JP7133468B2 - マイクロrna認識エレメントを含むcmvベクター - Google Patents

マイクロrna認識エレメントを含むcmvベクター Download PDF

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JP7133468B2
JP7133468B2 JP2018526190A JP2018526190A JP7133468B2 JP 7133468 B2 JP7133468 B2 JP 7133468B2 JP 2018526190 A JP2018526190 A JP 2018526190A JP 2018526190 A JP2018526190 A JP 2018526190A JP 7133468 B2 JP7133468 B2 JP 7133468B2
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cmv
protein
mir
vector
antigen
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JP2019502371A (ja
JP2019502371A5 (cg-RX-API-DMAC7.html
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ジェイ ネルソン
スコット ハンセン
メーガン エイチ. ハンコック
ルイス ピッカー
クラウス フリュー
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Oregon Health and Science University
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JP2018526190A 2015-11-20 2016-11-20 マイクロrna認識エレメントを含むcmvベクター Active JP7133468B2 (ja)

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US201562258393P 2015-11-20 2015-11-20
US62/258,393 2015-11-20
US201662365259P 2016-07-21 2016-07-21
US62/365,259 2016-07-21
PCT/US2016/062973 WO2017087921A1 (en) 2015-11-20 2016-11-20 Cmv vectors comprising microrna recognition elements

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US (2) US10688164B2 (cg-RX-API-DMAC7.html)
EP (1) EP3377636A4 (cg-RX-API-DMAC7.html)
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CN (2) CN116926128A (cg-RX-API-DMAC7.html)
AU (1) AU2016355468B2 (cg-RX-API-DMAC7.html)
CA (1) CA3005136A1 (cg-RX-API-DMAC7.html)
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2772265T1 (en) 2010-05-14 2018-06-29 Oregon Health & Science University HCMV AND RHCMV RECOMBINANT VECTORS AND THEIR APPLICATIONS
SI2691530T1 (en) 2011-06-10 2018-08-31 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
ES2696703T3 (es) 2013-03-05 2019-01-17 Univ Oregon Health & Science Vectores de citomegalovirus que permiten el control del direccionamiento de los linfocitos T
CA3113595A1 (en) 2014-07-16 2016-01-21 Oregon Health & Science University Human cytomegalovirus comprising exogenous antigens
KR20170136512A (ko) 2015-02-10 2017-12-11 오레곤 헬스 앤드 사이언스 유니버시티 넌-캐노니컬 cd8+ t 세포 반응 생성에 유용한 방법 및 조성물
CA3005136A1 (en) 2015-11-20 2017-05-26 Oregon Health & Science University Cmv vectors comprising microrna recognition elements
AU2017280065B2 (en) 2016-06-22 2021-07-01 International Aids Vaccine Initiative, Inc. Recombinant cytomegalovirus vectors as vaccines for tuberculosis
CA3040303A1 (en) 2016-10-18 2018-04-26 Oregon Health & Science University Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules
GB201714430D0 (en) * 2017-09-07 2017-10-25 Micol Romain Compositions and processes for targeted delivery and expression and modulation of therapeutic components in tissue
WO2019079155A1 (en) 2017-10-17 2019-04-25 International Aids Vaccine Initiative, Inc. CASSETTES OF ANTIGENS OF TUBERCULOSIS
WO2020247859A2 (en) * 2019-06-07 2020-12-10 Oregon Health & Science University Tumor-associated antigen-specific t cell responses
US20220307054A1 (en) 2019-08-20 2022-09-29 Oregon Health & Science University Modulation of t cell responses by ul18 of human cytomegalovirus
WO2021168405A1 (en) 2020-02-21 2021-08-26 Combined Therapeutics, Inc. Compositions and methods for organ-protective expression and modulation of coding ribonucleic acids
IL310663A (en) 2021-08-31 2024-04-01 Vir Biotechnology Inc Recombinant hcmv vectors and uses thereof
EP4396208A1 (en) 2021-08-31 2024-07-10 VIR Biotechnology, Inc. Tuberculosis vaccines

