JP7198813B2 - 気泡迂回領域を備えるマイクロ流体デバイス - Google Patents

気泡迂回領域を備えるマイクロ流体デバイス Download PDF

Info

Publication number
JP7198813B2
JP7198813B2 JP2020518628A JP2020518628A JP7198813B2 JP 7198813 B2 JP7198813 B2 JP 7198813B2 JP 2020518628 A JP2020518628 A JP 2020518628A JP 2020518628 A JP2020518628 A JP 2020518628A JP 7198813 B2 JP7198813 B2 JP 7198813B2
Authority
JP
Japan
Prior art keywords
region
microchannel
bubble
substrate
observed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020518628A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020536724A (ja
JP2020536724A5 (enExample
Inventor
マダディ ホジャット
マイケル ウィルシェア トーマス
オハロラン ジョナサン
トーマス スカリー フィリップ
マーシャル ポール
ボアダ エドゥアルド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
QuantumDx Group Ltd
Original Assignee
QuantumDx Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by QuantumDx Group Ltd filed Critical QuantumDx Group Ltd
Publication of JP2020536724A publication Critical patent/JP2020536724A/ja
Publication of JP2020536724A5 publication Critical patent/JP2020536724A5/ja
Application granted granted Critical
Publication of JP7198813B2 publication Critical patent/JP7198813B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0854—Double walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP2020518628A 2017-10-16 2018-10-15 気泡迂回領域を備えるマイクロ流体デバイス Active JP7198813B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1716961.6A GB201716961D0 (en) 2017-10-16 2017-10-16 Microfluidic devices with bubble diversion
GB1716961.6 2017-10-16
PCT/GB2018/052958 WO2019077323A1 (en) 2017-10-16 2018-10-15 MICROFLUIDIC DEVICES WITH BUBBLE DEVIATION

Publications (3)

Publication Number Publication Date
JP2020536724A JP2020536724A (ja) 2020-12-17
JP2020536724A5 JP2020536724A5 (enExample) 2021-09-16
JP7198813B2 true JP7198813B2 (ja) 2023-01-04

Family

ID=60419290

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020518628A Active JP7198813B2 (ja) 2017-10-16 2018-10-15 気泡迂回領域を備えるマイクロ流体デバイス

Country Status (6)

Country Link
US (1) US11596944B2 (enExample)
EP (1) EP3697532A1 (enExample)
JP (1) JP7198813B2 (enExample)
CN (1) CN111212688B (enExample)
GB (1) GB201716961D0 (enExample)
WO (1) WO2019077323A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018183744A1 (en) 2017-03-29 2018-10-04 The Research Foundation For The State University Of New York Microfluidic device and methods
WO2019107763A1 (ko) 2017-11-28 2019-06-06 인제대학교 산학협력단 다공성 박막을 이용하여 채널 내 미세 버블의 제거가 가능한 마이크로 플루이딕 디바이스와 버블 유입 방지용 시료주입 장치 및 이형필름을 이용한 미세유체 소자의 패널 본딩방법
CN110354523B (zh) * 2019-07-14 2024-02-06 河北龙亿环境工程有限公司 一种具有多微孔气泡罩的新型塔板
GB2636565A (en) 2023-11-16 2025-06-25 Quantumdx Group Ltd Flow regulators for the control of liquid fronts in microfluidic structures

