JP7148987B2 - 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 - Google Patents

眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 Download PDF

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JP7148987B2
JP7148987B2 JP2019518175A JP2019518175A JP7148987B2 JP 7148987 B2 JP7148987 B2 JP 7148987B2 JP 2019518175 A JP2019518175 A JP 2019518175A JP 2019518175 A JP2019518175 A JP 2019518175A JP 7148987 B2 JP7148987 B2 JP 7148987B2
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chitosan
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ダウリング，マシュー・ビー
レイザー，スティーブン・イー
ジェンティル，ヘルガ・エム
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アイ・ケア・インターナショナル，エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4869—Determining body composition
    • A61B5/4875—Hydration status, fluid retention of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
JP2019518175A 2016-06-16 2017-06-16 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法 Active JP7148987B2 (ja)

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JP2022145970A JP7473237B2 (ja) 2016-06-16 2022-09-14 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法
JP2024060611A JP2024096781A (ja) 2016-06-16 2024-04-04 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法

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US201662350772P 2016-06-16 2016-06-16
US62/350,772 2016-06-16
PCT/US2017/037954 WO2017218942A1 (en) 2016-06-16 2017-06-16 Compositions and methods of treating dry syndrome and other traumatized non-keratinized epithelial surfaces

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JP2019525951A5 JP2019525951A5 (https=) 2020-07-30
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JP2022145970A Active JP7473237B2 (ja) 2016-06-16 2022-09-14 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法
JP2024060611A Pending JP2024096781A (ja) 2016-06-16 2024-04-04 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法

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JP2024060611A Pending JP2024096781A (ja) 2016-06-16 2024-04-04 眼乾燥症候群および他の外傷を受けた非角化上皮表面を処置する組成物および方法

