダイヤモンド テクノロジーズ インク. 磁気ビーズベースの検体検出のためのビーズシステム、方法、および装置
US11971464B1 (en) * 2019-12-20 2024-04-30 The United States Of America, Represented By The Secretary Of The Navy Magnon excitation and detection systems, apparatus, and methods
US20220308048A1 (en) * 2020-06-15 2022-09-29 Case Western Reserve University Point of care device for early and rapid disease diagnosis
KR102313685B1 (ko) * 2020-07-13 2021-10-18 한양대학교 산학협력단 Dnv 센터를 이용한 형광신호 측정 시스템
US11585870B2 (en) * 2020-09-15 2023-02-21 Massachusetts Institute Of Technology Absorption-based diamond spin microscopy on a plasmonic quantum metasurface
WO2022091802A1 (ja) * 2020-10-28 2022-05-05 京セラ株式会社 磁気センサ、検出ユニット、検出システム、磁気センサ用基板、磁気センサ用導波体、磁気センサ用光電気混載基板及び検出ユニット用検出基板
FR3120127B1 (fr) * 2021-02-24 2023-09-15 Magia Diagnostics Procede et dispositif d’analyse d’un liquide susceptible de contenir un analyte
WO2023121990A1 (en) * 2021-12-20 2023-06-29 Hach Company Methods and kits for assaying a large fluid volume using flow cytometry
WO2023141319A1 (en) * 2022-01-24 2023-07-27 Amgen Inc. Methods for detecting antibody self-association
JP2024018233A (ja) * 2022-07-29 2024-02-08 スミダコーポレーション株式会社 測定装置および測定方法
DE102023100856B4 (de) * 2023-01-16 2024-10-02 Quantum Technologies Gmbh Schnelle, zeitlich und räumlich hochauflösende Magnetfeldkamera

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010506191A (ja) 2006-10-12 2010-02-25 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 試薬層を有した高速バイオセンサ
JP2012121748A (ja) 2010-12-07 2012-06-28 Sumitomo Electric Ind Ltd ダイヤモンド及びこれを用いた磁気センサー
JP2013503352A (ja) 2009-08-31 2013-01-31 エムバイオ ダイアグノスティクス,インコーポレイティド 統合されたサンプル調製及び検体検出
JP2014095025A (ja) 2012-11-08 2014-05-22 Osaka Univ ダイヤモンド複合粒子
JP2016188828A (ja) 2015-03-30 2016-11-04 東ソー株式会社 磁気信号を利用した標的物質の測定方法

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2045431B (en) 1979-02-26 1983-04-20 Technicon Instr Immunoassay utilising two particulate reagents
US4628037A (en) 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
US4695392A (en) 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US5145784A (en) 1988-05-04 1992-09-08 Cambridge Biotech Corporation Double capture assay method employing a capillary flow device
CA2013014A1 (en) 1989-11-30 1991-05-31 Linda A. Mauck Dry immunoassay analytical element comprising monodispersed beads
US5547555A (en) 1993-02-22 1996-08-20 Ohmicron Technology, Inc. Electrochemical sensor cartridge
US5648124A (en) 1993-07-09 1997-07-15 Seradyn, Inc. Process for preparing magnetically responsive microparticles
JP3854680B2 (ja) 1997-02-26 2006-12-06 キヤノン株式会社 圧力隔壁およびこれを用いた露光装置
US5998224A (en) 1997-05-16 1999-12-07 Abbott Laboratories Magnetically assisted binding assays utilizing a magnetically responsive reagent
US6050138A (en) 1997-10-22 2000-04-18 Exponent, Inc. System and method for performing bulge testing of films, coatings and/or layers
US6979424B2 (en) 1998-03-17 2005-12-27 Cepheid Integrated sample analysis device
ATE356669T1 (de) 1998-06-17 2007-04-15 Univ Ohio Elektroabscheider mit membran
US6178033B1 (en) 1999-03-28 2001-01-23 Lucent Technologies Micromechanical membrane tilt-mirror switch
AU1591301A (en) 1999-11-09 2001-06-06 Sri International Workstation, apparatus, and methods for the high-throughput synthesis, screeningand characterization of combinatorial libraries
US7635571B2 (en) 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
US6896850B2 (en) 2001-03-26 2005-05-24 Kumetrix, Inc. Silicon nitride window for microsampling device and method of construction
US7474180B2 (en) 2002-11-01 2009-01-06 Georgia Tech Research Corp. Single substrate electromagnetic actuator
US7086288B2 (en) 2002-11-27 2006-08-08 Northwestern University Thin membrane transducer
DE10309132A1 (de) * 2003-02-28 2004-11-18 Forschungszentrum Jülich GmbH Verfahren und Vorrichtung zum selektiven Nachweis magnetischer Partikel
