JP7194440B2 - 心臓病変を改善するための方法 - Google Patents
心臓病変を改善するための方法 Download PDFInfo
- Publication number
- JP7194440B2 JP7194440B2 JP2019532072A JP2019532072A JP7194440B2 JP 7194440 B2 JP7194440 B2 JP 7194440B2 JP 2019532072 A JP2019532072 A JP 2019532072A JP 2019532072 A JP2019532072 A JP 2019532072A JP 7194440 B2 JP7194440 B2 JP 7194440B2
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- Prior art keywords
- plasminogen
- administered
- mice
- agents
- pbs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016110168 | 2016-12-15 | ||
| CNPCT/CN2016/110168 | 2016-12-15 | ||
| CN2016110174 | 2016-12-15 | ||
| CNPCT/CN2016/110172 | 2016-12-15 | ||
| CN2016110172 | 2016-12-15 | ||
| CNPCT/CN2016/110174 | 2016-12-15 | ||
| PCT/CN2017/089068 WO2018107707A1 (zh) | 2016-12-15 | 2017-06-19 | 一种改善心脏病变的方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502155A JP2020502155A (ja) | 2020-01-23 |
| JP2020502155A5 JP2020502155A5 (cg-RX-API-DMAC7.html) | 2020-08-06 |
| JP7194440B2 true JP7194440B2 (ja) | 2022-12-22 |
Family
ID=62558191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019532072A Active JP7194440B2 (ja) | 2016-12-15 | 2017-06-19 | 心臓病変を改善するための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11389515B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3556385A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7194440B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110114081A (cg-RX-API-DMAC7.html) |
| CA (1) | CA3047175A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI677348B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018107707A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3047175A1 (en) | 2016-12-15 | 2018-06-21 | Talengen International Limited | Method for mitigating heart disease |
| WO2018107690A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗肥胖症的方法 |
| WO2018107697A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗肺纤维化的方法 |
| CN110114079A (zh) | 2016-12-15 | 2019-08-09 | 泰伦基国际有限公司 | 一种预防和治疗肥胖症的方法和药物 |
| JP7335609B2 (ja) | 2017-06-19 | 2023-08-30 | タレンゲン インターナショナル リミテッド | Glp-1/glp-1rを調節制御する方法および薬剤 |
Citations (4)
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|---|---|---|---|---|
| JP2005507244A (ja) | 2001-08-10 | 2005-03-17 | ノバルティス アクチエンゲゼルシャフト | アテローム硬化性病変に結合するペプチド |
| JP2005525798A (ja) | 2002-02-06 | 2005-09-02 | トロムスドルフ ゲーエムベーハー ウント コー.カーゲー アルツナイミッテル | 微生物内での組み換えタンパク質の生産方法 |
| JP2008534508A (ja) | 2005-03-22 | 2008-08-28 | メドスター ヘルス インコーポレイテッド | 心血管疾患を診断および処置するための送達システムおよび方法 |
| JP6783870B2 (ja) | 2015-12-18 | 2020-11-11 | タレンゲン インターナショナル リミテッドTalengen International Limited | 心血管病を予防及び治療するための新しい方法 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4245051A (en) | 1978-03-30 | 1981-01-13 | Rockefeller University | Human serum plasminogen activator |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| JPS62153224A (ja) | 1985-12-27 | 1987-07-08 | Green Cross Corp:The | プラスミノゲン製剤 |
| GB8721951D0 (en) * | 1987-09-18 | 1987-10-28 | Thrombosis Research Trust | Organic compounds |
| JP2764264B2 (ja) | 1987-10-01 | 1998-06-11 | 株式会社ミドリ十字 | 線溶活性増強剤 |
| AT402367B (de) | 1990-10-11 | 1997-04-25 | Immuno Ag | Pharmazeutische zubereitung auf basis von lys-plasminogen |
| AU4661493A (en) | 1992-07-01 | 1994-01-31 | Beth Israel Hospital Boston | Enhancement of thrombolytic therapy with deglycosylated plasminogen |
| US5520912A (en) | 1993-07-02 | 1996-05-28 | Immuno Aktiengesellschaft | Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen |
| DK125693D0 (cg-RX-API-DMAC7.html) | 1993-11-05 | 1993-11-05 | Novo Nordisk As | |
