JP7145079B2 - 剛性のスペーシング基を有する超明色ダイマーまたはポリマー染料 - Google Patents
剛性のスペーシング基を有する超明色ダイマーまたはポリマー染料 Download PDFInfo
- Publication number
- JP7145079B2 JP7145079B2 JP2018549448A JP2018549448A JP7145079B2 JP 7145079 B2 JP7145079 B2 JP 7145079B2 JP 2018549448 A JP2018549448 A JP 2018549448A JP 2018549448 A JP2018549448 A JP 2018549448A JP 7145079 B2 JP7145079 B2 JP 7145079B2
- Authority
- JP
- Japan
- Prior art keywords
- occurrence
- independently
- linker
- compound according
- covalent bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/101—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an anthracene dye
- C09B69/102—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an anthracene dye containing a perylene dye
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/103—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a diaryl- or triarylmethane dye
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/109—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing other specific dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/583—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Optics & Photonics (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662316836P | 2016-04-01 | 2016-04-01 | |
| US62/316,836 | 2016-04-01 | ||
| PCT/US2017/025513 WO2017173348A1 (en) | 2016-04-01 | 2017-03-31 | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019516812A JP2019516812A (ja) | 2019-06-20 |
| JP2019516812A5 JP2019516812A5 (cg-RX-API-DMAC7.html) | 2020-05-07 |
| JP7145079B2 true JP7145079B2 (ja) | 2022-09-30 |
Family
ID=58609994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018549448A Active JP7145079B2 (ja) | 2016-04-01 | 2017-03-31 | 剛性のスペーシング基を有する超明色ダイマーまたはポリマー染料 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11434377B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3436528B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7145079B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102525252B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109415574B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017173348A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015027176A1 (en) | 2013-08-22 | 2015-02-26 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| EP3262055A4 (en) | 2015-02-26 | 2018-09-05 | Sony Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
| EP3262022A4 (en) | 2015-02-26 | 2018-08-15 | Sony Corporation | Phenylethynylnaphthalene dyes and methods for their use |
| EP3294811B1 (en) * | 2015-05-11 | 2024-02-28 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
| WO2017173348A1 (en) | 2016-04-01 | 2017-10-05 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| CN114806218A (zh) | 2016-04-01 | 2022-07-29 | 索尼公司 | 超亮二聚或多聚染料 |
| AU2017248165B2 (en) | 2016-04-06 | 2021-08-26 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes with spacing linker groups |
| WO2017196954A1 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| US11390754B2 (en) | 2016-05-10 | 2022-07-19 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| JP7071286B2 (ja) | 2016-05-11 | 2022-05-18 | ソニーグループ株式会社 | 超明色ダイマーまたはポリマー染料 |
| US11377563B2 (en) | 2016-06-06 | 2022-07-05 | Sony Corporation | Ionic polymers comprising fluorescent or colored reporter groups |
| WO2018022925A1 (en) | 2016-07-29 | 2018-02-01 | Sony Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
| KR102795781B1 (ko) | 2017-06-16 | 2025-04-15 | 듀크 유니버시티 | 개선된 라벨 검출, 계산, 분석물 감지, 및 조정 가능한 난수 생성을 위한 공진기 네트워크 |
