JP7158464B2 - カリウムチャネル阻害剤としての置換ベンゾイミダゾール - Google Patents

カリウムチャネル阻害剤としての置換ベンゾイミダゾール Download PDF

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JP7158464B2
JP7158464B2 JP2020508323A JP2020508323A JP7158464B2 JP 7158464 B2 JP7158464 B2 JP 7158464B2 JP 2020508323 A JP2020508323 A JP 2020508323A JP 2020508323 A JP2020508323 A JP 2020508323A JP 7158464 B2 JP7158464 B2 JP 7158464B2
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alkyl
amino
phenyl
methyl
trifluoromethyl
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JP2020530479A (ja
JP2020530479A5 (https=
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スバーネ ソレンセン、ウルリク
メテ、アントニオ
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アセシオン ファーマ エイピーエス
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020508323A 2017-08-14 2018-08-13 カリウムチャネル阻害剤としての置換ベンゾイミダゾール Active JP7158464B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17020353 2017-08-14
EP17020353.3 2017-08-14
PCT/EP2018/071911 WO2019034603A1 (en) 2017-08-14 2018-08-13 SUBSTITUTED BENZIMIDAZOLES USEFUL AS INHIBITORS OF THE POTASSIUM CHANNEL

Publications (3)

Publication Number Publication Date
JP2020530479A JP2020530479A (ja) 2020-10-22
JP2020530479A5 JP2020530479A5 (https=) 2021-07-26
JP7158464B2 true JP7158464B2 (ja) 2022-10-21

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ID=59699444

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JP2020508323A Active JP7158464B2 (ja) 2017-08-14 2018-08-13 カリウムチャネル阻害剤としての置換ベンゾイミダゾール

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Country Link
US (1) US11098018B2 (https=)
EP (1) EP3668841A1 (https=)
JP (1) JP7158464B2 (https=)
CN (1) CN111344281B (https=)
CA (1) CA3072648A1 (https=)
WO (1) WO2019034603A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3013237A1 (en) * 2016-02-24 2017-08-31 Acesion Pharma Aps Novel potassium channel inhibitors
EP3672953B1 (en) * 2017-08-23 2021-07-28 Acesion Pharma ApS Benzimidazole derivatives useful as potassium channel inhibitors
WO2022200162A1 (en) * 2021-03-22 2022-09-29 Acecion Pharma Aps Novel potassium channel inhibitors
EP4245753A1 (en) * 2022-03-17 2023-09-20 Acesion Pharma ApS Imidazole derivatives as potassium channel inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008509111A (ja) 2004-08-05 2008-03-27 ノイロサーチ アクティーゼルスカブ ２−アミノベンズイミダゾール誘導体及び小コンダクタンスカルシウム依存性カリウムチャネルのモジュレーターとしてのその使用
JP2008526815A (ja) 2005-01-11 2008-07-24 ノイロサーチ アクティーゼルスカブ 低コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしての新規２−アミノベンゾイミダゾール誘導体及びそれらの使用
WO2008113747A1 (en) 2007-03-22 2008-09-25 Neurosearch A/S Medicaments useful as potassium channel modulators
WO2013104577A1 (en) 2012-01-11 2013-07-18 Acesion Pharma Aps Benzimidazolyl-acetamide derivatives useful as potassium channel modulators
JP2019506442A (ja) 2016-02-24 2019-03-07 アセシオン ファーマ エイピーエス 新規なカリウムチャネル阻害剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005030726A1 (en) * 2003-09-23 2005-04-07 Merck & Co., Inc. Isoquinolinone potassium channel inhibitors
JP4794446B2 (ja) * 2003-09-23 2011-10-19 メルク・シャープ・エンド・ドーム・コーポレイション イソキノリン系カリウムチャンネル阻害薬
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008509111A (ja) 2004-08-05 2008-03-27 ノイロサーチ アクティーゼルスカブ ２−アミノベンズイミダゾール誘導体及び小コンダクタンスカルシウム依存性カリウムチャネルのモジュレーターとしてのその使用
JP2008526815A (ja) 2005-01-11 2008-07-24 ノイロサーチ アクティーゼルスカブ 低コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしての新規２−アミノベンゾイミダゾール誘導体及びそれらの使用
WO2008113747A1 (en) 2007-03-22 2008-09-25 Neurosearch A/S Medicaments useful as potassium channel modulators
WO2013104577A1 (en) 2012-01-11 2013-07-18 Acesion Pharma Aps Benzimidazolyl-acetamide derivatives useful as potassium channel modulators
JP2019506442A (ja) 2016-02-24 2019-03-07 アセシオン ファーマ エイピーエス 新規なカリウムチャネル阻害剤

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AJAY L CHANDGUDE，DIRECT AMINATION OF α-HYDROXY AMIDES，ASIAN JOURNAL OF ORGANIC CHEMISTRY，ドイツ，2017年06月14日，VOL:6, NR:8，PAGE(S):981 - 983，http://dx.doi.org/10.1002/ajoc.201700277，https://onlinelibrary.wiley.com/doi/abs/10.1002/ajoc.201700277
FLOCH L，2-AMINO-SUBSTITUTED DERIVATIVES OF BENZIMIDAZOLES FROM 2-ISOTHIOCYANATO CARBOXYLATES，COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS，1989年，VOL:54，PAGE(S):206 - 214，http://cccc.uochb.cas.cz/54/1/0206/
KRASIKOVS,A. et al.，Iodoacetic acid is an efficient reagent for the synthesis of amino acid derived 2-aminobenzimidazoles，Synthesis，2013年，Vol.45, No.5，p.683-693
SRIRAM R，RETRACTED : MICROWAVE ASSISTED SYNTHESIS OF TRIFLUORO SUBSTITUTED 2-以下備考，JOURNAL OF HETEROCYCLIC CHEMISTRY，米国，2017年07月，VOL:54, NR:4，PAGE(S):2440 - 2446，http://dx.doi.org/10.1002/jhet.2841，AMINOBENZIMIDAZOLE DERIVATIVES VIA IODOACETIC ACID MEDIATED ONE-POT CONDENSATION

Also Published As

Publication number Publication date
JP2020530479A (ja) 2020-10-22
EP3668841A1 (en) 2020-06-24
CN111344281A (zh) 2020-06-26
WO2019034603A1 (en) 2019-02-21
US11098018B2 (en) 2021-08-24
CN111344281B (zh) 2023-11-14
CA3072648A1 (en) 2019-02-21
US20200216398A1 (en) 2020-07-09

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