JP7136763B2 - フェニル酪酸ナトリウムを含む口当たりの良い組成物及びその使用 - Google Patents

フェニル酪酸ナトリウムを含む口当たりの良い組成物及びその使用 Download PDF

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JP7136763B2
JP7136763B2 JP2019500212A JP2019500212A JP7136763B2 JP 7136763 B2 JP7136763 B2 JP 7136763B2 JP 2019500212 A JP2019500212 A JP 2019500212A JP 2019500212 A JP2019500212 A JP 2019500212A JP 7136763 B2 JP7136763 B2 JP 7136763B2
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pharmaceutical composition
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sodium phenylbutyrate
composition according
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JP2019509345A (ja
JP2019509345A5 (ar
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イー． アッペル，レア
アール． ショッキー，ジョシュア
シェリング，ディー．クリストファー
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エイサー セラピューティクス インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
JP2019500212A 2016-03-15 2016-10-17 フェニル酪酸ナトリウムを含む口当たりの良い組成物及びその使用 Active JP7136763B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022076939A JP2022106927A (ja) 2016-03-15 2022-05-09 フェニル酪酸ナトリウムを含む口当たりの良い組成物及びその使用

Applications Claiming Priority (3)

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US201662308614P 2016-03-15 2016-03-15
US62/308,614 2016-03-15
PCT/US2016/057415 WO2017160345A1 (en) 2016-03-15 2016-10-17 Palatable compositions including sodium phenylbutyrate and uses thereof

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JP2022076939A Division JP2022106927A (ja) 2016-03-15 2022-05-09 フェニル酪酸ナトリウムを含む口当たりの良い組成物及びその使用

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JP2019509345A JP2019509345A (ja) 2019-04-04
JP2019509345A5 JP2019509345A5 (ar) 2019-11-28
JP7136763B2 true JP7136763B2 (ja) 2022-09-13

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JP2022076939A Withdrawn JP2022106927A (ja) 2016-03-15 2022-05-09 フェニル酪酸ナトリウムを含む口当たりの良い組成物及びその使用

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US (5) US20170266115A1 (ar)
EP (2) EP3429559B1 (ar)
JP (2) JP7136763B2 (ar)
KR (1) KR20190008840A (ar)
AU (1) AU2016398029B2 (ar)
BR (1) BR112018068665B1 (ar)
CA (1) CA3017573A1 (ar)
DK (1) DK3429559T3 (ar)
ES (1) ES2922749T3 (ar)
HR (1) HRP20220856T1 (ar)
HU (1) HUE059630T2 (ar)
IL (2) IL296490A (ar)
LT (1) LT3429559T (ar)
MX (2) MX2018011229A (ar)
PL (1) PL3429559T3 (ar)
PT (1) PT3429559T (ar)
RS (1) RS63383B1 (ar)
SA (1) SA518400020B1 (ar)
SG (1) SG11201807979SA (ar)
SI (1) SI3429559T1 (ar)
WO (1) WO2017160345A1 (ar)

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EP3429559B1 (en) 2016-03-15 2022-04-13 Acer Therapeutics Inc. Palatable compositions including sodium phenylbutyrate and uses thereof
CA3184989A1 (en) * 2020-07-07 2022-01-13 Christopher D. Schelling Methods of administering taste masked phenylbutyrate and compositions therefor
CN113332267A (zh) * 2021-03-31 2021-09-03 中山大学孙逸仙纪念医院 苯丁酸钠在制备预防或治疗帕金森病的药物中的应用
IT202100019613A1 (it) 2021-07-23 2023-01-23 Kolfarma S R L Formulazione farmaceutica o di integratore alimentare contenente alfa-lattoalbumina e acido butirrico o un suo sale
CN216570857U (zh) * 2021-08-11 2022-05-24 Acer治疗公司 改善药物物质适口性的剂型和多个剂型

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JP2005508901A (ja) 2001-09-10 2005-04-07 ルナメト アクチェンゲゼルシャフト 活性成分を徐放する剤形
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JP2008280351A5 (ar) 2008-06-17 2009-04-23
JP2012240917A (ja) 2011-05-16 2012-12-10 Zensei Yakuhin Kogyo Kk 製剤化用微粒子とそれを含む製剤
JP2014521713A (ja) 2011-08-12 2014-08-28 ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング 味をマスキングした医薬組成物
JP2015533164A (ja) 2012-10-15 2015-11-19 ニュー ジャージー インスティチュート オブ テクノロジー 味マスクされた活性医薬粉末組成物およびその製造方法
JP2016006025A (ja) 2014-05-26 2016-01-14 富士フイルム株式会社 医薬用組成物及びその製造方法、並びに口腔内崩壊錠及びその製造方法