| CN111093711A (zh) | 2017-10-05 | 2020-05-01 | 索尼公司 | 可编程的树枝状药物 |
| JP7551056B2 (ja) | 2017-10-05 | 2024-09-17 | ソニーグループ株式会社 | プログラマブルなポリマー薬物 |
| WO2019099789A1 (en) | 2017-11-16 | 2019-05-23 | Sony Corporation | Programmable polymeric drugs |
| CN111565756A (zh) * | 2018-01-12 | 2020-08-21 | 索尼公司 | 包含生物活性化合物的具有刚性间隔基团的聚合物 |
| WO2019140227A1 (en) | 2018-01-12 | 2019-07-18 | Sony Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| JP2021520423A (ja) | 2018-03-19 | 2021-08-19 | ソニーグループ株式会社 | 蛍光シグナルを増強するための二価金属の使用 |
| JP7515786B2 (ja) * | 2018-03-21 | 2024-07-16 | ソニーグループ株式会社 | リンカー基を有するポリマータンデム色素 |
| CN119220109A (zh) | 2018-03-30 | 2024-12-31 | 贝克顿·迪金森公司 | 含侧基发色团的水溶性聚合染料 |
| KR102854332B1 (ko) | 2018-06-27 | 2025-09-03 | 소니그룹주식회사 | 디옥시리보오스를 포함하는 링커 군을 갖는 중합체성 염료 |
| WO2020210689A1 (en) * | 2019-04-11 | 2020-10-15 | Sony Corporation | Programmable polymeric drugs |
| WO2021062176A2 (en) | 2019-09-26 | 2021-04-01 | Sony Corporation | Polymeric tandem dyes with linker groups |
| CN111103761B (zh) * | 2019-12-27 | 2023-10-17 | Tcl华星光电技术有限公司 | 一种染料色阻及其制备方法、彩膜基板 |
| WO2022125564A1 (en) | 2020-12-07 | 2022-06-16 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| CN116917738A (zh) | 2021-04-07 | 2023-10-20 | 贝克顿·迪金森公司 | 水溶性荧光聚合物染料 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010055789A1 (ja) | 2008-11-14 | 2010-05-20 | 独立行政法人科学技術振興機構 | オリゴヌクレオチド誘導体、ラベル化剤及びその利用 |
| JP2013511700A (ja) | 2009-11-09 | 2013-04-04 | ユニバーシティ オブ ワシントン センター フォー コマーシャライゼーション | 官能化発色性ポリマードットおよびその生物共役体 |
| WO2015027176A1 (en) | 2013-08-22 | 2015-02-26 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| US20150159198A1 (en) | 2012-06-14 | 2015-06-11 | Affymetrix, Inc. | Methods and compositions for amplification of nucleic acids |
Family Cites Families (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450305A (en) | 1982-10-25 | 1984-05-22 | American Cyanamid Company | Poly(ethyleneoxy)-substituted-9,10-bis(phenylethynyl)anthracenes |
| US4476229A (en) | 1982-11-08 | 1984-10-09 | Abbott Laboratories | Substituted carboxyfluoresceins |
| SU1121931A1 (ru) | 1983-01-10 | 1988-04-15 | Институт Биологической Химии Ан Бсср | Конъюгаты тиреоидных гормонов с альбумином дл выработки антител к тиреоидным гормонам у животных |
| EP0355864A3 (en) | 1984-03-15 | 1991-09-18 | Wako Pure Chemical Industries, Ltd. | Method of quantitatively measuring an oxidative substance by using triphenyl methane type leuco compounds as coloring matter |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US5053054A (en) | 1988-09-12 | 1991-10-01 | Ortho Pharmaceutical Corporation | Methods and reagents for staining intracellular components |
| US5318894A (en) | 1990-01-30 | 1994-06-07 | Miles Inc. | Composition, device and method of assaying for peroxidatively active substances |
| US6365730B1 (en) | 1990-06-19 | 2002-04-02 | Gene Shears Pty. Limited | DNA-Armed ribozymes and minizymes |
| JPH04282391A (ja) | 1991-03-08 | 1992-10-07 | Fujisawa Pharmaceut Co Ltd | エタノールアミン誘導体およびその製造法 |
| EP0605655B1 (en) | 1991-09-16 | 1997-05-07 | Molecular Probes, Inc. | Dimers of unsymmetrical cyanine dyes |
| AU667497B2 (en) | 1991-11-07 | 1996-03-28 | Nanotronics, Inc. | Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
| DE69434649T2 (de) | 1993-07-13 | 2007-02-22 | Abbott Laboratories, Abbott Park | Durch fluoreszierenden polymer markierte konjugate und zwischenprodukte |
