JP7237951B2 - Ｃｄ３８調節抗体 - Google Patents

Ｃｄ３８調節抗体 Download PDF

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JP7237951B2
JP7237951B2 JP2020518573A JP2020518573A JP7237951B2 JP 7237951 B2 JP7237951 B2 JP 7237951B2 JP 2020518573 A JP2020518573 A JP 2020518573A JP 2020518573 A JP2020518573 A JP 2020518573A JP 7237951 B2 JP7237951 B2 JP 7237951B2
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antibody
seq
sequence
antigen
acd38
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JP2020522281A5 (Direct
JP2020522281A (ja
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パスカル メルヒールス
アンヌ グビエ
ケヴィン モウルダー
ニナ アイスラー
ジョセフィン サリム
シモーヌ フィロスト
コルソ ベアトリス ゴイエンチェア
ヘマンタ バルーア
ビアンカ プリンツ
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ブラック ベルト セラピューティクス リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2020518573A 2017-06-08 2018-06-08 Ｃｄ３８調節抗体 Active JP7237951B2 (ja)

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
US201762517150P 2017-06-08 2017-06-08
US201762517149P 2017-06-08 2017-06-08
US62/517,150 2017-06-08
US62/517,149 2017-06-08
US201762517740P 2017-06-09 2017-06-09
US201762517745P 2017-06-09 2017-06-09
US201762517734P 2017-06-09 2017-06-09
US201762517753P 2017-06-09 2017-06-09
US201762517165P 2017-06-09 2017-06-09
US201762517164P 2017-06-09 2017-06-09
US62/517,165 2017-06-09
US62/517,740 2017-06-09
US62/517,745 2017-06-09
US62/517,734 2017-06-09
US62/517,164 2017-06-09
US62/517,753 2017-06-09
US201762582653P 2017-11-07 2017-11-07
US201762582666P 2017-11-07 2017-11-07
US201762582681P 2017-11-07 2017-11-07
US201762582676P 2017-11-07 2017-11-07
US62/582,681 2017-11-07
US62/582,676 2017-11-07
US62/582,666 2017-11-07
US62/582,653 2017-11-07
PCT/EP2018/065243 WO2018224685A1 (en) 2017-06-08 2018-06-08 Cd38 modulating antibody

Publications (3)

Publication Number Publication Date
JP2020522281A JP2020522281A (ja) 2020-07-30
JP2020522281A5 JP2020522281A5 (Direct) 2021-07-26
JP7237951B2 true JP7237951B2 (ja) 2023-03-13

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JP2020518573A Active JP7237951B2 (ja) 2017-06-08 2018-06-08 Ｃｄ３８調節抗体
JP2020518572A Active JP7237950B2 (ja) 2017-06-08 2018-06-08 Ｃｄ３８調節抗体
JP2022202855A Active JP7467584B2 (ja) 2017-06-08 2022-12-20 Ｃｄ３８調節抗体

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JP2022202855A Active JP7467584B2 (ja) 2017-06-08 2022-12-20 Ｃｄ３８調節抗体

Country Status (8)

Country Link
US (3) US12343394B2 (Direct)
EP (2) EP3635002A1 (Direct)
JP (3) JP7237951B2 (Direct)
KR (3) KR20250025514A (Direct)
CN (2) CN110997723B (Direct)
AU (3) AU2018280869B2 (Direct)
CA (2) CA3066555A1 (Direct)
WO (2) WO2018224685A1 (Direct)

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CN110144008B (zh) * 2018-02-12 2021-03-19 杭州尚健生物技术有限公司 Cd38蛋白抗体及其应用
BR112021012685A2 (pt) 2019-01-11 2021-12-28 Omeros Corp Métodos para tratar câncer, para aumentar o nível de citocinas th1 nas células mononucleares de sangue periférico humanas, para realçar uma resposta imune antitumoral e para estimular e/ou amplificar uma resposta imune em um sujeito mamífero sofrendo de ou em risco de desenvolver câncer ou metástase de câncer, e, composição farmacêutica
KR20210119448A (ko) * 2019-01-23 2021-10-05 앙세파 Cd31 경쟁인자(competitor) 및 이의 용도
KR20210137162A (ko) 2019-03-12 2021-11-17 아르커스 바이오사이언시즈 인코포레이티드 종양유전자-유발 암의 치료
EP3947465A4 (en) * 2019-03-29 2023-01-04 Sorrento Therapeutics, Inc. ANTIBODIES MANIPULATED VARIANTS BINDING TO CD38
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EP4211476A4 (en) * 2020-09-10 2024-11-13 CASI Pharmaceuticals, Inc. BLOOD SCREENING PROCEDURES
CN114457028A (zh) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 一种表达cd38抗体的多能干细胞及其衍生物与应用
CN114437215B (zh) * 2020-11-05 2023-02-07 上海麦济生物技术有限公司 抗人cd38抗体及其制备方法和用途

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Also Published As

Publication number Publication date
AU2025201908A1 (en) 2025-04-03
KR20200021068A (ko) 2020-02-27
NZ760342A (en) 2025-03-28
JP7237950B2 (ja) 2023-03-13
JP7467584B2 (ja) 2024-04-15
AU2018280871A8 (en) 2020-01-30
US12343394B2 (en) 2025-07-01
KR102719065B1 (ko) 2024-10-17
AU2018280869B2 (en) 2025-01-02
US20250367286A1 (en) 2025-12-04
WO2018224683A1 (en) 2018-12-13
KR102770106B1 (ko) 2025-02-21
NZ760448A (en) 2025-03-28
CN110997723A (zh) 2020-04-10
JP2020522280A (ja) 2020-07-30
KR20250025514A (ko) 2025-02-21
AU2018280869A1 (en) 2020-01-16
CN110997723B (zh) 2023-09-26
CN110997722B (zh) 2023-09-26
CN110997722A (zh) 2020-04-10
AU2018280871A1 (en) 2020-01-16
CA3066553A1 (en) 2018-12-13
US20210277138A1 (en) 2021-09-09
JP2020522281A (ja) 2020-07-30
EP3635002A1 (en) 2020-04-15
JP2023030071A (ja) 2023-03-07
WO2018224685A1 (en) 2018-12-13
AU2018280871B2 (en) 2024-09-26
US20230103584A1 (en) 2023-04-06
CA3066555A1 (en) 2018-12-13
EP3635003A1 (en) 2020-04-15
KR20200021069A (ko) 2020-02-27
US12161717B2 (en) 2024-12-10

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