JP7170634B2 - Ｉｒａｋ阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法 - Google Patents

Ｉｒａｋ阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法 Download PDF

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JP7170634B2
JP7170634B2 JP2019522385A JP2019522385A JP7170634B2 JP 7170634 B2 JP7170634 B2 JP 7170634B2 JP 2019522385 A JP2019522385 A JP 2019522385A JP 2019522385 A JP2019522385 A JP 2019522385A JP 7170634 B2 JP7170634 B2 JP 7170634B2
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pyrazol
oxazole
carboxamide
compound
alkyl
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JP2019537577A5 (https=
JP2019537577A (ja
Inventor
ホイ リー
ティロ ヘックロード
ヤン チェン
ライアン ケリー
ダレン マクマツリー
キン ツォ
バネッサ タイラー
ラジンダー シング
ローズ イェン
ジャック マウン
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ライジェル ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2019522385A 2016-10-26 2017-10-25 Ｉｒａｋ阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法 Active JP7170634B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022175223A JP7379640B2 (ja) 2016-10-26 2022-11-01 Ｉｒａｋ阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662413217P 2016-10-26 2016-10-26
US62/413,217 2016-10-26
PCT/US2017/058339 WO2018089199A1 (en) 2016-10-26 2017-10-25 Oxazole derivatives for use as irak inhibitors and method for their preparation

Related Child Applications (1)

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JP2022175223A Division JP7379640B2 (ja) 2016-10-26 2022-11-01 Ｉｒａｋ阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法

Publications (3)

Publication Number Publication Date
JP2019537577A JP2019537577A (ja) 2019-12-26
JP2019537577A5 JP2019537577A5 (https=) 2020-12-03
JP7170634B2 true JP7170634B2 (ja) 2022-11-14

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JP2019522385A Active JP7170634B2 (ja) 2016-10-26 2017-10-25 Ｉｒａｋ阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法
JP2022175223A Active JP7379640B2 (ja) 2016-10-26 2022-11-01 Ｉｒａｋ阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法

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JP2022175223A Active JP7379640B2 (ja) 2016-10-26 2022-11-01 Ｉｒａｋ阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法

Country Status (9)

Country Link
US (4) US10370367B2 (https=)
EP (1) EP3532470B1 (https=)
JP (2) JP7170634B2 (https=)
CN (1) CN110099899B (https=)
CA (1) CA3041587A1 (https=)
DK (1) DK3532470T3 (https=)
ES (1) ES2939232T3 (https=)
PT (1) PT3532470T (https=)
WO (1) WO2018089199A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110862375B (zh) * 2018-08-27 2022-10-25 深圳铂立健医药有限公司 吡唑化合物及其药物组合物和应用
MX2022001596A (es) * 2019-08-08 2022-03-11 Rigel Pharmaceuticals Inc Compuestos y metodos para tratar sindrome de liberacion de citocinas.
PE20220970A1 (es) * 2019-08-30 2022-06-10 Rigel Pharmaceuticals Inc Compuestos de pirazol, formulaciones de los mismos y un metodo para usar los compuestos y/o formulaciones
IL315677A (en) 2022-03-23 2024-11-01 Rigel Pharmaceuticals Inc Pyrimid-2-yl-pyrazole compounds as irak inhibitors
CN121270516A (zh) * 2024-07-03 2026-01-06 科辉智药(深圳)新药研究中心有限公司 一种irak抑制剂化合物的晶型及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008526723A (ja) 2004-12-30 2008-07-24 アステックス、セラピューティックス、リミテッド Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するピラゾール誘導体
WO2011043371A1 (ja) 2009-10-07 2011-04-14 アステラス製薬株式会社 オキサゾール化合物

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4738851A (en) 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US4882150A (en) 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5521222A (en) 1989-09-28 1996-05-28 Alcon Laboratories, Inc. Topical ophthalmic pharmaceutical vehicles
DK0431519T3 (da) 1989-12-04 1994-07-04 Searle & Co System til transdermal indgivelse af albuterol
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
DE69228827T2 (de) 1991-12-18 1999-10-21 Minnesota Mining And Mfg. Co., Saint Paul Mehrschichtige sperrstrukturen
ATE132381T1 (de) 1992-01-29 1996-01-15 Voelkl Franz Ski Ballspielschläger, insbesondere tennisschläger
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6261547B1 (en) 1998-04-07 2001-07-17 Alcon Manufacturing, Ltd. Gelling ophthalmic compositions containing xanthan gum
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
JP6787892B2 (ja) 2014-11-20 2020-11-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｉｒａｋインヒビターとしてのヘテロアリール化合物及びその使用
LT3286181T (lt) * 2015-04-22 2021-04-26 Rigel Pharmaceuticals, Inc. Pirazolo junginiai ir junginių gamybos bei naudojimo būdas
JP2019196309A (ja) 2016-09-15 2019-11-14 武田薬品工業株式会社 複素環化合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008526723A (ja) 2004-12-30 2008-07-24 アステックス、セラピューティックス、リミテッド Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するピラゾール誘導体
WO2011043371A1 (ja) 2009-10-07 2011-04-14 アステラス製薬株式会社 オキサゾール化合物

Also Published As

Publication number Publication date
US20210179601A1 (en) 2021-06-17
DK3532470T3 (da) 2023-02-20
ES2939232T3 (es) 2023-04-20
US10370367B2 (en) 2019-08-06
CA3041587A1 (en) 2018-05-17
CN110099899B (zh) 2024-01-02
WO2018089199A1 (en) 2018-05-17
US11492349B2 (en) 2022-11-08
JP2023011795A (ja) 2023-01-24
US20190300518A1 (en) 2019-10-03
JP2019537577A (ja) 2019-12-26
US20230062818A1 (en) 2023-03-02
US20180111923A1 (en) 2018-04-26
JP7379640B2 (ja) 2023-11-14
EP3532470A1 (en) 2019-09-04
US10941140B2 (en) 2021-03-09
CN110099899A (zh) 2019-08-06
EP3532470B1 (en) 2022-12-07
US11993594B2 (en) 2024-05-28
PT3532470T (pt) 2023-02-28

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