| US6171859B1 (en) | 1994-03-30 | 2001-01-09 | Mitokor | Method of targeting conjugate molecules to mitochondria |
| US5994143A (en) | 1996-02-01 | 1999-11-30 | Abbott Laboratories | Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment |
| US6218108B1 (en) | 1997-05-16 | 2001-04-17 | Research Corporation Technologies, Inc. | Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor |
| US6893868B2 (en) | 1997-02-20 | 2005-05-17 | Onco Immunin, Inc. | Homo-doubly labeled compositions for the detection of enzyme activity in biological samples |
| US5986030A (en) | 1997-04-15 | 1999-11-16 | Nalco Chemical Company | Fluorescent water soluble polymers |
| DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| JP3078793B2 (ja) | 1998-04-30 | 2000-08-21 | 株式会社分子バイオホトニクス研究所 | ロタキサン構造を有する色素、ラベル化剤、およびラベル化方法 |
| US7060708B2 (en) | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6627400B1 (en) | 1999-04-30 | 2003-09-30 | Aclara Biosciences, Inc. | Multiplexed measurement of membrane protein populations |
| US6514700B1 (en) | 1999-04-30 | 2003-02-04 | Aclara Biosciences, Inc. | Nucleic acid detection using degradation of a tagged sequence |
| AU5935300A (en) | 1999-07-22 | 2001-02-13 | Nalco Chemical Company | Fluorescent water-soluble polymers |
| US6479650B1 (en) | 1999-12-14 | 2002-11-12 | Research Corporation Technologies, Inc. | Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same |
| US20020012947A1 (en) | 2000-03-14 | 2002-01-31 | Bevers Susan Ann | Biomarkers for the labeling, visual detection and quantification of biomolecules |
| JP2004515208A (ja) | 2000-03-28 | 2004-05-27 | ナノスフェアー インコーポレイテッド | オリゴヌクレオチドを付着させたナノ粒子とその使用方法 |
| AU2001262994B2 (en) | 2000-05-08 | 2005-09-15 | Qtl Biosystems Llc | Improvements to the fluorescent polymer-qtl approach to biosensing |
| AU2001265252A1 (en) | 2000-05-31 | 2001-12-11 | The Johns-Hopkins University | Biologically useful polyphosphates |
| US20020099013A1 (en) | 2000-11-14 | 2002-07-25 | Thomas Piccariello | Active agent delivery systems and methods for protecting and administering active agents |
| WO2002022883A1 (en) | 2000-09-11 | 2002-03-21 | The Trustees Of Columbia University In The City Of New York | Combinatorial fluorescence energy transfer tags and uses thereof |
| CA2424454C (en) | 2000-09-19 | 2010-07-20 | Li-Cor, Inc. | Cyanine dyes |
| US6448407B1 (en) | 2000-11-01 | 2002-09-10 | Pe Corporation (Ny) | Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| GB2372256A (en) | 2001-02-14 | 2002-08-21 | Kalibrant Ltd | Detectable entity comprising a plurality of detectable units releasably connected together by stimulus-cleavable linkers for use in fluorescence detection |
| US8323903B2 (en) | 2001-10-12 | 2012-12-04 | Life Technologies Corporation | Antibody complexes and methods for immunolabeling |
| JP3813890B2 (ja) | 2002-03-22 | 2006-08-23 | 富士写真フイルム株式会社 | 3層レジストプロセス用中間層材料組成物及びそれを用いたパターン形成方法 |
| WO2004019002A2 (en) | 2002-08-23 | 2004-03-04 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent glycosides and methods for their use |
| KR20050055717A (ko) | 2002-08-26 | 2005-06-13 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 집광 다발색단을 사용하여 폴리뉴클레오티드를 검출 및 분석하기 위한 방법 및 조성물 |
| US20040138467A1 (en) | 2002-11-26 | 2004-07-15 | French Roger Harquail | Aromatic and aromatic/heteroaromatic molecular structures with controllable electron conducting properties |
| WO2004062475A2 (en) | 2003-01-10 | 2004-07-29 | Albert Einstein College Of Medicine Of Yeshiva University | Fluorescent assays for protein kinases |
