JP7234349B2 - メリチンベースのアポトシース促進ペプチドペプチドでｍ２様腫瘍関連マクロファージの標的化 - Google Patents

メリチンベースのアポトシース促進ペプチドペプチドでｍ２様腫瘍関連マクロファージの標的化 Download PDF

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JP7234349B2
JP7234349B2 JP2021512351A JP2021512351A JP7234349B2 JP 7234349 B2 JP7234349 B2 JP 7234349B2 JP 2021512351 A JP2021512351 A JP 2021512351A JP 2021512351 A JP2021512351 A JP 2021512351A JP 7234349 B2 JP7234349 B2 JP 7234349B2
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ヒュンス ベ
チャン－ジュ リ
ジン－ヒュン ジョン
ドー－ハ リ
ジョン－ドン キム
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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JP2021512351A 2018-05-04 2019-05-07 メリチンベースのアポトシース促進ペプチドペプチドでｍ２様腫瘍関連マクロファージの標的化 Active JP7234349B2 (ja)

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KR10-2018-0051800 2018-05-04
KR20180051800 2018-05-04
PCT/KR2019/005438 WO2019212324A1 (ko) 2018-05-04 2019-05-07 멜리틴-기반 세포사멸 유발 펩타이드로 m2 유사 종앙관련 대식세포의 표적화

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JP2021526548A5 JP2021526548A5 (https=) 2021-11-18
JP7234349B2 true JP7234349B2 (ja) 2023-03-07

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US (1) US11484601B2 (https=)
EP (1) EP3789041A4 (https=)
JP (1) JP7234349B2 (https=)
KR (1) KR102250412B1 (https=)
CN (1) CN112533640B (https=)
AU (1) AU2019264092B2 (https=)
CA (1) CA3099434C (https=)
WO (1) WO2019212324A1 (https=)

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US20240009269A1 (en) * 2020-11-20 2024-01-11 The Johns Hopkins University Membrane-active peptides and methods for reversible blood- brain barrier opening
CA3153060A1 (en) * 2021-05-07 2022-11-07 Twinpig Biolab, Inc. Peptides targeting macrophages, and conjugates, compositions, and uses thereof
US20220354957A1 (en) * 2021-05-07 2022-11-10 Twinpig Biolab, Inc. Peptides targeting macrophages, and conjugates, compositions, and uses thereof
CN113336828B (zh) * 2021-06-30 2022-03-25 中国海洋大学 抗菌肽yhx-3及其组合物和应用
CN114437193A (zh) * 2022-01-29 2022-05-06 陕西未来多肽生物科技有限公司 一种金-蜂毒肽纳米杂化物及其应用
KR20230144960A (ko) * 2022-04-07 2023-10-17 트윈피그바이오랩(주) 신규 펩타이드 기반 면역항암제
WO2023204329A1 (ko) * 2022-04-22 2023-10-26 트윈피그바이오랩(주) 신규 펩타이드 기반 면역항암제
CN115317622B (zh) * 2022-08-12 2025-08-22 青岛科技大学 一种抗肿瘤多肽偶联药物的制备及其应用
CN116589555B (zh) * 2023-03-31 2024-02-06 广东医科大学 一种细胞穿梭肽及其应用
CN119896743B (zh) * 2023-10-26 2025-09-26 华南理工大学 一种基质金属蛋白酶响应的多功能仿生铁蛋白纳米材料及其制备方法与应用
KR20250091126A (ko) * 2023-12-12 2025-06-20 트윈피그바이오랩(주) 신규 펩타이드를 유효성분으로 포함하는 항암제와의 병용투여를 위한 항암 조성물
CN120053399A (zh) * 2025-02-27 2025-05-30 滁州学院 一种蜂毒肽靶向制剂及应用

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JP2002543111A (ja) 1999-05-04 2002-12-17 バイオテック・オーストラリア・ピーティーワイ・リミテッド ポリマーを使用する葉酸で仲介された腫瘍細胞へのターゲッティングの増幅
CN1572797A (zh) 1993-09-08 2005-02-02 拉卓拉药物公司 化学上定义的非聚合价平台分子和其偶联物
US20050196383A1 (en) 2003-11-05 2005-09-08 Zurbriggen Rinaldo E. Compositions and methods for the potentiation of immune responses against target antigens
CN106795205A (zh) 2014-09-04 2017-05-31 迪沃势股份有限公司 新细胞膜穿透肽及其作为生物活性物质传递体的用途

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KR20110117789A (ko) 2010-04-22 2011-10-28 대한민국(농촌진흥청장) 멜리틴을 함유하는 동맥경화 치료용 조성물
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JP2002543111A (ja) 1999-05-04 2002-12-17 バイオテック・オーストラリア・ピーティーワイ・リミテッド ポリマーを使用する葉酸で仲介された腫瘍細胞へのターゲッティングの増幅
US20050196383A1 (en) 2003-11-05 2005-09-08 Zurbriggen Rinaldo E. Compositions and methods for the potentiation of immune responses against target antigens
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US20210244823A1 (en) 2021-08-12
CA3099434A1 (en) 2019-11-04
AU2019264092A8 (en) 2021-01-07
WO2019212324A1 (ko) 2019-11-07
KR102250412B1 (ko) 2021-05-17
US11484601B2 (en) 2022-11-01
EP3789041A4 (en) 2022-07-13
CN112533640B (zh) 2025-02-28
CN112533640A (zh) 2021-03-19
EP3789041A1 (en) 2021-03-10
KR20190127609A (ko) 2019-11-13
AU2019264092B2 (en) 2024-02-15
CA3099434C (en) 2023-09-05
AU2019264092A1 (en) 2020-12-24
JP2021526548A (ja) 2021-10-07

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