JP7150707B2 - マイクロドロップを処理するためのマイクロ流体方法 - Google Patents

マイクロドロップを処理するためのマイクロ流体方法 Download PDF

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Publication number
JP7150707B2
JP7150707B2 JP2019517429A JP2019517429A JP7150707B2 JP 7150707 B2 JP7150707 B2 JP 7150707B2 JP 2019517429 A JP2019517429 A JP 2019517429A JP 2019517429 A JP2019517429 A JP 2019517429A JP 7150707 B2 JP7150707 B2 JP 7150707B2
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Prior art keywords
microdrops
microdrop
trapping
zone
capture
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Japanese (ja)
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JP2019532805A (ja
JP2019532805A5 (enExample
Inventor
シャルル・バルー
ラファエル・トマシ
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Centre National de la Recherche Scientifique CNRS
Ecole Polytechnique
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Centre National de la Recherche Scientifique CNRS
Ecole Polytechnique
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3035—Micromixers using surface tension to mix, move or hold the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Extraction Or Liquid Replacement (AREA)
JP2019517429A 2016-09-30 2017-09-29 マイクロドロップを処理するためのマイクロ流体方法 Active JP7150707B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022117270A JP7438280B2 (ja) 2016-09-30 2022-07-22 マイクロドロップを処理するためのマイクロ流体方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1659418 2016-09-30
FR1659418A FR3056927B1 (fr) 2016-09-30 2016-09-30 Procede microfluidique de manipulation de microgouttes
PCT/EP2017/074859 WO2018060471A1 (fr) 2016-09-30 2017-09-29 Procede microfluidique de manipulation de microgouttes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022117270A Division JP7438280B2 (ja) 2016-09-30 2022-07-22 マイクロドロップを処理するためのマイクロ流体方法

Publications (3)

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JP2019532805A JP2019532805A (ja) 2019-11-14
JP2019532805A5 JP2019532805A5 (enExample) 2020-11-05
JP7150707B2 true JP7150707B2 (ja) 2022-10-11

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JP2019517429A Active JP7150707B2 (ja) 2016-09-30 2017-09-29 マイクロドロップを処理するためのマイクロ流体方法
JP2022117270A Active JP7438280B2 (ja) 2016-09-30 2022-07-22 マイクロドロップを処理するためのマイクロ流体方法

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Country Status (6)

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US (1) US11179722B2 (enExample)
EP (1) EP3519092A1 (enExample)
JP (2) JP7150707B2 (enExample)
CN (1) CN110035825B (enExample)
FR (1) FR3056927B1 (enExample)
WO (1) WO2018060471A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3566772A1 (en) * 2018-05-11 2019-11-13 Agilent Technologies, Inc. (A Delaware Corporation) Immobilizing fluidic sample for inhibiting spatial broadening
EP3924729A1 (en) 2019-02-11 2021-12-22 Agilent Technologies, Inc. Pre-shaping fluidic sample in a planar way before processing
FR3098128B1 (fr) * 2019-07-05 2023-11-17 Commissariat Energie Atomique Dispositif microfluidique comportant une microgoutte présentant une matrice sol-gel.
WO2023002057A2 (en) * 2021-07-22 2023-01-26 Institut Pasteur In vitro generation of organized 3d cell structures including head-trunk embryo-like structures, using epigenetic remodeling factors - microfluidic platform suitable for their generation
EP4219685A1 (en) * 2022-01-31 2023-08-02 Institut Pasteur In vitro generation of organized 3d cell structures including head-trunk embryo-like structures, using epigenetic remodeling factors - microfluidic platform suitable for their generation
DE102022202862A1 (de) * 2022-03-24 2023-09-28 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidisches Aufnahmeelement, mikrofluidische Vorrichtung mit Aufnahmeelement, Verfahren zum Herstellen eines mikrofluidischen Aufnahmeelements und Verfahren zum Verwenden eines mikrofluidischen Aufnahmeelements
DE102022209421A1 (de) 2022-09-09 2024-03-14 Robert Bosch Gesellschaft mit beschränkter Haftung Array für eine mikrofluidische Vorrichtung

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100190263A1 (en) 2009-01-23 2010-07-29 Advanced Liquid Logic, Inc. Bubble Techniques for a Droplet Actuator
JP2010273655A (ja) 2009-05-29 2010-12-09 Canon Inc 細胞保持方法、細胞試験方法及び細胞処理装置
US20130078163A1 (en) 2011-09-22 2013-03-28 Georgia Tech Research Corporation Deterministic High-Density Single-Cell Trap Array
JP2014100672A (ja) 2012-11-20 2014-06-05 Kanagawa Academy Of Science And Technology 脂質二重膜の形成方法及びそのための器具
JP2015534072A (ja) 2012-10-08 2015-11-26 エコール ポリテクニック 複数の流体の液滴を接触させることを可能にするマイクロ流体回路および対応するマイクロ流体方法
JP2017537772A (ja) 2014-10-17 2017-12-21 エコール ポリテクニック サンプルを含むマイクロ液滴を取り扱うための方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10326607A1 (de) * 2003-06-13 2005-01-05 Steag Microparts Gmbh Vorrichtung zum Handhaben von Flüssigkeiten
FR2950544B1 (fr) 2009-09-29 2011-12-09 Ecole Polytech Circuit microfluidique
US9476811B2 (en) * 2010-10-01 2016-10-25 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods incorporating a solid phase

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100190263A1 (en) 2009-01-23 2010-07-29 Advanced Liquid Logic, Inc. Bubble Techniques for a Droplet Actuator
JP2010273655A (ja) 2009-05-29 2010-12-09 Canon Inc 細胞保持方法、細胞試験方法及び細胞処理装置
US20130078163A1 (en) 2011-09-22 2013-03-28 Georgia Tech Research Corporation Deterministic High-Density Single-Cell Trap Array
JP2015534072A (ja) 2012-10-08 2015-11-26 エコール ポリテクニック 複数の流体の液滴を接触させることを可能にするマイクロ流体回路および対応するマイクロ流体方法
JP2014100672A (ja) 2012-11-20 2014-06-05 Kanagawa Academy Of Science And Technology 脂質二重膜の形成方法及びそのための器具
JP2017537772A (ja) 2014-10-17 2017-12-21 エコール ポリテクニック サンプルを含むマイクロ液滴を取り扱うための方法

Also Published As

Publication number Publication date
JP2019532805A (ja) 2019-11-14
JP7438280B2 (ja) 2024-02-26
CN110035825A (zh) 2019-07-19
FR3056927A1 (fr) 2018-04-06
US20200038867A1 (en) 2020-02-06
WO2018060471A1 (fr) 2018-04-05
CN110035825B (zh) 2021-10-26
EP3519092A1 (fr) 2019-08-07
FR3056927B1 (fr) 2021-07-09
US11179722B2 (en) 2021-11-23
JP2022136156A (ja) 2022-09-15

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