| US7238792B2 (en) | 2003-03-18 | 2007-07-03 | Washington State University Research Foundation | Foldable polymers as probes |
| JP4566985B2 (ja) * | 2003-03-18 | 2010-10-20 | チバ ホールディング インコーポレーテッド | カチオン性二量体染料 |
| US7172907B2 (en) | 2003-03-21 | 2007-02-06 | Ge Healthcare Bio-Sciences Corp. | Cyanine dye labelling reagents with meso-substitution |
| US7667024B2 (en) | 2003-11-19 | 2010-02-23 | Allelogic Biosciences Corp. | Oligonucleotides labeled with a plurality of fluorophores |
| AU2003296419A1 (en) | 2003-12-09 | 2005-07-21 | Molecular Probes, Inc. | Pyrenyloxysulfonic acid fluorescent agents |
| EP1768998A2 (en) | 2004-04-27 | 2007-04-04 | Alnylam Pharmaceuticals Inc. | Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety |
| US20060035302A1 (en) | 2004-06-21 | 2006-02-16 | Applera Corporation | Kinase substrates with multiple phosphorylation sites |
| CN1727370A (zh) * | 2004-07-29 | 2006-02-01 | 丰田合成株式会社 | 刚性聚合物及其制造方法 |
| ES2461858T3 (es) | 2004-08-13 | 2014-05-21 | Epoch Biosciences, Inc. | Colorantes fluorescentes de fosfonato y conjugados |
| WO2006031851A1 (en) | 2004-09-14 | 2006-03-23 | Applera Corporation | Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes |
| US8153706B2 (en) | 2004-10-25 | 2012-04-10 | Hewlett-Packard Development Company, L.P. | Polymeric colorants having pigment and dye components and corresponding ink compositions |
| PL1655317T3 (pl) | 2004-11-09 | 2007-10-31 | Ipagsa Ind Sl | Termoreaktywne polimery absorbujące promieniowanie podczerwone i ich zastosowanie w termoczułej litograficznej płycie drukarskiej |
| EP1838752B1 (en) | 2005-01-10 | 2017-10-04 | The Regents of The University of California | Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays |
| JP2008535945A (ja) | 2005-03-09 | 2008-09-04 | セファイド | 極性色素 |
| US8227621B2 (en) | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
| WO2007038659A1 (en) | 2005-09-26 | 2007-04-05 | Invitrogen Corporation | Violet laser excitable dyes and their method of use |
| BRPI0618713B8 (pt) | 2005-11-18 | 2021-07-27 | The Government Of The United State Of America Representado Por The Secretary Of The Dept Of Health A | cardiolipina modificada e seus usos |
| JP5410760B2 (ja) | 2005-12-12 | 2014-02-05 | チバ ホールディング インコーポレーテッド | 半導体素子、化合物、半導体素子の半導体層及び薄膜トランジスタ素子を作製する方法 |
| US20070148094A1 (en) | 2005-12-22 | 2007-06-28 | Uzgiris Egidijus E | Polymeric imaging agents and medical imaging methods |
| WO2007122388A2 (en) | 2006-04-13 | 2007-11-01 | Midatech Limited | Nanoparticles containing three various ligands for providing immune responses against infectious agents |
| EP2054770A2 (en) | 2006-08-12 | 2009-05-06 | STX Aprilis, Inc. | Sensitizer dyes for photoacid generating systems using short visible wavelengths |
| KR20090077779A (ko) | 2006-10-12 | 2009-07-15 | 이데미쓰 고산 가부시키가이샤 | 유기 박막 트랜지스터 소자 및 유기 박막 발광 트랜지스터 |
| JP5636189B2 (ja) | 2006-10-27 | 2014-12-03 | ライフ テクノロジーズ コーポレーション | 蛍光発生性pH感受性色素およびその使用方法 |
| US8053588B2 (en) | 2007-03-07 | 2011-11-08 | Kabushiki Kaisha Toyota Chuo Kenkyusho | Organosilane compound and organosilica obtained therefrom |
| WO2008129548A2 (en) | 2007-04-23 | 2008-10-30 | Segev Laboratories Limited | A system for delivering therapeutic agents into living cells and cells nuclei |
| US9556210B2 (en) | 2007-04-23 | 2017-01-31 | Sabag-Rfa Ltd. | System for delivering therapeutic agents into living cells and cells nuclei |
