JP7213799B2 - 非細胞傷害性改変細胞およびその使用 - Google Patents

非細胞傷害性改変細胞およびその使用 Download PDF

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JP7213799B2
JP7213799B2 JP2019519313A JP2019519313A JP7213799B2 JP 7213799 B2 JP7213799 B2 JP 7213799B2 JP 2019519313 A JP2019519313 A JP 2019519313A JP 2019519313 A JP2019519313 A JP 2019519313A JP 7213799 B2 JP7213799 B2 JP 7213799B2
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モンソネゴ，アロン
ポルガドール，アングル
アトラス，ロエー
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ザ ナショナル インスティチュート フォー バイオテクノロジー イン ザ ネゲヴ，リミテッド
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
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JP2019519313A 2016-10-10 2017-10-10 非細胞傷害性改変細胞およびその使用 Active JP7213799B2 (ja)

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US201662406005P 2016-10-10 2016-10-10
US62/406,005 2016-10-10
PCT/IL2017/051133 WO2018069927A1 (en) 2016-10-10 2017-10-10 Non-cytotoxic modified cells and use thereof

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JP2020503841A5 JP2020503841A5 (https=) 2020-11-12
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US (2) US12098202B2 (https=)
EP (1) EP3522936A4 (https=)
JP (1) JP7213799B2 (https=)
CN (1) CN110022907A (https=)
AU (1) AU2017342176A1 (https=)
CA (1) CA3039774A1 (https=)
IL (1) IL265962B2 (https=)
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JP2021514187A (ja) * 2018-02-15 2021-06-10 ザ ナショナル インスティテュート フォー バイオテクノロジー イン ザ ネゲヴ リミテッドＴｈｅ Ｎａｔｉｏｎａｌ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｉｎ Ｔｈｅ Ｎｅｇｅｖ Ｌｔｄ． キメラ抗原受容体の腫瘍環境特異的発現
EP3768707A4 (en) * 2018-03-19 2022-01-26 The Invention Science Fund II, LLC COMPOSITIONS AND METHODS FOR MODIFIED B CELLS EXPRESSING REALIZED BIOLOGICAL AGENTS
CN110357962B (zh) * 2018-07-06 2021-11-26 北京天成新脉生物技术有限公司 低adcc/cdc功能性单抗及其制备方法与应用
US12473361B2 (en) 2019-01-11 2025-11-18 The Wistar Institute Of Anatomy And Biology DNA monoclonal antibodies targeting PD-1 for the treatment and prevention of cancer
US20240424167A1 (en) * 2021-04-27 2024-12-26 Beijing Biosis Healing Biological Technology Co., Ltd. Chimeric peptide-modified sis membrane, preparation method therefor and application thereof
CN117736329B (zh) * 2023-12-25 2024-11-12 华润生物医药有限公司 抗pd-1抗体及其用途

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