JP7155127B2 - 阻害性炭酸カルシウム添加剤 - Google Patents
阻害性炭酸カルシウム添加剤 Download PDFInfo
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- JP7155127B2 JP7155127B2 JP2019535441A JP2019535441A JP7155127B2 JP 7155127 B2 JP7155127 B2 JP 7155127B2 JP 2019535441 A JP2019535441 A JP 2019535441A JP 2019535441 A JP2019535441 A JP 2019535441A JP 7155127 B2 JP7155127 B2 JP 7155127B2
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- Prior art keywords
- calcium carbonate
- weight
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- acid
- polymer
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title claims description 505
- 229910000019 calcium carbonate Inorganic materials 0.000 title claims description 239
- 230000002401 inhibitory effect Effects 0.000 title claims description 52
- 239000000654 additive Substances 0.000 title claims description 13
- 230000000996 additive effect Effects 0.000 title claims description 9
- 239000002245 particle Substances 0.000 claims description 403
- 239000000203 mixture Substances 0.000 claims description 220
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- 239000002131 composite material Substances 0.000 claims description 81
- 239000002253 acid Substances 0.000 claims description 70
- 238000000034 method Methods 0.000 claims description 64
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical group CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 40
- 239000011575 calcium Substances 0.000 claims description 34
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims description 32
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 24
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 24
- 239000008139 complexing agent Substances 0.000 claims description 22
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 20
- 239000004310 lactic acid Substances 0.000 claims description 20
- 235000014655 lactic acid Nutrition 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000002250 absorbent Substances 0.000 claims description 17
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 12
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 12
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 11
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 11
- 238000005516 engineering process Methods 0.000 claims description 10
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical group [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 10
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 9
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical group OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 8
- 238000010146 3D printing Methods 0.000 claims description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 6
- 235000013305 food Nutrition 0.000 claims description 5
- 239000003446 ligand Substances 0.000 claims description 5
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- VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 claims description 3
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical group OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims description 3
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 claims description 3
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims description 3
- 235000006408 oxalic acid Nutrition 0.000 claims description 3
- 235000010216 calcium carbonate Nutrition 0.000 description 225
- 239000000843 powder Substances 0.000 description 95
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- 239000000463 material Substances 0.000 description 53
- 239000000047 product Substances 0.000 description 47
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- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 30
- 239000004626 polylactic acid Substances 0.000 description 30
- 239000007943 implant Substances 0.000 description 27
- 238000009826 distribution Methods 0.000 description 23
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- 239000000126 substance Substances 0.000 description 18
- 159000000007 calcium salts Chemical class 0.000 description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 16
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 16
- 229910002092 carbon dioxide Inorganic materials 0.000 description 15
- 239000008187 granular material Substances 0.000 description 15
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 15
- 238000001878 scanning electron micrograph Methods 0.000 description 15
- 238000006243 chemical reaction Methods 0.000 description 14
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- 239000012634 fragment Substances 0.000 description 12
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 12
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- 235000011007 phosphoric acid Nutrition 0.000 description 10
- 239000000725 suspension Substances 0.000 description 10
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 9
- 239000000920 calcium hydroxide Substances 0.000 description 9
- 235000011116 calcium hydroxide Nutrition 0.000 description 9
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- 210000000988 bone and bone Anatomy 0.000 description 8
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 8
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- 239000007789 gas Substances 0.000 description 8
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 239000004698 Polyethylene Substances 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000470 constituent Substances 0.000 description 6
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- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 6
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 6
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- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
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- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 3
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- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
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- C08K9/04—Ingredients treated with organic substances
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
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- C08J3/203—Solid polymers with solid and/or liquid additives
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- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
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- C—CHEMISTRY; METALLURGY
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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- C08K3/26—Carbonates; Bicarbonates
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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- C08K9/02—Ingredients treated with inorganic substances
