JP7135068B2 - Egfr阻害剤と抗ヒトvegfr-2抗体との組み合わせ - Google Patents

Egfr阻害剤と抗ヒトvegfr-2抗体との組み合わせ Download PDF

Info

Publication number
JP7135068B2
JP7135068B2 JP2020508540A JP2020508540A JP7135068B2 JP 7135068 B2 JP7135068 B2 JP 7135068B2 JP 2020508540 A JP2020508540 A JP 2020508540A JP 2020508540 A JP2020508540 A JP 2020508540A JP 7135068 B2 JP7135068 B2 JP 7135068B2
Authority
JP
Japan
Prior art keywords
seq
patient
osimertinib
amino acid
egfr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020508540A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020530851A5 (enExample
JP2020530851A (ja
Inventor
ボー・ホア・チャオ
サンミン・リー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune Ltd
Original Assignee
MedImmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune Ltd filed Critical MedImmune Ltd
Publication of JP2020530851A publication Critical patent/JP2020530851A/ja
Publication of JP2020530851A5 publication Critical patent/JP2020530851A5/ja
Priority to JP2022109875A priority Critical patent/JP2022133436A/ja
Application granted granted Critical
Publication of JP7135068B2 publication Critical patent/JP7135068B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2020508540A 2017-08-21 2018-08-20 Egfr阻害剤と抗ヒトvegfr-2抗体との組み合わせ Active JP7135068B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022109875A JP2022133436A (ja) 2017-08-21 2022-07-07 Egfr阻害剤と抗ヒトvegfr-2抗体との組み合わせ

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762548069P 2017-08-21 2017-08-21
US62/548,069 2017-08-21
US201862664529P 2018-04-30 2018-04-30
US62/664,529 2018-04-30
US201862672153P 2018-05-16 2018-05-16
US62/672,153 2018-05-16
PCT/US2018/047031 WO2019040348A1 (en) 2017-08-21 2018-08-20 COMBINATIONS OF EGFR INHIBITORS AND ANTI-VEGFR -2 HUMAN ANTIBODIES

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022109875A Division JP2022133436A (ja) 2017-08-21 2022-07-07 Egfr阻害剤と抗ヒトvegfr-2抗体との組み合わせ

Publications (3)

Publication Number Publication Date
JP2020530851A JP2020530851A (ja) 2020-10-29
JP2020530851A5 JP2020530851A5 (enExample) 2020-12-10
JP7135068B2 true JP7135068B2 (ja) 2022-09-12

Family

ID=63638326

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020508540A Active JP7135068B2 (ja) 2017-08-21 2018-08-20 Egfr阻害剤と抗ヒトvegfr-2抗体との組み合わせ
JP2022109875A Withdrawn JP2022133436A (ja) 2017-08-21 2022-07-07 Egfr阻害剤と抗ヒトvegfr-2抗体との組み合わせ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022109875A Withdrawn JP2022133436A (ja) 2017-08-21 2022-07-07 Egfr阻害剤と抗ヒトvegfr-2抗体との組み合わせ

Country Status (4)

Country Link
US (1) US11471457B2 (enExample)
EP (1) EP3672633A1 (enExample)
JP (2) JP7135068B2 (enExample)
WO (1) WO2019040348A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022003286A2 (pt) * 2019-08-23 2022-05-24 Spectrum Pharmaceuticals Inc Combinação de poziotinibe com inibidores de vegfr2 e métodos de uso da mesma

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015134242A1 (en) 2014-03-04 2015-09-11 Eli Lilly And Company Anti-met in combination with anti-vegfr2 antibodies therapy for cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2362931T3 (es) 2002-03-04 2011-07-15 Imclone Llc Anticuerpos humanos específicos contra kdr y usos de los mismos.
ES2791308T3 (es) 2011-07-27 2020-11-03 Astrazeneca Ab Derivados de 2-(2,4,5-anilino sustituido)pirimidina como moduladores de EGFR útiles para tratar el cáncer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015134242A1 (en) 2014-03-04 2015-09-11 Eli Lilly And Company Anti-met in combination with anti-vegfr2 antibodies therapy for cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Therapeutic Advances in Respiratory Disease,2016年,Vol.10, No.6,p.549-565

Also Published As

Publication number Publication date
US20200155551A1 (en) 2020-05-21
US11471457B2 (en) 2022-10-18
WO2019040348A1 (en) 2019-02-28
JP2022133436A (ja) 2022-09-13
JP2020530851A (ja) 2020-10-29
EP3672633A1 (en) 2020-07-01

Similar Documents

Publication Publication Date Title
ES3031468T3 (en) Combinations of cabozantinib and atezolizumab for the treatment of castration-resistant prostate cancer
TW201922793A (zh) Pd-1抗體和vegfr抑制劑聯合治療小細胞肺癌的用途
RU2677245C2 (ru) Комплексная терапия
CN107614011A (zh) Hdac抑制剂和抗pd‑1抗体联合用于癌症的治疗
JP2024112968A (ja) Kras g12c阻害剤の投与レジメン
CN107921108A (zh) 用于治疗癌症的hdac抑制剂和抗‑pd‑l1抗体的组合
JP2022133436A (ja) Egfr阻害剤と抗ヒトvegfr-2抗体との組み合わせ
AU2025252564A1 (en) Combination treatments for melanoma
KR20230047359A (ko) 트라스투주맙, 탁산 및 vegfr-2 길항제와 병용하여 투카티닙을 이용하는 her2 양성 암의 치료 방법
TWI569808B (zh) 肝細胞腫瘤(hcc)之治療
WO2021213523A1 (zh) 抗pd-1抗体和抗ctla-4抗体的组合在预防或治疗癌症中的用途
JP2024174997A (ja) Cd47阻害物質、免疫チェックポイント阻害物質および標準療法の併用によるがん治療法
CN112915203A (zh) 喹啉衍生物与pd-1单抗的药物组合
CN113117072A (zh) 喹啉衍生物与pd-1单抗的药物组合
JP7574079B2 (ja) 小児患者における癌の治療のためのラムシルマブ
JP2019513767A (ja) マントル細胞リンパ腫の治療における使用のためのラムシルマブ及びアベマシクリブの組み合わせ療法
TW202541838A (zh) 抗cd38抗體在治療新診斷的多發性骨髓瘤中之用途
WO2024155790A2 (en) Novel approach for treatment of cancer using immunomodulation
WO2023136837A1 (en) Use of tivozanib and durvalumab for treating hepatocellular carcinoma (hcc)
WO2025122791A1 (en) Use of anti-cd38 antibody in the treatment of new diagnosed multiple myeloma
WO2024100663A1 (en) Anti carcinoembryonic antigen-related cell adhesion molecule 1 (ceacam1) antibodies for inhibition of neutrophil extracellular traps (net)-mediated activities
CN117460534A (zh) 基于cd47抑制物质、免疫检查点抑制物质和标准疗法的联用的癌症治疗方法
CA2980297C (en) Combination of hdac inhibitor and anti-pd-1 antibody for treatment of cancer
WO2023072043A1 (zh) 治疗肿瘤的联用药物
WO2021143671A1 (zh) 抗pd-1抗体和喹唑啉衍生物的药物组合以及其用途、使用其的方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200214

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200214

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210202

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210430

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210531

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210802

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20211019

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220117

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20220308

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220707

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20220707

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20220713

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20220719

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220823

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220831

R150 Certificate of patent or registration of utility model

Ref document number: 7135068

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150