ES2939232T3 - Derivados de oxazol para uso como inhibidores de IRAK y método para su preparación - Google Patents
Derivados de oxazol para uso como inhibidores de IRAK y método para su preparación Download PDFInfo
- Publication number
- ES2939232T3 ES2939232T3 ES17797495T ES17797495T ES2939232T3 ES 2939232 T3 ES2939232 T3 ES 2939232T3 ES 17797495 T ES17797495 T ES 17797495T ES 17797495 T ES17797495 T ES 17797495T ES 2939232 T3 ES2939232 T3 ES 2939232T3
- Authority
- ES
- Spain
- Prior art keywords
- pyrazol
- oxazole
- compound
- carboxamide
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003112 inhibitor Substances 0.000 title abstract description 18
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- 125000003118 aryl group Chemical group 0.000 claims description 48
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- 125000001424 substituent group Chemical group 0.000 claims description 36
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 31
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- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 description 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
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- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
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- 229960003165 vancomycin Drugs 0.000 description 1
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- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
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- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
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- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
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- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413217P | 2016-10-26 | 2016-10-26 | |
| PCT/US2017/058339 WO2018089199A1 (en) | 2016-10-26 | 2017-10-25 | Oxazole derivatives for use as irak inhibitors and method for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2939232T3 true ES2939232T3 (es) | 2023-04-20 |
Family
ID=60302473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17797495T Active ES2939232T3 (es) | 2016-10-26 | 2017-10-25 | Derivados de oxazol para uso como inhibidores de IRAK y método para su preparación |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10370367B2 (https=) |
| EP (1) | EP3532470B1 (https=) |
| JP (2) | JP7170634B2 (https=) |
| CN (1) | CN110099899B (https=) |
| CA (1) | CA3041587A1 (https=) |
| DK (1) | DK3532470T3 (https=) |
| ES (1) | ES2939232T3 (https=) |
| PT (1) | PT3532470T (https=) |
| WO (1) | WO2018089199A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110862375B (zh) * | 2018-08-27 | 2022-10-25 | 深圳铂立健医药有限公司 | 吡唑化合物及其药物组合物和应用 |
| BR112022001418A2 (pt) * | 2019-08-08 | 2022-06-07 | Rigel Pharmaceuticals Inc | Compostos e método para tratar a síndrome de liberação de citocinas |
| CN121159524A (zh) * | 2019-08-30 | 2025-12-19 | 里格尔药品股份有限公司 | 吡唑化合物，其配制品以及使用所述化合物和/或配制品的方法 |
| JP2025513716A (ja) * | 2022-03-23 | 2025-04-30 | ライジェル・ファーマシューティカルズ・インコーポレイテッド | Ｉｒａｋ阻害剤としてのピリミド－２－イル－ピラゾール化合物 |
| CN121270516A (zh) * | 2024-07-03 | 2026-01-06 | 科辉智药(深圳)新药研究中心有限公司 | 一种irak抑制剂化合物的晶型及其制备方法和应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| US5521222A (en) | 1989-09-28 | 1996-05-28 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| EP0431519B1 (en) | 1989-12-04 | 1994-06-15 | G.D. Searle & Co. | System for transdermal albuterol administration |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| DE69228827T2 (de) | 1991-12-18 | 1999-10-21 | Minnesota Mining And Mfg. Co., Saint Paul | Mehrschichtige sperrstrukturen |
| EP0553769B1 (de) | 1992-01-29 | 1996-01-03 | FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG | Ballspielschläger, insbesondere Tennisschläger |
| IL114193A (en) | 1994-06-20 | 2000-02-29 | Teva Pharma | Ophthalmic pharmaceutical compositions based on sodium alginate |
| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US6197934B1 (en) | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
| US20100160324A1 (en) | 2004-12-30 | 2010-06-24 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
| JP2012254939A (ja) | 2009-10-07 | 2012-12-27 | Astellas Pharma Inc | オキサゾール化合物 |
| CA2964982C (en) | 2014-11-20 | 2022-07-05 | Merck Patent Gmbh | Heteroaryl compounds as irak inhibitors and uses thereof |
| EA039043B1 (ru) * | 2015-04-22 | 2021-11-25 | Райджел Фармасьютикалз, Инк. | Пиразольные соединения и способ получения и применения данных соединений |
| JP2019196309A (ja) * | 2016-09-15 | 2019-11-14 | 武田薬品工業株式会社 | 複素環化合物 |
-
2017
- 2017-10-25 CN CN201780080581.6A patent/CN110099899B/zh active Active
- 2017-10-25 PT PT177974953T patent/PT3532470T/pt unknown
- 2017-10-25 US US15/793,770 patent/US10370367B2/en active Active
- 2017-10-25 DK DK17797495.3T patent/DK3532470T3/da active
- 2017-10-25 ES ES17797495T patent/ES2939232T3/es active Active
- 2017-10-25 CA CA3041587A patent/CA3041587A1/en active Pending
- 2017-10-25 WO PCT/US2017/058339 patent/WO2018089199A1/en not_active Ceased
- 2017-10-25 JP JP2019522385A patent/JP7170634B2/ja active Active
- 2017-10-25 EP EP17797495.3A patent/EP3532470B1/en active Active
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2019
- 2019-06-18 US US16/444,093 patent/US10941140B2/en active Active
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2022
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- 2022-11-01 JP JP2022175223A patent/JP7379640B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110099899B (zh) | 2024-01-02 |
| CA3041587A1 (en) | 2018-05-17 |
| US20190300518A1 (en) | 2019-10-03 |
| DK3532470T3 (da) | 2023-02-20 |
| EP3532470B1 (en) | 2022-12-07 |
| US10370367B2 (en) | 2019-08-06 |
| JP7379640B2 (ja) | 2023-11-14 |
| JP7170634B2 (ja) | 2022-11-14 |
| US20180111923A1 (en) | 2018-04-26 |
| US20210179601A1 (en) | 2021-06-17 |
| JP2023011795A (ja) | 2023-01-24 |
| US20230062818A1 (en) | 2023-03-02 |
| EP3532470A1 (en) | 2019-09-04 |
| WO2018089199A1 (en) | 2018-05-17 |
| US11993594B2 (en) | 2024-05-28 |
| CN110099899A (zh) | 2019-08-06 |
| PT3532470T (pt) | 2023-02-28 |
| JP2019537577A (ja) | 2019-12-26 |
| US11492349B2 (en) | 2022-11-08 |
| US10941140B2 (en) | 2021-03-09 |
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