| DE4411143C2 (de) | 1994-03-30 | 1996-08-01 | Immuno Ag | Thrombosemittel |
| PT2275119E (pt) | 1995-07-27 | 2013-11-21 | Genentech Inc | Formulação de proteína liofilizada isotónica estável |
| AU7951798A (en) | 1997-06-26 | 1999-01-19 | Karolinska Innovations Ab | Kringle domains 1-5 of plasminogen, capable of modulating angiogenesis in vivo |
| US7317003B2 (en) | 1998-09-04 | 2008-01-08 | National University Of Singapore | Small peptides having anti-angiogenic and endothelial cell inhibition activity |
| WO2000049871A1 (en) | 1999-02-24 | 2000-08-31 | Henry Ford Health System | An anti-angiogenic kringle protein and its mutants |
| US6899877B2 (en) | 1999-03-09 | 2005-05-31 | Minu, L.L.C. | Process for generating plasmin in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina |
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| CN101563100B (zh) | 2006-08-28 | 2013-08-07 | 李季男 | 用于预防和治疗牙周病、改善牙周创伤愈合以及促进口腔健康的新药物靶标 |
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| DK3395354T3 (da) | 2015-12-18 | 2024-06-03 | Talengen Int Ltd | Plasminogen til anvendelse i behandling af diabetisk nefropati |
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| ES2982294T3 (es) | 2015-12-18 | 2024-10-15 | Talengen Int Ltd | Plasminógeno para su uso en el tratamiento o prevención de lesiones nerviosas por diabetes mellitus |
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| CA3047175A1 (en) | 2016-12-15 | 2018-06-21 | Talengen International Limited | Method for mitigating heart disease |
| WO2018107690A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗肥胖症的方法 |
| CN110114079A (zh) | 2016-12-15 | 2019-08-09 | 泰伦基国际有限公司 | 一种预防和治疗肥胖症的方法和药物 |
| TWI868051B (zh) | 2017-06-23 | 2025-01-01 | 美商波麥堤克生物治療股份有限公司 | 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療 |
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-
2017
- 2017-06-19 CA CA3047175A patent/CA3047175A1/en not_active Abandoned
- 2017-06-19 WO PCT/CN2017/089068 patent/WO2018107707A1/zh not_active Ceased
- 2017-06-19 CN CN201780078125.8A patent/CN110114081A/zh active Pending
- 2017-06-19 JP JP2019532072A patent/JP7194440B2/ja active Active
- 2017-06-19 EP EP17880564.4A patent/EP3556385A4/en active Pending
- 2017-06-19 TW TW106120460A patent/TWI677348B/zh active
- 2017-06-19 US US16/470,160 patent/US11389515B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005507244A (ja) | 2001-08-10 | 2005-03-17 | ノバルティス アクチエンゲゼルシャフト | アテローム硬化性病変に結合するペプチド |
| JP2005525798A (ja) | 2002-02-06 | 2005-09-02 | トロムスドルフ ゲーエムベーハー ウント コー.カーゲー アルツナイミッテル | 微生物内での組み換えタンパク質の生産方法 |
| JP2008534508A (ja) | 2005-03-22 | 2008-08-28 | メドスター ヘルス インコーポレイテッド | 心血管疾患を診断および処置するための送達システムおよび方法 |
| JP6783870B2 (ja) | 2015-12-18 | 2020-11-11 | タレンゲン インターナショナル リミテッドTalengen International Limited | 心血管病を予防及び治療するための新しい方法 |
Non-Patent Citations (3)
| Title |
|---|
| Academic Journal of Shanghai Second Medical University,2005年,Vol.25, No.2,pp.151-154 |
| BIOSIS [online]; Biological Abstracts Inc., Retrieved from STN,BIOSIS Accession No.2002:354449,(Entered STN: 2002) |
| Journal of Thrombosis and Haemostasis,2009年,Vol.8,pp.194-201 |
Also Published As
| Publication number | Publication date |
|---|---|
| US11389515B2 (en) | 2022-07-19 |
| EP3556385A4 (en) | 2020-12-30 |
| TWI677348B (zh) | 2019-11-21 |
| CA3047175A1 (en) | 2018-06-21 |
| TW201822798A (zh) | 2018-07-01 |
| CN110114081A (zh) | 2019-08-09 |
| JP2020502155A (ja) | 2020-01-23 |
| US20190343931A1 (en) | 2019-11-14 |
| WO2018107707A1 (zh) | 2018-06-21 |
| EP3556385A1 (en) | 2019-10-23 |
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