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520409A (ja) 2004-11-16 2008-06-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロ流体素子
WO2011050110A1 (en) 2009-10-20 2011-04-28 Boston Microfluidics Methods and systems to collect and prepare samples, to implement, initiate and perform assays, and to control and manage fluid flow
US20150101422A1 (en) 2012-05-14 2015-04-16 Nanoentek, Inc. Sample analyzing chip
JP2017508956A (ja) 2014-02-10 2017-03-30 ナノバイオシス インコーポレーテッドＮａｎｏｂｉｏｓｙｓ Ｉｎｃ． 微少流体チップ及びこれを用いたリアルタイム分析装置
JP2017122618A (ja) 2016-01-06 2017-07-13 信越ポリマー株式会社 分析用基板およびその製造方法
JP2017519996A (ja) 2014-07-10 2017-07-20 ナノバイオシス インコーポレーテッドＮａｎｏｂｉｏｓｙｓ Ｉｎｃ． マイクロ流体チップ、その製造方法及びそれを用いた分析装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635226B1 (en) * 1994-10-19 2003-10-21 Agilent Technologies, Inc. Microanalytical device and use thereof for conducting chemical processes
US20080317632A1 (en) 2005-03-01 2008-12-25 Rohm Co., Ltd. Microchannel and Microfluid Chip
JP4685611B2 (ja) 2005-12-02 2011-05-18 株式会社エンプラス 微小流体装置
US9962698B2 (en) * 2012-09-05 2018-05-08 President And Fellows Of Harvard College Removing bubbles in microfluidic systems
JP2015166707A (ja) * 2014-03-04 2015-09-24 キヤノン株式会社 マイクロ流路デバイス
US20150352547A1 (en) 2014-06-06 2015-12-10 Berkeley Lights, Inc. Isolating Microfluidic Structures and Trapping Bubbles
KR101696259B1 (ko) * 2014-07-23 2017-01-13 나노바이오시스 주식회사 멀티플렉스 ｐｃｒ 칩 및 이를 포함하는 멀티플렉스 ｐｃｒ 장치
EP2985063A1 (en) 2014-08-15 2016-02-17 Carpegen GmbH Device for separating bubbles from a fluid
CN104225964B (zh) * 2014-09-17 2016-09-28 清华大学 微流体气泡排除装置及其制备方法以及微流体器件
JP6665548B2 (ja) * 2015-03-06 2020-03-13 ソニー株式会社 マイクロチップ、並びに分析装置及び分析方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520409A (ja) 2004-11-16 2008-06-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロ流体素子
WO2011050110A1 (en) 2009-10-20 2011-04-28 Boston Microfluidics Methods and systems to collect and prepare samples, to implement, initiate and perform assays, and to control and manage fluid flow
US20150101422A1 (en) 2012-05-14 2015-04-16 Nanoentek, Inc. Sample analyzing chip
JP2017508956A (ja) 2014-02-10 2017-03-30 ナノバイオシス インコーポレーテッドＮａｎｏｂｉｏｓｙｓ Ｉｎｃ． 微少流体チップ及びこれを用いたリアルタイム分析装置
JP2017519996A (ja) 2014-07-10 2017-07-20 ナノバイオシス インコーポレーテッドＮａｎｏｂｉｏｓｙｓ Ｉｎｃ． マイクロ流体チップ、その製造方法及びそれを用いた分析装置
JP2017122618A (ja) 2016-01-06 2017-07-13 信越ポリマー株式会社 分析用基板およびその製造方法

Also Published As

Publication number Publication date
CN111212688A (zh) 2020-05-29
US20200298232A1 (en) 2020-09-24
WO2019077323A1 (en) 2019-04-25
CN111212688B (zh) 2022-06-17
EP3697532A1 (en) 2020-08-26
GB201716961D0 (en) 2017-11-29
JP2020536724A (ja) 2020-12-17
US11596944B2 (en) 2023-03-07

Similar Documents

Publication Publication Date Title
JP7198813B2 (ja) 気泡迂回領域を備えるマイクロ流体デバイス
JP4888394B2 (ja) マイクロリアクタおよびそれを用いた送液方法
US12435329B2 (en) Capillary barriers for staged loading of microfluidic devices
CN103210079B (zh) 用于聚合酶链式反应的可增压筒
JP6516761B2 (ja) 微少流体チップ及びこれを用いたリアルタイム分析装置
US20120245042A1 (en) Debubbler for microfluidic systems
JP2018511779A (ja) スペーサによって分離された個別液体体積の配列を供給するためのマイクロ流体プローブ・ヘッド
TWI678522B (zh) 檢體萃取及製備裝置
CN105555406B (zh) 用于执行聚合酶链式反应的分析单元、用于运行以及用于制造这样的分析单元的方法
JP2018522220A (ja) 連続気相を伴うマイクロ流体チップにおける水滴の生成及び捕捉
US20170274379A1 (en) Device for separating bubbles from a fluid
JP6665548B2 (ja) マイクロチップ、並びに分析装置及び分析方法
US20170241977A1 (en) Vacuum-assisted plasma separation
Jiang et al. A microfluidic chip for blood plasma separation using electro-osmotic flow control
CN107429301A (zh) 用于分析核酸的方法和系统
US11255769B2 (en) Up-concentration and size sorting of nanoparticles in microfluidic devices
JP2016165704A (ja) マイクロ流路チップ及びマイクロ流路装置
JP2007244389A (ja) 核酸増幅基板
JP2013208127A (ja) マイクロ反応容器及びマイクロ反応容器を用いたポリメラーゼ連鎖反応方法
KR20120061579A (ko) 수력학 필터, 이를 구비한 필터링 장치 및 이에 의한 필터링 방법
JP7404639B2 (ja) 流路構造体への流体充填方法
CN110191944A (zh) 微尺度细胞过滤器
JP2006115741A (ja) 核酸増幅基板
US20210299659A1 (en) Liquid handling device and liquid handling method
WO2019230485A1 (ja) カートリッジ

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210803

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210803

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220517

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220621

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220916

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20221213

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20221219

R150 Certificate of patent or registration of utility model

Ref document number: 7198813

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250