CA3041587A1 - Oxazole derivatives for use as irak inhibitors and method for their preparation - Google Patents
Oxazole derivatives for use as irak inhibitors and method for their preparation Download PDFInfo
- Publication number
- CA3041587A1 CA3041587A1 CA3041587A CA3041587A CA3041587A1 CA 3041587 A1 CA3041587 A1 CA 3041587A1 CA 3041587 A CA3041587 A CA 3041587A CA 3041587 A CA3041587 A CA 3041587A CA 3041587 A1 CA3041587 A1 CA 3041587A1
- Authority
- CA
- Canada
- Prior art keywords
- pyrazol
- substituted
- compound
- oxazole
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413217P | 2016-10-26 | 2016-10-26 | |
| US62/413,217 | 2016-10-26 | ||
| PCT/US2017/058339 WO2018089199A1 (en) | 2016-10-26 | 2017-10-25 | Oxazole derivatives for use as irak inhibitors and method for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3041587A1 true CA3041587A1 (en) | 2018-05-17 |
Family
ID=60302473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3041587A Pending CA3041587A1 (en) | 2016-10-26 | 2017-10-25 | Oxazole derivatives for use as irak inhibitors and method for their preparation |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10370367B2 (https=) |
| EP (1) | EP3532470B1 (https=) |
| JP (2) | JP7170634B2 (https=) |
| CN (1) | CN110099899B (https=) |
| CA (1) | CA3041587A1 (https=) |
| DK (1) | DK3532470T3 (https=) |
| ES (1) | ES2939232T3 (https=) |
| PT (1) | PT3532470T (https=) |
| WO (1) | WO2018089199A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110862375B (zh) * | 2018-08-27 | 2022-10-25 | 深圳铂立健医药有限公司 | 吡唑化合物及其药物组合物和应用 |
| MX2022001596A (es) * | 2019-08-08 | 2022-03-11 | Rigel Pharmaceuticals Inc | Compuestos y metodos para tratar sindrome de liberacion de citocinas. |
| PE20220970A1 (es) * | 2019-08-30 | 2022-06-10 | Rigel Pharmaceuticals Inc | Compuestos de pirazol, formulaciones de los mismos y un metodo para usar los compuestos y/o formulaciones |
| IL315677A (en) | 2022-03-23 | 2024-11-01 | Rigel Pharmaceuticals Inc | Pyrimid-2-yl-pyrazole compounds as irak inhibitors |
| CN121270516A (zh) * | 2024-07-03 | 2026-01-06 | 科辉智药(深圳)新药研究中心有限公司 | 一种irak抑制剂化合物的晶型及其制备方法和应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| US5521222A (en) | 1989-09-28 | 1996-05-28 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| DK0431519T3 (da) | 1989-12-04 | 1994-07-04 | Searle & Co | System til transdermal indgivelse af albuterol |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| JP2594486B2 (ja) | 1991-01-15 | 1997-03-26 | アルコン ラボラトリーズ インコーポレイテッド | 局所的眼薬組成物 |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| DE69228827T2 (de) | 1991-12-18 | 1999-10-21 | Minnesota Mining And Mfg. Co., Saint Paul | Mehrschichtige sperrstrukturen |
| ATE132381T1 (de) | 1992-01-29 | 1996-01-15 | Voelkl Franz Ski | Ballspielschläger, insbesondere tennisschläger |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6197934B1 (en) | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
| WO2006070198A1 (en) * | 2004-12-30 | 2006-07-06 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
| JP2012254939A (ja) * | 2009-10-07 | 2012-12-27 | Astellas Pharma Inc | オキサゾール化合物 |
| JP6787892B2 (ja) | 2014-11-20 | 2020-11-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｉｒａｋインヒビターとしてのヘテロアリール化合物及びその使用 |
| LT3286181T (lt) * | 2015-04-22 | 2021-04-26 | Rigel Pharmaceuticals, Inc. | Pirazolo junginiai ir junginių gamybos bei naudojimo būdas |
| JP2019196309A (ja) | 2016-09-15 | 2019-11-14 | 武田薬品工業株式会社 | 複素環化合物 |
-
2017
- 2017-10-25 JP JP2019522385A patent/JP7170634B2/ja active Active
- 2017-10-25 EP EP17797495.3A patent/EP3532470B1/en active Active
- 2017-10-25 CA CA3041587A patent/CA3041587A1/en active Pending
- 2017-10-25 DK DK17797495.3T patent/DK3532470T3/da active
- 2017-10-25 ES ES17797495T patent/ES2939232T3/es active Active
- 2017-10-25 CN CN201780080581.6A patent/CN110099899B/zh active Active
- 2017-10-25 PT PT177974953T patent/PT3532470T/pt unknown
- 2017-10-25 WO PCT/US2017/058339 patent/WO2018089199A1/en not_active Ceased
- 2017-10-25 US US15/793,770 patent/US10370367B2/en active Active
-
2019
- 2019-06-18 US US16/444,093 patent/US10941140B2/en active Active
-
2021
- 2021-02-24 US US17/184,182 patent/US11492349B2/en active Active
-
2022
- 2022-09-27 US US17/953,570 patent/US11993594B2/en active Active
- 2022-11-01 JP JP2022175223A patent/JP7379640B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20210179601A1 (en) | 2021-06-17 |
| JP7170634B2 (ja) | 2022-11-14 |
| DK3532470T3 (da) | 2023-02-20 |
| ES2939232T3 (es) | 2023-04-20 |
| US10370367B2 (en) | 2019-08-06 |
| CN110099899B (zh) | 2024-01-02 |
| WO2018089199A1 (en) | 2018-05-17 |
| US11492349B2 (en) | 2022-11-08 |
| JP2023011795A (ja) | 2023-01-24 |
| US20190300518A1 (en) | 2019-10-03 |
| JP2019537577A (ja) | 2019-12-26 |
| US20230062818A1 (en) | 2023-03-02 |
| US20180111923A1 (en) | 2018-04-26 |
| JP7379640B2 (ja) | 2023-11-14 |
| EP3532470A1 (en) | 2019-09-04 |
| US10941140B2 (en) | 2021-03-09 |
| CN110099899A (zh) | 2019-08-06 |
| EP3532470B1 (en) | 2022-12-07 |
| US11993594B2 (en) | 2024-05-28 |
| PT3532470T (pt) | 2023-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12043620B2 (en) | Benzazole compounds and methods for making and using the compounds | |
| US11059814B2 (en) | Kinase inhibitors and methods for making and using | |
| AU2019262142B2 (en) | RIP1 inhibitory compounds and methods for making and using the same | |
| US11530194B2 (en) | Amide compounds and method for making and using | |
| IL299784A (en) | RIP1 inhibitory compounds and methods for their preparation and use | |
| US11993594B2 (en) | IRAK inhibitors and method for making and using | |
| CA3028997A1 (en) | 2,4-diamino-pyrimidine compounds and method for making and using the compounds | |
| HK40013639A (en) | Oxazole derivatives for use as irak inhibitors and method for their preparation | |
| HK40013639B (en) | Oxazole derivatives for use as irak inhibitors and method for their preparation | |
| HK40013987B (en) | Pyrazole amide compounds as irak inhibitors | |
| HK40013987A (en) | Pyrazole amide compounds as irak inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220916 |