JP7173964B2 - 抗ｐ５３抗体 - Google Patents

抗ｐ５３抗体 Download PDF

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Publication number
JP7173964B2
JP7173964B2 JP2019520556A JP2019520556A JP7173964B2 JP 7173964 B2 JP7173964 B2 JP 7173964B2 JP 2019520556 A JP2019520556 A JP 2019520556A JP 2019520556 A JP2019520556 A JP 2019520556A JP 7173964 B2 JP7173964 B2 JP 7173964B2
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Japan
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polypeptide
antibody
mutant
sequence
seq
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Japanese (ja)
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JP2019535241A (ja
JP2019535241A5 (enExample
Inventor
サバパシー，トル・カナガ
レイン，デビッド・ピー
ウォン，リ－アン
コー，シン・ユ
ワ，リュー・オイ
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Agency for Science, Technology and Research
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Agency for Science, Technology and Research
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2019520556A 2016-10-17 2017-10-17 抗ｐ５３抗体 Active JP7173964B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1617564.8 2016-10-17
GBGB1617564.8A GB201617564D0 (en) 2016-10-17 2016-10-17 Anti-p53 antibodies
PCT/SG2017/050522 WO2018074978A1 (en) 2016-10-17 2017-10-17 Anti-p53 antibodies

Publications (3)

Publication Number Publication Date
JP2019535241A JP2019535241A (ja) 2019-12-12
JP2019535241A5 JP2019535241A5 (enExample) 2020-11-26
JP7173964B2 true JP7173964B2 (ja) 2022-11-16

Family

ID=57680660

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019520556A Active JP7173964B2 (ja) 2016-10-17 2017-10-17 抗ｐ５３抗体

Country Status (7)

Country Link
US (3) US11613568B2 (enExample)
EP (1) EP3526251A4 (enExample)
JP (1) JP7173964B2 (enExample)
CN (1) CN110770252A (enExample)
GB (1) GB201617564D0 (enExample)
SG (1) SG11201903411YA (enExample)
WO (1) WO2018074978A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11234452B2 (en) * 2016-12-27 2022-02-01 Hills Pet Nutrition, Inc. Pet food compositions
WO2021127184A1 (en) * 2019-12-17 2021-06-24 The Johns Hopkins University MANAbodies TARGETING TUMOR ANTIGENS AND METHODS OF USING
GB202008688D0 (en) 2020-06-09 2020-07-22 Cancer Research Tech Ltd Chimeric antigen receptor cell
CN113403286B (zh) * 2021-06-24 2024-01-16 新乡学院 一种靶向性三展示噬菌体及其制备方法和应用
EP4412650A1 (en) * 2021-10-05 2024-08-14 The Penn State Research Foundation Methods for treating cancers with mutated p53
CN116178501B (zh) * 2021-11-29 2025-08-29 深圳碳云智肽药物科技有限公司 靶向p53的多肽及其在制备用于治疗癌症的药物中的应用
US20250034252A1 (en) * 2021-12-16 2025-01-30 The Johns Hopkins University Manabodies targeting p53 tumor antigens and methods of using
TW202340474A (zh) * 2022-01-11 2023-10-16 大陸商深圳市珈鈺生物科技有限公司 樹突細胞腫瘤疫苗和其用途
CN114574524A (zh) * 2022-03-14 2022-06-03 深圳市体内生物医药科技有限公司 一种从全基因组中筛选肝癌抑癌基因的方法及其应用
EP4669328A1 (en) * 2023-02-22 2025-12-31 Elysion Therapeutics, Inc. LYSIS DETECTION RECEIVERS AND RELATED USES
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
WO2025259636A1 (en) * 2024-06-10 2025-12-18 Baylor College Of Medicine Targeting p53 mutants

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008533986A (ja) 2005-03-25 2008-08-28 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド 変異型ｐ５３の共通エピトープに対するヒト合成単鎖抗体およびその使用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083709A (en) 1985-08-21 2000-07-04 Osi Pharmaceuticals, Inc. Immunoassay for detection of mutant P53 polypeptide in serum
WO1992013970A1 (en) 1991-02-01 1992-08-20 Oncogene Science, Inc. Immunoassay for detection of mutant p53 polypeptide in biological fluids
DE69133528T2 (de) 1990-06-27 2006-09-07 Princeton University Proteinkomplex p53/p90
US5646016A (en) 1991-02-06 1997-07-08 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules
EP1421947A1 (en) * 1992-07-22 2004-05-26 The Trustees Of Princeton University p53 vaccine
US20030086935A1 (en) * 1992-07-22 2003-05-08 Levine Arnold J. p53 vaccine
GB9224784D0 (en) * 1992-11-26 1993-01-13 Univ Dundee Cellular protein
US6630584B1 (en) 2000-03-16 2003-10-07 Ramot At Tel-Aviv University Ltd. Single chain antibody against mutant p53
EP2268658B1 (en) * 2008-03-13 2015-12-09 Universita'Degli Studi di Trieste Peptides and aptamers thereof as specific modulators of mutant p53 function
WO2010120514A2 (en) * 2009-03-31 2010-10-21 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
SG10201601840RA (en) 2011-09-09 2016-04-28 Agency Science Tech & Res P53 activating peptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008533986A (ja) 2005-03-25 2008-08-28 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド 変異型ｐ５３の共通エピトープに対するヒト合成単鎖抗体およびその使用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Elena Canali et al.，SCIENTIFIC REPORTS，2014年04月22日，4 : 4729，p. 1-11
Jonas Bethuyne et al.，Nucleic Acids Research，2014年，Vol. 42, no. 20，p. 12928-12938
Philippa J. Barrell et al.，Protein Expression and Purification，2004年，Vol. 33，p. 153-159

Also Published As

Publication number Publication date
JP2019535241A (ja) 2019-12-12
GB201617564D0 (en) 2016-11-30
SG11201903411YA (en) 2019-05-30
EP3526251A4 (en) 2020-06-10
WO2018074978A1 (en) 2018-04-26
CN110770252A (zh) 2020-02-07
EP3526251A1 (en) 2019-08-21
US11613568B2 (en) 2023-03-28
US20190248879A1 (en) 2019-08-15
US20230257457A1 (en) 2023-08-17
US20250263475A1 (en) 2025-08-21
US12195526B2 (en) 2025-01-14

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