| US9156865B2 (en) | 2007-04-23 | 2015-10-13 | Deliversir Ltd | System for delivering therapeutic agents into living cells and cells nuclei |
| EP2155805A2 (en) | 2007-05-11 | 2010-02-24 | Basf Se | Polymeric dyes |
| EP2014698A1 (en) | 2007-07-12 | 2009-01-14 | Crystax Pharmaceuticals S.L. | Polymers and their use as fluorescent labels |
| TWI409280B (zh) | 2007-07-31 | 2013-09-21 | American Dye Source Inc | 聚合物染料、塗覆層組合物及熱微影印刷板 |
| GB2456298A (en) | 2008-01-07 | 2009-07-15 | Anthony Ian Newman | Electroluminescent materials comprising oxidation resistant fluorenes |
| JP5467366B2 (ja) | 2008-03-10 | 2014-04-09 | 国立大学法人 東京大学 | 非荷電性親水性ブロック及び側鎖の一部に疎水性基が導入されたカチオン性のポリアミノ酸ブロックを含んでなる共重合体、その使用 |
| CA2721980C (en) | 2008-04-21 | 2017-01-03 | The Regents Of The University Of California | Selective high-affinity poly dentate ligands and methods of making such |
| KR101041446B1 (ko) | 2008-07-21 | 2011-06-14 | 부산대학교 산학협력단 | 공액고분자 2단계 fret 시스템 및 바이오센서 |
| WO2010026957A1 (ja) | 2008-09-03 | 2010-03-11 | 国立大学法人 富山大学 | 水溶性ロタキサン型蛍光色素および蛍光性有機分子 |
| AU2009324490A1 (en) | 2008-12-12 | 2011-06-23 | University Of Massachusetts | Zwitterionic polymers with therapeutic moieties |
| US9400273B1 (en) | 2009-12-09 | 2016-07-26 | Life Technologies Corporation | 7-hydroxycoumarin-based cell-tracking reagents |
| US9221759B2 (en) | 2010-01-13 | 2015-12-29 | Rutgers, The State University Of New Jersey | Fluorophore chelated lanthanide luminescent probes with improved quantum efficiency |
| EP2545373B1 (en) | 2010-03-11 | 2022-08-24 | Medtronic Minimed, Inc. | Measuring analyte concentration incorporating temperature and ph correction |
| WO2011120053A1 (en) | 2010-03-26 | 2011-09-29 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| WO2011150079A1 (en) | 2010-05-25 | 2011-12-01 | Carnegie Mellon University | Targeted probes of cellular physiology |
| CN102971283A (zh) | 2010-07-08 | 2013-03-13 | 旭硝子株式会社 | 含氟芳香族化合物、有机半导体材料和有机薄膜器件 |
| WO2012080836A2 (en) | 2010-12-13 | 2012-06-21 | Marek Kwiatkowski | Functionalized polymers |
| EP2769226B1 (en) | 2011-07-15 | 2017-05-24 | Medtronic Minimed, Inc. | Combinations of fluorphores and pyridinium boronic acid quenchers for use in analyte sensors |
| US20130059343A1 (en) | 2011-09-06 | 2013-03-07 | Li-Cor, Inc. | Nucleotide derivatives |
| WO2014043289A2 (en) | 2012-09-12 | 2014-03-20 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide molecules to ddit4 and methods of use thereof |
| US20150258217A1 (en) | 2012-10-04 | 2015-09-17 | The General Hospital Corporation | Methods of Synthesizing and Using Peg-Like Fluorochromes |
| EP2908864B1 (en) | 2012-10-22 | 2019-12-11 | Sabag-Rfa Ltd. | Phosphate compounds for delivering therapeutic agents into living cells and cells nuclei |
| WO2014102806A1 (en) | 2012-12-31 | 2014-07-03 | Yeda Research And Development Co. Ltd. | Protein biosensors, cross reactive sensor arrays and methods of use thereof |
| US9545447B2 (en) | 2013-01-04 | 2017-01-17 | The Texas A&M University System | Polymer-drug systems |
| US9714946B2 (en) | 2013-03-14 | 2017-07-25 | Dana-Farber Cancer Institute, Inc. | Bromodomain binding reagents and uses thereof |
| CA2901379C (en) | 2013-03-15 | 2023-05-16 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| WO2014147642A1 (en) | 2013-03-19 | 2014-09-25 | Council Of Scientific & Industrial Research | Substituted fluoranthene-7-carbonitriles as fluorescent dyes for cell imaging applications |
