JP2020530479A5 - - Google Patents
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- Publication number
- JP2020530479A5 JP2020530479A5 JP2020508323A JP2020508323A JP2020530479A5 JP 2020530479 A5 JP2020530479 A5 JP 2020530479A5 JP 2020508323 A JP2020508323 A JP 2020508323A JP 2020508323 A JP2020508323 A JP 2020508323A JP 2020530479 A5 JP2020530479 A5 JP 2020530479A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- compound according
- alkylene
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 56
- 150000001875 compounds Chemical class 0.000 claims 33
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 26
- -1 1H-1,3-benzodiazole-2-yl Chemical group 0.000 claims 23
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 125000002947 alkylene group Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 208000019622 heart disease Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 206010003130 Arrhythmia supraventricular Diseases 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 208000020446 Cardiac disease Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010049447 Tachyarrhythmia Diseases 0.000 claims 2
- 208000001871 Tachycardia Diseases 0.000 claims 2
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000033764 rhythmic process Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- YAISTTXSRPJHFL-UHFFFAOYSA-N 3-(1H-benzimidazol-2-ylamino)-3-(4-fluoro-3,5-dimethylphenyl)-N-methylpropanamide Chemical compound N1C(=NC2=C1C=CC=C2)NC(CC(=O)NC)C1=CC(=C(C(=C1)C)F)C YAISTTXSRPJHFL-UHFFFAOYSA-N 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- VNJHJEMPNDGGEU-UHFFFAOYSA-N CNC(=O)CC(NC1=NC2=CC=CC=C2N1)C1=CC(C)=C(Cl)C=C1 Chemical compound CNC(=O)CC(NC1=NC2=CC=CC=C2N1)C1=CC(C)=C(Cl)C=C1 VNJHJEMPNDGGEU-UHFFFAOYSA-N 0.000 claims 1
- RWNWVUUEIRTLBT-UHFFFAOYSA-N CNC(=O)CC(NC1=NC2=CC=CC=C2N1)C1=CC(Cl)=C(Cl)C=C1 Chemical compound CNC(=O)CC(NC1=NC2=CC=CC=C2N1)C1=CC(Cl)=C(Cl)C=C1 RWNWVUUEIRTLBT-UHFFFAOYSA-N 0.000 claims 1
- LKJPYSCBVHEWIU-UHFFFAOYSA-N N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide Chemical compound C=1C=C(C#N)C(C(F)(F)F)=CC=1NC(=O)C(O)(C)CS(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-UHFFFAOYSA-N 0.000 claims 1
- ZXQSCWYGIBRWOJ-UHFFFAOYSA-N N1C(=NC2=C1C=CC=C2)NC(CC(=O)NC)C1=CC(=CC=C1)C#N Chemical compound N1C(=NC2=C1C=CC=C2)NC(CC(=O)NC)C1=CC(=CC=C1)C#N ZXQSCWYGIBRWOJ-UHFFFAOYSA-N 0.000 claims 1
- 201000001068 Prinzmetal angina Diseases 0.000 claims 1
- 206010065341 Ventricular tachyarrhythmia Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 230000001746 atrial effect Effects 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 238000007675 cardiac surgery Methods 0.000 claims 1
- 238000013153 catheter ablation Methods 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 239000008141 laxative Substances 0.000 claims 1
- 230000002475 laxative effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 206010047302 ventricular tachycardia Diseases 0.000 claims 1
- 0 CC(Cc1c(*)c(*)c(*)c([Re])c1*)([C@@](C)(*)C(*)=O)Nc1nc2c(C)c(*)c(*)c(*)c2[n]1 Chemical compound CC(Cc1c(*)c(*)c(*)c([Re])c1*)([C@@](C)(*)C(*)=O)Nc1nc2c(C)c(*)c(*)c(*)c2[n]1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17020353 | 2017-08-14 | ||
| EP17020353.3 | 2017-08-14 | ||
| PCT/EP2018/071911 WO2019034603A1 (en) | 2017-08-14 | 2018-08-13 | SUBSTITUTED BENZIMIDAZOLES USEFUL AS INHIBITORS OF THE POTASSIUM CHANNEL |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020530479A JP2020530479A (ja) | 2020-10-22 |
| JP2020530479A5 true JP2020530479A5 (https=) | 2021-07-26 |
| JP7158464B2 JP7158464B2 (ja) | 2022-10-21 |
Family
ID=59699444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020508323A Active JP7158464B2 (ja) | 2017-08-14 | 2018-08-13 | カリウムチャネル阻害剤としての置換ベンゾイミダゾール |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11098018B2 (https=) |
| EP (1) | EP3668841A1 (https=) |
| JP (1) | JP7158464B2 (https=) |
| CN (1) | CN111344281B (https=) |
| CA (1) | CA3072648A1 (https=) |
| WO (1) | WO2019034603A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3013237A1 (en) * | 2016-02-24 | 2017-08-31 | Acesion Pharma Aps | Novel potassium channel inhibitors |
| EP3672953B1 (en) * | 2017-08-23 | 2021-07-28 | Acesion Pharma ApS | Benzimidazole derivatives useful as potassium channel inhibitors |
| WO2022200162A1 (en) * | 2021-03-22 | 2022-09-29 | Acecion Pharma Aps | Novel potassium channel inhibitors |
| EP4245753A1 (en) * | 2022-03-17 | 2023-09-20 | Acesion Pharma ApS | Imidazole derivatives as potassium channel inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005030726A1 (en) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| JP4794446B2 (ja) * | 2003-09-23 | 2011-10-19 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリン系カリウムチャンネル阻害薬 |
| AU2005268782A1 (en) | 2004-08-05 | 2006-02-09 | Neurosearch A/S | 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
| US7842817B2 (en) | 2005-01-11 | 2010-11-30 | Neurosearch A/S | 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
| WO2008113747A1 (en) * | 2007-03-22 | 2008-09-25 | Neurosearch A/S | Medicaments useful as potassium channel modulators |
| AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| WO2013104577A1 (en) | 2012-01-11 | 2013-07-18 | Acesion Pharma Aps | Benzimidazolyl-acetamide derivatives useful as potassium channel modulators |
| CA3013237A1 (en) * | 2016-02-24 | 2017-08-31 | Acesion Pharma Aps | Novel potassium channel inhibitors |
-
2018
- 2018-08-13 EP EP18750455.0A patent/EP3668841A1/en active Pending
- 2018-08-13 JP JP2020508323A patent/JP7158464B2/ja active Active
- 2018-08-13 WO PCT/EP2018/071911 patent/WO2019034603A1/en not_active Ceased
- 2018-08-13 CA CA3072648A patent/CA3072648A1/en active Pending
- 2018-08-13 US US16/638,590 patent/US11098018B2/en active Active
- 2018-08-13 CN CN201880065901.5A patent/CN111344281B/zh active Active
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