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130136768A1 (en) 2010-05-14 2013-05-30 Oregon Health & Science University Recombinant HCMV and RHCMV vectors and uses thereof
WO2014089148A1 (en) 2012-12-05 2014-06-12 Qualcomm Incorporated Successive interference cancellation (sic) ordering algorithms for improved multiple-input multiple-output (mimo) performance
WO2014138209A1 (en) 2013-03-05 2014-09-12 Oregon Health & Science University Cytomegalovirus vectors enabling control of t cell targeting

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
DE3853139T2 (de) 1987-06-26 1995-06-14 Syntro Corp Rekombinanter, fremde gene enthaltender menschlicher cytomegalovirus und seine verwendung.
US5273876A (en) 1987-06-26 1993-12-28 Syntro Corporation Recombinant human cytomegalovirus containing foreign gene
JP2708960B2 (ja) * 1990-08-16 1998-02-04 アイシス・ファーマシューティカルス・インコーポレーテッド サイトメガウイルス感染の作用を変調するオリゴヌクレオチド
SG49046A1 (en) 1991-07-05 1998-05-18 American Cyanamid Co Method for identifying non-essential genes of the human cytomegalovirus genome and for screening for inhibitors of human cytomegaloverirus
WO1995003399A2 (en) 1993-07-19 1995-02-02 Cantab Pharmaceuticals Research Limited Production method for preparation of disabled viruses
JPH09512177A (ja) 1994-04-29 1997-12-09 ファルマシア・アンド・アップジョン・カンパニー ネコ免疫不全ウイルスワクチン
US5846806A (en) 1994-07-29 1998-12-08 American Cyanamid Company Identification of a human cytomegalovirus gene region involved in down-regulation of MHC class I heavy chain expression
AU711121B2 (en) 1995-02-21 1999-10-07 Cantab Pharmaceuticals Research Limited Viral preparations, vectors, immunogens, and vaccines
JPH11503024A (ja) 1995-04-04 1999-03-23 セル・ジェネシス・インコーポレイテッド 細胞表面のクラスi mhcタンパク質の低レベルを有する遺伝子学的に修飾された細胞の移植
ES2237800T3 (es) 1996-07-31 2005-08-01 Ortho-Mcneil Pharmaceutical, Inc. Identificacion de genes del citomegalovirus humano implicados en la retro-regulacion de la expresion de las cadenas pesadas de la clase i del cmh.
US20030138454A1 (en) 1997-06-09 2003-07-24 Oxxon Pharmaccines, Ltd. Vaccination method
DE19733364A1 (de) 1997-08-01 1999-02-04 Koszinowski Ulrich H Prof Verfahren zur Klonierung eines großen Virusgenoms
WO1999007869A1 (en) 1997-08-05 1999-02-18 University Of Florida Live recombinant vaccine comprising inefficiently or non-replicating virus
US6884785B2 (en) * 1999-06-17 2005-04-26 The Scripps Research Institute Compositions and methods for the treatment or prevention of autoimmune diabetes
US7204990B1 (en) 2000-11-28 2007-04-17 Medimmune Vaccines, Inc. Attenuation of cytomegalovirus virulence
WO2002062296A2 (en) 2001-02-02 2002-08-15 Chemocentryx, Inc. Methods and compositions useful for stimulating an immune response
WO2002066629A2 (en) * 2001-02-21 2002-08-29 Gabriele Hahn Recombinant vector containing infectious human cytomegalovirus genome with preserved wild-type characteristics of clinical isolates
GB0122232D0 (en) 2001-09-14 2001-11-07 Medical Res Council Gene expression
IL160809A0 (en) 2001-09-20 2004-08-31 Glaxo Group Ltd HIV-gag CODON-OPTIMISED DNA VACCINES
US20030118568A1 (en) 2001-12-18 2003-06-26 Board Of Trustees Of The University Of Arkansas Viral stealth technology to prevent T cell-mediated rejection of xenografts
JP2005523942A (ja) 2002-04-30 2005-08-11 アヴィオル セラピューティクス インコーポレイテッド 免疫療法のためのアデノウイルスベクター
DE10232322A1 (de) 2002-07-16 2004-07-29 Hahn, Gabriele, Dr. Viral kodierte CxC determinieren den Gewebetropismus von HCMV
US7407744B2 (en) * 2003-07-25 2008-08-05 The Regents Of The University Of California Cytomegalovirus gene function and methods for developing antivirals, anti-CMV vaccines, and CMV-based vectors