| CN103319378B (zh) | 2013-06-27 | 2015-06-10 | 中国科学院宁波材料技术与工程研究所 | 两性离子有机小分子太阳能电池阴极界面材料及其制法和用途 |
| KR101572901B1 (ko) | 2013-07-12 | 2015-12-15 | 부산대학교 산학협력단 | 2-단계 fret를 이용한 공액고분자 전해질 및 압타머 프로브 기반 표적 물질의 검출 방법 및 형광 센서 |
| US10406246B2 (en) | 2013-10-17 | 2019-09-10 | Deutsches Kresbsforschungszentrum | Double-labeled probe for molecular imaging and use thereof |
| JP5802865B1 (ja) | 2013-11-11 | 2015-11-04 | オリンパス株式会社 | 処置システム |
| JP6503354B2 (ja) | 2013-12-06 | 2019-04-17 | モノソル リミテッド ライアビリティ カンパニー | 水溶性フィルムのための蛍光トレーサー、関連方法、及び関連物品 |
| EP3094687B1 (en) | 2014-01-16 | 2020-02-12 | Sony Corporation | Water soluble fluorescent or colored dyes |
| JP6374172B2 (ja) | 2014-01-31 | 2018-08-15 | 富士フイルム株式会社 | 着色組成物、およびこれを用いた硬化膜、カラーフィルタ、パターン形成方法、カラーフィルタの製造方法、固体撮像素子、画像表示装置ならびに染料多量体 |
| CN104072727A (zh) | 2014-06-23 | 2014-10-01 | 华南理工大学 | 一种含磷脂酰胆碱基的2,7-芴的共轭聚合物及其制备方法与应用 |
| WO2016077625A1 (en) | 2014-11-12 | 2016-05-19 | Stayton Patrick S | Stabilized polymeric carriers for therapeutic agent delivery |
| WO2016074093A1 (en) | 2014-11-14 | 2016-05-19 | Angiochem Inc. | Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin |
| EP3262022A4 (en) | 2015-02-26 | 2018-08-15 | Sony Corporation | Phenylethynylnaphthalene dyes and methods for their use |
| EP3262055A4 (en) | 2015-02-26 | 2018-09-05 | Sony Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
| JP7390778B2 (ja) | 2015-03-12 | 2023-12-06 | ベクトン・ディキンソン・アンド・カンパニー | ポリマーbodipy色素およびそれを使用する方法 |
| EP3294811B1 (en) | 2015-05-11 | 2024-02-28 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
| US9670318B2 (en) | 2015-05-28 | 2017-06-06 | Miltenyi Biotec Gmbh | Bright fluorochromes based on multimerization of fluorescent dyes |
| US9913992B2 (en) | 2015-12-22 | 2018-03-13 | Colgate-Palmolive Company | Oral treatment device |
| CN114806218A (zh) | 2016-04-01 | 2022-07-29 | 索尼公司 | 超亮二聚或多聚染料 |
| WO2017173348A1 (en) | 2016-04-01 | 2017-10-05 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| AU2017248165B2 (en) | 2016-04-06 | 2021-08-26 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes with spacing linker groups |
| WO2017196954A1 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| US11390754B2 (en) | 2016-05-10 | 2022-07-19 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| JP7071286B2 (ja) | 2016-05-11 | 2022-05-18 | ソニーグループ株式会社 | 超明色ダイマーまたはポリマー染料 |
| US11377563B2 (en) | 2016-06-06 | 2022-07-05 | Sony Corporation | Ionic polymers comprising fluorescent or colored reporter groups |
| WO2018022925A1 (en) | 2016-07-29 | 2018-02-01 | Sony Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
| GB2554666B (en) | 2016-09-30 | 2019-12-18 | Sumitomo Chemical Co | Composite Particle |
| CN106589005B (zh) | 2016-11-01 | 2019-08-06 | 北京擎科生物科技有限公司 | 一种荧光信号放大探针中间体、荧光探针及其制备方法 |
| JP7551056B2 (ja) | 2017-10-05 | 2024-09-17 | ソニーグループ株式会社 | プログラマブルなポリマー薬物 |
| CN111093711A (zh) | 2017-10-05 | 2020-05-01 | 索尼公司 | 可编程的树枝状药物 |
| WO2019099789A1 (en) | 2017-11-16 | 2019-05-23 | Sony Corporation | Programmable polymeric drugs |
| KR102773157B1 (ko) | 2017-12-13 | 2025-02-27 | 소니그룹주식회사 | 생물학적 활성 화합물을 함유하는 이온성 중합체 |
| EP3737419B1 (en) | 2018-01-12 | 2024-04-10 | Sony Group Corporation | Phosphoalkyl polymers comprising biologically active compounds |
| WO2019140227A1 (en) | 2018-01-12 | 2019-07-18 | Sony Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| CN111565756A (zh) | 2018-01-12 | 2020-08-21 | 索尼公司 | 包含生物活性化合物的具有刚性间隔基团的聚合物 |