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US (3) US11191781B2 (https=)
EP (1) EP3471742A4 (https=)
JP (3) JP7148987B2 (https=)
CN (1) CN109862899A (https=)
CA (1) CA3027969A1 (https=)
WO (1) WO2017218942A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109862899A (zh) 2016-06-16 2019-06-07 护眼国际有限责任公司 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法
WO2019231133A1 (ko) * 2018-05-31 2019-12-05 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 모공 축소용 조성물
US20200170998A1 (en) * 2018-11-29 2020-06-04 Cellula Llc Umbilical cord blood serum and umbilical cord blood plasma preparation in combination with a nonsteroidal anti-inflammatory drug and freeze-drying the composition
EP3968965A1 (en) * 2019-05-13 2022-03-23 Bone Therapeutics S.A. Improved lyophilized formulations involving hyaluronic acid and plasmatic proteins, and uses thereof
IT201900010740A1 (it) * 2019-07-02 2021-01-02 Medacta Int Sa Biocompatible compositions comprising a biocompatible thickening polymer and a chitosan derivative
JP2025521429A (ja) * 2022-06-28 2025-07-10 コンプライアンス コンサルティング アンド エンジニアリング サーヴィシーズ， ソシエダ リミターダ プレートスタックシステムを備えた凍結乾燥機における凍結乾燥プロセスを制御するためのシステムおよび設計空間を生成するための方法
US20240226181A1 (en) * 2023-01-11 2024-07-11 Biostem Technologies, Inc. Human umbilical cord composition for treatment of peyronie's disease
CN117017945B (zh) * 2023-08-14 2026-02-06 珠海横琴澳叶健康科技有限公司 一种离子响应型蒙花苷纳米粒子及其制备方法和应用
WO2025165681A1 (en) * 2024-01-31 2025-08-07 Serorepair Llc Serum compositions with additive for ocular delivery in animals
CN118662706B (zh) * 2024-06-17 2025-01-10 韶关朗圣药业有限公司 一种人体润滑液及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000030609A1 (en) 1998-11-20 2000-06-02 Laboratoire Medidom S.A. Aqueous ophthalmic formulations comprising chitosan
JP2010522176A (ja) 2007-03-19 2010-07-01 ヘムコン メディカル テクノロジーズ， インコーポレイテッド 凍結乾燥された血漿などの凍結乾燥材料を製造、貯蔵、および投与するための装置および方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713980D0 (en) 1997-07-03 1997-09-10 Danbiosyst Uk New conjugates
BR0309890A (pt) 2002-05-09 2005-05-10 Medigenes Composição farmacêutica contendo plasma sanguìneo, ou soro sanguìneo utilizada no tratamento de lesões, bem como seu método e processo de aplicação
WO2006091038A1 (en) * 2005-02-25 2006-08-31 Medigenes Co., Ltd. Pharmaceutical composition for treating avellino cornea dystrophy comprising blood plasma or serum
ES2668551T3 (es) * 2005-09-26 2018-05-18 Lifecell Corporation Composición seca de plaquetas
US20090170059A1 (en) * 2005-11-14 2009-07-02 Hans Klingemann Methods for Preparing Cord Matrix Stem Cells (CMSC) for Long Term Storage and for Preparing a Segment of umbilical cord for cryopreservation
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
US20090223080A1 (en) 2007-03-19 2009-09-10 Hemcon Medical Technologies, Inc. Apparatus and methods for making, storing, and administering freeze-dried materials such as freeze-dried plasma
WO2010085792A1 (en) * 2009-01-26 2010-07-29 Oregon Biomedical Engineering Institute Dehydrated plasma kit
CN101829048B (zh) * 2010-01-21 2012-04-18 厦门大学 一种滴眼液及其制备方法
ES2368394B1 (es) * 2011-07-13 2012-06-08 Banc De Sang I Teixits Composición que comprende plasma de sangre de cordon umbilical para el tratamiento de patologías de la superficie ocular y procedimiento de obtención de la misma.
WO2014028745A2 (en) * 2012-08-17 2014-02-20 Archon Pharmaceutical Consulting Llc A system for compounding and packaging ready to reconstitute drug powders of solutions to a solution or to a suspension or to an injectable
WO2014160136A1 (en) 2013-03-13 2014-10-02 University Of Maryland, Office Of Technology Commercialization Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
US9981067B2 (en) * 2013-09-30 2018-05-29 Bioactive Regenerative Therapeutics, Inc. Biomimetic hybrid gel compositions and methods of use
JP6721514B2 (ja) 2014-02-20 2020-07-15 オルト リジェネレイティヴ テクノロジーズ インク．Ｏｒｔｈｏ Ｒｅｇｅｎｅｒａｔｉｖｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． 多血小板血漿と混合し、組織修復のためのインプラントを形成するための凍結乾燥ポリマー組成物及び／又は治療用関節内注射のための組成物
EP3119392A4 (en) * 2014-03-17 2017-10-11 Encompass Development Inc. Ocular formulations
JP2017534605A (ja) * 2014-10-06 2017-11-24 フォンダツィオネ・イルクス・カ’グランダ−オスペダレ・マジョーレ・ポリクリニコＦｏｎｄａｚｉｏｎｅ Ｉｒｃｃｓ Ｃａ’Ｇｒａｎｄａ−Ｏｓｐｅｄａｌｅ Ｍａｇｇｉｏｒｅ Ｐｏｌｉｃｌｉｎｉｃｏ 眼科用組成物
DE102015205293A1 (de) * 2015-03-24 2016-09-29 Marc Schrott Verfahren zur Herstellung von Augentropfen
CN109862899A (zh) 2016-06-16 2019-06-07 护眼国际有限责任公司 治疗干眼综合征及其他创伤性非角质化上皮表面的组合物和方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000030609A1 (en) 1998-11-20 2000-06-02 Laboratoire Medidom S.A. Aqueous ophthalmic formulations comprising chitosan
JP2010522176A (ja) 2007-03-19 2010-07-01 ヘムコン メディカル テクノロジーズ， インコーポレイテッド 凍結乾燥された血漿などの凍結乾燥材料を製造、貯蔵、および投与するための装置および方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Am. J. Ophthalmol., (2007), 144, [1], p.86-92

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Publication number Publication date
JP2019525951A (ja) 2019-09-12
EP3471742A4 (en) 2020-03-04
US20220168341A1 (en) 2022-06-02
WO2017218942A8 (en) 2019-01-24
EP3471742A1 (en) 2019-04-24
WO2017218942A1 (en) 2017-12-21
JP2024096781A (ja) 2024-07-17
JP7473237B2 (ja) 2024-04-23
US11534459B2 (en) 2022-12-27
JP2022191232A (ja) 2022-12-27
US20230321145A1 (en) 2023-10-12
CA3027969A1 (en) 2017-12-21
US11191781B2 (en) 2021-12-07
US20190175647A1 (en) 2019-06-13
CN109862899A (zh) 2019-06-07

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