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- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
- C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
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- C09C1/021—Calcium carbonates
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
- C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
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- C09C1/021—Calcium carbonates
- C09C1/022—Treatment with inorganic compounds
- C09C1/024—Coating
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
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- C09C3/06—Treatment with inorganic compounds
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- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/03—Particle morphology depicted by an image obtained by SEM
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- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
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- C01P2004/32—Spheres
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- C—CHEMISTRY; METALLURGY
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- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/54—Particles characterised by their aspect ratio, i.e. the ratio of sizes in the longest to the shortest dimension
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- C—CHEMISTRY; METALLURGY
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- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/80—Particles consisting of a mixture of two or more inorganic phases
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
- C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/24—Acids; Salts thereof
- C08K3/26—Carbonates; Bicarbonates
- C08K2003/265—Calcium, strontium or barium carbonate
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/016—Additives defined by their aspect ratio
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/018—Additives for biodegradable polymeric composition
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Wrappers (AREA)
- Packging For Living Organisms, Food Or Medicinal Products That Are Sensitive To Environmental Conditiond (AREA)
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JP2022123797A JP2022169563A (ja) | 2016-09-08 | 2022-08-03 | 阻害性炭酸カルシウム添加剤 |
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EP16001955 | 2016-09-08 | ||
EP16001955.0 | 2016-09-08 | ||
PCT/EP2017/001064 WO2018046127A1 (de) | 2016-09-08 | 2017-09-07 | Inhibierendes calciumcarbonatadditiv |
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US (1) | US11548998B2 (es) |
EP (1) | EP3510083A1 (es) |
JP (2) | JP7155127B2 (es) |
CN (1) | CN109661419B (es) |
CA (1) | CA3033785A1 (es) |
MY (1) | MY193329A (es) |
RU (1) | RU2738378C2 (es) |
WO (1) | WO2018046127A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2018046572A1 (de) | 2016-09-08 | 2018-03-15 | Schaefer Kalk Gmbh & Co. Kg | Calciumcarbonat-enthaltendes verbundpulver mit mikrostrukturierten teilchen |
RU2742340C2 (ru) | 2016-09-08 | 2021-02-04 | Шефер Кальк Гмбх Унд Ко. Кг | Содержащий соль кальция композиционный порошок с микроструктурированными частицами |
JP7155127B2 (ja) | 2016-09-08 | 2022-10-18 | シェーファー・カーク・ゲーエムベーハー・ウント・コンパニー・カーゲー | 阻害性炭酸カルシウム添加剤 |
ES2975371T3 (es) | 2016-09-08 | 2024-07-04 | Schaefer Kalk Gmbh & Co Kg | Polvo de material composite que contiene carbonato cálcico con partículas microestructuradas con carbonato cálcico inhibidor |
WO2019241478A1 (en) * | 2018-06-15 | 2019-12-19 | Wm. Wrigley Jr. Company | Edible confectionery coatings including calcium carbonate |
CN111471320B (zh) * | 2020-05-25 | 2021-09-28 | 合肥学院 | 一种碳酸钙粉体的制备方法 |
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JP2010511751A (ja) | 2006-11-30 | 2010-04-15 | スミス アンド ネフュー インコーポレーテッド | 繊維強化複合材料 |
WO2012073660A1 (ja) | 2010-11-30 | 2012-06-07 | 株式会社白石中央研究所 | 樹脂組成物 |
JP2014508840A (ja) | 2011-03-18 | 2014-04-10 | シェーファー カルク ゲーエムベーハー ウント コー. カーゲー | 微細構造複合粒子 |
JP2016153354A (ja) | 2015-02-20 | 2016-08-25 | 古手川産業株式会社 | 炭酸カルシウム複合体 |
JP2019528841A (ja) | 2016-09-08 | 2019-10-17 | カール ライビンガー メディツィンテクニック ゲーエムベーハー ウント コー. カーゲーKarl Leibinger Medizintechnik GmbH & Co. KG | 抑制性炭酸カルシウムを含有するインプラント |
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FR2612085B1 (fr) | 1987-03-13 | 1989-06-16 | Insat | Materiau granulaire de traitement d'eau et procede de fabrication |
US5011862A (en) | 1988-07-29 | 1991-04-30 | Pierce & Stevens Corporation | Coating media containing low density composite opacifiers |
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JP2946224B2 (ja) * | 1990-04-23 | 1999-09-06 | 日本石油化学株式会社 | 樹脂組成物 |
JPH06114099A (ja) | 1991-06-12 | 1994-04-26 | Nara Kikai Seisakusho:Kk | 医用材料とその製造方法 |
JPH0751288B2 (ja) | 1991-12-25 | 1995-06-05 | 株式会社奈良機械製作所 | 粒子の複合化方法 |
JP3087573B2 (ja) * | 1994-06-01 | 2000-09-11 | 東レ株式会社 | 二軸延伸ポリエステルフィルム |
WO1997014847A1 (en) * | 1995-10-20 | 1997-04-24 | Ecc International Inc. | Acid resistant calcium carbonate filler |
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ES2975371T3 (es) | 2016-09-08 | 2024-07-04 | Schaefer Kalk Gmbh & Co Kg | Polvo de material composite que contiene carbonato cálcico con partículas microestructuradas con carbonato cálcico inhibidor |
JP7155127B2 (ja) | 2016-09-08 | 2022-10-18 | シェーファー・カーク・ゲーエムベーハー・ウント・コンパニー・カーゲー | 阻害性炭酸カルシウム添加剤 |
RU2742340C2 (ru) | 2016-09-08 | 2021-02-04 | Шефер Кальк Гмбх Унд Ко. Кг | Содержащий соль кальция композиционный порошок с микроструктурированными частицами |
WO2018046572A1 (de) | 2016-09-08 | 2018-03-15 | Schaefer Kalk Gmbh & Co. Kg | Calciumcarbonat-enthaltendes verbundpulver mit mikrostrukturierten teilchen |
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JP2010511751A (ja) | 2006-11-30 | 2010-04-15 | スミス アンド ネフュー インコーポレーテッド | 繊維強化複合材料 |
WO2012073660A1 (ja) | 2010-11-30 | 2012-06-07 | 株式会社白石中央研究所 | 樹脂組成物 |
JP2014508840A (ja) | 2011-03-18 | 2014-04-10 | シェーファー カルク ゲーエムベーハー ウント コー. カーゲー | 微細構造複合粒子 |
JP2016153354A (ja) | 2015-02-20 | 2016-08-25 | 古手川産業株式会社 | 炭酸カルシウム複合体 |
JP2019528841A (ja) | 2016-09-08 | 2019-10-17 | カール ライビンガー メディツィンテクニック ゲーエムベーハー ウント コー. カーゲーKarl Leibinger Medizintechnik GmbH & Co. KG | 抑制性炭酸カルシウムを含有するインプラント |
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RU2019110163A (ru) | 2020-10-08 |
RU2019110163A3 (es) | 2020-10-08 |
CN109661419A (zh) | 2019-04-19 |
RU2738378C2 (ru) | 2020-12-11 |
CA3033785A1 (en) | 2018-03-15 |
EP3510083A1 (de) | 2019-07-17 |
US11548998B2 (en) | 2023-01-10 |
CN109661419B (zh) | 2022-05-27 |
JP2019534932A (ja) | 2019-12-05 |
WO2018046127A1 (de) | 2018-03-15 |
US20210179814A1 (en) | 2021-06-17 |
MY193329A (en) | 2022-10-05 |
JP2022169563A (ja) | 2022-11-09 |
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