EP2497831B1 (en) 2004-05-25 2014-07-16 Oregon Health and Science University TB vaccination using HCMV-based vaccine vectors
EP1602676A1 (en) 2004-06-01 2005-12-07 SOLVAY (Société Anonyme) Catalytic compositions
WO2006004661A1 (en) 2004-06-25 2006-01-12 Medimmune Vaccines, Inc. Recombinant human cytomegalovirus and vaccines comprising heterologous antigens
EP1888622A1 (en) 2005-05-23 2008-02-20 Oxxon Therapeutics Ltd. Compositions for inducing an immune response against hepatitis b
BRPI0615400A2 (pt) 2005-08-31 2011-05-17 Genvec Inc vacinas para malária baseadas em vetor adenoviral
US20100142823A1 (en) 2007-03-07 2010-06-10 Ze Wang 2d partially parallel imaging with k-space surrounding neighbors based data reconstruction
CN101990439A (zh) 2007-07-06 2011-03-23 特鲁比昂药品公司 具有置于c末端的特异性结合结构域的结合肽
RU2498991C2 (ru) 2007-10-30 2013-11-20 Дженентек, Инк. Очистка антител с помощью катионообменной хроматографии
US8074351B2 (en) * 2008-07-25 2011-12-13 Panasonic Corporation Part mounting device and part mounting method
CA2754826A1 (en) * 2009-03-06 2010-09-10 Mount Sinai School Of Medicine Live attenuated influenza virus vaccines comprising microrna response elements
MX2012007489A (es) 2009-12-23 2012-11-29 4Antibody Ag Miembros enlazadores para citomegalovirus.
EP2529227B1 (en) 2010-01-27 2015-10-07 Oregon Health & Science University Cytomegalovirus-based immunogenic preparations
CA2793959C (en) 2010-03-25 2019-06-04 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
JP2013527758A (ja) 2010-05-05 2013-07-04 ティリオン,クリスティアン ベータヘルペスウイルス感染に対するワクチンおよびその使用
SI2691530T1 (en) 2011-06-10 2018-08-31 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
US20130156808A1 (en) 2011-11-22 2013-06-20 Stipan Jonjic Vaccine comprising beta-herpesvirus
EP3623478A1 (en) * 2012-10-25 2020-03-18 Tocagen Inc. Retroviral vector with mini-promoter cassette
CA3113595A1 (en) 2014-07-16 2016-01-21 Oregon Health & Science University Human cytomegalovirus comprising exogenous antigens
EP3048114A1 (en) 2015-01-22 2016-07-27 Novartis AG Cytomegalovirus antigens and uses thereof
KR20170136512A (ko) 2015-02-10 2017-12-11 오레곤 헬스 앤드 사이언스 유니버시티 넌-캐노니컬 cd8+ t 세포 반응 생성에 유용한 방법 및 조성물
CA3005136A1 (en) 2015-11-20 2017-05-26 Oregon Health & Science University Cmv vectors comprising microrna recognition elements
AU2017280065B2 (en) 2016-06-22 2021-07-01 International Aids Vaccine Initiative, Inc. Recombinant cytomegalovirus vectors as vaccines for tuberculosis
CA3028002A1 (en) 2016-06-27 2018-01-04 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
CA3040303A1 (en) 2016-10-18 2018-04-26 Oregon Health & Science University Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130136768A1 (en) 2010-05-14 2013-05-30 Oregon Health & Science University Recombinant HCMV and RHCMV vectors and uses thereof
WO2014089148A1 (en) 2012-12-05 2014-06-12 Qualcomm Incorporated Successive interference cancellation (sic) ordering algorithms for improved multiple-input multiple-output (mimo) performance
WO2014138209A1 (en) 2013-03-05 2014-09-12 Oregon Health & Science University Cytomegalovirus vectors enabling control of t cell targeting

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GREY, F., et al.,"A human cytomegalovirus-encoded microRNA regulates expression og multiple viral genes involved in replication.",PLOS PATHOGENS,2007年11月02日,Vol.3, No.11,e163(pp.1-10),doi: 10.1371/journal.ppat.0030163
PERNG, Y.C., et al.,"The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts.",JOURNAL OF VIROLOGY,2011年05月15日,Vol.85, No.10,pp.4841-4852,doi: 10.1128/jvi.02344-10

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