| JP2021520423A (ja) | 2018-03-19 | 2021-08-19 | ソニーグループ株式会社 | 蛍光シグナルを増強するための二価金属の使用 |
| JP7515786B2 (ja) | 2018-03-21 | 2024-07-16 | ソニーグループ株式会社 | リンカー基を有するポリマータンデム色素 |
| WO2020014634A1 (en) | 2018-07-13 | 2020-01-16 | Sony Corporation | Polymeric dyes having a backbone comprising organophosphate units |
| WO2020210694A1 (en) | 2019-04-11 | 2020-10-15 | Sony Corporation | Programmable polymeric drugs |
| KR20210152524A (ko) | 2019-04-11 | 2021-12-15 | 소니그룹주식회사 | 프로그램 가능한 중합체성 약물 |
| WO2020210689A1 (en) | 2019-04-11 | 2020-10-15 | Sony Corporation | Programmable polymeric drugs |
| WO2021062176A2 (en) | 2019-09-26 | 2021-04-01 | Sony Corporation | Polymeric tandem dyes with linker groups |
| CN114981451A (zh) | 2019-09-30 | 2022-08-30 | 索尼集团公司 | 核苷酸探针 |
-
2017
- 2017-03-31 WO PCT/US2017/025513 patent/WO2017173348A1/en not_active Ceased
- 2017-03-31 KR KR1020187031703A patent/KR102525252B1/ko active Active
- 2017-03-31 EP EP17719074.1A patent/EP3436528B1/en active Active
- 2017-03-31 CN CN201780019799.0A patent/CN109415574B/zh active Active
- 2017-03-31 US US16/090,560 patent/US11434377B2/en active Active
- 2017-03-31 JP JP2018549448A patent/JP7145079B2/ja active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010055789A1 (ja) | 2008-11-14 | 2010-05-20 | 独立行政法人科学技術振興機構 | オリゴヌクレオチド誘導体、ラベル化剤及びその利用 |
| JP2013511700A (ja) | 2009-11-09 | 2013-04-04 | ユニバーシティ オブ ワシントン センター フォー コマーシャライゼーション | 官能化発色性ポリマードットおよびその生物共役体 |
| US20150159198A1 (en) | 2012-06-14 | 2015-06-11 | Affymetrix, Inc. | Methods and compositions for amplification of nucleic acids |
| WO2015027176A1 (en) | 2013-08-22 | 2015-02-26 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
Also Published As
| Publication number | Publication date |
|---|---|
| US20200392345A1 (en) | 2020-12-17 |
| US11434377B2 (en) | 2022-09-06 |
| WO2017173348A1 (en) | 2017-10-05 |
| CN109415574B (zh) | 2021-05-28 |
| JP2019516812A (ja) | 2019-06-20 |
| CN109415574A (zh) | 2019-03-01 |
| KR102525252B1 (ko) | 2023-04-26 |
| KR20180129896A (ko) | 2018-12-05 |
| EP3436528A1 (en) | 2019-02-06 |
| EP3436528B1 (en) | 2025-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7145079B2 (ja) | 剛性のスペーシング基を有する超明色ダイマーまたはポリマー染料 | |
| JP7239904B2 (ja) | リンカー基を有するポリマータンデム色素 | |
| KR102773661B1 (ko) | 초휘도 이량체성 또는 중합체성 염료 | |
| JP7515786B2 (ja) | リンカー基を有するポリマータンデム色素 | |
| JP7312929B2 (ja) | 超明色二量体またはポリマー色素およびその調製のための方法 | |
| JP7580689B2 (ja) | デオキシリボースを含むリンカー基を有するポリマー色素 | |
| KR102526802B1 (ko) | 초고명도 이량체성 또는 중합체성 염료 | |
| KR102765335B1 (ko) | 초휘도 이량체성 또는 중합체성 염료 | |
| JP7527537B2 (ja) | ペプチド骨格を有する超明色ポリマー染料 | |
| JP2019523787A (ja) | 蛍光または有色レポーター基を含むイオン性ポリマー | |
| JP2019522066A (ja) | ポリマー染料およびシクロデキストリンを含む組成物、ならびにその使用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20190515 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20190523 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200327 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200327 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210421 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210721 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220104 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220404 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220817 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220916 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7145079 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313117 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |