JP7213188B2 - Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド - Google Patents

Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド Download PDF

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JP7213188B2
JP7213188B2 JP2019540532A JP2019540532A JP7213188B2 JP 7213188 B2 JP7213188 B2 JP 7213188B2 JP 2019540532 A JP2019540532 A JP 2019540532A JP 2019540532 A JP2019540532 A JP 2019540532A JP 7213188 B2 JP7213188 B2 JP 7213188B2
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compound
pharmaceutically acceptable
cancer
compounds
formula
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JP2020514316A (ja
JP2020514316A5 (https=
Inventor
エマニュエル，スチュアート
リヒター，マーク
ジェイ． コノリー，ピーター
パトリック エドワーズ，ジェームス
ワン，グアンイ
クマール タティコンダ，サンソッシュ
ベイゲルマン，レオニド
ゾン，ミンホン
ビグナン，ギルス
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ヤンセン バイオテツク，インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2019540532A 2017-01-27 2018-01-26 Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド Active JP7213188B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022129286A JP2022163188A (ja) 2017-01-27 2022-08-15 Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762451285P 2017-01-27 2017-01-27
US62/451,285 2017-01-27
US201762454131P 2017-02-03 2017-02-03
US62/454,131 2017-02-03
PCT/IB2018/050497 WO2018138684A1 (en) 2017-01-27 2018-01-26 Cyclic dinucleotides as sting agonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022129286A Division JP2022163188A (ja) 2017-01-27 2022-08-15 Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド

Publications (3)

Publication Number Publication Date
JP2020514316A JP2020514316A (ja) 2020-05-21
JP2020514316A5 JP2020514316A5 (https=) 2021-03-04
JP7213188B2 true JP7213188B2 (ja) 2023-01-26

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JP2019540532A Active JP7213188B2 (ja) 2017-01-27 2018-01-26 Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド
JP2022129286A Pending JP2022163188A (ja) 2017-01-27 2022-08-15 Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド

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Country Link
US (1) US11021511B2 (https=)
EP (1) EP3573717B1 (https=)
JP (2) JP7213188B2 (https=)
CN (1) CN110234404A (https=)
AU (1) AU2018212787B2 (https=)
ES (1) ES2891326T3 (https=)
WO (1) WO2018138684A1 (https=)

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US11110106B2 (en) 2018-10-29 2021-09-07 Venenum Biodesign, LLC Sting agonists for treating bladder cancer and solid tumors
WO2020092127A1 (en) 2018-10-29 2020-05-07 Venenum Biodesign, LLC Novel sting agonists
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WO2020227159A2 (en) 2019-05-03 2020-11-12 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity
WO2020227421A1 (en) 2019-05-09 2020-11-12 Aligos Therapeutics, Inc. Modified cyclic dinucleoside compounds as sting modulators
WO2021007160A1 (en) 2019-07-05 2021-01-14 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
TW202200136A (zh) 2020-04-10 2022-01-01 日商小野藥品工業股份有限公司 癌治療方法
WO2021252904A1 (en) * 2020-06-11 2021-12-16 Massachusetts Institute Of Technology Ribonucleoprotein approach to boost the sting signaling for cancer immunotherapy
CN116056765A (zh) 2020-08-07 2023-05-02 坦伯公司 反式环辛烯生物正交剂及在癌症和免疫疗法中的用途
IL302390A (en) 2020-11-09 2023-06-01 Takeda Pharmaceuticals Co Drug antibody conjugates
IL310724A (en) 2021-08-10 2024-04-01 Ifm Due Inc COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH STING ACTIVITY
CN120757600B (zh) * 2025-09-10 2025-11-11 天津法尔玛制药有限公司 环二核苷酸2′,3′-cG4′-MeAMP、制备方法及其在制备先天免疫激活剂中的应用

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WO2016100261A2 (en) 2014-12-17 2016-06-23 Lipogen Llc Method of treating cancer with cgamp or cgasmp
JP2018522914A (ja) 2015-08-13 2018-08-16 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド化合物
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Also Published As

Publication number Publication date
CN110234404A (zh) 2019-09-13
ES2891326T3 (es) 2022-01-27
EP3573717B1 (en) 2021-07-28
AU2018212787A1 (en) 2019-07-25
WO2018138684A1 (en) 2018-08-02
US20190375781A1 (en) 2019-12-12
JP2020514316A (ja) 2020-05-21
AU2018212787B2 (en) 2023-10-26
EP3573717A1 (en) 2019-12-04
US11021511B2 (en) 2021-06-01
JP2022163188A (ja) 2022-10-25

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