JP7179030B2 - Ｒｏｒ１ ｃａｒ ｔ細胞 - Google Patents

Ｒｏｒ１ ｃａｒ ｔ細胞 Download PDF

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JP7179030B2
JP7179030B2 JP2019572402A JP2019572402A JP7179030B2 JP 7179030 B2 JP7179030 B2 JP 7179030B2 JP 2019572402 A JP2019572402 A JP 2019572402A JP 2019572402 A JP2019572402 A JP 2019572402A JP 7179030 B2 JP7179030 B2 JP 7179030B2
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amino acid
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acid sequence
set forth
chain variable
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JP2020529838A (ja
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ナスワニ，アミット
ゴヒル，サティエン
ペルタ，マルコ デラ
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UCL Business Ltd
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61K40/41—Vertebrate antigens
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    • A61K40/421—Immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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JP2019572402A 2017-07-05 2018-07-05 Ｒｏｒ１ ｃａｒ ｔ細胞 Active JP7179030B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1710836.6A GB201710836D0 (en) 2017-07-05 2017-07-05 ROR1 Car T-Cells
GB1710836.6 2017-07-05
PCT/GB2018/051915 WO2019008378A1 (en) 2017-07-05 2018-07-05 Ror1 car t-cells

Publications (3)

Publication Number Publication Date
JP2020529838A JP2020529838A (ja) 2020-10-15
JP2020529838A5 JP2020529838A5 (enExample) 2021-08-12
JP7179030B2 true JP7179030B2 (ja) 2022-11-28

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JP2019572402A Active JP7179030B2 (ja) 2017-07-05 2018-07-05 Ｒｏｒ１ ｃａｒ ｔ細胞

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US (1) US11723925B2 (enExample)
EP (1) EP3649150B1 (enExample)
JP (1) JP7179030B2 (enExample)
CN (1) CN110997709B (enExample)
AU (1) AU2018295478A1 (enExample)
CA (1) CA3068197A1 (enExample)
GB (1) GB201710836D0 (enExample)
MX (1) MX2019015352A (enExample)
WO (1) WO2019008378A1 (enExample)

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