JP7200120B2 - Mk2阻害剤として有用なヘテロアリール化合物 - Google Patents

Mk2阻害剤として有用なヘテロアリール化合物 Download PDF

Info

Publication number
JP7200120B2
JP7200120B2 JP2019550579A JP2019550579A JP7200120B2 JP 7200120 B2 JP7200120 B2 JP 7200120B2 JP 2019550579 A JP2019550579 A JP 2019550579A JP 2019550579 A JP2019550579 A JP 2019550579A JP 7200120 B2 JP7200120 B2 JP 7200120B2
Authority
JP
Japan
Prior art keywords
formula
hydrogen
deuterium
certain embodiments
oglu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019550579A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020512315A5 (enExample
JP2020512315A (ja
Inventor
ジアン・グオ
ジョン・マロナ
アレクサンダー・エル・ルチェルマン
セカル・エス・スラパネニ
Original Assignee
セルジーン シーエーアール エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by セルジーン シーエーアール エルエルシー filed Critical セルジーン シーエーアール エルエルシー
Publication of JP2020512315A publication Critical patent/JP2020512315A/ja
Publication of JP2020512315A5 publication Critical patent/JP2020512315A5/ja
Application granted granted Critical
Publication of JP7200120B2 publication Critical patent/JP7200120B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2019550579A 2017-03-16 2018-03-15 Mk2阻害剤として有用なヘテロアリール化合物 Active JP7200120B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762472019P 2017-03-16 2017-03-16
US62/472,019 2017-03-16
PCT/US2018/022544 WO2018170200A1 (en) 2017-03-16 2018-03-15 Heteroaryl compounds useful as mk2 inhibitors

Publications (3)

Publication Number Publication Date
JP2020512315A JP2020512315A (ja) 2020-04-23
JP2020512315A5 JP2020512315A5 (enExample) 2021-04-30
JP7200120B2 true JP7200120B2 (ja) 2023-01-06

Family

ID=63523329

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019550579A Active JP7200120B2 (ja) 2017-03-16 2018-03-15 Mk2阻害剤として有用なヘテロアリール化合物

Country Status (4)

Country Link
US (2) US11124525B2 (enExample)
EP (1) EP3596083A4 (enExample)
JP (1) JP7200120B2 (enExample)
WO (1) WO2018170200A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023051962A (ja) * 2017-03-16 2023-04-11 セルジーン シーエーアール エルエルシー 9,10,11,12-テトラヒドロ-8h-[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2-f]キノリン-8-オン化合物およびその使用

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20210529T1 (hr) 2014-09-17 2021-08-06 Celgene Car Llc Inhibitori za mk2 i njihove uporabe
WO2018170201A1 (en) * 2017-03-16 2018-09-20 Celgene Car Llc Deuterated analogs of mk2 inhibitors and uses thereof
AU2018236290B2 (en) 2017-03-16 2022-06-02 Bristol-Myers Squibb Company MK2 inhibitors, synthesis thereof, and intermediates thereto
AU2018236286B2 (en) 2017-03-16 2022-02-17 Bristol-Myers Squibb Company Forms and compositions of a MK2 inhibitor
EP3596083A4 (en) 2017-03-16 2020-12-02 Celgene CAR LLC USEFUL HETERARYL COMPOUNDS AS MK2 INHIBITORS
KR20220041042A (ko) * 2019-05-17 2022-03-31 셀젠 카르 엘엘씨 Mk2-매개 장애를 치료하는 방법
US12049470B2 (en) 2021-02-01 2024-07-30 Celgene Corporation MK2 inhibitors, the synthesis thereof, and intermediates thereto
WO2023025298A1 (zh) * 2021-08-27 2023-03-02 瑞石生物医药有限公司 喹啉并呋喃衍生物及其用途
WO2023134764A1 (zh) 2022-01-14 2023-07-20 上海翰森生物医药科技有限公司 含吡啶多环类衍生物、其制备方法和应用
CN115925718A (zh) * 2022-12-27 2023-04-07 瑞石生物医药有限公司 一种四环内酰胺衍生物及其用途
WO2024229401A2 (en) * 2023-05-04 2024-11-07 Matchpoint Therapeutics Inc. Diazepino-thieno-quinoxaline compounds and their use in therapy

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016032882A1 (en) 2014-08-25 2016-03-03 Stc.Unm Inhibition of mk2 in the treatment of cancer
WO2016044463A2 (en) 2014-09-17 2016-03-24 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof
JP2016518316A (ja) 2013-03-15 2016-06-23 セルジーン アビロミクス リサーチ, インコーポレイテッド Mk2阻害剤およびそれらの使用
JP2020510063A (ja) 2017-03-16 2020-04-02 セルジーン シーエーアール エルエルシー Mk2阻害剤、その合成、およびそれに至るまでの中間体
JP2020511468A (ja) 2017-03-16 2020-04-16 セルジーン シーエーアール エルエルシー Mk2阻害剤の重水素化アナログおよびその使用
JP2020514361A (ja) 2017-03-16 2020-05-21 セルジーン シーエーアール エルエルシー 9,10,11,12−テトラヒドロ−8h−[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2−f]キノリン−8−オン化合物およびその使用
JP2020514360A (ja) 2017-03-16 2020-05-21 セルジーン シーエーアール エルエルシー Mk2阻害剤の形態および組成物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015778A (en) 1989-12-18 1991-05-14 The Dow Chemical Company Catalytic method to produce hydroxy substituted arylophenones
WO1995026325A2 (en) * 1994-03-25 1995-10-05 Isotechnika Inc. Enhancement of the efficacy of drugs by deuteration
US5441946A (en) 1994-04-14 1995-08-15 Rhone-Poulenc-Rorer Pharmaceuticals, Inc. Phosphonate derivatives of lipophilic amines
TW200413273A (en) 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
CA2510298A1 (en) 2002-12-20 2004-07-15 Pharmacia Corporation Acyclic pyrazole compounds
US20060106020A1 (en) 2004-04-28 2006-05-18 Rodgers James D Tetracyclic inhibitors of Janus kinases
CA2693904A1 (en) 2007-07-16 2009-01-22 Novartis Ag Heterocyclic compounds useful as mk2 inhibitors
WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
NZ604716A (en) 2010-07-02 2014-12-24 Gilead Sciences Inc 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
CA2815169C (en) 2010-10-29 2015-10-06 Pfizer Inc. N1/n2-lactam acetyl-coa carboxylase inhibitors
HK1210696A1 (en) 2012-07-11 2016-05-06 Nimbus Iris, Inc. Irak inhibitors and uses thereof
EP3596083A4 (en) 2017-03-16 2020-12-02 Celgene CAR LLC USEFUL HETERARYL COMPOUNDS AS MK2 INHIBITORS
KR20220041042A (ko) 2019-05-17 2022-03-31 셀젠 카르 엘엘씨 Mk2-매개 장애를 치료하는 방법
EP4185382A4 (en) 2020-07-24 2024-09-04 Bristol-Myers Squibb Company Methods of treating acute respiratory disorders
US12049470B2 (en) 2021-02-01 2024-07-30 Celgene Corporation MK2 inhibitors, the synthesis thereof, and intermediates thereto