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WO2011011781A1 (en) * 2009-07-24 2011-01-27 Baylor College Of Medicine Methods of modulation of branched chain acids and uses thereof
FR2959129B1 (fr) * 2010-04-21 2013-02-01 Lucane Pharma Particules comprenant du 4-phenylbutyrate de sodium, procede de preparation et utilisations
EP2389932A1 (en) * 2010-05-28 2011-11-30 Lunamed AG Compositions for use in genetic disorders comprising 4-phenyl-butyric acid and its salts
BR112013014044A2 (pt) 2010-12-06 2017-10-31 Degama Barrier Ltd composição, produto alimentício e processo para prepará-lo
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Publication number Priority date Publication date Assignee Title
JP2005508901A (ja) 2001-09-10 2005-04-07 ルナメト アクチェンゲゼルシャフト 活性成分を徐放する剤形
JP2007525413A (ja) 2003-01-24 2007-09-06 アール．ピー． シェーラー テクノロジーズ インコーポレイテッド 味をマスクした有効物質の結晶または顆粒の分散体、分散体を詰めた咀嚼ソフトカプセル、およびその調製方法
JP2005060310A (ja) 2003-08-13 2005-03-10 Towa Yakuhin Kk 不快な味をマスキングする経口投与用製剤
JP2008280351A5 (ar) 2008-06-17 2009-04-23
JP2012240917A (ja) 2011-05-16 2012-12-10 Zensei Yakuhin Kogyo Kk 製剤化用微粒子とそれを含む製剤
JP2014521713A (ja) 2011-08-12 2014-08-28 ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング 味をマスキングした医薬組成物
JP2015533164A (ja) 2012-10-15 2015-11-19 ニュー ジャージー インスティチュート オブ テクノロジー 味マスクされた活性医薬粉末組成物およびその製造方法
JP2016006025A (ja) 2014-05-26 2016-01-14 富士フイルム株式会社 医薬用組成物及びその製造方法、並びに口腔内崩壊錠及びその製造方法

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Publication number Publication date
WO2017160345A1 (en) 2017-09-21
US20210186908A1 (en) 2021-06-24
US20170266115A1 (en) 2017-09-21
AU2016398029B2 (en) 2023-03-02
CA3017573A1 (en) 2017-09-21
IL261777B (en) 2022-10-01
US11433041B2 (en) 2022-09-06
ES2922749T3 (es) 2022-09-20
RS63383B1 (sr) 2022-08-31
US11154521B2 (en) 2021-10-26
MX2018011229A (es) 2019-05-30
PT3429559T (pt) 2022-07-20
US20210220304A1 (en) 2021-07-22
IL261777B2 (en) 2023-02-01
BR112018068665A2 (pt) 2019-02-05
JP2022106927A (ja) 2022-07-20
WO2017160345A8 (en) 2018-02-22
EP4104822A1 (en) 2022-12-21
EP3429559B1 (en) 2022-04-13
JP2019509345A (ja) 2019-04-04
SG11201807979SA (en) 2018-10-30
SA518400020B1 (ar) 2022-12-21
DK3429559T3 (da) 2022-07-11
LT3429559T (lt) 2022-08-10
IL296490A (en) 2022-11-01
KR20190008840A (ko) 2019-01-25
HRP20220856T1 (hr) 2022-10-14
US20230133629A1 (en) 2023-05-04
PL3429559T3 (pl) 2022-11-07
AU2016398029A1 (en) 2018-10-11
EP3429559A4 (en) 2019-11-06
EP3429559A1 (en) 2019-01-23
US20200261385A1 (en) 2020-08-20
HUE059630T2 (hu) 2022-11-28
US11202767B2 (en) 2021-12-21
MX2022003969A (es) 2022-04-25
SI3429559T1 (sl) 2022-11-30
BR112018068665B1 (pt) 2023-12-26
IL261777A (en) 2018-10-31

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