US7385266B2 (en) 2003-05-14 2008-06-10 Nantero, Inc. Sensor platform using a non-horizontally oriented nanotube element
US7279286B2 (en) 2003-09-11 2007-10-09 Sanofi-Aventis Deutschland Gmbh High-throughput-assay with high sensitivity for measuring of the activity of β-adrenergic receptor kinase and for determining the impact of test substances on such activity
US7531366B2 (en) 2004-07-23 2009-05-12 Platypus Technologies, Llc Bead based assays using a liquid crystal reporter
EP1662256A1 (en) 2004-11-25 2006-05-31 Spinomix S.A. Tailored magnetic particles and method to produce same
US7489593B2 (en) 2004-11-30 2009-02-10 Vermon Electrostatic membranes for sensors, ultrasonic transducers incorporating such membranes, and manufacturing methods therefor
WO2006079998A1 (en) 2005-01-31 2006-08-03 Koninklijke Philips Electronics N.V. Rapid and sensitive biosensing
US20070103697A1 (en) 2005-06-17 2007-05-10 Degertekin Fahrettin L Integrated displacement sensors for probe microscopy and force spectroscopy
US7637149B2 (en) 2005-06-17 2009-12-29 Georgia Tech Research Corporation Integrated displacement sensors for probe microscopy and force spectroscopy
US8220318B2 (en) 2005-06-17 2012-07-17 Georgia Tech Research Corporation Fast microscale actuators for probe microscopy
JP5377972B2 (ja) 2005-11-22 2013-12-25 マイクロラボ ピーティーワイ エルティーディー 流体構造、装置、方法、及び機器構成方法
CA2656686A1 (en) 2006-07-05 2008-01-10 Aida Engineering, Ltd. Micro passage chip and fluid transferring method
US20080108122A1 (en) 2006-09-01 2008-05-08 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Microchemical nanofactories
CN101681695B (zh) 2006-09-06 2013-04-10 伊利诺伊大学评议会 在用于可拉伸电子元件的半导体互连和纳米膜中的受控弯曲结构
US10529003B2 (en) 2008-04-07 2020-01-07 Mohammad A. Mazed Optical biomodule for detection of diseases at an early onset
WO2008101196A1 (en) 2007-02-15 2008-08-21 Osmetech Molecular Diagnostics Fluidics devices
US20090134481A1 (en) 2007-11-28 2009-05-28 Analog Devices, Inc. Molded Sensor Package and Assembly Method
EP2108938A1 (en) 2008-04-09 2009-10-14 Koninklijke Philips Electronics N.V. A carrier for optical detection in small sample volumes
WO2010007580A1 (en) 2008-07-14 2010-01-21 Ecole Polytechnique Federale De Lausanne (Epfl) Viscosimetric biosensor for monitoring analyte levels
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US8766630B2 (en) 2008-11-04 2014-07-01 The University Of Melbourne Method and apparatus for monitoring a property of a sample
JP5715068B2 (ja) 2009-01-30 2015-05-07 マイクロニクス, インコーポレイテッド 携帯型高利得蛍光検出システム
US8059271B2 (en) 2009-02-04 2011-11-15 The United States Of America As Represented By The Secretary Of The Army Reusable sample holding device permitting ready loading of very small wet samples
US8691557B2 (en) 2009-02-06 2014-04-08 The Ohio State University Magnetic platforms for biomolecule trappings, manipulations, and sorting
FI122507B (fi) 2009-05-26 2012-02-29 Outotec Oyj Analysaattorin mittausikkunan sovitelma
EP2457078A4 (en) 2009-07-23 2014-07-30 Insight Nanofluidics Inc NANOFLUIDIC CELL
US8193808B2 (en) * 2009-09-11 2012-06-05 Hewlett-Packard Development Company, L.P. Optically integrated biosensor based on optically detected magnetic resonance
FR2950153B1 (fr) 2009-09-15 2011-12-23 Commissariat Energie Atomique Dispositif optique a membrane deformable a actionnement piezoelectrique
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
EP2596356A1 (en) * 2010-07-23 2013-05-29 Merck Patent GmbH Method of performing an assay
GB201014805D0 (en) 2010-09-07 2010-10-20 Multi Sense Technologies Ltd Microfluidics based assay device
AU2012211141B2 (en) 2011-01-27 2016-11-03 Invisible Sentinel, Inc. Analyte detection devices, multiplex and tabletop devices for detection of analytes, and uses thereof
US8989354B2 (en) 2011-05-16 2015-03-24 Brigham Young University Carbon composite support structure
GB201108644D0 (en) * 2011-05-24 2011-07-06 Element Six Ltd Diamond sensors, detectors, and quantum devices
GB2497317A (en) * 2011-12-06 2013-06-12 Univ Dublin System and method for the detection of analytes using rod-shaped nanoparticles
WO2013059404A1 (en) 2011-10-19 2013-04-25 The Trustees Of Columbia University In The City Of New York Systems and methods for deterministic emitter switch microscopy
US9632045B2 (en) * 2011-10-19 2017-04-25 The Trustees Of Columbia University In The City Of New York Systems and methods for deterministic emitter switch microscopy
KR20130051647A (ko) 2011-11-10 2013-05-21 한국전자통신연구원 자성 입자를 이용한 바이오 물질의 분석 방법
US9797817B2 (en) 2012-05-03 2017-10-24 The Regents Of The University Of Michigan Multi-mode separation for target detection
WO2014008518A1 (en) 2012-07-10 2014-01-16 Lexogen Gmbh Flexible dna sensor carrier and method
EP2888596B1 (en) 2012-08-22 2022-07-20 President and Fellows of Harvard College Nanoscale scanning sensors
US9551704B2 (en) * 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
WO2014108185A1 (en) 2013-01-09 2014-07-17 Tecan Trading Ag Disposable cartridge for microfluidics systems
WO2014210486A1 (en) 2013-06-28 2014-12-31 Dirk Robert Englund Wide-field sensing using nitrogen vacancies
US9778329B2 (en) 2014-02-19 2017-10-03 Infinitum Solutions, Inc. Integrated optical nanoscale probe measurement of electric fields from electric charges in electronic devices
US9910105B2 (en) 2014-03-20 2018-03-06 Lockheed Martin Corporation DNV magnetic field detector
JP6298728B2 (ja) 2014-06-26 2018-03-20 ルネサスエレクトロニクス株式会社 磁気計測装置
US9435791B2 (en) 2014-06-27 2016-09-06 Verily Life Sciences, LLC Method for using nanodiamonds to detect nearby magnetic nanoparticles
EP3248021A4 (en) 2015-01-23 2018-12-12 Lockheed Martin Corporation Dnv magnetic field detector
JP6655415B2 (ja) 2016-02-16 2020-02-26 ルネサスエレクトロニクス株式会社 磁気計測装置
US10845449B2 (en) 2016-10-20 2020-11-24 Quantum Diamond Technologies Inc. Methods and apparatus for magnetic particle analysis using diamond magnetic imaging
WO2018119367A1 (en) 2016-12-23 2018-06-28 Quantum Diamond Technologies Inc. Methods and apparatus for magnetic multi-bead assays
IT201700017061A1 (it) 2017-02-15 2018-08-15 Technoprobe Spa Scheda di misura perfezionata per applicazioni ad alta frequenza
WO2019027917A1 (en) 2017-07-31 2019-02-07 Quantum Diamond Technologies, Inc METHODS AND APPARATUS FOR SAMPLE MEASUREMENT
JP2023500413A (ja) 2019-11-12 2023-01-05 クアンタム ダイヤモンド テクノロジーズ インク. 磁気ビーズベースの検体検出のためのビーズシステム、方法、および装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010506191A (ja) 2006-10-12 2010-02-25 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 試薬層を有した高速バイオセンサ
JP2013503352A (ja) 2009-08-31 2013-01-31 エムバイオ ダイアグノスティクス,インコーポレイティド 統合されたサンプル調製及び検体検出
JP2012121748A (ja) 2010-12-07 2012-06-28 Sumitomo Electric Ind Ltd ダイヤモンド及びこれを用いた磁気センサー
JP2014095025A (ja) 2012-11-08 2014-05-22 Osaka Univ ダイヤモンド複合粒子
JP2016188828A (ja) 2015-03-30 2016-11-04 東ソー株式会社 磁気信号を利用した標的物質の測定方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
David R Glenn,Single-cell magnetic imaging using a quantum diamond microscope,Nature Methods,2015年,Vol.12,pp.736-738
ISSADORE D.,Magnetic sensing technology for molecular analyses,Lab on a Chip,2014年07月21日,Vol.14 No.14,pp.2385-2397

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JP2020514709A (ja) 2020-05-21
EP3559668B1 (en) 2023-07-19
EP3559668A1 (en) 2019-10-30
US20190331674A1 (en) 2019-10-31
CA3046849A1 (en) 2018-06-28
US20230071162A1 (en) 2023-03-09
US11513115B2 (en) 2022-11-29
WO2018119367A1 (en) 2018-06-28
EP3559668A4 (en) 2020-07-22

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