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016518316A (ja) 2013-03-15 2016-06-23 セルジーン アビロミクス リサーチ, インコーポレイテッド Mk2阻害剤およびそれらの使用
WO2016032882A1 (en) 2014-08-25 2016-03-03 Stc.Unm Inhibition of mk2 in the treatment of cancer
WO2016044463A2 (en) 2014-09-17 2016-03-24 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof
JP2020510063A (ja) 2017-03-16 2020-04-02 セルジーン シーエーアール エルエルシー Mk2阻害剤、その合成、およびそれに至るまでの中間体
JP2020511468A (ja) 2017-03-16 2020-04-16 セルジーン シーエーアール エルエルシー Mk2阻害剤の重水素化アナログおよびその使用
JP2020514361A (ja) 2017-03-16 2020-05-21 セルジーン シーエーアール エルエルシー 9,10,11,12−テトラヒドロ−8h−[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2−f]キノリン−8−オン化合物およびその使用
JP2020514360A (ja) 2017-03-16 2020-05-21 セルジーン シーエーアール エルエルシー Mk2阻害剤の形態および組成物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANDERSON,D.R. et al.,Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency,Bioorganic & Medicinal Chemistry Letters,2009年,Vol.19, No.16,p.4882-4884
NATESAN,S. et al.,Binding Affinity Prediction for Ligands and Receptors Forming Tautomers and Ionization Species: Inhibition of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2),Journal of Medicinal Chemistry,2012年,Vol.55, No.5,p.2035-2047

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023051962A (ja) * 2017-03-16 2023-04-11 セルジーン シーエーアール エルエルシー 9,10,11,12-テトラヒドロ-8h-[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2-f]キノリン-8-オン化合物およびその使用

Also Published As

Publication number Publication date
US20220064183A1 (en) 2022-03-03
EP3596083A1 (en) 2020-01-22
US11760763B2 (en) 2023-09-19
JP2020512315A (ja) 2020-04-23
EP3596083A4 (en) 2020-12-02
WO2018170200A1 (en) 2018-09-20
US20200102325A1 (en) 2020-04-02
US11124525B2 (en) 2021-09-21

Similar Documents

Publication Publication Date Title
JP7200120B2 (ja) Mk2阻害剤として有用なヘテロアリール化合物
JP7394074B2 (ja) 治療用化合物
JP2020511468A (ja) Mk2阻害剤の重水素化アナログおよびその使用
JP5406725B2 (ja) タンパク質キナーゼ阻害剤として有用な化合物
JP6802251B2 (ja) 癌の処置のためのdub阻害剤としてのシアノピロリジン
CN108602776B (zh) 用作irak抑制剂的杂芳基化合物及其用途
KR101432316B1 (ko) 증식성 장애의 치료를 위한 단백질 키나제 plk1 억제제로서의 4,5-디히드로-[1,2,4]트리아졸로[4,3-f]프테리딘
EP4092024A1 (en) Pyrimidine-4(3h)-ketone heterocyclic compound, preparation method therefor and use thereof in medicine and pharmacology
AU2019382504B2 (en) Cyclic ureas
JP2023051962A (ja) 9,10,11,12-テトラヒドロ-8h-[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2-f]キノリン-8-オン化合物およびその使用
TW202023550A (zh) 作為vanin抑制劑之雜芳族化合物
CA3120037A1 (en) Heteroaromatic compounds as vanin inhibitors
CN117279636A (zh) 用于调节强直性肌营养不良1型的方法和化合物
JP2009538305A (ja) プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド
EP4596544A1 (en) Ep300/cbp regulator, and preparation method therefor and use thereof
JP2023526839A (ja) アゼチジン環状尿素類
WO2025114459A1 (en) Tetracyclic compounds for use in antibody-drug conjugates for the treatment of cancer
HK40043591B (zh) 用作ii型irak抑制剂的杂芳基化合物及其用途
HK1141512A (en) Compounds useful as protein kinase inhibitors
HK1253238B (en) Gls1 inhibitors for treating disease
HK1253238A1 (en) Gls1 inhibitors for treating disease

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210312

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210312

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20211130

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220228

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220323

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220517

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220729

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20221206

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20221221

R150 Certificate of patent or registration of utility model

Ref document number: 7200120

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350